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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Simple but Effective Ferrocene Derivative as aRedox, Colorimetric,and Fluorescent Receptor forHighly Selective Recognition of Zn2+ Ions 显示文摘 | ZAPATA F CABALLERO A ESPINOSA A etal | 2007 | OrgLett2007，，9： | 1 |
| 3 | Immobilized redox mediators on anion exchange resins and their role on the reductive decolorization of azo dyes显示文摘 | CERVANTES F J GARCIA ESPINOSA A MORENO REY- NOSA M A | 2010 | Environmental Science and Technology2010，44，5： | 1 |
| 4 | Monitoring of heavy metals in topsoils, atmospheric particles and plant leaves to identify possible contamination sources 显示文摘 | Oliva S R Espinosa A J F | 2007 | Microehemical Journal2007，86，： | 1 |
| 5 | Involvement of a Na^+/HCO3^- cotransporter in mouse sperm capacitation显示文摘 | Demarco I A Espinosa F Edwards J | 2007 | Boil Chem2007，278，9： | 1 |
| 6 | Coda wave: a review显示文摘 | HERRAIZ M ESPINOSA A F | 1987 | Pure Appl Geophys1987，125，4： | 1 |
| 7 | A chemical speciation of trace metals for fine urbanparticles 显示文摘 | Espinosa A J F Rodriguez M T De La Rosa F J B | 2002 | Atmospheric Environment2002，36，5： | 1 |
| 8 | Infectivity and genome persistence of rotavirus and astrovirus in groundwater and surface water显示文摘 | Espinosa A C Mazari-Hiriart M Espinosa R MaruriAvidal L Méndez E Arias C F | 2008 | Water Res2008，42，1011： | 1 |
| 9 | A Simple but Effective Ferrocene Derivative as a Redox, Colorimetric, and luorescent Receptor for Highly Selective Recognition of Zn~ ~ Ions 显示文摘 | Zapata F Caballero A Espinosa A | 2007 | Org Lett2007，9，12： | 1 |
| 10 | Monitoring of heavy metals intopsoils,atmospheric particles and plant leaves to identifypossible contamination sources 显示文摘 | Oliva S R Espinosa A J F | 2007 | Microchemical Journal2007，86，1： | 1 |
| 11 | Involvement of a Na+/HCO3-cotransporter in mouse sperm capacitation显示文摘 | Demarco L A Espinosa F Edwards J | 2003 | Biol Chem2003，278，9： | 1 |
| 12 | NMR Investigations of Protein-carbohydrate Interactions Binding Studies and Refined Three-dimensional Solution Structure of the Complex Between the B Domain of Wheat Germ Agglutinin and N,N',N'-triacetylchitotriose显示文摘 | Espinosa J F Asensio J L García J L | 2000 | Eur J Biochem2000，267，： | 1 |
| 13 | Central nervous system involvement in a child with polyarteritis nodosa and severe atopic dermatitis显示文摘 | Morfín-Maciel B Medina A Espinosa Rosales F | 2002 | Rev Alerg Mex2002，49，6： | 1 |
| 14 | Involvement of a Na^+/ HCO3^-cotransporter in mouse sperm capacitation显示文摘 | Demarco I A Espinosa F Edwards J etal | 2003 | J Boil Chem2003，278，9： | 1 |
| 15 | On the resonance frequencies of water-loaded circular plates 显示文摘 | Montero De Espinosa F Gallego-Juarez J A | 1984 | Journal of Sound and Vibration1984，94，2： | 1 |
| 16 | Synthesis, Biological Activity, and Quantitative Structure-Activity Relationship Study of Azanaphthalimide and Arylnaphthalimide Derivatives显示文摘 | Bra(n) M.F Gradillas A Gómez A Acero N Linares F Mu(n)oz-Mingarro D.M Abradelo C Rey-Stolle F Yuste M Campos J Gallo M Espinosa A | | 0，，9： | 1 |
| 17 | Diatom based inference mod-el for paleosalinity reconstructions in estuaries along the northeastern coast of Argentina显示文摘 | Hassan G S Espinosa M A Isla F I-2009 | 2009 | Palaeogeography Palaeoclimatology Palaeo-eeolog2009，275，1： | 1 |
| 18 | Determination of Oxytetracycline and Deoxycycline in Pharmaceutical Compounds,Urine and Honey by Derivative Spectrophotometry显示文摘 | Salinas F Nevado J J B Espinosa A | 1989 | Analyst1989，114，9： | 1 |
| 19 | Adsorptive properties of fish scales of Oreochromis Niloticus (Mojarra Tilapia) for metallic ion removal from waste water显示文摘 | Vfllanueeva- Espinosa J F Hemandez - Esparza M Ruiz- Trevino F A | 2001 | Industrial and Engineering Chemistry Research2001，40，16： | 1 |
| 20 | A new spec-trophotometric method for quantitative multicomponent analysis resolution of muxtures of salicylic and salicyluric acids 显示文摘 | Salinas F Berzas J J Espinosa A | 1990 | Talanta1990，37，3： | 1 |
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