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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Performance of nanocrystalline graphite field emitters显示文摘 | Busta H H Espinosa R J Rakhimov A T Suetin N V | 2001 | Solid State Electronics2001，，45： | 1 |
| 3 | Loss of the lupus au- toantigen Ro52/Trim21 induces tissue inflammation and systemic au-toimmunity by disregulating the IL-23-Th17 pathway 显示文摘 | Espinosa A Dardalhon V Brauner S | 2009 | J Exp Med2009，206，8： | 1 |
| 4 | Cytokines and the regulation of fungus- specific CD4 T cell differentiation 显示文摘 | Espinosa V Rivera A | 2012 | Cytokine2012，58，1： | 1 |
| 5 | Novel Phosphorilated Flame Retardant Thermozets : Epoxy - benzoxazine - novolac Systems 显示文摘 | Espinosa M A Galia M Cadiz V | 2004 | Polymer2004，45，： | 1 |
| 6 | Novel phosphorilated flame retardant thermosets : Epoxy -benzoxazine -novolac systems显示文摘 | ESPINOSA M A GALIA M CADIZ V | 2004 | Polymer2004，45，18： | 1 |
| 7 | Novel flame-retardant thermo- sets:Phosphine oxide-containing diglycidylether as curing agent of phenolic novolac resins显示文摘 | Espinosa M A M Galia V Cadia | 2004 | Polym Sci Part A :Polymm Chem2004，42，： | 1 |
| 8 | Gene expression and functional evidence of epitheli-al-to-mesenchymal transition in papillary thyroid carcinoma invasion显示文摘 | VASKO V ESPINOSA A V SCOUTEN W | 2007 | Proc Natl Acad Sci USA2007，104，： | 1 |
| 9 | High Ro52 expres- sion in spontaneous and UV-induced cutaneous inflamma- tion显示文摘 | Oke V Vassilaki I Espinosa A | 2009 | J Invest Dermatol2009，129，8： | 1 |
| 10 | New cholesterol liquid-crystal epoxy resins derived from 6-hydroxy-20naphthoic显示文摘 | Espinosa M A Cadiz V Calia M | 2001 | J Poly Sci Part A Poly Chem2001，39，： | 1 |
| 11 | 查看详情显示文摘 | Gutiérrez I H Sánchez-Palomo L E Espinosa A V | | 0，，： | 1 |
| 12 | High R052 expression in spontaneous and UV -induced cutaneous inflammation显示文摘 | Oke V Vassilaki I Espinosa A | 2009 | J Invest Dermatol2009，129，20： | 1 |
| 13 | Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway显示文摘 | ESPINOSA A DARDALHON V BRAUNER S | 2009 | J Exp Med2009，206，8： | 1 |
| 14 | Novel phosphorilated flame retardant thermosets: Epoxy-benzoxazine-novolac systems显示文摘 | ESPINOSA M A GALIAK M CADIZ V | 2004 | Polymer2004，45，18： | 1 |
| 15 | Novel phosphorilated flame retardant thermosets : epoxy-benzoxazine-novolac systems 显示文摘 | Espinosa M A Galia M Cadiz V | 2004 | Polymer2004，45，18： | 1 |
| 16 | New cholesteric liquidcryatal epoxy resins derived from 6-hydroxy-2-naphthoic acid 显示文摘 | Espinosa M A Cadiz V Galia M | 2001 | J Poly Sci Part A Poly Chem2001，39，： | 1 |
| 17 | Phenolic composi- tion and magnitude of copigmentation in young and shortly aged red wines made from the cultivars, Cabernet Sauvignon, Cenci- bel, and Syrah显示文摘 | Gutirrrez I H Lorenzo E S P Espinosa A V | 2005 | Food Chem2005，92，2： | 1 |
| 18 | The autoantigen Ro52 is an E3 lig- ase resident in the cytoplasm but enters the nucleus upon cellular expo- sure to nitric oxide显示文摘 | Espinosa A Oke V Elfving A | 2008 | Exp Cell Res2008，314，20： | 1 |
| 19 | Gene expression andfunctional evidence of epithelial-to-mesenchymal transition in papillarythyroid carcinoma invasion显示文摘 | Vasko V Espinosa A V Scouten W | 2007 | Proc Natl Acad Sci USA2007，104，8： | 1 |
| 20 | Gene expressinn and functional evidence of epithelial-to-mesenchymal transition in papillary thy- roid carcinoma invasion显示文摘 | Vasko V Espinosa A V Scouten W | 2007 | Proc Natl Acad Sci U S A2007，104，8： | 1 |
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