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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | A computer model for teaching the dynamic behavior of AC contac- tors显示文摘 | RUIZ J R ESPINOSA A G ROMERAL L | 2010 | IEEE Transactions on Education2010，53，2： | 1 |
| 3 | The acute respiratory distress syndrome in catastrophic antiphospholipid syndrome:analysis of a series of 47patients显示文摘 | Bucciarelli S Espinosa G Asherson RA | 2006 | Ann Rheum Dis2006，65，1： | 1 |
| 4 | Numerical study of penetration in ceramic targets with a multiple-plane model显示文摘 | Espinosa H D Yuan G Dwivedi S | | 0，，： | 1 |
| 5 | Nephropathy associated with antiphospholipid antibodies in patients with systemic lupus erythematosus显示文摘 | Silvarifio R Sant F Espinosa G | 2011 | Lupus2011，20，7： | 1 |
| 6 | Optimal investment under relative performance concerns 显示文摘 | Espinosa G E Touzi N | 2013 | Mathematical Finance2013，，： | 1 |
| 7 | On speed control of induction motors 显示文摘 | Ortega R Nicklasson P J Espinosa G | 1996 | Automatic1996，32，3： | 1 |
| 8 | 查看详情显示文摘 | Duclos S J Jayaraman A Espinosa G P Cooper A S Maines G R | | 0，，： | 1 |
| 9 | Transverse myelitis affect- ing more than 4 spinal segments associated with systemic lupus erythematosus: clinical, immunological, and radiological characteristics of 22 patients 显示文摘 | Espinosa G Mendizabal A Minguez S Ramo - Tello C Capellades J Olive A Cervera R | 2010 | Semin Arthritis Rheum2010，39，4： | 1 |
| 10 | State Observers are Unnecessary for Induction Motor Control显示文摘 | Espinosa G Ortega R | 1994 | System & Control Letters1994，23，5： | 1 |
| 11 | Characterization of wine yeasts by temperature gradient gel electrophoresis (TGGE) 显示文摘 | Hernan G S Espinosa J C Ubeda J F | 2000 | FEMS Microbiology Letters2000，193，： | 1 |
| 12 | Multi- centered study of viral acute lower respiratory infections in children from four cities of Argentina, 1993-1994 显示文摘 | CARBALLAL G VIDELA C ESPINOSA M | 2001 | J Med Virol2001，64，： | 1 |
| 13 | Catastrophic antiphospholipid syndrome - 20 years later显示文摘 | Rodriguez-Pint6 I Espinosa G Cervera R | 2013 | Curr Rheumatol Rev2013，9，2： | 1 |
| 14 | 17beta-estradiol inhibits proliferation and migration of human vascular smooth muscle cells:similar effects in cells from postmenopausal females and males显示文摘 | Dai-Do D Espinosa E Liu G | 1996 | Cardiovasc Res1996，32，5： | 1 |
| 15 | Catastrophic an- tiphospholipid syndrome: diagnosis and management in preg- nancy显示文摘 | Gómez-Puerta JA Espinosa G Cervera R | 2013 | Clin Lab Med2013，33，2： | 1 |
| 16 | Adaptive UAV Attitude EstimationEmploying Unscented Kalman Filter, FOAM and Low-Cost MEMSSensors显示文摘 | Marina H G Espinosa F Santos C | 2012 | Sensors2012，12，7： | 1 |
| 17 | Advances in understanding damage by salt cl'ystallization 显示文摘 | Espinosa - MarzaI R Scherer G W | 2010 | Accounts Chem Res2010，43，6： | 1 |
| 18 | Clinical features and prognosis ofacute myocardial infarction among patients aged 80 year orolder显示文摘 | Ugalde H Espinosa P Pizarro G | 2008 | Rev Med Chil2008，136，6： | 1 |
| 19 | Effect of endothelin-1 on neutrophil adhesion to endothelial cells and cell and perfused heart显示文摘 | Lopez Farre A Riesco A Espinosa G | 1993 | Circulation1993，88，： | 1 |
| 20 | Effects of Echerichia coli lipopolysaccharides and dissolved ammonia on immune response in southern white shrimp Litopenaeus schmitti显示文摘 | Rodriguez-Ramos T Espinosa G Hernindez-L6pez J | 2008 | Aquaculture2008，274，： | 1 |
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