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| 1 | A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion显示文摘heterodimeric 的激活(α /β) 由 cytosolic 蛋白质 talin 的 integrin transmembrane 受体为调整多样的 cell-adhesion-dependent 过程是关键的包括血凝结,改变的组织,和癌症转移。这进程被 talin (talin-FERM ) 的 N 终端 FERM (four-point-one-protein/ezrin/radixin/moesin ) 领域的重合的绑定触发到内部膜表面和 integrin β细胞质的尾巴,但是这些有约束力的事件怎么空间与时间地被调整,仍然保持阴暗。这里,我们报导休眠 talin 的水晶结构,揭示怎么一个 C 终端 talin 杆片断(talin-RS ) 自我面具经由一个大接口的 talin-FERM 上的一个关键 integrin 有约束力的地点。出人意料地,结构也在静电地妨碍 talin-FERM 绑定到膜的 talin-RS 上揭示不同否定地控告的表面。为 talin 的如此的双禁止的拓扑学与生物化学、功能的数据一致,但是与一个以前的模型显著地不同。我们与 phosphotidylinositol-4,5-bisphosphate (PIP2 ) 在丰富之上显示出那 - 已知的 talin 使活跃之物,膜强烈在 talin-FERM 上吸引断然控告的表面并且同时在 talin-RS 上排斥否定地控告的表面。如此的静电的 “ pull-push”过程支持 talin-FERM 的双抑制的消除,它不同于经典 “位的 clash”为常规导致 PIP2 的 FERM 领域激活当模特儿。这些数据因此解开膜依赖者 FERM 领域规定的一种新类型并且说明它怎么调停 talin 开/关换到调整 integrin transmembrane 发信号和房间粘附。 | Xianqiang Song Jun Yang Jamila Hirbawi Sheng Ye H Dhanuja Perera Esen Goksoy Pallavi Dwivedi Edward F Plow Rongguang Zhang Jun Qin | 2012 | Cell Research2012，22，11： | 5 |
| 2 | Economics and politics of cross-border oil pipelines the case of the Caspian basin显示文摘 | RABALLAND G ESEN F | 2006 | Asia Europe Journal2006，5，1： | 1 |
| 3 | Comparison of the effects of an adhe- sion barrier and chitin on experimental epidural fibrosis 显示文摘 | Keskin F Esen H | 2010 | Turk Neurosurg2010，20，4： | 1 |
| 4 | Concentration and gas/particle partitioning of polychlorinated biphenyls (PCBs) at an industrial site at Bursa, Turkey 显示文摘 | Cindoruk S S Esen F Tasdemir Y | 2007 | Atmospheric Research2007，85，34： | 1 |
| 5 | Modeling of a new solar air heater through least squares support vector machine显示文摘 | ESEN H OZGEN F ESEN M | 2009 | Expert Systems with Applications2009，36，10： | 1 |
| 6 | Pituitary dimensions and volume measurements in pregnancy and post partum MR assessment显示文摘 | Dinc H Esen F Demiric A | 1998 | Acta Radiol1998，39，1： | 1 |
| 7 | Reliability of procalcitonin as a severity marker in critically ill patients with inflammatory respones显示文摘 | Tugrul S Esen F Celebi S | 2002 | Anaesth Intersive Care2002，30，6： | 1 |
| 8 | Are we aware how contaminated our mobile phones with nosocomial pathogens? 显示文摘 | Ulger F Esen S Dilek A | 2009 | Ann Clin Microbiol Antimicrob2009，6，8： | 1 |
| 9 | Reliability of procalcitonin as a severity marker in critically ill patients with inflammatory response 显示文摘 | Tugrul S Esen F Celebi S | 2002 | Anaesth Intensive Care2002，30，6： | 1 |
| 10 | Modeling of a new solar air heater through least squares support vector machines显示文摘 | Esen H Ozgen F Esen M | | 0，，07： | 1 |
| 11 | Hypothyroidism-associated testicular enlargement: is it a form of precocious puberty or not? A case report显示文摘 | Esen I Demirel F | 2011 | Turk J Pediatr2011，53，2： | 1 |
| 12 | Evaluation of discectomy and dermis-fat grafting on the contralateral side 显示文摘 | Candirli C Esen A Taskesen F | 2012 | J Craniofac Surg2012，23，6： | 1 |
| 13 | Concentration and gas/particle partitioning of polychlorinated biphenyls(PCBs) at an industrial site at Bursa, Turkey 显示文摘 | CINDORUK S S ESEN F TASDEMIR Y | 2007 | Atmos Res2007，85，34： | 1 |
| 14 | Are we aware how contaminated our mobile phones with nosocomial pathogens? 显示文摘 | Ulger F Esen S Dilek A | 2009 | Nurs Crit Care2009，14，4： | 1 |
| 15 | Evaluation of effects of magnesium sulphate in reducing intraoperative anaesthetic requirements显示文摘 | TELCI L ESEN F AKCORA D | 2002 | Br J Anaesth2002，89，： | 1 |
| 16 | Clinicoradiological evaluation of dermis-fat grafts after temporomandibular joint discectomy: a retrospective study 显示文摘 | Candirli C Esen A Taskesen F | 2012 | Natl J Maxillofac Surg2012，3，1： | 1 |
| 17 | Reliability of procalcitonin as a severity marker in critically ill patients with inflammatory response 显示文摘 | Tugruk S Esen F Celebi S | 2002 | Anaesth Intensive Care2002，30，6： | 1 |
| 18 | Are we aware how contaminated our mobile phones with nosocomial pathogens显示文摘 | Ulger F Esen S Dilek A | 2009 | Ann Clin Microb Anti2009，14，4： | 1 |
| 19 | Effects of magnesium administration on brain edema and blood-brain barrier breakdown after experimental traumatic brain injury in rats显示文摘 | Esen F Erdem T Aktan D et aI | 2003 | J Neurosurg Anesthesiol2003，15，： | 1 |
| 20 | Effect of magnesium sulfate administration on blood-brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study 显示文摘 | Esen F Erdem T Aktan D | 2005 | Critical Care2005，9，1： | 1 |
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