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1英国胃肠病学会关于胃癌风险患者的诊断和管理指南显示文摘胃癌预后较差,部分原因在于诊断较晚。胃癌的危险因素包括幽门螺杆菌(H.pylori,HP)感染和胃癌家族史,尤其是遗传性弥漫性胃癌和恶性贫血。胃癌发展的阶段包括慢性胃炎、胃黏膜萎缩(GA)、胃黏膜肠化生(GIM)和异型增生。胃癌早期发现和提高生存率的关键是在内镜检查前以非侵入性方式识别高危人群。然而,尽管生物标志物可能有助于检测慢性萎缩性胃炎,但尚无足够的证据支持其用于人群筛查。高质量内镜检查是胃癌早期发现的重要组成部分,图像增强内镜结合组织病理学活检是GA和GIM最佳的诊断方法,并能准确进行风险分层。按照悉尼标准从胃窦、角切迹、小弯和大弯进行活检,既能明确诊断,也能对胃癌进行风险分层。理想状态应当是在高质量内镜检查中对GA或GIM区域活检。英国属于低危地区,可根据需要接受常规诊断性胃镜检查,但没有足够证据支持筛查,对于广泛GA或GIM的患者,每3年检查内镜。对于胃异型增生和早期癌,只要满足标准,内镜下黏膜切除术或内镜黏膜下剥离术的治疗有效,成功率高,复发率低。Matthew Banks David Graham Marnix Jansen TakujiGotoda Sergio Coda Massimiliano di Pietro NoriyaUedo Pradeep Bhandari D Mark Pritchard Ernst J Kuipers Manuel Rodriguez-Justo Marco R Novelli KrishRagunath Neil Shepherd Mario Dinis-Ribeiro 乌雅罕(译) 张冬雪(译) 牛占岳(校) 刘鑫(校) 丁士刚(译/校) 2020中华胃肠内镜电子杂志2020,7,2:10
2维生素D对心力衰竭患者全因死亡率的影响:4000U/d维生素D口服3年随机临床试验结果显示文摘循环25-羟基维生素D[25-hydroxyvitamin D,25(OH)D]〈75nmol/L与死亡率风险的非线性增加相关。这种低25(OH)D水平在心力衰竭患者中很常见。因此,Zittermann等进行研究检查口服维生素D补充剂能否降低晚期心力衰竭患者的死亡率。刘莉 叶鹏 Zittermann A Ernst JB Prokop S Fuchs U Dreier J Kuhn J Knabbe C Birschmann I Schulz U Berthold HK Pilz S Gouni-Berthold I Gummert JF Dittrich M Brgermann J 2017中华高血压杂志2017,25,10:7
3Adenoma detection with cap-assisted colonoscopy versus regular colonoscopy: a randomised controlled trial显示文摘Thomas R de Wijkerslooth Esther M Stoop Patrick M Bossuyt Elisabeth M H Mathus-Vliegen Jan Dees Kristien M A J Tytgat Monique E van Leerdam Paul Fockens Ernst J Kuipers Evelien Dekker 2012Gut2012,,10:3
4Challenges in the management of acute peptic ulcer bleeding显示文摘James YW Lau Alan Barkun Dai-ming Fan Ernst J Kuipers Yun-sheng Yang Francis KL Chan 2013The Lancet2013,,9882:3
5Hemorrheologic changes following acute myocardialin farction显示文摘Dormandy J Ernst E Matrai A 1982Am Heart J1982,104,8:2
6Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study显示文摘Markus Ketteler Philipp Bongartz Ralf Westenfeld Joachim Ernst Wildberger Andreas Horst Mahnken Roland B?hm Thomas Metzger Christoph Wanner Willi Jahnen-Dechent Jürgen Floege 2003The Lancet2003,,9360:2
7Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett’s oesophagus显示文摘Florine Kastelein Katharina Biermann Ewout W Steyerberg Joanne Verheij Marit Kalisvaart Leendert H J Looijenga Hans A Stoop Laurens Walter Ernst J Kuipers Manon C W Spaander Marco J Bruno 2013Gut2013,,12:2
8Seasonal and spatial variation in the occurrence of vesicular - arbuscular (VA) mycorrkiza in salt marsh plants 显示文摘Van Duin WE Rozema J Ernst WHO 1989Agriculture Ecosystems and Environment1989,29,:1
9Coating Bores of light metal engine blocks with a nano- composite material using the Plasma trans--ferred wire arc thermal spray process 显示文摘Bobzin K Ernst F Zwick J 2008Journal of thermal spray technology2008,17,3:1
10Der E-Modul von seilen unter brucksichtigung des durchhangers 显示文摘Ernst H J 1965Der Bauingenieur1965,40,2:1
11Interferon-g-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis 显示文摘DesVignes L Ernst J D 2009Immunity2009,31,6:1
12Dynamically discovering likely program invariants to support program evolution 显示文摘Ernst M D Cockrell J Griswold W G 2001IEEE Transactions on Software Engineering2001,27,:1
13Regulated binding of PTP1B-like phosphatase to N-cadherin:control of cadherin-mediated adhesion by dephosphorylation of beta-catenin显示文摘Balsamo J Leung T Ernst H 1996J Cell Biol1996,134,3:1
14Patent portfolio analysis as a useful tool for identifying R&D and busi- ness opportunities--an empirical application in the nutri- tion and health industry 显示文摘Fabry B Ernst H Langholz J 2006World Patent Information2006,28,:1
15Antidepressant effects of exercise: evidence for an adult-neurogenesis hypothesis? 显示文摘ERNST C OLSON A K PINEL J P 2006J Psy Neuro2006,31,2:1
16Differential activation of the c - Ki - ras - 2 proto - oucogene in human colorectal carcinoma 显示文摘Halatsch ME Hirsch - Ernst KI Weinel R J 1998Anticancer Res1998,18,4:1
17Hardware-software cosynthesis for microcontrollers显示文摘Ernst R Henkel J Benner T 1993IEEE Design & Test of Computers1993,10,4:1
18Some effects of oxygen breathing in man显示文摘ERNSTING J 1960Proc Roy Soc Med1960,53,1:1
19Methods for causality assessment of adverse drug reactions:a systematic review显示文摘Agbabiaka TB Savovic J Ernst E 2008Drug Saf2008,31,1:1
20Patent portfolio analysis as a useful tool for identifying R&D and business opportunities An empirical application in the nutrition and health industry 显示文摘Fabry B Ernst H Langholz J 2006World Patent Information2006,28,3:1
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