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| 1 | Two-dimensional speckle tracking echocardiography for the assessment of atrial function显示文摘Echocardiography is the most common diagnostic method for assessing atrial function but the technique has some limitations. Traditionally, assessment of left atrial function has been performed by measuring volumes with 2D echocardiography. Additionally, it can be assessed with transmitral Doppler and pulmonary vein Doppler. Recently, an alternative method has been incorporated, namely, measurement of myocardial deformation with color tissue Doppler-derived strain. However, this method has several limitations, such as suboptimal reproducibility, angle-dependence, signal artifacts and the fact that it only measures regional strain and does not obtain information about the curved portion of the atrial roof. To overcome these limitations in the quantification of atrial function, the use of speckle tracking echocardiography (STE) strain has been proposed. This technique is not derived from Doppler but rather from 2D echocardiography; it is angle-independent and allows one to measure global as well as regional atrial strain. In this editorial, we describe the physical and pathophysiological concepts of STE and underline the clinical usefulness of this new technique. | Tomás Francisco Cianciulli María Cristina Saccheri Jorge Alberto Lax Alejandra Marina Bermann Daniel Ernesto Ferreiro | 2010 | World Journal of Cardiology2010，2，7： | 39 |
| 2 | Heart failure with preserved ejection fraction in the elderly: pathophysiology, diagnostic and therapeutic approach显示文摘Heart failure with preserved ejection fraction(HFpEF)is a clinical syndrome characterized by symptoms and sings of heart failure with elevated left ventricular filling pressures at rest or during exercise.It is the most common type of heart failure in the elderly and its prevalence increases with age and is higher in females at any given age.HFpEF is frequently accompanied of comorbid conditions such as diabetes mellitus,obesity,atrial fibrillation and renal dysfunction.The diagnosis relies in the integration of clinical information,laboratory data and interpretation of cardiac imaging and hemodynamic findings at rest and during exercise.Conditions that have a specific treatment such as coronary artery disease,valvular disease,cardiac amyloidosis and constrictive pericarditis should be considered and evaluated as appropriate.Aggressive management of comorbidities,optimization of blood pressure control and volume status using diuretics as needed are among the current treatment recommendations.There are no specific therapies that have shown to decrease mortality in HFpEF.In symptomatic patients with history of hospital admission for decompensated heart failure,the implantation of a wireless pulmonary artery pressure monitor should be considered.Finally,given the high mortality of this condition,goals of care discussion should be initiated early and involvement of palliative care medicine should be considered. | Ernesto Ruiz Duque Alexandros Briasoulis Paulino A Alvarez | 2019 | Journal of Geriatric Cardiology2019，16，5： | 13 |
| 3 | Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin显示文摘AIM To evaluate the association of Helicobacter pylori(H. pylori), cag A genotype, and type of gastric pathology with ghrelin, leptin and nutritional status.METHODS Fasted dyspeptic adults(18-70 years) referred for an upper digestive endoscopy were enrolled in this crosssectional study. Height and weight were assessed for body mass index(BMI) calculation. A sociodemographic survey was administered and nutrient intake was evaluated with 24 h dietary recalls. Serum total ghrelin and leptin levels were analyzed by enzymelinked immunosorbent assay. 13 C-Urea Breath Test was performed and four gastric biopsies were obtained during endoscopy for histopathology and H. pylori DNA amplification and genotyping. Data analysis was performed using χ2, Mann-Whitney U, Kruskal-Wallis tests, Spearman's correlation and linear regression.RESULTS One hundred and sixty-three patients(40.8 ± 14.0 years), 98/65 females/males, were included. Overall, persistent H. pylori prevalence was 53.4%(95%CI: 45.7%-65.8%). Neither nutrient intake nor BMI differed significantly between H. pylori positive and negative groups. Serum ghrelin was significantly lower in infected patients [median 311.0 pg/m L(IQR 230.0-385.5)] than in uninfected ones [median 355.0 pg/m L(IQR 253.8-547.8)](P = 0.025), even after adjusting for BMI and gender(P = 0.03). Ghrelin levels tended to be lower in patients carrying cag A positive strains both in the antrum and the corpus; however, differences with those carrying cag A negative strains did not reach statistical significance(P = 0.50 and P = 0.49, respectively). In addition, the type and severity of gastric pathology in the corpus was associated with lower serum ghrelin(P = 0.04), independently of H.pylori status. Conversely, leptin levels did not differ significantly between infected and uninfected patients [median 1.84 ng/m L(0.80-4.85) vs 1.84 ng/m L(0.50-5.09),(P = 0.51)]. CONCLUSION H. pylori infection and severity of gastric corpus pathology are associated with lower serum ghrelin. Further studies could confirm a lower ghrelin prevalence in cag A-positive patients. | Paula Mantero Gonzalo Sebastián Matus Rodolfo Ernesto Corti Ana María Cabanne Gerardo Gabriel Zerbetto de Palma Liliana Marchesi Olid María Marta Piskorz Marcela Beatriz Zubillaga Mariana Andrea Janjetic Cinthia Gabriela Goldman | 2018 | World Journal of Gastroenterology2018，24，3： | 8 |
| 4 | Pathogenesis and diagnosis of contact dermatitis:Applications of reflectance confocal microscopy显示文摘Contact dermatitis(CD) is the most common professional skin disease, with frequencies ranging from 24 to 170 every 100000 individuals. Approximately 20% of the United States population suffers from CD. CD can be classified according to its origin and severity. ICD stands for irritant CD, whereas ACD means allergic CD. Their clinical presentation includes acute, sub-acute and chronic eczema. Despite their different origin, ICD and ACD often present similar clinical and histologic findings. The current gold standard for diagnosis is patchtesting. However, patch-testing is being questioned in terms of validity and reproducibility, as it relies heavily on the skill of the observer. Real-time reflectance confocal microscopy is a non-invasive imaging technique that bears strong promise for the study of CD, and it enables the evaluation of cellular and subcellular changes over time with similar resolution compared to that of conventional histology. | Jorge A Suárez-Pérez Ricardo Bosch Salvador González Ernesto González | 2014 | World Journal of Dermatology2014，3，3： | 2 |
| 5 | 轨枕间距对钢轨波磨的影响显示文摘主要研究轨枕间距对钢轨波磨发展的影响。研究小半径曲线内轨的小矢跨比波磨。这些出现问题的曲线段属于西班牙毕尔巴鄂区域的地铁轨道,铺设着混凝土道床和两层STEDEF型支承垫层。当初始轨枕间距为1000mm时,仅有92万组轮对通过后所测得的波磨深度峰-峰值已经达到0.42mm。随后更换产生波磨的钢轨,比较列车通过时轨枕上方和轨间中部的内轨垂向、横向加速度。当轨枕间距为1000mm时,轨间中部出现频率为204和244Hz的强烈响应,在轨枕上方却未出现。在相邻轨枕中间铺设一个轨枕,使轨枕间距变为500mm,钢轨波磨停止发展。该结论是根据2年的观测结果得到的。 | Ernesto García Vadillo José A.Tárrago Gorka Garate Zubiaurre Carlos Angulo Duque 孙晓静 聂志理 | 2010 | 都市快轨交通2010，23，2： | 2 |
| 6 | Spark plasma sintering of Ti x Ta 1? x C 0.5 N 0.5 -based cermets: Effects of processing conditions on chemistry, microstructure and mechanical properties显示文摘 | José M. Córdoba Ernesto Chicardi Rosalía Poyato Francisco J. Gotor Valentina Medri Stefano Guicciardi Cesare Melandri | 2013 | Chemical Engineering Journal2013，，： | 1 |
| 7 | Microprocessor- Controlled Nanovolt Measurements 显示文摘 | ERNESTO A UMBERTO Potentiometric System for P | 1978 | IEEE Transactions On Instrumentation And Measurement1978，，： | 1 |
| 8 | Carbon supported Pt70Co30 electrocatalyst prepared by the formic acid method for the oxygen reduction reaction in polymer electrolyte fuel eells显示文摘 | Jose R C S Ermete A Ernesto R G | 2005 | J Power Sources2005，141，1： | 1 |
| 9 | Induced dendritic cell differentiation of chronic myeloid leukemia blasts is associated with down-regulation of BCR-ABL显示文摘 | Inna Lindner Mohamed A Kharfan-Dabaja Ernesto Ayala | 2003 | J Immunology2003，171，： | 1 |
| 10 | Endothelial Dysfunction in Salt-Sensitive Essential Hypertension显示文摘 | Ernesto Bragulat Alejandro de la Sierra María Teresa Antonio Antonio Coca | | 2001 (2, P)0，，： | 1 |
| 11 | Effect of temperature on the measurement of moisture content in schinopsis balansae显示文摘 | Maria A J JosrM P Ernesto S | 2001 | Journal of Quebracho2001，33，6： | 1 |
| 12 | The impact of a 100% smoke- free law on the health of hospitality workers from the city of Neuquen, Argentina显示文摘 | Veronica S Mariela A Ernesto R | 2010 | Tob Control2010，19，： | 1 |
| 13 | Anti-ulcerogenic and anti-inflammatory activity of the methanolic extract of Larrea divaricata Cav. in rat显示文摘 | Ana María Pedernera Teresita Guardia Carola Guardia Calderón Alejandra Ester Rotelli Nadir Ernesto de la Rocha Silvia Di Genaro Lilian Eugenia Pelzer | 2005 | Journal of Ethnopharmacology2005，，3： | 1 |
| 14 | Cox maze III procedure: The best alternative in surgery for atrial fibrillation显示文摘 | Ovidio A. Garcia-Villarreal Ernesto Fernández-Cese?a Raquel Vega-Hernández | 2014 | The Journal of Thoracic and Cardiovascular Surgery2014，，1： | 1 |
| 15 | Advantages of fungal enzyme production in solid state over liquid fermentation systems 显示文摘 | GUSTAVO V G ERNESTO F T CRISTOBAL N A | 2003 | J Biochem Eng2003，13，： | 1 |
| 16 | Performance analysis of cross-coupled controllers for CNC machines based upon precise real-time contour error measurement 显示文摘 | Conway J R Ernesto C A Farouki R T | 2012 | International Journal of Machine Tools and Manufacture2012，52，1： | 1 |
| 17 | Myocardial fibrosis in DOCA-salt hypertensive rats effect of endothelin ETA receptor antagonism显示文摘 | Fatima A Isabelle L Ernesto LS | 2001 | Circulation2001，103，： | 1 |
| 18 | Salinity and nitrogen rate effects on the growth and yield chile pepper plant显示文摘 | Magdalena V C April L U Ernesto A C | 2003 | Soil Science Society of America Journal2003，，67： | 1 |
| 19 | Peroxi- some proliferator-activated receptors: vascular and cardiac effects in hypertension 显示文摘 | Ernesto LS Farhad A Karim B | 2003 | Hyper- tension2003，42，4： | 1 |
| 20 | Advantages of fungal enzyme production in solid state over liquid fermentation systems 显示文摘 | GUSTAVO V G ERNESTO F T CRISTOBAL N A | 2003 | Biochem Eng J2003，13，： | 1 |
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