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| 1 | Constitutive STAT3 phosphorylation and IL-6/IL-10 co-expression are associated with impaired T-cell function in tuberculosis patients显示文摘T-cells critically contribute to protection against Mycobacterium tuberculosis infection,and impaired T-cell responses can lead to disease progression.Pro-inflammatory and immunosuppressive cytokines affect T-cells,and fine-tuned regulation of cytokine signaling via the Jak/STAT signaling pathways is crucial for appropriate T-cell function.Constitutive STAT3 phosphorylation as a consequence of aberrant cytokine signaling has been described to occur in pathognomonic T-cell responses in inflammatory and autoimmune diseases.We characterized blood samples from tuberculosis patients(n=28)and healthy contacts(n=28)from Ghana for M.tuberculosis-specific T-cell responses,constitutive cytokine production,and SOCS3 and pSTAT3 expression.Lentiviral modulation of primary CD4+T-cells was performed to determine the effects of SOCS3 on T-cell functions.T-cells from tuberculosis patients expressed higher levels of IL-10 and IL-6 and lower levels of T helper type(TH)17 cytokines after M.tuberculosis-specific stimulation compared to healthy contacts.In addition,tuberculosis patients had higher IL-10 and IL-6 levels in the supernatants of non-stimulated immune cells and plasma samples compared to healthy contacts.Notably,aberrant cytokine expression was accompanied by high constitutive pSTAT3 levels and SOCS3 expression in T-cells.Multivariate analysis identified an IL-6/IL-10 co-expression-based principal component in tuberculosis patients that correlated with high pSTAT3 levels.SOCS3 contributed to a regulatory component,and tuberculosis patients with high SOCS3 expression showed decreased TH1 cytokine expression and impaired IL-2-induced STAT5 phosphorylation.SOCS3 over-expression in primary CD4+T-cells confirmed the SOCS3 inhibitory function on IL-2-induced STAT5 phosphorylation.We conclude that constitutive pSTAT3 and high SOCS3 expression are influential factors that indicate impaired T-cell functions in tuberculosis patients. | Kirstin Harling Ernest Adankwah Alptekin Güler Anthony Afum-Adjei Awuah Louis Adu-Amoah Ertan Mayatepek Ellis Owusu-Dabo Norman Nausch Marc Jacobsen | 2019 | Cellular & Molecular Immunology2019，16，3： | 15 |
| 2 | Role of capsule endoscopy in inflammatory bowel disease显示文摘Videocapsule endoscopy(VCE) has revolutionized our ability to visualize the small bowel mucosa. This modality is a valuable tool for the diagnosis of obscure small bowel Crohn's disease(CD), and can also be used for monitoring of disease activity in patients with established small-bowel CD, detection of complications such as obscure bleeding and neoplasms, evaluation of response to anti-inflammatory treatment and postoperative recurrence following small bowel resection. VCE could also be an important tool in the management of patients with unclassified inflammatory bowel disease, potentially resulting in reclassification of these patients as having CD. Reports on postoperative monitoring and evaluation of patients with ileal pouch-anal anastomosis who have developed pouchitis have recenty been published. Monitoring of colonic inflammatory activity in patients with ulcerative colitis using the recently developed colonic capsule has also been reported. Capsule endoscopy is associated with an excellent safety profile. Although retention risk is increased in patients with small bowel CD, this risk can be significanty decreased by a routine utilization of a dissolvable patency capsule preceding the ingestion of the diagnostic capsule. This paper contains an overview of the current and future clinical applications of capsule endoscopy in inflammatory bowel disease. | Uri Kopylov Ernest G Seidman | 2014 | World Journal of Gastroenterology2014，20，5： | 4 |
| 3 | Modeling coagulation kinetics incorporating fractal theories:a fractal rectilinear approach显示文摘 | Lee D G Bonner J S Garton L S Ernest A N S Auternrieth R L | 2000 | Water Research2000，34，7： | 1 |
| 4 | Virtual topology reconfiguration in IP/WDM optical ring networks显示文摘 | Mohan G Ernest P H H Bharadwaj V | 2003 | Computer Communications2003，26，2： | 1 |
| 5 | How do radiographic techniques affect image quality and patient doses in CT?显示文摘 | Walter Huda James G Ravenel Ernest M Scalzetti | 2002 | Seminars in Ultrasound CT and MRI2002，，5： | 1 |
| 6 | Developing paediatric medicines: identifying the needs and recognizing the challenges 显示文摘 | ERNEST T B ELDER D P MARTINI L G | 2007 | J Pharm Pharacol2007，59，8： | 1 |
| 7 | Endothelial cell loss after 4 mm cataract surgery 显示文摘 | Lavery KT Mcdermot ML Ernest PH Edelhauser HF Kiessling LA Holley G | 1995 | J Cataract Refract Surg1995，21，7： | 1 |
| 8 | A model for the complex between the hypoxia inducib-le factor-1(HIF-1) and its consensus DNA sequence显示文摘 | Michel G Minet E Ernest I | | 0，，02： | 1 |
| 9 | Current status of platinum-based antitumor drugs显示文摘 | ERNEST W CHHRISTEN M G | 1999 | Chem Rev1999，99，： | 1 |
| 10 | Long-term results in 64 patients operated upon for pheochromcytoma显示文摘 | Stenstrom G Ernest I Tisell LE | 1988 | Acta Med Sand1988，223，： | 1 |
| 11 | Fantasy and rhetorical vision: The rhetorical crit- icism of social reality 显示文摘 | Bormann Ernest G | 1972 | Quarterly Journal of Speech1972，58，4： | 1 |
| 12 | Molecular modeling of the hypoxia-inducible factor I(HIF-1)显示文摘 | Michel G Minet E Ernest I | 1999 | Theor Chem Ace1999，101，： | 1 |
| 13 | Fantasy and rhetorical vision: Ten years later 显示文摘 | Bormann Ernest G | 1982 | Quarterly Journal of Speech1982，68，3： | 1 |
| 14 | Fantasy and Rhetorical Vision : A Rhe- torical Criticism of Social Reality 显示文摘 | Bormann Ernest G | 1972 | Quarterly Journal of Speech1972，，58： | 1 |
| 15 | Feature selection on node statisticsbased embedding of graphs 显示文摘 | Jaume G Ernest V Horst B | 2012 | Pattern Recognition Letters2012，33，15： | 1 |
| 16 | Current status of platinum-based antitumor drugs显示文摘 | ERNEST W CHHRISTEN M G | 1999 | Chem Rev1999，99，： | 1 |
| 17 | Complex species interactions and the dynamics of ecological systems: Long-term experiments显示文摘 | Brown J H Whithmu T G M Ernest S K | 2001 | Science2001，293，5530： | 1 |
| 18 | Mechanism of action of and resistance to quinolones显示文摘 | Anna F Sergi M Ernest G | 2009 | Microb Biotechnol2009，2，3： | 1 |
| 19 | Theoretical framework for spectrum analysis in ultrasonic tissue characterization显示文摘 | Frederic L Michael G Ernest F | 1983 | Journal of the Acoustical Society of America1983，73，4： | 1 |
| 20 | The release of fatty acids as a consequence of yeast autolysis显示文摘 | Ernest C H Jamieson A M Gheluwe G V | 1980 | ASBC1980，38，1： | 1 |
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