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| 1 | Conducting health policy analysis in primary care research: turning clinical ideas into action显示文摘Healthcare guidelines play a prominent role in the daytoday practice of primary care providers,and health policy research leads to the formation of these guidelines.Health policy research is the multidisciplinary approach to public policy explaining the interaction between health institutions,special interests and theoretical constructs.In this article,we demonstrate how primary care providers can conduct high-impact health policy research using Eugene Bardach’s eightfold policy analysis framework in a primary care context.In a medical case,a woman with a history of total hysterectomy had scheduled a visit for a Papanicolaou(Pap)smear screening test as part of a well-woman health check-up with a family medicine resident.Conflicting recommendations on Pap smear screening after total hysterectomy sparked an investigation using the US Preventive Services Task Force criteria for conducting a health policy analysis.We illustrate broadly how clinical care dilemmas can be examined by using Bardach’s broadly applicable health policy framework in order to inform meaningful policy change.Bardach’s framework includes(1)defining the problem,(2)assembling evidence,(3)constructing alternatives,(4)selecting criteria,(5)projecting outcomes,(6)confronting trade-offs,(7)decision-making and(8)sharing the results of the process.The policy analysis demonstrated insufficient evidence to recommend Pap test screening after hysterectomy and the findings contributed to national recommendations.By following Bardach’s steps,primary care researchers have a feasible and powerful tool for conducting meaningful health policy research and analysis that can influence clinical practice. | Alina Engelman Ben Case Lisa Meeks Michael D Fetters | 2019 | Family Medicine and Community Health2019，7，2： | 6 |
| 2 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 3 | Retroviral integrase protein and intasome nucleoprotein complex structures显示文摘Retroviral replication proceeds through the integration of a DNA copy of the viral RNA genome into the host cellular genome, a process that is mediated by the viral integrase(IN) protein. IN catalyzes two distinct chemical reactions: 3'-processing, whereby the viral DNA is recessed by a di- or trinucleotide at its 3'-ends, and strand transfer, in which the processed viral DNA ends are inserted into host chromosomal DNA. Although IN has been studied as a recombinant protein since the 1980 s, detailed structural understanding of its catalytic functions awaited high resolution structures of functional IN-DNA complexes or intasomes, initially obtained in 2010 for the spumavirus prototype foamy virus(PFV). Since then, two additional retroviral intasome structures, from the α-retrovirus Rous sarcoma virus(RSV) and β-retrovirus mouse mammary tumor virus(MMTV), have emerged. Here, we briefly review the history of IN structural biology prior to the intasome era, and then compare the intasome structures of PFV, MMTV and RSV in detail. Whereas the PFV intasome is characterized by a tetrameric assembly of IN around the viral DNA ends, the newer structures harbor octameric IN assemblies. Although the higher order architectures of MMTV and RSV intasomes differ from that of the PFV intasome, they possess remarkably similar intasomal core structures. Thus, retroviral integration machineries have adapted evolutionarily to utilize disparate IN elements to construct convergent intasome core structures for catalytic function. | Julia Grawenhoff Alan N Engelman | 2017 | World Journal of Biological Chemistry2017，8，1： | 2 |
| 4 | Targeted downregulation of caveolin- 1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade 显示文摘 | Galbiati F Volonte D Engelman JA | 1998 | EMBO J1998，17，22： | 2 |
| 5 | The PI3 K path way as drug target in human cancer 显示文摘 | Courtney KD Corcoran RB Engelman JA | 2010 | J Clin Oncol2010，28，6： | 1 |
| 6 | Ischemic preconditioning attenuates apoptotic cell death associated with ischemia/reperfusion 显示文摘 | Maulik N Yoshida T Engelman RM | 1998 | Mol Cell Biochem1998，186，12： | 1 |
| 7 | Sodium intake and mortality 显示文摘 | Engelman K | 1998 | Lancet1998，351，： | 1 |
| 8 | MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling显示文摘 | ENGELMAN J A ZEJNULLAHU K MITSUDOMI T | 2007 | Science2007，316，5827： | 1 |
| 9 | MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling显示文摘 | Engelman JA Zejnullahu K Mitsudomi T etal | 2007 | Science2007，316，5827： | 1 |
| 10 | MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling显示文摘 | Engelman JA Zejnullahu K Mitsudomi T | | 0，，5827： | 1 |
| 11 | Caveolin-3 null mice show a loss of caveolae,changes in the microdomain distribution of the dystrophin- glycoprotein complex,and t-tubule abnormalities显示文摘 | Galbiati F Engelman J A Volonte D | 2001 | The Journal of Biological Chemistry2001，276，21： | 1 |
| 12 | Clinical activity of crizotinib in patients with advanced non-small cell lung cancer (NSCLC) harboring ROS1 gene rearrangement 显示文摘 | Shaw AT Camidge DR Engelman J | 2012 | Ann Oncol2012，30，： | 1 |
| 13 | Myocardial protection by preconditioning of heart with losartan, an angiotensin II type 1-receptor blocker显示文摘 | Sato M Engelman RM Otani H | 2000 | Circulation2000，102，： | 1 |
| 14 | Percutaneous dilational tracheostomy in a medical ICU显示文摘 | Petros S Engelman L | 1997 | Intensive CareMed1997，23，： | 1 |
| 15 | MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling显示文摘 | Engelman JA Zejnullahu K Mitsudomi T | 2007 | Science2007，316，5827： | 1 |
| 16 | Mechanisms of acquired resistance to epidermal growth receptor tyrosine kinase inhibitors in non-small cell lung cancer显示文摘 | Engelman JA J(o)nne PA | | 0，，10： | 1 |
| 17 | MET amplification leads to gefitinib resistance in lung cancer by activating ErbB3 signaling显示文摘 | Engelman JA Zejnullahu K Mitsudomi T | 2007 | Science2007，316，5827： | 1 |
| 18 | Tar- geted down-regulation of caveolin-3 is sufficient to inhibit myotube formation in differentiating C2C12 myoblasts-transient activation of p38 mitogen- activated protein kinase is required for induction of caveolin-3 expression and subsequent myotube for- mation显示文摘 | Galbiati F Volonte D Engelman J A | 1999 | Journal of Biological Chemistry1999，274，30： | 1 |
| 19 | Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers 显示文摘 | Engelman J A Chert L Tan X | 2008 | Nat Med2008，14，12： | 1 |
| 20 | Ferrule design and fracture resistance of endodontically treated teeth显示文摘 | Sorensen JA Engelman MJ | 1990 | J Prosthet Dent1990，63，： | 1 |
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