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| 1 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 2 | Highly efficient GaAs solar cells by limiting light emission angle显示文摘In a conventional flat plate solar cell under direct sunlight,light is received from the solar disk,but is re-emitted isotropically.This isotropic emission corresponds to a significant entropy increase in the solar cell,with a corresponding drop in efficiency.Here,using a detailed balance model,we show that limiting the emission angle of a high-quality GaAs solar cell is a feasible route to achieving power conversion efficiencies above 38%with a single junction.The highest efficiencies are predicted for a thin,light trapping cell with an ideal back reflector,though the scheme is robust to a non-ideal back reflector.Comparison with a conventional planar cell geometry illustrates that limiting emission angle in a light trapping geometry not only allows for much thinner cells,but also for significantly higher overall efficiencies with an excellent rear reflector.Finally,we present ray-tracing and detailed balance analysis of two angular coupler designs,show that significant efficiency improvements are possible with these couplers,and demonstrate initial fabrication of one coupler design. | Emily D Kosten Jackson H Atwater James Parsons Albert Polman Harry A Atwater | 2013 | Light(Science & Applications)2013，2，1： | 9 |
| 3 | Reducing anastomotic leak in colorectal surgery: The old dogmas and the new challenges显示文摘Anastomotic leak(AL)constitutes a significant issue in colorectal surgery,and its incidence has remained stable over the last years.The use of intra-abdominal drain or the use of mechanical bowel preparation alone have been proven to be useless in preventing AL and should be abandoned.The role or oral antibiotics preparation regimens should be clarified and compared to other routes of administration,such as the intravenous route or enema.In parallel,preoperative antibiotherapy should aim at targeting collagenase-inducing pathogens,as identified by the microbiome analysis.AL can be further reduced by fluorescence angiography,which leads to significant intraoperative changes in surgical strategies.Implementation of fluorescence angiography should be encouraged.Progress made in AL comprehension and prevention might probably allow reducing the rate of diverting stoma and conduct to a revision of its indications. | Jeremy Meyer Surennaidoo Naiken Niki Christou Emilie Liot Christian Toso Nicolas Christian Buchs Frédéric Ris | 2019 | World Journal of Gastroenterology2019，25，34： | 3 |
| 4 | Trough levels and antibodies to infliximab may not predict response to intensification of infliximab therapy in patients with inflammatory bowel disease显示文摘 | Benjamin Pariente Guillaume Pineton de Chambrun Roman Krzysiek Marine Desroches Gauthier Louis Chiara De Cassan Clotilde Baudry Jean‐Marc Gornet Pierre Desreumaux Dominique Emilie Jean‐Frédéric Colombel Matthieu Allez | 2011 | Inflamm Bowel Dis2011，，7： | 2 |
| 5 | Interleukin 10:a new therapeutic target in systemic lupus erythematosus 显示文摘 | Emilie D Mariette X | 2001 | Joint Bone Spine2001，68，1： | 2 |
| 6 | Membrane redistributions through multi-intercellular exchanges and serial trogocytosis显示文摘Trogocytosis 是在膜的房间之间的快速的转移并且联系蛋白质。Trogocytic 交换在不同房间类型之间被调查了,主要在二房间的系统,包含一个施主和一种领受人房间类型。这里,我们在一个更复杂的系统学习了 trogocytosis,包含不仅几个有免疫力的房间子集而且多重肿瘤房间。我们证明 CD4+ T 房间, CD8+ T 房间和单核白血球能获得膜补丁和他们由多重同时的 trogocytoses 从不同肿瘤房间包含的未经触动的蛋白质。CD4+ 和 CD8+ T 房间的 trogocytic 能力被发现类似于自体同源的单核白血球的,却劣等。激活的外部血的 mononuclear 房间(PBMC ) 可以也在一个所有自体同源的系统交换在自己之间的膜。为这个原因,单核白血球能够从多重肿瘤房间来源获得膜,并且再把他们转移到自体同源的 T 房间,与一些他们的自己的膜(连续 trogocytosis ) 一起。我们的数据说明在自体同源的激活的有免疫力的受动器房间和他们的环境之间的膜交换的程度,并且包括鈥渂y stander 鈥 ? 房间,本地环境的细胞的内容怎么可以影响有免疫力的受动器房间的功能。 | Estlbahz Alegre Klave-Yune HoWangYin Benolt Favier Jeremy Baudhuin Emilie Lesport Marina Daouya Alvaro Gonzalez Edgardo D Carosella Joel LeMaoult | 2010 | Cell Research2010，20，11： | 2 |
| 7 | Pneumonia in the intensive care unit显示文摘 | Jordi R Emili D | 2003 | Cri Care Med2003，31，12： | 1 |
| 8 | Engineering of the Pyruvate Dehydrogenase Bypass in Saccharomyces cerevisiae: Role of the Cytosolic Mg2+ and Mitochondrial K + Acetaldehyde Dehydrogenases Ald6p and Ald4p in Acetate Formation during Alcoholic Fermentation显示文摘 | Fabienne R Emilie A Sylvie D | 2000 | Applied and Environmental Microbiology2000，66，8： | 1 |
| 9 | Genetic diversity among witchhazel cultivars based on Randomly Amplified Polymorphic DNA markers显示文摘 | Robert D Marquard Eric P Davis Emily L Stowe | 1997 | J Amer Soc Hort Sci1997，122，4： | 1 |
| 10 | Induction of tolerance by Por- phyromonas gingivalis on APCs:a mechanism implicated in peri- odontal infection 显示文摘 | Cohen N Morisset J Emilie D | 2004 | J Dent Res2004，83，5： | 1 |
| 11 | Chemical composition of dissolved organic matter in agroecosystems~ Correlations with soil enzyme activity and carbon and nitrogen mineralization 显示文摘 | TIAN L EMILY D WEI S | 2010 | Applied Soil Ecology2010，46，： | 1 |
| 12 | Chemokine macrophage inflammatory protein-lalpha mRNA expression in lung biopsy specimens of primary pulmonary hypertension显示文摘 | Fartoukh M Emilie D Le Gall C | 1998 | Chest1998，114，： | 1 |
| 13 | Dynamic Interaction of DNA Damage Checkpoint Protein Rad53 with Chromatin Assembly Factor Asf1显示文摘 | Emili A Schieltz D M Yates J R | 2001 | Mol Cell2001，7，1： | 1 |
| 14 | Pneumonia in the intensive care unit显示文摘 | Jordi R Emili D | 2003 | Cri Med2003，31，12： | 1 |
| 15 | The un-predictable nature of internal tides on continental shelves显示文摘 | Nash Jonathan D Kelly Samuel M Shroyer Emily L | | 0，，： | 1 |
| 16 | Management of multidrug-resistant organisms in healthcare settings,2006显示文摘 | Jane D S Emily R Marguerite J | 2007 | Am J Infect Control2007，35，102： | 1 |
| 17 | Plasma levels of soluble tumor necrosis factor receptors p55 and p75 in patients with alcoholic liver disease of increasing severity 显示文摘 | Naveau s Emilie D Balian A | 1998 | Hepatol1998，28，： | 1 |
| 18 | Self-esteem and coping strategies in child molesters显示文摘 | Marshall W L Emily C Anderson D | | Journal of Interpersonal Violence0，，9： | 1 |
| 19 | Reducing the content of nornicotine in tobacco via targeted mutation breeding显示文摘 | Emilie Julio Frédéric Laporte Stéphanie Reis Christophe Rothan Fran?ois Dorlhac de Borne | 2008 | Molecular Breeding2008，，3： | 1 |
| 20 | Chemical composition of dissolved organic matter in agroecosystems : Correlations with soil enzyme activity and carbon and nitrogen mineralization 显示文摘 | Lei T Emily D Wei Shi | 2010 | Applied Soil Ecology2010，46，4： | 1 |
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