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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Glutamine and glutamate supplementation raise milk glutamine concentrations in lactating gilts显示文摘Glutamine is the most abundant amino acid in milk, and lactation is associated with increased glutamine utilization both for milk synthesis and as a fuel for the enlarged small intestine. A number of recent studies have indicated that lactation is accompanied by a mild catabolic state in which skeletal muscle proteins are degraded to provide amino acids that are used to synthesize additional glutamine. In this study we tested the hypothesis that supplemental L-glutamine or the commercially available glutamine supplement Aminogut (2.5% by weight mixed into daily feed) provided to gilts from 30 days prior to parturition until 21 days post-parturition would prevent a decrease in skeletal muscle glutamine while increasing the glutamine content of the milk. Muscle glutamine content decreased (P < 0.05) in control animals during lactation but this was prevented by supplementation with either L-glutamine or Aminogut. In this study, neither lactation nor supplementation had any effect on plasma glutamine or glutamate content. Free glutamine, and the total glutamine plus glutamate concentrations in milk from the control and the Aminogut group rose (P < 0.05) during the first 7 days of lactation, with milk concentrations in the L-glutamine supplemented group showing a similar trend (P = 0.053). Milk glutamate remained constant between day 7 and 21 of lactation in the control and L-glutamine supplemented groups, but by day 21 of lactation the free glutamine, glutamate, and glutamine plus glutamate concentrations in milk from Aminogut-treated gilts were higher than those of control gilts. Thus dietary glutamine supplementation can alleviate the fall in intramuscular glutamine content during lactation in gilts, and may alleviate some of the catabolic effects of lactation. Furthermore, the increased milk glutamine content in the supplemented gilts may provide optimum nutrition for piglet development. | Helena Emilia CCC Manso Helio C Manso Filho Luiz E de Carvalho Marianne Kutschenko Eduardo T Nogueira Malcolm Watford | 2012 | Journal of Animal Science and Biotechnology2012，3，1： | 3 |
| 3 | Age-related changes in the avian primary lymphoid organs (thymus and bursa of Fabricius)显示文摘 | Emilia C Pablo P P Belen D | 2003 | Mierosc Res Techniq2003，62，： | 1 |
| 4 | Evaluation of induction of systemic resistance in pepper plants (Capsicum annum) to Phytophtora capsici using Trichoderma harzianum and its relation with capsidiol accumulation 显示文摘 | Perez S C Emilia C M | 2000 | European Journal of Plant Pathology2000，106，9： | 1 |
| 5 | Hydrophobic grafted and cross-linked starch nanoparticles for drug delivery显示文摘 | C K Simi T Emilia Abraham | 2007 | Bioprocess and Biosystems Engi- neering2007，30，： | 1 |
| 6 | Liquid ammonia treatment of linen fabrics显示文摘 | EMILIA C BARBAA D PETER S | 2006 | AATCC Review2006，，： | 1 |
| 7 | Long -term salvage treatment by cyclosporin in refractory autoimmune haematological disorders 显示文摘 | Messora C Longo G | 1996 | Br J Haematol1996，93，： | 1 |
| 8 | Evaluation of induction of systemic resistance in pepper plants ( Capsicum annum ) to Phytophtora capsici using Trichoderma harzianum and its relation with capsidiol accumulation 显示文摘 | Ahmed S A Perez S C Emilia C M | 2000 | European Journal of Plant Pathology2000，106，9： | 1 |
| 9 | Long -term salvage treatment by cyelosporin in refratory autoimmune hae matological disorders显示文摘 | Emilia G Messora C Long OG | 1996 | Br J Haematol1996，93，： | 1 |
| 10 | Evidence that a Ca^2+ chelator and a calmodulin blocker interfere with the structure of inter-sertoli junctions显示文摘 | Emilia F Marina C | 1985 | Tissue Cell1985，17，1： | 1 |
| 11 | Characterization of hsp genes in planarian stem cells显示文摘 | Maria C Paolo D Maria Emilia I | 2010 | Belgian Journal of Zoology2010，140，3： | 1 |
| 12 | The clinical and genetic manifestations of hereditary nonpolyposis colorectal carcinoma 显示文摘 | D'Emilia J C Rodriguez-Bigas M A Petrelli N J | 1995 | Am J Surg1995，169，： | 1 |
| 13 | Lipochromes,vi- tamins, aromas and other components of virgin olive oil are affected by processing technology 显示文摘 | ALFONSO R PAOLO C EMILIA I | 2001 | Food Chem2001，73，4： | 1 |
| 14 | Determination of trans-resveratrol in plas- ma by HPLC显示文摘 | Emilia Juan M Lamuela-Raventos R M de la Torre-Bor- onat M C | 1999 | Anal Chem1999，71，： | 1 |
| 15 | Electrochemicaloxidation of synthetic tannery wastewater in chloride-free aqueousmedia 显示文摘 | CARLA R C FRANCISCO M EMILIA M | 2010 | Journal of Hazardous Materials2010，180，123： | 1 |
| 16 | long-term salrage treatment by Cyclosporin in refacriry atoimjmune hematological disorders显示文摘 | Emilia G Messorra C longo G | 1996 | Br J Haematol1996，93，2： | 1 |
| 17 | Effect of liquid ammonia on fine structure of linen fabrics 显示文摘 | Barbara D Emilia C Csisizar S | 2006 | Textile Res J2006，，8： | 1 |
| 18 | Gluten immunogenic peptide excretion detects dietary transgressions in treated celiac disease patients显示文摘BACKGROUND Life-long removal of gluten from the diet is currently the only way to manage celiac disease(CeD). Until now, no objective test has proven useful to objectively detect ingested gluten in clinical practice. Recently, tests that determine consumption of gluten by assessing excretion of gluten immunogenic peptides(GIP) in stool and urine have been developed. Their utility, in comparison with conventional dietary and analytical follow-up strategies, has not been fully established.AIM To assess the performance of enzyme-linked immunosorbent assay(ELISA) and point-of-care tests(PoCTs) for GIP excretion in CeD patients on gluten-free diet(GFD).METHODS We conducted an observational, prospective, cross-sectional study in patients following a GFD for at least two years. Using the Gastrointestinal Symptom Rating Scale questionnaire, patients were classified at enrollment as asymptomatic or symptomatic. Gluten consumption was assessed twice by 3-d dietary recall and GIP excretion(by ELISA in stool and PoCTs(commercial kits for stool and urine) in two consecutive samples. These samples and dietary reports were obtained 10 day apart one from the other. Patients were encouraged to follow their usual GFD during the study period.RESULTS Forty-four patients were enrolled, of which 19(43.2%) were symptomatic despite being on a GFD. Overall, 83 sets of stool and/or urine samples were collected.Eleven out of 44 patients(25.0%) had at least one positive GIP test. The occurrence of at least one positive test was 32% in asymptomatic patients compared with 15.8% in symptomatic patients. GIP was concordant with dietary reports in 65.9% of cases(Cohen′s kappa: 0.317). PoCT detected dietary indiscretions. Both ELISA and PoCT in stool were concordant(concomitantly positive or negative) in 67 out of 74(90.5%) samples. Excretion of GIP was detected in 7(8.4%) stool and/or urine samples from patients considered to be strictly compliant with the GFD by dietary reports.CONCLUSION GIP detects dietary transgressions in patients on long-term GFD, irrespective of the presence of symptoms. PoCT for GIP detection constitutes a simple homebased method for self-assessment of dietary indiscretions. | Ana Florencia Costa Emilia Sugai María de la Paz Temprano Sonia Isabel Niveloni Horacio Vázquez María Laura Moreno M.Remedios Domínguez-Flores Alba Mu?oz-Suano Edgardo Smecuol Juan Pablo Stefanolo Andrea F González Angel Cebolla-Ramirez Eduardo Mauri?o Elena F Verdú Julio César Bai | 2019 | World Journal of Gastroenterology2019，25，11： | 1 |
| 19 | Lipochromes, vitamins, aromas and other components of virgin olive oil are affected by processing technology 显示文摘 | ALFONSO R PAOLO C EMILIA L | 2001 | Food Chem2001，73，4： | 1 |
| 20 | Failure behaviour wellbore cement in the presence of water and supercritical CO2显示文摘 | EMILIA L CHRISTOPHER J SPIERS C | 2009 | Energy Procedia2009，1，1： | 1 |
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