|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | mRNA expression, functional profiling and multivariate classification of colon biopsy specimen by cDNA overall glass microarray显示文摘AIM: To understand the local pathophysiological altera- tions and gene ontology-based functional classification of colonic biopsies into inflammatory and neoplastic dis- eases. METHODS: Total RNA was extracted from frozen biop- sies and amplified by T7-method. Expression profile was evaluated by Atlas Glass 1K microarrays. After microar- ray quality control, applicable data were available from 10 adenomas, 6 colorectal adenocarcinomas (CRCs), and 6 inflammatory bowel diseases (IBDs). Multivariate statistical and cell functional analyses were performed. Real-time RT-PCR and immunohistochemistry were used for validation. RESULTS: Discriminant analysis of selected genes, could correctly reclassify all 22 samples using 4 parameters (heat shock transcription factor-1, bystin-like, calgranu- lin-A, TRAIL receptor 3). IBD samples were characterized by overregulated chemokine (C-X-C motif) ligand 13, replication protein A1, E74-like factor 2 and downregu- lated TNF receptor-associated factor 6, BCL2-interacting killer genes. In adenomas upregulation of TNF receptor- associated factor 6, replication protein A1, E74-like factor 2 and underexpression of BCL2-associated X protein, cal- granulin-A genes were found. CRC cases had significantly increased epidermal growth factor receptor, topoisomer- ase-1, v-jun, TNF receptor-associated factor 6 and TRAIL receptor 3, and decreased RAD51 and RAD52 DNA repair gene, protein phosphatase-2A and BCL2-interacting killer mRNA levels. Epidermal growth factor receptor RT-PCR and immunohistochemistry, topoisomerase-1 RT-PCRconfirmed the chip results. CONCLUSION: Different histological alterations can be reclassified by functional, multivariate analysis using cDNA microarrays. Further studies with expanded sample number are needed for subclassification of pathological alterations. | Orsolya Galamb Ferenc Sipos Elek Dinya Sandor Spisak Zsolt Tulassay Bela Molnar | 2006 | World Journal of Gastroenterology2006，12，43： | 2 |
| 2 | Environmental trichlorfon and cluster of congenital abnormalities显示文摘 | Elek CS Gundy J | 1993 | Lancet1993，341，： | 1 |
| 3 | Polymorphism for shell color in the Atlantic bay scallop Argopecten irradians (Lamarck) (MoUusca: Bivalvia) on Martha's Vineyard Island显示文摘 | Elek J A Adamkewicz S L | 1990 | American Malacological Bulletin1990，7，2： | 1 |
| 4 | Effects of rumen-protected choline supplementation on milk production and choline supply of periparturient dairy cows显示文摘 | Elek P Newbold J R Gaal T | 2008 | Animal2008，2，： | 1 |
| 5 | The appreciation of mineral element accumulation level in some herbaceous plants species by ICP-AES method显示文摘 | Carmen Cristina Elekes Irina Dumitriu Gabriela Busuioc | 2010 | Environ Sci Pollut Res2010，17，： | 1 |
| 6 | Influence of rumen-protected choline on liver composition and blood variables indicating energy balance in periparturient dairy cows显示文摘 | Elek P Gaal T Husveth F | 2013 | Acta Veterinaria Hungarica2013，61，1： | 1 |
| 7 | Determination ofgun propellants erosivity:experimental and theoreticalstudies 显示文摘 | JARAMAZ S MICKOVIC D ELEK P | 2010 | Experimental Thermal and Fluid Science2010，34，6： | 1 |
| 8 | The Bieaecumulation of Some Heavy Metals in the Fruiting Body of Wild Growing Mushrooms显示文摘 | ELEKES C C BUSUIOC G IONITA G | 2010 | Notulae Botanieae Horti Agrobotanici Cluj-Napoca2010，38，2： | 1 |
| 9 | The free radical signal of pigment gallstones显示文摘 | Rockenbauer A | 1982 | Klin Wochenschr1982，60，1： | 1 |
| 10 | Environmental trichlorfon and cluster of congenital abnormalities 显示文摘 | Czeizel AE Elek C Gundy S | 1993 | Lancet1993，341，8844： | 1 |
| 11 | Malignancies after renal transplantation during 33 years at a single center显示文摘 | Gyula Végs? Maria Tóth Márta Hídvégi éva Toronyi Robert Mlanger Elek Dinya András Tóth Ferenc Perner Jen? Járay | 2007 | Pathology & Oncology Research2007，，1： | 1 |
| 12 | China's Dilemma: Economic Growth, the Environment and Climate Change 显示文摘 | Elek A | 2009 | Asian-Pacific Economic Literature2009，23，1： | 1 |
| 13 | Assessing the impact of leaf beetles in eucalypt planta- tions and exploring options for their management 显示文摘 | Elek J | 1997 | Tasfore- sts1997，9，： | 1 |
| 14 | Diversity and composition of carabids during a forestry cycle显示文摘 | Magura T Tothmeresz B Elek Z | 2003 | Biodiversity and Conservation2003，12，： | 1 |
| 15 | Modeling of Fragmentation of Rapidly Expanding Cylinders显示文摘 | Elek P Jaramaz S | 2005 | Theoret Appl Mech2005，32，2： | 1 |
| 16 | Attenuation of pathological tremors by functional electrical stimulation-Ⅰ:method显示文摘 | PROCHAZKA A ELEK J JAVIDAN M | | 0，，01： | 1 |
| 17 | Attenuation of pathological tremors by functional electrical stimulation-Ⅱ:clinical evaluation显示文摘 | JAVIDAN M ELEK J PROCHAZKA A | | 0，，01： | 1 |
| 18 | Optimization of the Performance of a CsI(Tl) Scintillator + Si-PIN Photodiode Detector for Medium-energy Light-charged Particle Hybrid Array显示文摘 | Elekes Z Kalinka G Füloep Zs | 2003 | Nuclear Phys A2003，719，： | 1 |
| 19 | Selective formation of methanol from synthesis gas over palladium catalysts 显示文摘 | POUTSMA M L ELEK L F IBARBIA P A RISCH A P RABO J A | 1978 | JCatal1978，52，1： | 1 |
| 20 | Tissue doppler evaluation of intravent-ficular asynchreny in isolated left bundle branch block显示文摘 | Elek M Esen O Esen AM | 2006 | Echocardio-graphy2006，23，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员