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| 1 | Cytokines as biomarkers of inflammatory response after open versus endovascular repair of abdominal aortic aneurysms: a systematic review显示文摘一个腹的大动脉的动脉瘤(AAA ) 的修理是与有煽动性的串联的随后的激活的神经质、新陈代谢的压力相关的反应有关的一个高风险的外科的过程。与开的修理相对照(或) , endovascular 大动脉的动脉瘤修理(EVAR ) 由为更少提供广泛的切口,解剖,和织物操作似乎是手术后的压力到减少。然而,这些有益的效果可以是由代谢物在用在 endovascular 的导管的血栓的 intra 钠操作期间修理的 cytokines 和 arachidonic 酸的版本的偏移量,导致全身的煽动性的反应(先生) ,它是临床上叫的培植以后的症候群。在我们比较了的这系统的评论或与 EVAR,以 post-interventional,从改变导致传播 cytokine 的煽动性的反应铺平。我们寻求了在 EVAR 以后关于培植以后的症候群总结所有最近的证据。我们寻找了为临床的研究作为煽动性的反应的部分在 cytokines 的版本上报导在以后的 Medline (PubMed ) , ClinicalTrials.gov 和 Cochrane 图书馆开 / 常规并且 AAA 的 endovascular 修理。我们鉴别 17 学习检验 cytokine 层次在以后或对 EVAR。或似乎特别地比 EVAR 与一位更大的先生被联系,由增加的 cytokine 层次证实了 IL-6 和 IL-8 而 IL-1, IL-10 和 TNF- 出现了,冲突在二之间的结果或没有差别组织。聚酯 endografts 看起来断然在 EVAR 以后与培植以后的症候群的发生被相关。未来大未来的研究被保证位于在 surgical 以后的 cytokine 相互作用下面描出的机制煽动性的反应背景。 | Diamantis I TSILIMIGRAS Fragiska SIGALA Georgios KARAOLANIS Ioannis NTANASIS-STATHOPOULOS Eleftherios SPARTALIS Michael SPARTALIS Nikolaos PATELIS Alexandros PAPALAMPROS Chandler LONG Demetrios MORIS | 2018 | Acta Pharmacologica Sinica2018，39，7： | 5 |
| 2 | Concept of histone deacetylases in cancer:Reflections on esophageal carcinogenesis and treatment显示文摘Esophageal cancer (EC) presents a high mortality rate, mainly due to its aggressive nature. Squamous cell carcinoma is the most common histological type world-wide, though, a continuous increase in esophageal adenocarcinomas has been noted in the past decades. Common risk factors associated with EC include smoking, alcohol consumption, gastroesophageal reflux disease, Barrett's esophagus and obesity. In an effort to overcome chemotherapy resistance in oncology, it was discovered that histone acetylation/deacetylation equilibrium is altered in carcinogenesis, leading to changes in chromatin structure and altering expression of genes important in the cell cycle, differentiation and apoptosis. Based on this knowledge, histone acetylation was addressed as a potential novel chemotherapy drug target to repress cancer cell proliferation. There are four classes of histone deacetylases (HDACs) inhibitors with a variety of different mechanisms of actions that render them possible anticancer drugs. They arrest the cell cycle, inhibit differentiation and angiogenesis and induce apoptosis. They do not necessarily act on histone proteins, since they can also exert indirect anti-cancer effects, by modifying various cellular proteins.In addition,HDACs have also been associated with increased chemotherapy resistance.Based on the literature,HDACs have been associated with EC,with surveys revealing that increased expression of certain HDACs correlates with advanced TNM stages,tumor grade,metastatic potential and decreased 5-year overall and disease-free survival.The aim of this survey is to elucidate the molecular identity and mechanism of action of HDAC inhibitors as well as verify their potential utility as anti-cancer agents in esophageal cancer. | Dimitrios Schizas Aikaterini Mastoraki Leon Naar Eleftherios Spartalis Diamantis I Tsilimigras Georgia-Sofia Karachaliou George Bagias Dimitrios Moris | 2018 | World Journal of Gastroenterology2018，24，41： | 3 |
| 3 | Novel approaches for the treatment of ventricular tachycardia显示文摘Ventricular tachycardia(VT) is a crucial cause of sudden cardiac death(SCD) and a primary cause of mortality and morbidity in patients with structural cardiac disease. VT includes clinical disorders varying from benign to lifethreatening. Most life-threatening episodes are correlated with coronary artery disease, but the risk of SCD varies in certain populations, with various underlying heart conditions, specific family history, and genetic variants. The targets of VT management are symptom alleviation, improved quality of life, reduced implantable cardioverter defibrillator shocks, prevention of reduction of left ventricular function, reduced risk of SCD, and improved overall survival. Antiarrhythmic drug therapy and endocardial catheter ablation remains the cornerstone of guideline-endorsed VT treatment strategies in patients with structural cardiac abnormalities. Novel strategies such as epicardial ablation, surgical cryoablation, transcoronary alcohol ablation, pre-procedural imaging, and stereotactic ablative radiotherapy are an appealing area of res-earch. In this review, we gathered all recent advances in innovative therapies as well as experimental evidence focusing on different aspects of VT treatment that could be significant for future favorable clinical applications. | Michael Spartalis Eleftherios Spartalis Eleni Tzatzaki Diamantis I Tsilimigras Demetrios Moris Christos Kontogiannis Efthimios Livanis Dimitrios C Iliopoulos Vassilis Voudris George N Theodorakis | 2018 | World Journal of Cardiology2018，10，7： | 2 |
| 4 | Vehicle fleet planning in the car rental industry 显示文摘 | Julian P Eleftherios I Ip C | 2006 | Journal of Revenue and Pricing Management2006，5，3： | 1 |
| 5 | A System Dynamics Model for Dynamic Capacity Planning of Remanufacturing in Closed-loop Supply Chains 显示文摘 | Dimitrios V Patroklos G Eleftherios I | 2007 | Computers & Operations Research2007，43，2： | 1 |
| 6 | A system dynamics model for dynamic capacity planning of remanufacturing in closed-loop supply chains显示文摘 | Dimitrios V Patroklos G Eleftherios I | 2007 | Computers & Operations Research2007，34，： | 1 |
| 7 | A system dynamic model for dynamic capacity planning of remanufacturing in closed-loop supply chains显示文摘 | Dimitrios V Patroklos G Eleftherios I | 2007 | Computer & operations research2007，34，2： | 1 |
| 8 | A system dynamics model for dynamic capacity planning of remanufacturing in closed-loop supply显示文摘 | Dimitrios V Patroklos G Eleftherios I | 2007 | Computers and Operations Research2007，43，2： | 1 |
| 9 | Optimal newsvendor policies for dual-sourcing supply chain: a disruption risk management framework显示文摘 | ANASTASIOS X DIMITRIOS V ELEFTHERIOS I | 2012 | Computers & Operations Res2012，39，4： | 1 |
| 10 | A system dynamics model for dynamic capacity planning of remanufacturing in Closed-Loop Supply Chains显示文摘 | Dimitrios V Patroklos G Eleftherios I | 2005 | Computers & Operations Research2005，，： | 1 |
| 11 | A system dynamics model for dynamic capacity planning of remanufacturing in closed-loop supply chains 显示文摘 | Dimitrios V Patroklos G Eleftherios I | 2007 | Computers & Operations Research2007，43，2： | 1 |
| 12 | A synthesis of tactical fleet planning models for the car rental industry显示文摘 | Julian EP Eleftherios I Chi I | 2003 | IIE Transactions2003，35，9： | 1 |
| 13 | Vehicle fleet planning in the car rental industry显示文摘 | Julian P Eleftherios I Ip C | 2006 | Journal of Revenue and Pricing Management2006，5，3： | 1 |
| 14 | A system dynamic model for dynamic capacity planning of remanufacturing in closed-loop supply chains显示文摘 | Dimitrios V Patroklos G Eleftherios I | 2007 | Computer&operations research2007，34，： | 1 |
| 15 | A system dynamic model for dynamic capacity planning of remanufacturing in closed-loop supply chains 显示文摘 | Dimitrios V Patroklos G Eleftherios I | 2007 | Computer & operations research2007，34，： | 1 |
| 16 | A system dynamic model for dynamic capacity planning of remanufacturlng in closed-loop supply chains 显示文摘 | Dimitrios V Patroklos G Eleftherios I | 2007 | Computer & operations research2007，，34： | 1 |
| 17 | A synthesis of tactical fleet planning models for the car rental industry 显示文摘 | Julian E P Eleftherios I Chi I | 2003 | IIE Transactions2003，35，9： | 1 |
| 18 | Global transformer optimization method using evolutionary design and numerical field Computation显示文摘 | Eleftherios I Amoiralis Pavlos S Georgilakis | | 0，，03： | 1 |
| 19 | A system dynamics model for dynamic capacity planning of remanufactuting in closed-loop supply chains显示文摘 | Dimitrios V Patroklos G Eleftherios I | 2007 | Computers&Operations Research2007，43，2： | 1 |
| 20 | A system dynamics model for dynamic capacity planning of remanufacturing in closed-loop supply chain 显示文摘 | Dimitrios V Patroklos G Eleftherios I | 2007 | Computers & Operations Research2007，34，： | 1 |
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