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| 1 | Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions显示文摘AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic diseases.METHODS Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow cytometry.Serum levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by ELISA.RESULTS Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P < 0.001).CD40+ expression on active p DCs was decreased in HCC patients(P < 0.001),and its level was not significantly changed among other groups.Inactive p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P < 0.05).NKG2 D was statistically decreased in HCC,CH and cirrhosis(P < 0.001),and it was not expressed in 63%(12/20) of HCC patients.There was significant decrease of IL-2,IFN-α and IFN-γ(P < 0.001),and a significant increase in IL-10,IL-1β,and TNF-αR2(P <0.01,P < 0.001 and P < 0.001;respectively) in HCC patients.There was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P < 0.01),with a strong correlation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P < 0.05) as well as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P < 0.001).CONCLUSION NKG2 D,CD40,IL-2 and IL-10 are important modulators in the development and progression of HCC. | Abdel-Rahman N Zekri Somaya El Deeb Abeer A Bahnassy Abeer M Badr Mona S Abdellateif Gamal Esmat Hosny Salama Marwa Mohanad Ahmed Esam El-dien Shimaa Rabah Assmaa Abd Elkader | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 2 | 羊膜移植治疗睑球黏连的临床观察(英文)显示文摘目的:评估羊膜移植(AMT)在治疗睑球黏连中的应用效果。方法:这项无对照干预性病例研究于2013/01~2015/12,包括连续就诊的12名患者共14眼。患者均接受永久性羊膜移植,以治疗睑球黏连,使用冷冻保存或冷冻干燥的羊膜(AM)。这12例(14眼)患者,年龄在26~62岁,平均43.38±11.25岁,其中8例(4名男性,4名女性)10眼为翼状胬肉切除术后继发,4例患者(1名男性,3名女性)斜视手术后继发。所有患者距上次手术至少6mo。术后以恢复深度稳定的穹窿为手术成功,无瘢痕或炎症发生,6mo的随访期间无眼球运动的限制。结果:随访期平均为7±4.2mo(6-9mo)。在所有14只眼中,手术后3wk均观察到AM完全上皮化,手术部位无炎症表现。总共14眼中有8眼(成功率57%)显示穹窿重建成功,穹窿深,无复发。有4眼(29%)表现出部分成功,中度深度的穹窿和中度瘢痕。有2眼(14%)显示重建失败,穹窿完全闭合。有7眼手术后视力改善,7眼视力保持稳定。AMT术后并发症少,14眼中1眼(7%)发生严重的结膜反应和眼球运动受限。而在术后前3mo中,14眼中有2眼发生化脓性肉芽肿(14%),予以手术切除,局部糖皮质激素注射。结论:单用AMT是一种治疗睑球黏连安全有效的方法。考虑到与角膜缘切除有关的潜在不良反应,AMT也是一种有效的重建穹窿以修复各种眼表疾病所致睑球黏连的方法。 | Ahmed Tamer Sayed Saif Passant Sayed Saif Amr El Deeb | 2017 | 国际眼科杂志2017，17，5： | 4 |
| 3 | Corrosion of tin in citric acid solution and the effect of some inorganic anions显示文摘 | Abdel Rehim S S Sayyah S M El Deeb M M | 2003 | Materials Chemistry and Physics2003，80，3： | 1 |
| 4 | Electroplating of copper films on steel substrates from acidic gluconate baths显示文摘 | Abd S S El Rehim Sayyah D M El Deeb M M | 2000 | Applied Surface Science2000，165，4： | 1 |
| 5 | Evidence that the apolipoprotein E-genotype effects on lipid levels can change with age in males: a longitudinal analysis显示文摘 | Jarvik GP Goode EL Austin MA Auwerx J Deeb S Schellenberg GD | 1997 | Am J Hum Genet1997，61，1： | 1 |
| 6 | The potetial use of 29 kDa protein as a marker of pathogenicity and diagnosis of symptomatic infections with Blastocystis hominis显示文摘 | Gamra MM Elwakil HS El Deeb HK | 2011 | Parasitol Res2011，108，5： | 1 |
| 7 | Threedimensional computed tomography in maxillofacial surgical planning显示文摘 | Kurt P Schellhas Mohammed El Deeb Clyde H Wilkes | 1988 | Arch Otolaryngol Head Neck Surg1988，114，： | 1 |
| 8 | Prognostic implication of apoptosis and angiogenesis in cervical uteri cancer显示文摘 | Zaghloul MS El Naggar M El Deeb A | 2000 | Int J Radiat Oncol Biol Phys2000，48，5： | 1 |
| 9 | Electroplating of copper films on steel substrates from acidic gluconate baths 显示文摘 | ABD El REHIM S S SAYYAH S M El DEEB M M | 2000 | Applied Surface Science2000，165，4： | 1 |
| 10 | Electroplating of copper films on steel substrates baths显示文摘 | Abd EI Rehim S S Sayyah S M El Deeb M M | 2000 | Applied Surface Science2000，165，： | 1 |
| 11 | Canine eruption into grafted bone in maxillary aleveolar cleft defects 显示文摘 | EL Deeb M Messer LB Lehnert MW | 1982 | Cleft Palate J1982，19，1： | 1 |
| 12 | Three-dimen sional corn put ed t omography in maxillof acial surgical planning 显示文摘 | Schel lhas KP el Deeb M Wilkes CH | 1988 | Arch Ot olaryngol Head Neck Surg1988，114，： | 1 |
| 13 | Three-dimensional computed tomngraphy in maxillofacial surgical planning显示文摘 | Schellhas KP EL Deeb M Wilkes CH | 1988 | Arch Otolaryngul Head Surg1988，114，3： | 1 |
| 14 | Three-dimensional computed tomography in maxillofacial surgical planning 显示文摘 | Schellhas KP el Deeb M Wilkes CH | 1988 | Arch Otolaryngol Head Neck Surg1988，114，4： | 1 |
| 15 | Long-term follow-up of the use of nonporous hydroxyapatite for augmentation of the alveolar ridge显示文摘 | el Deeb M Tompach PC Morstad AT | 1991 | J Oral Maxillofac Surg1991，49，： | 1 |
| 16 | An adaptive PR controller for inverter-based distribution generation with active damped LCL filter 显示文摘 | El Deeb H M Elserougi A Abdel-Khalik A S | 2013 | IEEE GCC Conference and Exhibition2013，，11： | 1 |
| 17 | Accelerated cheddar cheese ripening with encapsulated proteases显示文摘 | Kheadr E E Vuillemard J C El Deeb S A | 2000 | International Journal Food Science & Technology2000，35，： | 1 |
| 18 | Long-term follow-up of the use of nonporous hydroxyapatite for augmentation of the alveolar ridge显示文摘 | TOMPACH P C MORSTAD A T | 1991 | J Oral Maxillofac Surg1991，49，3： | 1 |
| 19 | Acceleration of cheddar cheese lipolysis by using liposome - entrapped lipases 显示文摘 | Kheadr E E Vuillemard J C El Deeb S A | 2002 | Journal of Food Science2002，67，： | 1 |
| 20 | Hepatic hydatid cysts,sonographic follow-up after percutaneous sonographically guided aspiration显示文摘 | Salama HM Ahmed NH el Deeb N | | 0，，09： | 1 |
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