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17篇 您的检索式:作者名="E Cooksley"
    题名 作者 年代 出处 被引量
1聚乙二醇干扰素-α2a治疗乙型肝炎病毒感染显示文摘 1乙型肝炎概况 大多数国家都已推荐采用乙型肝炎(乙肝)疫苗进行广泛性免疫预防,但乙肝仍然是一个严重的全球问题.目前,全世界大约有3.6亿慢性乙型肝炎(慢乙肝)患者,其中大多数患者在亚洲,然而这种疾病在全球各地都有发生.……W Graham E Cooksley 2005传染病信息2005,18,z1:3
2Serious postoperative infections following resection of common solid tumors:outcomes,costs, and impact of hospital surgical vo- lume显示文摘Avritscher E B Cooksley C D Roiston K V 2014Support Care Cancer2014,22,2:1
3Pegin- terferon Alfa-2a in Patients with Chronic Hepatitis C and Cirrhosis显示文摘Heathcote E J Shiffman M L Cooksley W G 2000N Engl J Med2000,343,23:1
4Living with chronic hepatitis C meansyou just haven't got a normal life any more' 显示文摘Conrad S Garrett L E Cooksley W G E 2006Chronic Illness2006,2,2:1
5Peginterferonα-2a (40 KD):an advance in the treatment of hepatitis B e antigen-positive chronic hepatitis B 显示文摘Cooksley W G E Piratvisuth T Lee S D 2003J Viral hepat2003,10,5:1
6Scope and epidemiology of cancer therapy-induced oral and gastrointestinal mucositis显示文摘Avritscher E B Cooksley C D Elting L S 2004Scmin Oncol Nuts2004,20,1:1
7The natural history of nonalcoholic steatohepatitis:a follow-up study of forty-two patients for up to 21 years显示文摘Powell E E Cooksley W G Hanson R 1990Hepatology1990,11,1:1
8Effectiveness of Modified Early Warning Score in predicting outcomes in oncology patients 显示文摘Cooksley T Kitlowski E Haji - Michael P 2012QJM2012,05,11:1
9Small-colony variants and phenotype switching of intracellular Staphylococcus aureus in chronic rhinosinusitis显示文摘TAN NC COOKSLEY CM ROSCIOLI E 2014Allergy2014,69,10:1
10The natural history of nonalcoholic steatohepatitis:a follow-up study of forty-two patients for up to 21years显示文摘POWELL E E COOKSLEY W G HANSON R 1990Hepatology1990,11,:1
11Antibodies to the glutamate dehydrogenase of Plasmodium falciparum显示文摘Ling IT Cooksley PA Bates E 1986Parasitol1986,92,:1
12Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B 显示文摘Lau GK Piratvisuth T Luo KX Marcellin P Thongsawat S Cooksley G Gane E Fried MW Chow WC Paik SW Chang WY Berg T Flisiak R McCloud P Pluck N Peginterferon Alfa-2a HBeAg-Positive Chronic Hepatitis B Study Group 2005NEngl J Med2005,352,26:1
13The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years显示文摘Powell E E Cooksley W G Hanson R 1990I-Iepatology1990,11,1:1
14The natural history of nonalcoholic steatohepatitis:a follow-up study of forty-two patients for up to 21 years显示文摘Powell E Cooksley WG Hanson R 1990Hepatology (Baltimore Md)1990,11,1:1
15The naturalhistory of nonalcoholic steatohepatitis: A follow - up study offorty- two patients for up to 21 yeaFs显示文摘 Cooksley W G E Hanson R 1990Hepatology1990,11,:1
16显示文摘Heathcote E J Shiffman ML Cooksley WG 2000N Engl J Med2000,343,23:1
17聚乙二醇干扰素α-2a对乙型肝炎病毒感染的治疗显示文摘1聚乙二醇千扰素的化学特性与药效学 聚乙二醇化是将一个蛋白质如干扰素(IFN)连接到无生物学活性的聚乙二醇聚合体上。聚乙二醇干扰素α-2a(分子量40kDa,派罗欣Pegasys-罗氏制药公司生产)为具有高分子量、支链结构的聚乙二醇,附着在IFN分子上,不会干扰细胞膜上IFN受体的干扰纯洁结合位点。其实,供共价链接的位点很多,在聚乙二醇干扰素α-2a中,聚乙二醇部分通过一个稳定的酰胺键共价结合到一个赖氨酸残基上。聚乙二醇干扰素α-2a在溶液中稳定。因此,使用剂型为注射液。聚乙二醇干扰素α-2a与其细胞膜受体相结合后才能发挥抗病毒活性。Graham W Cooksley E 2006传染病信息2006,19,4:0
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