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| 1 | Predictors of mortality after transjugular portosystemic shunt显示文摘AIM:To investigate if echocardiographic and hemodynamic determinations obtained at the time of transjugular intrahepatic portosystemic shunt(TIPS)can provide prognostic information that will enhance risk stratification of patients.METHODS:We reviewed medical records of 467 patients who underwent TIPS between July 2003 and December 2011 at our institution.We recorded information regarding patient demographics,underlying liver disease,indication for TIPS,baseline laboratory values,hemodynamic determinations at the time of TIPS,and echocardiographic measurements both before and after TIPS.We recorded patient comorbidities that may affect hemodynamic and echocardiographic determinations.We also calculated Model for Endstage Liver Disease(MELD)score and Child Turcotte Pugh(CTP)class.The following pre-and post-TIPS echocardiographic determinations were recorded:Left ventricular ejection fraction,right ventricular(RV)systolic pressure,subjective RV dilation,and subjective RV function.We recorded the following hemodynamic measurements:Right atrial(RA)pressure before and after TIPS,inferior vena cava pressure before and after TIPS,free hepatic vein pressure,portal vein pressure before and after TIPS,and hepatic venous pressure gradient(HVPG).RESULTS:We reviewed 418 patients with portal hypertension undergoing TIPS.RA pressure increased by a mean ± SD of 4.8 ± 3.9 mmH g(P < 0.001),HVPG decreased by 6.8 ± 3.5 mmH g(P < 0.001).In multivariate linear regression analysis,a higher MELD score,lower platelet count,splenectomy and a higher portal vein pressure were independent predictors of higher RA pressure(R = 0.55).Three variables predicted 3-mo mortality after TIPS in a multivariate analysis:Age,MELD score,and CTP grade C.Change in the RA pressure after TIPS predicted long-term mortality(per 1 mm Hg change,HR = 1.03,95%CI:1.01-1.06,P < 0.012).CONCLUSION:RA pressure increased immediately after TIPS particularly in patients with worse liver function,portal hypertension,emergent TIPS placement and history of splenectomy.The increase in RA pressure after TIPS was associated with increased mortality.Age,splenectomy,MELD score and CTP grade were independent predictors of long-term mortality after TIPS. | Mona Ascha Sami Abuqayyas Ibrahim Hanouneh Laith Alkukhun Mark Sands Raed A Dweik Adriano R Tonelli | 2016 | World Journal of Hepatology2016，8，11： | 13 |
| 2 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 3 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 4 | Identification of RAPD markers linked to the gene Pm1 for resistance to powdery mildew in wheat 显示文摘 | HU X Y OHM H W DWEIK A T I | 1997 | TheorApplGenet1997，94，67： | 1 |
| 5 | An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications 显示文摘 | Dweik RA Boggs PB Erzurum SC | 2011 | Am J Respir Crit Care Med2011，184，5： | 1 |
| 6 | An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications显示文摘 | Dweik RA Boggs PB Erzurum SC | 2011 | Am J Respir Crit Care Med2011，184，5： | 1 |
| 7 | Diagnosis of lung cancer by the analysis of exhaled breath with a calorimetric sensor array 显示文摘 | Mazzone P J Hammel J Dweik R | 2007 | Thorax2007，62，7： | 1 |
| 8 | An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications 显示文摘 | Dweik RA Boggs PB Erzurum SC | 2011 | Am J of Respir Crit Care Med2011，184，5： | 1 |
| 9 | Diagnosis of lung cancer by the analysis of exhaled breath with a eolorimetric sen- sor array 显示文摘 | Mazzone PJ Hammel J Dweik R | 2007 | Thorax2007，62，： | 1 |
| 10 | An official ATS clinical practice guideline: interpretation of ex- haled nitric oxide levels(FENO) for clinical applications 显示文摘 | Dweik RA Boggs PB Erzurum SC | 2011 | Am J Respir Crit Care Med2011，184，5： | 1 |
| 11 | An efficial ATS clinical practice guideline:interpretation of exhaled nitru,oxide levels(FENO)for clinical appiications显示文摘 | Dweik RA Boggs PB Erzurum SC | 2011 | Am J Respir Crit Care Med2011，184，5： | 1 |
| 12 | Role of bronchoscopy in massive hemoptysis显示文摘 | Dweik RA Stoller JK | 1999 | Clin Chest Med1999，20，1： | 1 |
| 13 | An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications显示文摘 | Dweik RA Boggs PB Erzurum SC | 2011 | Am J Respir Crit Care Med2011，184，5： | 1 |
| 14 | An ogicial ATS clini- cal practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications显示文摘 | Dweik R A Boggs P B Erzurum S C | 2011 | American Journal of Respi- ratory and Critical Care Medicine2011，184，5： | 1 |
| 15 | Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma显示文摘 | Dweik RA Sorkness RL Wenzel S | 2010 | Am J Respir Crit Care Med2010，181，10： | 1 |
| 16 | An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications 显示文摘 | Dweik RA Boggs PB Erzurum SC | 2011 | Am J Respir Crit Care Med2011，184，5： | 1 |
| 17 | Role of bronchoscopy in massive hemoptysis显示文摘 | Dweik RA Stoller JK | 1999 | Clin Chest Med1999，20，1： | 1 |
| 18 | Diagnosis and management of pleuraleffusions:a practical approach显示文摘 | Diaz-Guzman E Dweik RA | 2007 | Compr Ther2007，33，4： | 1 |
| 19 | An official ATS clinical practice guideline:interpretation of exhaled nil ric oxide levels(FENO)for clinical applications显示文摘 | Dweik RA Boggs PB Erzurum SC | 2011 | Am J Rcspir Crit Care Med2011，184，5： | 1 |
| 20 | Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma显示文摘 | Dweik RA Sorkness RL Wenzel S | 2010 | Am J Respir Crit Care Med2010，181，10： | 1 |
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