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| 1 | The trend on runoff variations in the Lhasa River Basin显示文摘作为一个学习区域在西藏的高原在拉萨水文学车站上面拿拉萨河盆,年度、每月的吝啬的流量的特征在 1956 ¨ C 期间, 2003 被分析。 | LIN Xuedong ZHANG Yili YAO Zhijun GONG Tongliang WANG Hong CHU Duo LIU Linshan ZHANG Fei | 2008 | Journal of Geographical Sciences2008，18，1： | 18 |
| 2 | Study on gastric cancer blood plasma based on surface-enhanced Raman spectroscopy combined with multivariate analysis显示文摘A surface-enhanced Raman spectroscopy (SERS) method combined with multivariate analysis was developed for non-invasive gastric cancer detection. SERS measurements were performed on two groups of blood plasma samples: one group from 32 gastric patients and the other group from 33 healthy volunteers. Tentative assignments of the Raman bands in the measured SERS spectra suggest interesting cancer-specific biomolecular changes, including an increase in the relative amounts of nucleic acid, collagen, phospholipids and phenylalanine and a decrease in the percentage of amino acids and saccharide in the blood plasma of gastric cancer patients as compared with those of healthy subjects. Principal components analysis (PCA) and linear discriminant analysis (LDA) were employed to develop effective diagnostic algorithms for classification of SERS spectra between normal and cancer plasma with high sensitivity (79.5%) and specificity (91%). A receiver operating characteristic (ROC) curve was employed to assess the accuracy of diagnostic algorithms based on PCA-LDA. The results from this exploratory study demonstrate that SERS plasma analysis combined with PCA-LDA has tremendous potential for the non-invasive detection of gastric cancers. | FENG ShangYuan PAN JianJi WU YanAn LIN Duo CHEN YanPing XI GangQin LIN JuQiang CHEN Rong | 2011 | Science China(Life Sciences)2011，54，9： | 15 |
| 3 | Solvent-free nanocasting toward universal synthesis of ordered mesoporous transition metal sulfide@N-doped carbon composites for electrochemical applications显示文摘Transition metal sulfides (TMSs) have a wide range of applications owing to their intriguing properties.Significant efforts have been devoted to nanostructuring TMSs to enhance their properties and performance,still there is a high need in general synthesis of TMS nanostructures.Herein,for the first time,a simple solvent free reactive nanocasting approach that integrates solid precursor loading,in-situ sulfuration and carbonization into a single heating step is developed for the universal synthesis of ordered mesoporous TMS@N-doped carbon composites (denoted as OM-TMS@NCs) with methionine (Met) and metal chlorides as the precursors and the mesoporous silica (SBA-15) as the hard template.A series of OM-TMS@NCs with a hexagonal mesostructure,ultra-high surface areas (430-754 m2·g-1),large pore volumes (0.85-1.32 cm3·g-1),and unique TMS stoichiometries,including MoS2,Fe7S8,Co9S8,NiS,Cu7S4 and ZnS,are obtained.Two distinct structure configurations,namely,highly dispersed ultrathin TMS nanosheets within NCs and TMS@NC co-nanowire arrays,can be obtained depending on different metals.The structure evolution of the OM-TMS@NCs over the solvent-free nanocasting process is studied in detail for a deep understanding of the synthesis.As demonstrations,these materials are promising for electrocatalytic hydrogen evolution reaction and lithium ion storage with high performances. | Jiahui Zhu Zhi Chen Lin Jia Yuqi Lu Xiangru Wei Xiaoning Wang Winston Duo Wu Na Han Yanguang Li Zhangxiong Wu | 2019 | Nano Research2019，12，9： | 5 |
| 4 | Individual particle analysis of aerosols collected at Lhasa City in the Tibetan Plateau显示文摘To understand the composition and major sources of aerosol particles in Lhasa City on the Tibetan Plateau(TP), individual particles were collected from 2 February to 8 March, 2013 in Tibet University. The mean concentrations of both PM2.5and PM10 during the sampling were25.7 ± 21.7 and 57.2 ± 46.7 μg/m3, respectively, much lower than those of other cities in East and South Asia, but higher than those in the remote region in TP like Nam Co, indicating minor urban pollution. Combining the observations with the meteorological parameters and back trajectory analysis, it was concluded that local sources controlled the pollution during the sampling. Transmission electron microscopy(TEM) combined with energydispersive X-ray spectra(EDS) was used to study 408 particles sampled on four days. Based on the EDS analysis, a total of 8 different particle categories were classified for all 408 particles, including Si-rich, Ca-rich, soot, K-rich, Fe-rich, Pb-rich, Al-rich and other particles.The dominant elements were Si, Al and Ca, which were mainly attributed to mineral dust in the earth's crust such as feldspar and clay. Fe-, Pb-, K-, Al-rich particles and soot mainly originated from anthropogenic sources like firework combustion and biomass burning during the sampling. During the sampling, the pollution mainly came from mineral dust,while the celebration ceremony and religious ritual produced a large quantity of anthropogenic metal-bearing particles on 9 and 25 February 2013. Cement particles also had a minor influence. The data obtained in this study can be useful for developing pollution control strategies. | Bu Duo Yunchen Zhang Lingdong Kong Hongbo Fu Yunjie Hu Jianmin Chen Lin Li A.Qiong | 2015 | Journal of Environmental Sciences2015，27，3： | 4 |
| 5 | 雷公藤红素通过靶向核受体Nur77促进损伤线粒体自噬而抑制炎症反应显示文摘文章简介线粒体在细胞死亡、自噬、免疫和炎症中起着不可或缺的作用。前期研究发现,孤儿核受体Nur77通过靶向线粒体诱导细胞凋亡。本文报道了Nur77作为具有抗炎作用的雷公藤红素的直接靶点,介导雷公藤红素通过自噬清除损伤线粒体,抑制炎症反应而达到治疗炎症疾病包括肥胖症的功能。 | Mengjie Hu Qiang Luo Gulimiran Alitongbieke Shuyi Chong Chenting Xu Lei Xie Xiaohui Chen Duo Zhang Yuqi Zhou Zhaokai Wang Xiaohong Ye Lijun Cai Fang Zhang Huibin Chen Fuquan Jiang Hui Fang Shanjun Yang Jie Liu Maria T.Diaz-Meco Ying Su Hu Zhou Jorge Moscat Xiangzhi Lin 张晓坤 | 2018 | 科学新闻2018，0，4： | 3 |
| 6 | Factors associated with needle sharing among people who inject drugs in Yunnan, China: a combined network and regression analysis显示文摘Background:Network analyses have been widely utilized to evaluate large datasets,but have not yet been used to explore factors associated with risk behaviours.In combination with traditional regression analysis,network analyses may provide useful information and highlight key factors for reducing needle sharing behaviours among people who inject drugs(PWID).Methods:Sociodemographic data,and information on injection behaviour and sexual practices were collected from a cross-sectional survey that was conducted with PWID in five prefectures of Yunnan province,China.A combination of logistic regression and correlation network analyses were used to explore key factors for reducing needle-sharing behaviours among PWID.Results:In a total of 1049 PWID,37.5%had a history of needle or syringe sharing.The logistic analysis showed that Zhaotong,Qujing,Dehong,or Lincang residents,diazepam use,longer injection duration,needle reuse,and infection with HIV,viral hepatitis,tuberculosis and/or malaria were independently associated with needle sharing.The correlation network analyses showed that,compared to PWID who had never shared needles,PWID who did share needles would achieve harm reduction goals faster and more permanently.HIV serostatus and marital status were found to be closely associated with other risk factors.By combining regression analyses with network analyses,it was shown that PWID who are HIV seropositive will be an ideal target group for harm reduction programs.Conclusion:Needle-sharing behaviours are common among PWID in Yunnan,and harm reduction programs may help PWID who are HIV seropositive reduce risk behaviours and prevent blood borne diseases. | Xin Chen Lin Zhu Yan-Heng Zhou Feng-Liang Liu Hong Li Zhi-Hong Yao Lin Duo Wei Pang Mei Ye Yong-Tang Zheng | 2016 | Infectious Diseases of Poverty2016，5，1： | 3 |
| 7 | An E-Commerce Recommender System Based on Click and Purchase Data to Items and Considered of Interest Shifting of Customers显示文摘A well-performed recommender system for an e-commerce web site can help customers easily find favorite items and then increase the turnover of merchants, hence it is important for both customers and merchants. In most of the existing recommender systems, only the purchase information is utilized data and the navigational and behavioral data are seldom concerned. In this paper, we design a novel recommender system for comprehensive online shopping sites. In the proposed recommender system, the navigational and behavioral data, such as access, click, read, and purchase information of a customer, are utilized to calculate the preference degree to each item; then items with larger preference degrees are recommended to the customer. The proposed method has several innovations and two of them are more remarkable: one is that nonexpendable items are distinguished from expendable ones and handled by a different way; another is that the interest shifting of customers are considered. Lastly, we structure an example to show the operation procedure and the performance of the proposed recommender system. The results show that the proposed recommender method with considering interest shifting is superior to Kim et al(2011) method and the method without considering interest shifting. | Duo Lin Wu Zhaoxia XU Shenggang | 2015 | China Communications2015，12，S2： | 3 |
| 8 | Preparation of Mg,N-co-doped lignin adsorbents for enhanced selectivity and high adsorption capacity of As(Ⅴ) from wastewater显示文摘Among various environmental problems,water pollution has drawn more and more attention.To develop an adsorbent with enhanced selectivity and high capacity for As(V)oxyanion,a novel lignin-based adsorbent was prepared by doping with N and modifying with Mg^(2+),using thiethylenetetramine(TETA)and MgCl_(2) as the source of N and Mg^(2+),respectively.N-doped lignin(NL)shows a high selectivity for As(Ⅴ),which is further enhanced by modifying with Mg^(2+)(MNL).MNL shows an excellent reusability.The adsorption isotherms and kinetics of MNL for As(Ⅴ)follow Langmuir isotherms model and pseudo-second-order kinetics model,respectively.The adsorption of MNL for As(Ⅴ)achieved a maximum adsorption capacity of 687.46 mg g^(−1) and the equilibrium was established within 30 min.This study offers a novel idea on the recycle of the waste of paper industry and provides a new technology for As(Ⅴ)adsorption from wastewater. | Xiaofeng Shi Junmao Hong Chao Wang Sifang Kong Junhua Li Duo Pan Jing Lin Qinglong Jiang Zhanhu Guo | 2021 | Particuology2021，19，5： | 2 |
| 9 | Zwitterionic glycine modified Fe/Mg-layered double hydroxides for highly selective and efficient removal of oxyanions from polluted water显示文摘Zwitterionic glycine was employed to modify Fe/Mg-layered double hydroxides(LDH)to realize an GFe/Mg-LDH adsorbent with high adsorption capacities of oxygen-containing anions including As(Ⅴ),P(Ⅴ)and Cr(Ⅵ).When the Fe/Mg mole ratio was 0.02 mol/0.02 mol,the G-Fe/Mg-LDH has a good adsorption performance.The optimum adsorption pH value of G-Fe/Mg-LDH for oxygen-containing anions was 6.The selectivity of three oxygen-containing anions was Cr(Ⅵ) | Xiaofeng Shi Chao Wang Jiaoxia Zhang Li Guo Jing Lin Duo Pan Juying Zhou Jincheng Fan Tao Ding Zhanhu Guo | 2020 | Journal of Materials Science & Technology2020，47，16： | 2 |
| 10 | High seroprevalence of toxoplasma gondii and HIV-1 co-infection among drug users in Yunnan province, southwest China显示文摘Dear Editor,Toxoplasma gondii was discovered more than 100 years ago and has a broad-spectrum of intermediate hosts in addition to its definitive host,felids.Although it does not cause symptomatic illness in most adults,it can lead to mental retardation in congenitally infected children and | Xin Chen Mei Ye Yan-Heng Zhou Feng-Liang Liu Lin Duo Hong Li Wei Pang Yong-Tang Zheng | 2016 | Science China(Life Sciences)2016，59，8： | 2 |
| 11 | Measurement of Trace Potassium Contaminations With Accelerator Mass SpectrometryMeasurement of Trace Potassium Contaminations With Accelerator Mass SpectrometryMeasurement of Trace Potassium Contaminations With Accelerator Mass Spectrometry显示文摘 | DONG Ke-jun HE Ming JIANG Shan WONG Henry Tsz-king QIU Jiu-zi GUAN Yong-jing WU Shao-yong LI Shi-hong LIN Min ZHOU Duo YIN Xin-yi PENG Bo DING Yan-qiu JU Zhi-ping YUAN Jian | 2005 | Annual Report of China Institute of Atomic Energy2005，，1： | 2 |
| 12 | Clonal integration benefits invasive alien plants under water variability in a native community显示文摘Aims Many invasive alien plant species are clonal and can greatly propa-gate and spread through clonal integration(sharing resources between connected ramets)in heterogeneous and variable environ-ments.Here,we tested whether water variability influences clonal integration of invasive alien plant species and consequently facili-tates their growth and dominance in a native community.Methods We selected four typical invasive clonal plant species in China.Connected(with clonal integration)and disconnected(without clonal integration)clonal fragments were established either under constant watering or variable watering condition in an experimental native plant community consisting of three naturally co-occurring grassland species.Proximal part of the container received high nu-trient and distal part received low nutrient.Important Findings Clonal integration significantly increased biomass,aboveground mass and belowground mass of invasive alien plants in the proximal ramets,the distal ramets and the whole clone and de-creased the growth of native community.Interestingly,clonal in-tegration significantly increased the growth of invasive plants in variable watering.The positive effect of clonal integration was stronger in variable watering than in constant watering.Invasive plants with clonal integration had high biomass proportion(>0.6)in the whole community.Our results suggest that invasive clonal plants benefit more from clonal integration in variable water en-vironments when established in a native community,and to some extent,clonal integration potentially contribute greatly to the inva-siveness of alien clonal plants when they enter a new community with resource variability. | Duo Chen Hao Xiong Chang-Gen Lin Wei He Zhuo-Wen Zhang Hui Wang Yong-Jian Wang | 2019 | Journal of Plant Ecology2019，12，3： | 2 |
| 13 | Presence of antibodies against low-density lipoprotein receptor-related protein 4 and impairment of neuromuscular junction in a Chinese cohort of amyotrophic lateral sclerosis显示文摘Amyotrophic lateral sclerosis (ALS) is a heterogeneous disorder characterized by a loss of upper and lower motor neurons with neither clear pathogenesis nor effective treatment. Thus, potential biomarkers are needed to classify the disease and find new drug targets. Previous studies have shown that auto-antibodies against the low-density lipoprotein receptor-related protein 4 (LRP4), called the anti-LRP4 antibodies, are found in ~23% patients of Greek and Italian ALS cohorts,[1] and in 10% of the American ALS population.[2] Anti-LRP4 antibodies were previously identified in myasthenia gravis (MG), the most common neuromuscular junction (NMJ) disorder, and were shown to cause NMJ abnormality in animal studies.[3] Here, we studied anti-LRP4 antibodies in Chinese patients and investigated the correlation between anti-LRP4 antibodies and abnormal neuromuscular transmission in ALS. | Lin Lei Xin-Ming Shen Shu-Yan Wang Yan Lu Suo-Bin Wang Hai Chen Zheng Liu Ya-Sheng Ouyang Jian-Ying Duo Yu-Wei Da Zhi-Guo Chen | 2019 | Chinese Medical Journal2019，，12： | 1 |
| 14 | In-situ constructing visible light CdS/Cd-MOF photocatalyst with enhanced photodegradation of methylene blue显示文摘Based on high specific surface area,high porosity of metal-organic frameworks(MOFs)and excellent vis-ible light response of CdS,the CdS/Cd-MOF nanocomposites were constructed by in-situ sulfurization to form CdS using Cd-MOF as precursor and the CdS loading was controlled by the dose of thioac-etamide.Under the irradiation of simulated sunlight,the degradation rate of methylene blue(MB)by 10mg MOF/CdS-6(mass ratio of MOF to thioacetamide is 6:1)was 91.9%in 100min,which was higher than that of pure Cd-MOF(62.3%)and pure CdS(67.5%).This is attributed to the larger specific surface area of the composite catalysts,which provides more active sites.Meanwhile,the loading of CdS obvi-ously broadens the light response range of Cd-MOF and improves the utilization of visible light.The Mott-Schottky model experiment shows that the formed type-Ⅱheterojunction between Cd-MOF and CdS can effectively inhibit the recombination of photogenerated electrons and holes.Meanwhile,the photocurrent intensity of MOF/CdS-6 is 8 times and 2.5 times of that of pure Cd-MOF and CdS.In addi-tion,MOF/CdS-6 showed good photocatalytic performance after five cycles,showing excellent stability and reusability. | Cheng Jing Yufei Zhang Junjie Zheng Shengsong Ge Jing Lin Duo Pan Nithesh Naik Zhanhu Guo | 2022 | Particuology2022，20，10： | 1 |
| 15 | Malaria Transmission Potential in the Three Gorges Reservoir of the Yangtze River, China显示文摘Objective To define and evaluate the malaria transmission potential in the Yangtze River, following construction of the Three Gorges Reservoir. Methods Six villages, namely, Kaixian, Fengjie, Wanzhou, Fuling, Yubei, and Zigui were selected for investigating the malaria transmission potential in the reservoir. Transmission potential was estimated by mathematical modeling and evaluation of the local malaria situation. Factors that influenced the transmission potential were analyzed using Poisson regression analysis in combination with Grey Systematic Theory (based on evaluation by the Delphi method). Results Indirect fluorescent antibody data and the incidence of malaria in the local population were consistent with the malaria transmission potential calculated for the area. Multivariate Poisson regression analysis showed a statistically significant association between the riparian zone and the man‐biting rate. Conclusion The risk of a malaria epidemic can be forecasted using the malaria transmission potential parameters investigated here which was closely correlated with the riparian zone. | WANG Duo Quan TANG Lin Hua GU Zhen Cheng ZHENG Xiang JIANG Wei Kang | 2013 | Biomedical and Environmental Sciences2013，26，1： | 1 |
| 16 | Alteration of metallothionein mRNA in bay scallop Argopectenirra dians under cadmium exposure and bacteria challenge显示文摘 | Ling L W Lin S S Duo J N | 2009 | Comparative Biochemistry and Physiology C:Pharmacology Toxicology and Endocrinology2009，149，： | 1 |
| 17 | An efficient method for the simultaneous determination of three flavone aglycones in Flos Chrysanthemi by acid hydrolysis and HPLC显示文摘 | Fu Gao Li Hui Zhou Duo Lin Sun | 2009 | Journal of Chinese Pharmaceutical Sciences2009，18，： | 1 |
| 18 | A novel PI3K inhibitor XH30 suppresses orthotopic glioblastoma and brain metastasis in mice models显示文摘Glioblastoma is carcinogenesis of glial cells in central nervous system and has the highest incidence among primary brain tumors.Brain metastasis,such as breast cancer and lung cancer,also leads to high mortality.The available medicines are limited due to blood-brain barrier.Abnormal activation of phosphatidylinositol 3-kinases(PI3 K)signaling pathway is prevalent in glioblastoma and metastatic tumors.Here,we characterized a 2-amino-4-methylquinazoline derivative XH30 as a potent PI3 K inhibitor with excellent anti-tumor activity against human glioblastoma.XH30 significantly repressed the proliferation of various brain cancer cells and decreased the phosphorylation of key proteins of PI3 K signaling pathway,induced cell cycle arrest in G1 phase as well.Additionally,XH30 inhibited the migration of glioma cells and blocked the activation of PI3 K pathway by interleukin-17 A(IL-17 A),which increased the migration of U87 MG.Oral administration of XH30 significantly suppressed the tumor growth in both subcutaneous and orthotopic tumor models.XH30 also repressed tumor growth in brain metastasis models of lung cancers.Moreover,XH30 reduced IL-17 A and its receptor IL-17 RA in vivo.These results indicate that XH30 might be a potential therapeutic drug candidate for glioblastoma migration and brain metastasis. | Ming Ji Dongjie Wang Songwen Lin Chunyang Wang Ling Li Zhihui Zhang Jing Jin Deyu Wu Yi Dong Heng Xu Duo Lu Xiaoguang Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 1 |
| 19 | Optimization of Extraction Process for Polysaccharides of Urtica fissa E. Pritz.显示文摘[Objectives] To study the optimal extraction process for polysaccharides of Urtica fissa E. Pritz. [Methods] Leaves of wild U. fissa E. Pritz. collected in Nyingchi of Tibet were used as raw materials. Water extraction method was used to extract polysaccharides from U. fissa E. Pritz. Besides,comparison was made for the effects of extraction time,extraction temperature and solid-to-liquid ratio on the yield rate of polysaccharides from U. fissa E. Pritz. In addition,using the extraction time,extraction temperature and solid-to-liquid ratio as factors,L9( 33) orthogonal experiment was carried out to determine the optimal process parameters for water extraction of polysaccharides from U. fissa E. Pritz.[Results] The optimal process parameters: hot water extraction time was 4 h,the extraction temperature was 90℃,and the mass ratio of water to leaves of U. fissa E. Pritz. was 1∶ 25. Under such extraction conditions,the yield rate of polysaccharides from U. fissa E. Pritz.was up to 11. 611%. [Conclusions]This experiment is expected to provide certain reference for reasonable development and utilization of wild U. fissa E. Pritz. resources in Tibet. | Lin YANG Duo CAO Xuedong GU Fumin CHI | 2018 | Medicinal Plant2018，9，2： | 1 |
| 20 | Laparoscopic Local Resection Based on Sentinel Node Evaluation for Early Gastric Cancer: A Preliminary Report显示文摘 | Lin Bo Wang Jian Guo Shen Li Feng Dong Chao Yang Xu Wen Jun Chen Shu Duo Xie Xiang Yang Song Ning Dai Xiao Ming Yuan | 2008 | Journal of Gastrointestinal Surgery2008，，8： | 1 |
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