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| 1 | Analogic China map constructed by DNA显示文摘In this research,a nanoscale DNA structure of analogic China map is created. The nanostructure of roughly 150 nm in diameter with a spatial resolution of 6 nm is purely constructed by folding DNA. The picture observed by atomic force microscopy (AFM) is almost identical with the de-signed shape. The DNA origami technology invented by Rothemund in 2006 is employed in the construc-tion of this shape,which has proved the capability of constructing almost any complicated shape enabled by DNA origami,and provides new bottom-up method for constructing nanostructures. | QIAN Lulu WANG Ying ZHANG Zhao ZHAO Jian PAN Dun ZHANG Yi LIU Qiang FAN Chunhai HU Jun HE Lin | 2006 | Chinese Science Bulletin2006，51，24： | 20 |
| 2 | 应用于三维生物打印的DNA超分子水凝胶显示文摘水凝胶因其高含水量和类似于细胞外基质的特点,是三维组织打印和人工器官制备的首选基材,也因此成为化学、材料学和生命医学领域研究的热点[1]。截止目前,用于生物打印的水凝胶主要包括海藻酸钠、壳聚糖、胶原蛋白、琼脂糖等天然水凝胶及其衍生产物,以及人工合成的聚乙二醇、聚多肽等化学类水凝胶[2]。无论是天然的物理类水凝胶还是人工合成的化学类水凝胶。 | 李闯 Alan Faulkner-Jones Alison R. Dun 金娟 陈平 邢永政 杨忠强 李志波 舒文淼 刘冬生 Rory R. Duncan | 2015 | 中国科学基金2015，29，3： | 18 |
| 3 | Saponins from Panax japonicus attenuate age-related neuroinflammation via regulation of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways显示文摘Neuroinflammation is recognized as an important pathogenic factor for aging and related cognitive disorders. Mitogen-activated protein kinase and nuclear factor kappa B signaling pathways may mediate neuroinflammation. Saponins from Panax japonicus are the most abundant and bioactive members in rhizomes of Panax japonicus, and show anti-inflammatory activity. However, it is not known whether saponin from Panax japonicus has an anti-inflammatory effect in the aging brain, and likewise its underlying mechanisms. Sprague-Dawley rats were divided into control groups(3-, 9-, 15-, and 24-month-old groups) and saponins from Panax japonicus-treated groups. Saponins from Panax japonicus-treated groups were orally administrated saponins from Panax japonicus at three doses of 10, 30, and 60 mg/kg once daily for 6 months until the rats were 24 months old. Immunohistochemical staining and western blot assay results demonstrated that many microglia were activated in 24-month-old rats compared with 3-and 9-month-old rats. Expression of interleukin-1β, tumor necrosis factor-α, cyclooxygenase-2, and inducible nitric oxide synthase increased. Each dose of saponins from Panax japonicus visibly suppressed microglial activation in the aging rat brain, and inhibited expression levels of the above factors. Each dose of saponins from Panax japonicus markedly diminished levels of nuclear factor kappa B, IκBα, extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38. These results confirm that saponins from Panax japonicus can mitigate neuroinflammation in the aging rat brain by inhibition of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways. | Li-li Deng Ding Yuan Zhi-yong Zhou Jing-zhi Wan Chang-cheng Zhang Chao-qi Liu Yao-yan Dun Hai-xia Zhao Bo Zhao Yuan-jian Yang Ting Wang | 2017 | Neural Regeneration Research2017，12，11： | 17 |
| 4 | Genetic analysis and molecular mapping of a presenescing leaf gene psll in rice (Oryza sativa L.)显示文摘A rice psl1 (presenescing leaf) mutant was obtained from a japonica variety Zhonghua 11 via radiation of 60Co-γ in M2 generation. Every leaf of the mutant began to wither after it reached the big-gest length,while the leaves of the wild variety could keep green for 25―35 d. In this study,genetic analysis and gene mapping were carried out for the mutant identified. The SSR marker analysis showed that the mutant was controlled by a single recessive gene (psl1) located on chromosome 2. Fine mapping of the psl1 locus was conducted with 34 new STS markers developed around psl1 anchored region based on the sequence diversity between Nippon-bare and 93-11. The psl1 was further mapped be-tween two STS markers,STS2-19 and STS2-26,with genetic distances of 0.43 and 0.11 cM,respectively,while cosegregated with STS2-25. A BAC contig was found to span the psl1 locus,the region being delim-ited to 48 kb. This result was very useful for cloning of the psl1 gene. | WANG dun WU Shujun ZHOU Yong ZHOU Lihui XU Jiefen HU Jing FANG Yunxia GU Minghong LIANG Guohua | 2006 | Chinese Science Bulletin2006，51，24： | 16 |
| 5 | Enteral nutrition in treatment of severe acute pancreatitis显示文摘Objective: To observe the role and the timing of EN inthe treatment of patients with severe acute pancreatitis(SAP).Methods: Eleven patients with severe acute pancreatitisunderwent systemic nutrition support were studied.EN was given through jejunostomy tube (or Beng-mark tube) after a period of PN maintenance. ENstarted when serum and urine amylase activity re-turned to normal with regular peristaltic sound, defe-cation or break wind. The sequence of preparationwas as follows: saline glucose→chemically defined di-et→polymeric diet→normal diet.Results: In all the patients, none died. The rate of latecomplications was lower, and the levels of serum albu-min and transferritin significantly increased in thepost-EN period as compared with the pre-EN period,although the count of lymphocytes was less changed.Conclusions: Nutritional support should be trans-formed from PN to EN as early as possible during thetreatment of patients with severe acute pancreatitis. ENcould not only continue sufficient nutritional support,but also avoid the unfavorable effects of long-timePN, thus reducing complications as well as mortality. | Dun Shi Cheng-Wu Zhang Jin-Song Jiang Zhi-Jie Xie Shou-Chun Zou From the Department of General Surgery, Zhejiang Provincial People’s Hospital, Hangzhou 310014, China | 2002 | Hepatobiliary & Pancreatic Diseases International2002，1，1： | 14 |
| 6 | Rapid report of the 8 January 2022 M_(S)6.9 Menyuan earthquake,Qinghai,China显示文摘The M_(S)6.9 Menyuan earthquake in Qinghai Province,west China is the largest earthquake by far in 2022.The earthquake occurs in a tectonically active region,with a background b-value of 0.87 within 100 km of the epicenter that we derived from the unified catalog produced by China Earthquake Networks Center since late 2008.Field surveys have revealed surface ruptures extending 22 km along strike,with a maximum ground displacement of 2.1 m.We construct a finite fault model with constraints from In SAR observations,which showed multiple fault segments during the Menyuan earthquake.The major slip asperity is confined within 10 km at depth,with the maximum slip of 3.5 m.Near real-time back-projection results of coseismic radiation indicate a northwest propagating rupture that lasted for~10 s.Intensity estimates from the back-projection results show up to a Mercalli scale of IX near the ruptured area,consistent with instrumental measurements and the observations from the field surveys.Aftershock locations(up to January 21,2022)exhibit two segments,extending to~20 km in depth.The largest one reaches M_(S)5.3,locating near the eastern end of the aftershock zone.Although the location and the approximate magnitude of the mainshock had been indicated by previous studies based on paleoearthquake records and seismic gap,as well as estimated stressing rate on faults,significant surfacebreaching rupture leads to severe damage of the high-speed railway system,which poses a challenge in accurately assessing earthquake hazards and risks,and thus demands further investigations of the rupture behaviors for crustal earthquakes. | Hongfeng Yang Dun Wang Rumeng Guo Mengyu Xie Yang Zang Yue Wang Qiang Yao Chuang Cheng Yanru An Yingying Zhang | 2022 | Earthquake Research Advances2022，2，1： | 14 |
| 7 | Classic axon guidance molecules control correct nerve bridge tissue formation and precise axon regeneration显示文摘The peripheral nervous system has an astonishing ability to regenerate following a compression or crush injury;however,the potential for full repair following a transection injury is much less.Currently,the major clinical challenge for peripheral nerve repair come from long gaps between the proximal and distal nerve stumps,which prevent regenerating axons reaching the distal nerve.Precise axon targeting during nervous system development is controlled by families of axon guidance molecules including Netrins,Slits,Ephrins and Semaphorins.Several recent studies have indicated key roles of Netrin1,Slit3 and EphrinB2 signalling in controlling the formation of new nerve bridge tissue and precise axon regeneration after peripheral nerve transection injury.Inside the nerve bridge,nerve fibroblasts express EphrinB2 while migrating Schwann cells express the receptor EphB2.EphrinB2/EphB2 signalling between nerve fibroblasts and migrating Schwann cells is required for Sox2 upregulation in Schwann cells and the formation of Schwann cell cords within the nerve bridge to allow directional axon growth to the distal nerve stump.Macrophages in the outermost layer of the nerve bridge express Slit3 while migrating Schwann cells and regenerating axons express the receptor Robo1;within Schwann cells,Robo1 expression is also Sox2-dependent.Slit3/Robo1 signalling is required to keep migrating Schwann cells and regenerating axons inside the nerve bridge.In addition to the Slit3/Robo1 signalling system,migrating Schwann cells also express Netrin1 and regenerating axons express the DCC receptor.It appears that migrating Schwann cells could also use Netrin1 as a guidance cue to direct regenerating axons across the peripheral nerve gap.Engineered neural tissues have been suggested as promising alternatives for the repair of large peripheral nerve gaps.Therefore,understanding the function of classic axon guidance molecules in nerve bridge formation and their roles in axon regeneration could be highly beneficial in developing engineered neural tissue for more effective peripheral nerve repair. | Xin-Peng Dun David BParkinson | 2020 | Neural Regeneration Research2020，15，1： | 13 |
| 8 | 远程护理教育的实施与评估显示文摘对在国内首次服务于护理教育的远程教育网络作全面考察并评估 ,用自行设计的调查表 ,对与远程教学课程传输有关的各类人员 (包括管理者、授课教师、技术人员、学历教育和继续教育学员 )进行询问调查。结果 :学历教育学员对远程教育大部分指标的评价均达到中等或满意以上 ,对教师的评定和各门课程的满意度均达到满意以上 ,但远程组满意程度低于医科大学组 ;86 .0 %以上的继续教育学员认为 :远程教育增加了继续教育的机会 ,远程教学内容新、容易理解 ,对护理知识的积累和护理技能的提高有帮助。 93.4%教师认为远程教学与课堂教学质量无差别。 89.9%的被调查者对远程教育表示支持。而在师生互动交流、声音图像传输、板书效果等方面遇到一些挑战 ,有待进一步改进。结论 :远程护理教育在国内的首次实施效果颇佳 ,提示应加强各部门之间的协调与合作 ,尽快提高各类人员运用远程设备的能力 ,使远程护理教育网络在护理人员的学历和继续教育中发挥更大的作用。 | 邹道慧 Nancy Edwards Betty Cragg Jean Dunning 罗茂红 宋丽欣 | 2002 | 护理研究2002，16，5： | 11 |
| 9 | The effect of hematoma puncture drainage before decompressive craniectomy on the prognosis of hypertensive intracerebral hemorrhage with cerebral hernia at a high altitude显示文摘Purpose:Rapid decompressive craniectomy(DC)was the most effective method for the treatment of hypertensive intracerebral hemorrhage(HICH)with cerebral hernia,but the mortality and disability rate is still high.We suspected that hematoma puncture drainage(PD)+DC may improve the therapeutic effect and thus compared the combined surgery with DC alone.Methods:From December 2013 to July 2019,patients with HICH from Linzhi,Tibet and Honghe,Yunnan Province were retrospectively analyzed.The selection criteria were as follows:(1)altitude≥1500 m;(2)HICH patients with cerebral hernia;(3)Glascow coma scale score of 4-8 and time from onset to admission≤3 h;(4)good liver and kidney function;and(5)complete case data.The included patients were divided into DC group and PD+DC group.The patients were followed up for 6 months.The outcome was assessed by Glasgow outcome scale(GOS)score,Kaplan-Meier survival curve and correlation between time from admission to operation and prognosis.A good outcome was defined as independent(GOS score,4-5)and poor outcome defined as dependent(GOS score,3-1).All data analyses were performed using SPSS 19,and comparison between two groups was conducted using separatet-tests or Chi-square tests.Results:A total of 65 patients was included.The age ranged 34-90 years(mean,63.00±14.04 years).Among them,31 patients had the operation of PD+DC,whereas 34 patients underwent DC.The two groups had no significant difference in the basic characteristics.After 6 months of follow-up,in the PD+DC group there were 8 death,4 vegetative state,4 severe disability(GOS score 1-3,poor outcome 51.6%);8 moderate disability,and 7 good recovery(GOS score 4-5,good outcome 48.4%);while in the DC group the result was 15 death,6 vegetative state,5 severe disability(poor outcome 76.5%),4 moderate disability and 4 good recovery(good outcome 23.5%).The GOS score and good outcome were significantly less in DC group than in PD+DC group(Z=-1.993,p=0.046;χ2=4.38,p=0.043).However,there was no significant difference regarding the survival curve between PD+DC group and DC group.The correlation between the time from admission to operation and GOS at 6 months(r=-0.41,R2=0.002,p=0.829)was not significant in the PD+DC group,but significant in the DC group(r=-0.357,R2=0.128,p=0.038).Conclusion:PD+DC treatment can improve the good outcomes better than DC treatment for HICH with cerebral hernia at a high altitude. | Lin-Jie Wei Chi Lin Xing-Sen Xue Guo-Dong Dun Jian-Bo Zhang Yan-Xiang Tong Jia-Xiong Wang Shi-Ji Yang Ling Wang Zhi Chen Hua Feng Gang Zhu | 2021 | Chinese Journal of Traumatology2021，24，6： | 11 |
| 10 | Jittor:a novel deep learning framework with meta-operators and unified graph execution显示文摘This paper introduces Jittor,a fully just-in-time(JIT)compiled deep learning framework.With JIT compilation,we can achieve higher performance while making systems highly customizable.Jittor provides classes of Numpy-like operators,which we call meta-operators.A deep learning model built upon these meta-operators is compiled into high-performance CPU or GPU code in real-time.To manage metaoperators,Jittor uses a highly optimized way of executing computation graphs,which we call unified graph execution.This approach is as easy to use as dynamic graph execution yet has the efficiency of static graph execution.It also provides other improvements,including operator fusion,cross iteration fusion,and unified memory. | Shi-Min HU Dun LIANG Guo-Ye YANG Guo-Wei YANG Wen-Yang ZHOU | 2020 | Science China(Information Sciences)2020，63，12： | 10 |
| 11 | Dynamics of Strigolactone Function and Shoot Branching Responses in Pisum sativum显示文摘Strigolactones (SL ) ,或他们的代谢物,最近作为射击分叉的内长的禁止者被识别。然而, SL 行动的某些特色和动力学尚待生理地被描绘。这里,我们证明到在沿着茎罐头的每个节点的腋的芽的 SL 的连续直接申请充分禁止分叉。早长出的 SL 抑制没从另外的成长的芽或射击尖端要求禁止的信号。除了长出的这很早或起始的抑制,我们也发现了 SL 有效,直到一个点,在节制腋的分支的持续生长。在影响芽和分支生长的 SL 的有效性与 SL 的能力相关调整 PsBRC1 的表示。PsBRC1 是在腋的芽强烈被表示并且为射击分叉的 SL 抑制被要求的一个抄写因素。与荷尔蒙的一个动态角色一致,芽生长的 SL 抑制没阻止芽以后对一个斩首杀头处理作出回应,尽管 SL 处理立即在斩首杀头以后禁止长出反应。另外在植物从假设分叉的控制网络期望外长的 SL 的处理在 2 h 以内引起了反馈 SL 生合成基因的下面规定。总的来说,这些结果表明进 SL 的动力学的新卓见工作并且支持 SL 或导出 SL 的代谢物作为分叉的射击动态地工作的前提荷尔蒙和那他们在腋的芽直接行动。 | Elizabeth A. Dun Alexandre de Saint Germain Catherine Rameau Christine A. Beveridge | 2013 | Molecular Plant2013，6，1： | 9 |
| 12 | Advances in BeiDou Navigation Satellite System(BDS)and satellite navigation augmentation technologies显示文摘Several noteworthy breakthroughs have been made with the BeiDou Navigation Satellite System(BDS)and other global navigation satellite systems as well as the associated augmentation systems,such as the commissioning of the BDS-3 preliminary system and the successful launch of the first BDS-3 GEO satellite which carries the satellite-based augmentation payload.Presently,BDS can provide basic services globally,and its augmentation system is also being tested.This paper gives an overview of BDS and satellite navigation augmentation technologies.This overview is divided into four parts,which include the system segment technologies,satellite segment technologies,propagation segment technologies,and user segment technologies.In each part,these technologies are described from the perspectives of preliminary information,research progress,and summary.Moreover,the significance and progress of the BeiDou Satellite-based Augmentation System(BDSBAS),low earth orbit augmentation,and the national BeiDou ground-based augmentation system are presented,along with the airborne-based augmentation system.Furthermore,the conclusions and discussions covering popular topics for research,frontiers in research and development,achievements,and suggestions are listed for future research. | Rui Li Shuaiyong Zheng Ershen Wang Jinping Chen Shaojun Feng Dun Wang Liwen Dai | 2020 | Satellite Navigation2020，1，1： | 9 |
| 13 | 老年2型糖尿病管理全球指南显示文摘国际糖尿病联盟(IDF)在2013年发布了《老年2型糖尿病管理全球指南》.从本期开始我们将连载该指南的中文译文,希望对广大医务工作者有所帮助。 | Alan Sinclair Trisha Dunning Stephan Colagiuri 罗燮 | 2014 | 糖尿病天地(临床)2014，8，2： | 9 |
| 14 | Game theory approach to optimal capital cost allocation in pollution control显示文摘GametheoryapproachtooptimalcapitalcostalocationinpolutioncontrolChenWenyingInstituteofNuclearEnergyTechnology,TsinghuaUniver... | Chen Wen ying Institute of Nuclear Energy Technology, Tsinghua University, Beijing 100084,China Hou Dun Urban Water Resources Center, Ministry of Construction, Beijing 100007,China | 1998 | Journal of Environmental Sciences1998，10，2： | 8 |
| 15 | Grape Seed Proanthocyanidin Extract Ameliorates Streptozotocin-induced Cognitive and Synaptic Plasticity Deficits by Inhibiting Oxidative Stress and Preserving AKT and ERK Activities显示文摘Progressive memory loss and cognitive impairment are the main clinical manifestations of Alzheimer’s disease(AD).Currently,there is no effective drug available for the treatment of AD.Previous studies have demonstrated that the cognitive impairment of AD is associated with oxidative stress and the inhibition of AKT and ERK phosphorylation.Grape seed proanthocyanidin extract(GSPE)has been shown to have strong antioxidant effect and can protect the nervous system from oxidative stress damage.This study aimed to investigate the protective effect of GSPE on the cognitive and synaptic impairments of AD using a sporadic AD rat model induced by intracerebroventricular(ICV)injection of streptozotocin(STZ)(ICV-STZ).Rats were treated with GSPE(50,100,or 200 mg/kg every day)by intragastrical(ig.)administration for continuous 7 weeks,and ICV-STZ(3 mg/kg)was performed on the first day and third day of week 5.Learning and memory abilities were assessed by the Morris water maze(MWM)test at week 8.After behavioral test,hippocampal long-term potentiation(LTP)was recorded,and the levels of malondialdehyde(MDA),superoxide dismutases(SOD),glutathione(GSH)and the protein expression of AKT and ERK were measured in the hippocampus and cerebral cortex of rats.Our study revealed that ICV-STZ significantly impaired the working learning ability and hippocampal LTP of rats,significantly increased the levels of MDA,and decreased the activity of SOD and GSH in the hippocampus and cerebral cortex.In contrast,GSPE treatment prevented the impairment of cognitive function and hippocampal LTP induced by ICV-STZ,decreased the level of MDA,and increased the level of SOD and GSH.Furthermore,Western blot results showed that GSPE treatment could prevent the loss of AKT and ERK activities in the hippocampus and cerebral cortex induced by ICV-STZ.Our findings demonstrate that GSPE treatment could ameliorate the impairment of cognitive ability and hippocampal synaptic plasticity in a rat model of sporadic AD by inhibiting oxidative stress and preserving AKT and ERK activities.Therefore,GSPE may be an effective agent for the treatment of cognitive deficits associated with sporadic AD. | Wei-li GAO Xiang-hua LI Xin-peng DUN Xiao-kuan JING Ke YANG Yan-kun LI | 2020 | Current Medical Science2020，40，3： | 8 |
| 16 | The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition显示文摘在人的不孕病人的精子在场的最普通的损害之一是精子鸡蛋识别的自发的失败。尽管这个唯一的细胞的相互作用现在能被象 intracytoplasmic 精子注射(ICSI ) 那样的帮助繁殖策略乐意地绕过,最近的大规模流行病学的研究鼓励了这种技术的小心的使用并且为对为有缺点的精子鸡蛋识别负责的机制的进一步的研究加亮需要。这个领域里的以前的工作证实了为卵母细胞相互作用负责的精子领域在动态地在女繁殖的道在 epididymal 成熟和 capacitation 期间被修改以前在精子发生期间被形成。当为这些顺序的 maturational 事件的规定负责的因素无疑是复杂的时,新兴的研究识别了分子的女伴,加热吃惊蛋白质 A2 (HSPA2 ) ,,在人的精子的这些事件的一个关键管理者。HSPA2 是支持合拢,运输,和集会蛋白质建筑群的 70 kDa 热吃惊蛋白质家庭的一个充实睾丸的成员并且断然被相关与在 vitro 授精(IVF ) 成功。而且,从人的精子 proteome 减少了 HSPA2 的表示为跟随 IVF 和 ICSI 的积云矩阵疏开,精子鸡蛋识别和授精导致一个损害能力。在这评论,我们考虑在精子功能支持 HSPA2 的角色的证据并且探索它被在不肥沃的病人的精子弄空的潜在的机制。进管理精子的分子的机制的如此的信息提议小说卓见工作。 | Brett Nixon Elizabeth G Bromfield Matthew D Dun Kate A Redgrove Eileen A McLaughlin R John Aitken | 2015 | Asian Journal of Andrology2015，17，4： | 8 |
| 17 | EMTP-type Program Realization of Krylov Subspace Based Model Reduction Methods for Large-Scale Active Distribution Network显示文摘Effective model reduction methods are required to deal with new challenges in active distribution network simulations that are on a large scale and have complicated structures.In the development of advanced electromagnetic transient simulation programs,automated model reduction plays an important role.This paper proposes an automated realization algorithm for the Krylov subspace based model reduction methods of an active distribution network with which the reduced model can be automatically established according to a given threshold of reduction error.The combined state-space nodal analysis framework is employed to apply the automated model reduction algorithm in popular EMTP-type simulation programs.Simulations are performed using PSCAD and a self-developed program to show the feasibility and validity of the proposed methods. | Chengshan Wang Hao Yu Peng Li Jianzhong Wu Chengdi Ding Guanyu Song Dun Lin Feng Xing | 2015 | CSEE Journal of Power and Energy Systems2015，1，1： | 8 |
| 18 | Specific shRNA targeting of FAK influenced collagen metabolism in rat hepatic stellate cells显示文摘AIM:To investigate the effects and mechanism of disruption of focal adhesion kinase(FAK) expression on collagen metabolism in rat hepatic stellate cells(HSC).METHODS:The plasmids expressing FAK short hairpin RNA(shRNA) were transfected into HSC-T6 cells,and the level of FAK expression was determined by both real-time quantitative polymerase chain reaction(QPCR) and Western blotting analysis.The production of type collagen and type collagen in FAK-disrupted cells was analyzed by real-time Q-PCR.The level of collagen metabolism proteins,including matrix metalloproteinases-13(MMP-13) and tissue inhibitors of metalloproteinases-1(TIMP-1) was also determined by both real-time Q-PCR and Western blotting analysis.RESULTS:The transfection of FAK shRNA plasmids into HSC resulted in disrupted FAK expression.Compared with the HK group,the levels of type collagen and type collagen mRNA transcripts in FAK shRNA plas-mid group were signif icantly decreased(0.69 ± 0.03 vs 1.96 ± 0.15,P = 0.000;0.59 ± 0.07 vs 1.62 ± 0.12,P = 0.020).The production of TIMP-1 in this cell type was also signif icantly reduced at both mRNA and protein levels(0.49 ± 0.02 vs 1.72 ± 0.10,P = 0.005;0.76 ± 0.08 vs 2.31 ± 0.24,P = 0.000).However,the expression of MMP-13 mRNA could be significantly up-regulated by the transfection of FAK shRNA plasmids into HSC(1.74 ± 0.20 vs 1.09 ± 0.09,P = 0.000).CONCLUSION:These data support the hypothesis that shRNA-mediated disruption of FAK expression could attenuate extracellular matrix(ECM) synthesis and promote ECM degradation,making FAK a potential target for novel anti-f ibrosis therapies. | Zhi-Na Dun Xiao-Lan Zhang Jun-Yan An Li-Bo Zheng Robert Barrett Shu-Rui Xie | 2010 | World Journal of Gastroenterology2010，16，32： | 8 |
| 19 | Positive Selection Analysis of VP1 Genes of Worldwide Human Enterovirus 71 Viruses显示文摘Human enterovirus 71 viruses have been long circulating throughout the world. In this study, we performed a positive selection analysis of the VP1 genes of capsid proteins from Enterovirus 71 viruses. Our results showed that although most sites were under negative or neutral evolution, four positions of the VP1 genes were under positive selection pressure. This might account for the spread and frequent outbreaks of the viruses and the enhanced neurovirulence. In particular, position 98 might be involved in neutralizing antibodies, modulating the virus-receptor interaction and enhancing the virulence of the viruses. Moreover, both positions 145 and 241 might correlate to determine the receptor specificity. However, these positions did not display much difference in amino acid polymorphism. In addition, no position in the VP1 genes of viruses isolated from China was under positive selection. | Wei-feng SHI Zhong ZHANG Ai-she DUN Yan-zhou ZHANG Guang-fu YU Dong-ming ZHUANG Chao-dong ZHU | 2009 | Virologica Sinica2009，24，1： | 8 |
| 20 | Complications in the management of metastatic spinal disease显示文摘Metastatic spine disease accounts for 10% to 30% of new cancer diagnoses annually. The most frequent presentation is axial spinal pain. No treatment has been proven to increase the life expectancy of patients with spinal metastasis. The goals of therapy are pain control and functional preservation. The most important prognostic indicator for spinal metastases is the initial functional score. Treatment is multidisciplinary, and virtually all treatment is palliative. Management is guided by three key issues; neurologic compromise, spinal instability, and individual patient factors. Site-directed radiation, with or without chemotherapy is the most commonly used treatment modality for those patients presenting with spinal pain, causative by tumours which are not impinging on neural elements. Operative intervention has, until recently been advocated for establishing a tissue diagnosis, mechanical stabilization and for reduction of tumor burden but not for a curative approach. It is treatment of choice patients with diseaseadvancement despite radiotherapy and in those with known radiotherapy-resistant tumors. Vertebral resection and ante-rior stabilization with methacrylate or hardware(e.g., cages) has been advocated.Surgical decompression and stabilization, however, along with radiotherapy, may provide the most promising treatment. It stabilizes the metastatic deposited areaand allows ambulation with pain relief. In general, patients who are nonambulatory at diagnosis do poorly, as do patients in whom more than one vertebra is involved. Surgical intervention is indicated in patients with radiation-resistant tumors, spinal instability, spinal compression with bone or disk fragments, progressive neurologic deterioration, previous radiation exposure, and uncertain diagnosis that requires tissue diagnosis. The main goal in the management of spinal metastatic deposits is always palliative rather than curative, with the primary aim being pain relief and improved mobility. This however, does not come without complications, regardless of the surgical intervention technique used. These complication range from the general surgical complications of bleeding, infection, damage to surrounding structures and post operative DT/PE to spinal specific complications of persistent neurologic deficit and paralysis. | Eilis Catherine Dunning Joseph Simon Butler Seamus Morris | 2012 | World Journal of Orthopedics2012，3，8： | 8 |
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