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198篇 您的检索式：作者名="Dunger"

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	题名	作者	年代	出处	被引量
1	Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs.	Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth	2007	World Journal of Gastroenterology2007，13，48：	4
2	Lessons from large population studies on timing and tempo of puberty ( secular trends and relation to body size ) : the European trend 显示文摘	Ong KK Ahmed ML Dunger DB	2006	Mol Cell Endocrinol2006，，254255：	1
3	A type 1 diabetes subgroup with a female bias is eharacterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the eytotoxie T-lymphocyte- associated antigen-4 gene显示文摘	Howson JM Dunger DB Nutland S	2007	Diabetologia2007，50，4：	1
4	The descriptive epidemiology of congenital and acquired cryptorchidism in a UK infant cohort显示文摘	Acerini CL Miles HL Dunger DB	2009	Arch Dis Child2009，，：	1
5	Polycystic ovaries and eating disorders: are they related 显示文摘	Michelmore K F Balen A H Dunger D B	2001	Hum Reprod2001，16，4：	1
6	Perinatal growth failure:the road to obesity, insulin resistance and cardiovascular disease in adults显示文摘	Ong KK Dunger DB	2002	Best Pract Res Clin Endocrinol Metab2002，16，：	1
7	Lessons from large population studies on timing and tempo of puberty (secular trends and relation to body size):the European trend显示文摘	Ong KK Ahmed ML Dunger DB	2006	Mol Cell Endocrinol2006，25，：	1
8	Peripubertal changes in circulating anti-mullerian hormone levels in girls 显示文摘	Lashen H Dunger DB Ness A	2013	Fertility & Sterility2013，99，：	1
9	Contrasting activity of cytosin-guanosin dinucleotide oligonucleotides in mice with experimental colitis显示文摘	Obermeier F Dunger N Strauch UG Grunwald N Herfarth H Scholmerich J	2003	Clin Exp Immunol2003，134，2：	1
10	Early development of adi- posity and insulin resistance after catch-up weight gain in small-for-gestational-age children 显示文摘	Ibanez L Ong K Dunger DB	2006	J Clin Endocrinol Metab2006，91，6：	1
11	Impact of treatment with ecombinant human GH and IGF-I on visceral adipose tissue and glucose homeostasis in adults显示文摘	Yuen KC Dunger DB	2006	Growth Horm IGF Res2006，16，：	1
12	European Society for Paediatric endocrinology/Lawson Wilkins Pediatric Endocrine Society consensus statement on diabetic ketoacidosis in children and adolescents 显示文摘	Dunger DB Sperling MA Acerini CL	2004	Pediatrics2004，113，2：	1
13	Muscle mass and insulin sensitivity in children and adolescents显示文摘	Dunger DB Salgin B Ong K	2006	Horm Res2006，66，：	1
14	Hybrid-rangier Locomotive:Technik und Anwendungen显示文摘	OOSTRA J DUNGER W	2009	ZEV Rail Glasers Annalen2009，133，9：	1
15	Identification of interleukin 1-induced apoptosis in rat islets using in situ specific labelling of fragmented DNA 显示文摘	Dunger A Augstein P Schmidt S	1996	J Autoimmun1996，9，3：	1
16	Persisting effects on fasting glucose levels and insulin sensitivity after 6 months of discontinuation of a very low-dose GH therapy in adults with severe GH deficiency 显示文摘	Yuen KC Dunger DB	2006	Clin Endocrinol (Oxf)2006，64，5：	1
17	Turner syndrome in adulthood显示文摘	Elsheikh M Dunger DB Conway GS	2002	Endocrine Review2002，23，1：	1
18	Insulin and carbohydratemetabolism显示文摘	Beardsall K Diderholm BM Dunger DB	2008	Best Pract Res Clin Endocrinol Metab2008，22，1：	1
19	Turner' s syndrome in adulthood 显示文摘	Elsheikh M Dunger D B Conway G S	2002	Endocrine Reviews2002，23，1：	1
20	A type I diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte- associated antigen-4 gene显示文摘	Howson JM Dunger DB Nutland S	2007	Diabetologia2007，50，：	1

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