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| 1 | Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia显示文摘Natural killer(NK)cells are innate cytotoxic lymphoid cells(ILCs)involved in the killing of infected and tumor cells.Among human and mouse NK cells from the spleen and blood,we previously identified by single-cell RNA sequencing(scRNAseq)two similar major subsets,NK1 and NK2.Using the same technology,we report here the identification,by single-cell RNA sequencing(scRNAseq),of three NK cell subpopulations in human bone marrow.Pseudotime analysis identified a subset of resident CD56^(bright) NK cells,NK0 cells,as the precursor of both circulating CD56dim NK1-like NK cells and CD56^(bright) NK2-like NK cells in human bone marrow and spleen under physiological conditions.Transcriptomic profiles of bone marrow NK cells from patients with acute myeloid leukemia(AML)exhibited stress-induced repression of NK cell effector functions,highlighting the profound impact of this disease on NK cell heterogeneity.Bone marrow NK cells from AML patients exhibited reduced levels of CD160,but the CD160high group had a significantly higher survival rate. | Adeline Crinier Pierre-Yves Dumas Bertrand Escalière Christelle Piperoglou Laurine Gil Arnaud Villacreces Frédéric Vély Zoran Ivanovic Pierre Milpied Émilie Narni-Mancinelli Éric Vivier | 2021 | Cellular & Molecular Immunology2021，18，5： | 5 |
| 2 | 水通道蛋白对人体皮肤重要性的研究显示文摘目的探讨水通道蛋白(AQPs)在人皮肤表皮上的功能和表达。方法免疫组化法检测30名30~40岁健康的白人女性大腿皮肤AQP3、Claudin-1和CD44表达。检测10名21~60岁亚洲健康妇女的前臂内侧AQP3表达与光暴露关系。结果在人表皮中,AQP3从基底层到粒层均有表达,但在角质层下方开始消失,AQP3和Claudin-1的表达与一种透明质酸盐受体CD44的表达呈负相关。对20~80岁之间的健康女性皮肤间接免疫荧光研究也发现,在衰老和长期慢性光暴露时皮肤AQP3表达会明显减少。结论人类皮肤供水系统缺陷可能与年龄有关,水通道蛋白在维持皮肤正常生理功能等方面具有重要意义。 | Frédéric Bonté Emmanuelle Noblesse Miléne Juan Jean Marc Verbawatz Marc Dumas | 2009 | 中华皮肤科杂志2009，42，5： | 4 |
| 3 | Microelectrode guided posteroventral medial radiofrequency pallidotomy for Parkinson's disease显示文摘 | KOPYOV O JACQUES D DUMA C | 1997 | J Neurosurg1997，87，： | 1 |
| 4 | Ascaleable synthesis of BAY 43-9006 : a potent Raf ki-nase inhibitor for the treatment of cancer 显示文摘 | BANKSTON D DUMAS J NATERO R | 2002 | OrgProc Res Dev2002，6，6： | 1 |
| 5 | Workshop: excess growth and apoptosis: is hyper- tension a case of accelerated aging of cardiovascular cells? 显示文摘 | Hamet P Thorin-Trescases N Moreau P Dumas P Tea BS de- Blois D | 2001 | Hypertension2001，37，22： | 1 |
| 6 | The S-locus receptor kinase is inhibited by thioredoxins and activated by pollen coat proteins显示文摘 | Cabrillac D Cock JM Dumas C | 2001 | Nature2001，410，： | 1 |
| 7 | Human cytosolic sulfotransferase 2B1:isoform expression,tissue specificity and subcellular localization显示文摘 | Falany CN He D Dumas N | | 0，，1： | 1 |
| 8 | Human cytosolic sulfo- transferase 2Bl: isoform expression, tissue specificity and subcellular localization 显示文摘 | Falany CN He D Dumas N | 2006 | J Steroid Biochem Mol Biol2006，102，： | 1 |
| 9 | Molecular insights into human daily behaviors 显示文摘 | Brown SA Kunz D Dumas A | 2008 | Proc Natl Aead Sci USA2008，105，5： | 1 |
| 10 | A generalized diffraction synthesis technique for high performance reflector antenna 显示文摘 | Duma D W Rahmat-Samii Y | 1995 | IEEE Trans on Antennas and Propagation1995，43，1： | 1 |
| 11 | Longevity, early emergence and body size in a pollinating fig wasp-implications for stability in a fig-pollinator mutualism 显示文摘 | Duma D W Yu D W Ridley J | 2008 | J Anim Ecol2008，77，5： | 1 |
| 12 | A scaleable synthesis of Bay 43-9006:a potent raf kinase inhibitor for the treatment of cancer显示文摘 | Bankston D Dumas J Natero R | 2002 | Org Process Res Dev2002，6，6： | 1 |
| 13 | The S-locus receptor kinase is inhibited by thioredoxins and activated by pollen coat proteins 显示文摘 | Cabrillac D Cock J M and Dumas C | 2001 | Nature2001，410，： | 1 |
| 14 | Magnetorheological Suspension-based Finishing Technology 显示文摘 | Kordonski W I Golini D Dumas P | 1998 | SPIE1998，3326，： | 1 |
| 15 | Different subceUu- lar localization of sulphotransferase 2Blb in human placenta and prostate 显示文摘 | He D Meloche CA Dumas NA | 2004 | Biochem J2004，379，： | 1 |
| 16 | Corticosterone modulates noradrenaline induced melatonin synthesis through inhibition of nuclear factor kappa B显示文摘 | Ferreira ZS Fernandes PA Duma D | 2005 | J Pineal Res2005，38，3： | 1 |
| 17 | Human cytosolic sulfotransferase 2B1:isoform expression,tissue specificity and subcellular localization显示文摘 | Falany CN He D Dumas N | 2006 | J Steroid Biochem Mol Biol2006，102，15： | 1 |
| 18 | A scalable synthesis of BAY 43-9006:A potent Rafkinase inhibitor for the treatment of cancer显示文摘 | Bankston D Dumas J Natero R | | 0，，06： | 1 |
| 19 | Cloning and mapping of a c DNA for methionine synthase reductase,a flavoprotein defective in patients with homocystinuria显示文摘 | Leclerc D Wilson A Dumas R | 1998 | Proc Natl Acad Sci U S A1998，95，6： | 1 |
| 20 | Human cytosolic sulfotransferase 2B1:isoform expression,tissue specificity and subcellular localization显示文摘 | Falany CN He D Dumas N | 2006 | J Steroid Biochem Mol Biol2006，102，： | 1 |
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