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| 1 | Current knowledge on diabetic retinopathy from human donor tissues显示文摘According to the American Diabetes Association,diabetes was the seventh leading cause of death,and diabetic retinopathy the leading cause of blindness in working age adults in the United States in 2010.Diabetes is characterized by hyperglycemia associated with either hypoinsulinemia or insulin resistance,and over time,this chronic metabolic condition may lead to various complications including kidney failure,heart attacks,and retinal degeneration.In order to better understand the molecular basis of this disease and its complications,animal models have been the primary approach used to investigate the effects of diabetes on various tissues or cell types of the body,including the retina.However,inherent to these animal models are critical limitations that make the insight gained from these models challenging to apply to the human pathology.These difficulties in translating the knowledge obtained from animal studies have led a growing number of research groups to explore the diabetes complications,especially diabetic retinopathy,on tissues from human donors.This review summarizes the data collected from diabetic patients at various stages of diabetic retinopathy and classifies the data based upon their relevance to the main aspects of diabetic retinopathy:retinal vasculature dysfunction,inflammation,and neurodegeneration.This review discusses the importance of those studies to discriminate and establish the relevance of the findings obtained from animal models but also the limitations of such approaches. | Jessica H Eisma Jennifer E Dulle Patrice E Fort | 2015 | World Journal of Diabetes2015，6，2： | 19 |
| 2 | Preparation and Properties of Zirconium Hydrideon the surface of MCM-41 Mesoporous Molecular Sieves显示文摘Zirconium monohydride bonded to the framework oxygen of MCM-41 surface was prepared by the reaction of tetraneopentyl zirconium with MCM-41 surface hydroxyl groups, followed by the hydrogenolysis of the resulted product. The surface hydride was characterized by using infrared spectroscopy, solid-state NMR, elemental analysis, gas-phase chromatography and chemical probing reaction. It was shown that this surface species is stable below 150 'C and can catalytically crack alkanes into methane and ethane at 100 . | WANG Xu-xu1* * , FU Xian-zhi1, LEFEBVRE Frederic2 and BASSET Jean-Marie2(1. Research Institute of Photocatalysis, Fuzhou University, Fuzhou 350002, P. R. China 2. Laboratoire de Chimie Organometallique de Surface, UMR CNRS-CPE 9986,43,Bd dull Novembre 1 | 2001 | Chemical Research in Chinese Universities2001，17，4： | 4 |
| 3 | The role of blood osmolality and volume in regulating vasopressin secretion in the rat显示文摘 | Dull FL Brennan TJ Nelson AE | 1973 | J Clin Invest1973，52，： | 2 |
| 4 | A third-generation lentivirus vector with a conditional packaging system显示文摘 | Dull T Zufferey R Kelly M | 1998 | J Virol1998，72，11： | 1 |
| 5 | Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis显示文摘 | Schwartz LB Yunginger JW Miller J Bokhari R Dull D | 1989 | J Clin Invest1989，83，5： | 1 |
| 6 | Zeigerwerte Von Pflanzen in Mitteleuropa显示文摘 | EUenberg H Weber H E Dull R | 1991 | Scripta Geobotanica1991，18，： | 1 |
| 7 | Gene organization and primarystructure of a ribosomal DNA operon from Escherichia coli显示文摘 | Brosius J Dull T J Sleeter D D | 1981 | Journal of Molecular Biology1981，148，： | 1 |
| 8 | Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery 显示文摘 | Zufferey R Dull T Mandel RJ | 1998 | J Virol1998，72，12： | 1 |
| 9 | A third-generation lentivirus vector with a conditional packaging system显示文摘 | Dull T Zufferey R Kelly M | | 0，，11： | 1 |
| 10 | Self-inactiva- ting lentivirus vector for safe and efficient in vivo gene de- livery 显示文摘 | Zufferey R Dull T Mandel R J | 1998 | J Virol1998，72，12： | 1 |
| 11 | Functionally distinct insulin receptors generated by tissue-specific alternative splicing显示文摘 | Mosthaf L Grako K Dull TJ | 1990 | EMBO J1990，9，8： | 1 |
| 12 | An optical method for estimating papaya maturity 显示文摘 | Birth G S Dull G G Magee J B | 1984 | J Am Sot Hortic Sci1984，109，： | 1 |
| 13 | The suitability ofthe Unified Theory of Acceptance and Use of Technology (U-TAUT) model in open access adoption studies 显示文摘 | Dulle F W Minishi-Majanja M K | 2011 | INFORMA-TION DEVELOPMENT2011，27，1： | 1 |
| 14 | A third-generation lentivirus vector with a conditional packaging system显示文摘 | Dull T Zufferey R Kelly M | 1998 | J Virol1998，72，11： | 1 |
| 15 | Chemistry of a new investigationat quadrivalent meningococcal conjugate vaccine that is immunogenic at all ages 显示文摘 | Boker M Dull PM Rappuoti R | 2009 | Vaccine2009，27，41： | 1 |
| 16 | Flow modulation of agonist (ATP)-response ( Ca^2+ ) coupling in vascular en- dothelial cells显示文摘 | Dull R O Davies P F | 1991 | Am J Physiol1991，261，12： | 1 |
| 17 | A third-generation lentivirus vector with a conditional packaging system显示文摘 | Dull T Zufferey R Kelly M | 1998 | J Virel1998，72，11： | 1 |
| 18 | A third-generation lentivirus vector with a conditional packaging system显示文摘 | Dull T Zufferey R Kelly M | 1998 | J Virol1998，72，11： | 1 |
| 19 | Propofol increases morbidity and mortality in a rat model of sepsis显示文摘 | Schlapfer M Piegeler T Dull RO | 2015 | Crit Care2015，19，： | 1 |
| 20 | Effect of lipophilie tail architecture and solvent engineering on the structure of tre- halose-based nonionic surfactant reverse micelles显示文摘 | SHRESTHA L K SATO T DULLE M | 2010 | The Journal of Physical Chemistry2010，114，12： | 1 |
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