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| 1 | Small-for-size syndrome in adult-to-adult living-related liver transplantation显示文摘Small-for-size syndrome (SFSS) in adult-to-adult living-related donor liver transplantation (LRLT) remains the greatest limiting factor for the expansion of segmental liver transplantation from either cadaveric or living donors. Portal hyperperfusion, venous pathology, and the arterial buffer response signif icantly contribute to clinical and histopathological manifestations of SFSS. Here, we review the technical aspects of surgical and radiological procedures developed to treat SFSS in LRLT, along with the pathophysiology of this condition. | Salvatore Gruttadauria Duilio Pagano Angelo Luca Bruno Gridelli | 2010 | World Journal of Gastroenterology2010，16，40： | 15 |
| 2 | Early graft dysfunction following adult-to-adult livingrelated liver transplantation:Predictive factors and outcomes显示文摘AIM:To describe a condition that we define as early graft dysfunction(EGD)which can be identified preoperatively. METHODS:Small-for-size graft dysfunction following living-related liver transplantation(LRLT)is characterized by EGD when the graft-to-recipient body weight ratio(GRBWR)is below 0.8%.However, patients transplanted with GRBWR above 0.8%can develop dysfunction of the graft.In 73 recipients of LRLT(GRBWR>0.8%),we identified 10 patients who developed EGD.The main measures of outcomes analyzed were overall mortality,number of re-transplants and length of stay in days(LOS).Furthermore we analyzed other clinical pre-transplant variables,intraoperative parameters and post transplant data.RESULTS:A trend in favor of the non-EGD group(3-mo actuarial survival 98%vs 88%,P=0.09;3-mo graft mortality 4.7%vs 20%,P=0.07)was observed as well as shorter LOS(13 d vs 41.5 d;P=0.001)and smaller requirement of peri-operative Units of Plasma (4 vs 14;P=0.036).Univariate analysis of pre- transplant variables identified platelet count,serum bilirubin,INR and Meld-Na score as predictors of EGD. In the multivariate analysis transplant Meld-Na score (P=0.025,OR:1.175)and pretransplant platelet count(P=0.043,OR:0.956)were independently associated with EGD. CONCLUSION:EGD can be identified preoperatively and is associated with increased morbidity after LRLT. A prompt recognition of EGD can trigger a timely treatment. | Salvatore Gruttadauria Fabrizio di Francesco Giovanni Battista Vizzini Angelo Luca Marco Spada Davide Cintorino Sergio Li Petri Giada Pietrosi Duilio Pagano Bruno Gridelli | 2009 | World Journal of Gastroenterology2009，15，36： | 2 |
| 3 | Liver regeneration after liver resection: Clinical aspects and correlation with infective complications显示文摘AIM:To investigate whether early liver regeneration after resection in patients with hepatic tumors might be influenced by post-operative infective complications.METHODS:A retrospective analysis of 27 liver resections for tumors performed in a single referral center from November 2004 to January 2010.Regeneration was evaluated by multidetector computed tomographyat a mean follow-up of 43.85 d.The Clavien-Dindo classification was used to evaluate postoperative events in the first 6 mo after transplantation,and Centers for Disease Control and Prevention definitions were used for healthcare associated infections data.Generalized linear regression models with Gaussian family distribution and log link function were used to reveal the principal promoters of early liver regeneration.RESULTS:Ten of the 27 patients(37%)underwent chemotherapy prior to surgery,with a statistically significant prevalence of patients with metastasis(P=0.007).Eight patients(30%)underwent embolization,3 with primary tumors,and 5 with secondary tumors.Twenty patients(74%)experienced complications,with 12(60%)experiencing Clavien-Dindo Grade 3a to 5 complications.Regeneration≥100%occurred in 10(37%)patients.The predictors were smaller future remnant liver volume(-0.002;P<0.001),and a greater spleen volume/future remnant liver volume ratio(0.499;P=0.01).Patients with a resection of≥5 Couinaud segments experienced greater early regeneration(P=0.04).Nine patients experienced surgical site infections,and in 7 cases Clavien-Dindo Grade 3a to 4 complications were detected(P=0.016).There were no significant differences between patients with primary or secondary tumors,and either onset or infections or severity of surgical complications.CONCLUSION:Regardless of the onset of infective complications,future remnant liver and spleen volumes may be reliable predictors of early liver regeneration after hepatic resection on an otherwise healthy liver. | Duilio Pagano Marco Spada Vishal Parikh Fabio Tuzzolino Davide Cintorino Luigi Maruzzelli Giovanni Vizzini Angelo Luca Alessandra Mularoni Paolo Grossi Bruno Gridelli Salvatore Gruttadauria | 2014 | World Journal of Gastroenterology2014，20，22： | 2 |
| 4 | Right hepatic lobe living donation: A 12 years single Italian center experience显示文摘Mini invasive techniques are taking over conventional open liver resections in the setting of left lateral segmentectomy for living liver donation,and hydride procedure are being implemented for the living related right hepatectomy.Our center routinely performs laparoscopic left lateral segmentectomy for pediatric recipient and has been the first in the Europe performing an entirely robotic right hepatectomy.Great emphasis is posed on living donor safety which is the first priority during the entire operation,then the most majority of our procedures are still conventional open right hepatectomy(RHLD),defined as removal of a portion of liver corresponding to Couinaud segments 5-8,in order to obtain a graft for adult to adult living related liver transplant.During this 10 years period some changes,herein highlighted,have occurred to our surgical techniques.This study reports the largest Italian experience with RHLD,focused on surgical technique evolution over a 10 years period.Donor safety must be the first priority in right-lobe living-related donation:the categorization of complications of living donors,specially,after this'highly sensitive'procedure,reflects the need for prompt and detailed reports. | Salvatore Gruttadauria Duilio Pagano Davide Cintorino Antonio Arcadipane Mario Traina Riccardo Volpes Angelo Luca Giovanni Vizzini Bruno Gridelli Marco Spada | 2013 | World Journal of Gastroenterology2013，19，38： | 2 |
| 5 | Neutrophils are primary source of 02 radicals during reperfusion after prolonged myocardial ischemia显示文摘 | Duilio C Ambrosio G Kuppusamy P | 2001 | Am J Physiol (Heart Circ Physiol)2001，280，： | 1 |
| 6 | Thedeoxyxylulose phosphate pathway of terpenoid biosynthesisin plants and microorganisms显示文摘 | Wolfgang Eisenreicha Matthias Schwarzb Alain Cartayradeb Duilio Arigonib Meinhart H Zenkc Adelbert Bacher | 1998 | Chemistry&Biology1998，5，9： | 1 |
| 7 | Neutrophils are primary source of O2 radicals during reperfusion after prolonged myocardial ischemia显示文摘 | Duilio C Ambrosio G Kuppusamy P | 2001 | Am J Physiol Heart Cire Physiol2001，280，6： | 1 |
| 8 | Neutrophils are primary source of O2 radicals during reperfusion after prolonged myocardial ischemia显示文摘 | Duilio C Ambrosio G Kuppusamy P | 2001 | Am J Physiol (Heart Circ Physiol)2001，280，： | 1 |
| 9 | Surgical Management of Complex Liver Trauma: A Single Liver Transplant Center Experience显示文摘 | Li Petri Sergio Gruttadauria Salvatore Pagano Duilio Echeverri Gabriel J Di Francesco Fabrizio Cintorino Davide Spada Marco Gridelli Bruno | 2012 | The American Surgeon2012，，1： | 1 |
| 10 | Neutrophils are primary source of radicals during reperfusion after prolonged myocardial ischemia显示文摘 | Duilio C Ambrosio G Kuppusamy P | 2001 | Am J Physiol Heart Circ Physiol2001，280，6： | 1 |
| 11 | A novel replication element from an Antarctic plasmid as a tool for the expression of proteins at low temperature显示文摘 | TUTINO M L DUILIO A PARRILLI R | 2001 | Extremophiles2001，5，： | 1 |
| 12 | Evidence thatmito- chondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow 显示文摘 | Ambrosio G Zweier JL Duilio C | 1993 | Biol Chem1993，268，18： | 1 |
| 13 | Crystal structures of a tetrahedral open pore ferritin from the hyperthermophilic archaeon archaeoglobus fulgidus显示文摘 | ERIC J DUILIO C SAWAYA M | 2005 | Structure2005，13，： | 1 |
| 14 | Promoters from a cold - adapted bacterium : definition of a consensus motif and molecular characterization of UP regulative elements显示文摘 | Duilio A Madonna S Tutino M L | 2004 | Extremophiles2004，8，2： | 1 |
| 15 | Neutrophils are the primary source of O2 radicals during reperfusion after prolonged myocardial ischemia显示文摘 | Duilio C Ambrosio G Kuppusamy P | 2001 | Am J Physiol Heart Circ Phyiol2001，280，6： | 1 |
| 16 | Oxygen Radicals Gencrated at Reflow Induce Pemxidation of Membrane Lipids in Reperfused Hearts 显示文摘 | AMBROSIO G FLAHERTY J T Duilio C | 1991 | J Clin Invest1991，87，6： | 1 |
| 17 | Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3显示文摘 | CATHERINE NL MARY JK DUILIO C | 2014 | BMC Structural Biology2014，14，： | 1 |
| 18 | On the high stress compression of bentonites 显示文摘 | Duilio Marcial Pierre Delage Yujun Cui | 2002 | Canadian Geotechnical Journal2002，39，： | 1 |
| 19 | Neutrophils are Primary Source of O2 Radicals during Reperfusion after Prolonged Myocardial Ischemia显示文摘 | Duilio C Anlbrosio G Kuppusamy P | 2001 | Am J Physiol Heart Circ Physiol2001，280，： | 1 |
| 20 | Digestible fibre to starch ratio and protein level in diets for growing rabbits显示文摘 | Angela T Duilio M Michail F | 2009 | Ital J anim Sci2009，8，： | 1 |
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