|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Assessment and impact of diastolic function by echocardiography in elderly patients显示文摘Doppler echocardiography 是为对心脏舒张的机能障碍的评价的标准答案,它逐渐地作为心失败的一个原因被认出,在特别老。用 Doppler echocardiography 技术的联合,识别心脏舒张的机能障碍的等级是可能的,估计左室的充满压力并且建立心脏舒张的机能障碍的慢性。这些导出 physiologically 的措施广泛地对左心压力的侵略大小被验证了并且被显示了在大量临床的背景预示地珍贵。这评论探索机制,并且来临到对心脏舒张的机能障碍的评价在老。为临床医生的挑战是从与正常变老联系的那些识别 pathophysiological 变化。当在联合,和花的很长时间使用了进报道时, Doppler echocardiographic 参数在对在更老的病人的 dyspnoea 的评价是有用的并且提供预示的卓见。 | Clementina Dugo Marzia Rigolli Andrea Rossi Gillian A Whalley | 2016 | Journal of Geriatric Cardiology2016，13，3： | 3 |
| 2 | The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial-mesenchymal transition, and immune response显示文摘Background:Desmoplastic small round cell tumor(DSRCT)is a rare,aggressive,and poorly investigated simple sarcoma with a low frequency of genetic deregulation other than an Ewing sarcoma RNA binding protein 1(EWSR1)-Wilm’s tumor suppressor(WT1)translocation.We used whole-exome sequencing to interrogate six consecutive pretreated DSRCTs whose gene expression was previously investigated.Methods:DNA libraries were prepared from formalin-fixed,paraffin-embedded archival tissue specimens following the Agilent SureSelectXT2 target enrichment protocol and sequenced on Illumina NextSeq 500.Raw sequence data were aligned to the reference genome with Burrows-Wheeler Aligner algorithm.Somatic mutations and copy number alterations(CNAs)were identified using MuTect2 and EXCAVATOR2,respectively.Biological functions associated with altered genes were investigated through Ingenuity Pathway Analysis(IPA)software.Results:A total of 137 unique somatic mutations were identified:133 mutated genes were case-specific,and 2 were mutated in two cases but in different positions.Among the 135 mutated genes,27%were related to two biological categories:DNA damage-response(DDR)network that was also identified through IPA and mesenchymal-epithelial reverse transition(MErT)/epithelial-mesenchymal transition(EMT)already demonstrated to be relevant in DSRCT.The mutated genes in the DDR network were involved in various steps of transcription and particularly affected pre-mRNA.Half of these genes encoded RNA-binding proteins or DNA/RNA-binding proteins,which were recently rec-ognized as a new class of DDR players.CNAs in genes/gene families,involved in MErT/EMT and DDR,were recurrent across patients and mostly segregated in the MErT/EMT category.In addition,recurrent gains of regions in chromosome 1 involving many MErT/EMT gene families and loss of one arm or the entire chromosome 6 affecting relevant immune-regulatory genes were recorded.Conclusions:The emerging picture is an extreme inter-tumor heterogeneity,characterized by the concurrent deregulation of the DDR and MErT/EMT dynamic and plastic programs that could favour genomic instability and explain the refractory DSRCT profile. | Andrea Devecchi Loris De Cecco Matteo Dugo Donata Penso Gianpaolo Dagrada Silvia Brich Silvia Stacchiotti Marialuisa Sensi Silvana Canevari Silvana Pilotti | 2018 | Cancer Communications2018，38，1： | 2 |
| 3 | Genetic mapping of QTLs controlling horticultural traits in diploid roses 显示文摘 | Dugo M L Satovie Z Millan T | 2005 | Theor Appl Genet2005，111，3： | 1 |
| 4 | Rosiglitazone, a ligand of the peroxisome proliferator-activated receptorgamma, reduces acute pancreatitis induced by cerulein 显示文摘 | Cuzzocrea S Pisano B Dugo L | 2004 | Intensive Care Med2004，30，5： | 1 |
| 5 | Reverse phase HPLC/DAD determination of biogenic amines as dansyl derivatives in experimental red wines 显示文摘 | Dugo G M Vilasi F Torre G L L | 2006 | Food Chemistry''2006，95，4： | 1 |
| 6 | Mir-30e*is an independent subtype-specific prognostic marker in breast cancer显示文摘 | D'Aiuto F Callari M Dugo M | 2015 | Br J Cancer2015，，： | 1 |
| 7 | Immediately preoperative laparoscopic staging for gastric cancer显示文摘 | Coppola R Persiani R | 1996 | Surg Endosc1996，10，： | 1 |
| 8 | Rosiglitazone and 15 deoxy-Delta12, 14-prostaglandin J2, ligands of the peroxisome proliferator activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut显示文摘 | Cuzzocrea S Pisano B Dugo L | 2003 | Br J Pharmacol2003，140，2： | 1 |
| 9 | The residual ovary after hysterectomy显示文摘 | Mancuso A D'Anna R Dugo C | 1991 | Clin Exp Obstet Gynecol1991，18，2： | 1 |
| 10 | LC-MS for the identification of oxygen heterocyclic compounds in citrus essential oils显示文摘 | DUGO P MONDELLO L DUGO L | 2000 | Journal of Pharmaceutical and Biomedical Analysis2000，24，1： | 1 |
| 11 | Rosiglitazone and 15-deoxy-Δ12,14-prostaglandin J2,ligands of the peroxisome proliferator-activated receptor-γ(PPAR-γ),reduce ischaemia/reperfusion injury of the gut显示文摘 | Cuzzocrea S Pisano B Dugo L | 2003 | Bri J Pharmacol2003，140，： | 1 |
| 12 | Rosiglitazone and 15-deoxy-delta12,14-prostaglandin J2,ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma),reduce ischaemia/reperfusion injury of the gut显示文摘 | Cuzzocrea S Pisano B Dugo L | 2003 | Br J Pharmacol2003，140，： | 1 |
| 13 | Phthalate, adipate and sebacate residues by HRGC -MS in olive oils from Sicily and Molise (Italy) 显示文摘 | DUGO G FOTIA V TURCO V L | 2011 | Food Control2011，22，6： | 1 |
| 14 | Rosiglitazone,a ligand of the peroxisome proliferator-activated receptorgamma,reduces the development of nonseptic shock induced by zymosan in mice显示文摘 | Cuzzocrea S Pisano B Dugo L | 2004 | Crit Care Med2004，32，： | 1 |
| 15 | Optimization of a comprehensive two-dimensional normal-phase and reversed-phase liquid chromatography system显示文摘 | Dugo P Fernández M M R Cotroneo A | 2006 | J Chromatogr Sci2006，44，9： | 1 |
| 16 | Authenticity control on lemon essential oilsemploying gas chromatography-combustion-isotoperatio mass spectrometry (GC-C-IRMS) 显示文摘 | SCHIPILLITI L DUGO P BONACCORSI I | 2012 | Food Chemistry2012，131，4： | 1 |
| 17 | Characterization of the anthocyanin fraction of sicilian blood orange juice by micro-HPLC-ESI/MS显示文摘 | Paola Dugo | 2003 | J Agric Food Chem2003，51，： | 1 |
| 18 | Metachronous Splenic Metastasis from Colonic Carcinoma Five Years After Surgery:A Case Report and Literature Review显示文摘 | Sileri P Dugo S Bennavoli D | | 0，，07： | 1 |
| 19 | Influence of the olive variety and the zone of provenience on selenium content determined by cathodic stripping potentiometry (CSP) in virgin olive oils显示文摘 | Dugo Giacomo | 2004 | Food Chemistry2004，88，： | 1 |
| 20 | Amelioration of joint disease in a rat model of collagen-induced arthritis by M40403,a superoxide dismutase mimetic显示文摘 | Salvemini D Mazzon E Dugo L | 2001 | Arthritis Rheum2001，44，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员