|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 急性心肌梗死阿昔单抗、瑞替普酶、支架联合研究(CARESS-in-AMI)中的即刻恤管成形术与常规治疗联合挽救性血管成形术的比较:一项前瞻性、开放、多中心随机试验显示文摘背景当90min内不能进行直接经皮冠状动脉介入术(PCI)时,溶栓就仍是ST段抬高型心肌梗死(STEMI)的治疗选择。然而,溶栓治疗之后患者的最佳后续处理仍不确定。为了评估最佳处理方案,作者把在非介入医院用溶栓和阿昔单抗治疗的STEMI患者随机分为即刻进行PCI与常规药物治疗联合挽救性血管成形术两组。
方法给予法国、意大利和波兰等国家的600例年龄≤75岁、有≥1项高危特征(广泛性ST段抬高、新发左柬支传导阻滞、既往有心肌梗死、Killip分级≥2级或左室射血分数≤35%)的住院患者半量瑞替普酶、阿昔单抗、肝素和阿司匹林治疗,并随机分配为转诊至最近的介入中心进行即刻PCI或仅在持续ST段抬高、临床征象加重时转诊。主要结局为30d时死亡、再梗死或顽固性心肌缺血的复合指标,采用意向治疗分析。研究在Clinical Trials.gov的注册编号为00220571。
结果分配至即刻PCI组的299例患者中,289例(97.0%)进行了血管造影,255例(85.6%)进行了PCI。在常规治疗/挽救性PCI组中有91例(30.3%)患者进行了挽救性PCI。即刻PCI组出现主要结局指标的患者为13例(4.4%),而常规治疗辟乞救性PCI组为32例(10.7%)(HR0-40,95%C10.21~0.76;对数秩检验P=0.004)。即刻PCI组严重出血患者为10例,而常规治疗/挽救性PCI组为7例(3.4%vs2.3%,P=0.47)。即刻PCI组卒中患者为2例.而常规治疗/挽救性PCI组为4例(0.7%vs 1.3%.P=0.50)。
结论 在非介入中心,采用半量瑞替普酶和阿昔单抗治疗的高危STEMI患者即刻转诊进行PCI可改善结局。 | Carlo Di Maria Dariusz Duded Federico Piscione Waldemar Mielecki Stefano Savonitto Ernesto Murena Konstantinos Dimopoulos 郭占宏(译) | 2008 | 世界临床医学2008，2，5： | 3 |
| 2 | Influence of plant, soil,and water on the leaching fraction显示文摘 | Dudely L M Ben-Gal A Shani U | 2008 | Vadose Zone Journal2008，7，2： | 1 |
| 3 | comparison of closed reduction alone versus primary open repair of acute nasoseptal fractures 显示文摘 | ROBERT J FATTA D DUDE Y | 2008 | J Otolaryngol Head Neck Surg2008，37，： | 1 |
| 4 | International staging system for multiple myeloma显示文摘 | Greipp PR Sanmiguel J Dude BG | | 0，，15： | 1 |
| 5 | Cross-correlation of polarity curves to predict partition coefficients of nonionic organic contaminants显示文摘 | XING Baoshan MCGILL W M DUDES M J | 1994 | Environmental Science and Technology1994，28，11： | 1 |
| 6 | Experiments in projection andclustering by simulated annealing 显示文摘 | KLEIN R W DUDES R C | 1989 | Pattern Recognition1989，22，2： | 1 |
| 7 | HIV infection, genital symptoms and sexual risk behavior among Indian truck drivers from a large transportation company in South India 显示文摘 | Dude Annie Omganti G Kumar V | 2009 | J Glob Infect Dis2009，1，1： | 1 |
| 8 | Pregnancy rates in donor oocyte cycles compared to similar autologous in vitro fertilization cycles: an analysis of 26,457 fresh cycles from the Society for Assisted Reproductive Technology显示文摘 | Yeh JS Steward RG Dude AM | 2014 | Fertil Steril2014，102，2： | 1 |
| 9 | High incidence of thrombotic events observed in patients receiving lenalidomide (L) 1 dexamethasone ( D ) (LD) as firstline therapy for multiple myeloma (MM) without aspirin (ASA) prophylaxis显示文摘 | Zonder J A Dude B G M McCoy J | 2005 | Blood2005，106，： | 1 |
| 10 | Pregnancy rates in donor oocyte cycles compared to similar autologous in vitro fertilization cycles:an analysis of 26,457fresh cycles from the Society for Assisted Reproductive Technology显示文摘 | Yeh JS Steward RG Dude AM | 2014 | Fertil Steril2014，102，： | 1 |
| 11 | Correlates of use of long-acting reversible methods of contraception among adolescent and young adult women显示文摘 | Whitaker AK Dude AM Neustadt A | | 0，，04： | 1 |
| 12 | Magnitude of response with myeloma frontlne therapy does not predict outcome:importance of time to progression in Southwest Oncology Group chemotherapy trials显示文摘 | Jacobson J | 2004 | Clin Oncol2004，22，10： | 1 |
| 13 | A clinical staging systcm for multiple myeloma显示文摘 | Salmon SE | 1975 | Cancer1975，36，： | 1 |
| 14 | Rapid determination of primary amino acids in grape juice using an o-Phthaldialdehyde/N-Acetyl-L-Cysteine Spectrophotometric assay显示文摘 | Bruce C Dudes Christian E Butzke | 1998 | American Journal of Enology and Viticulture1998，49，2： | 1 |
| 15 | International staging system for multiple myeloma 显示文摘 | Greipp PR SanMiguel J Dude BG | 2005 | J Clin 0ncol2005，23，15： | 1 |
| 16 | International uniform response criteria for multiple myeloma 显示文摘 | Dude BG Harousseau JL Miguel JS | 2006 | Leukemia2006，20，9： | 1 |
| 17 | International staging sys- tem for multiple myeloma 显示文摘 | Greipp PR San Mignal J Dude BG | 2005 | J Clin Oncol2005，23，15： | 1 |
| 18 | The evolution of de- pressive symptoms in coronary artery disease patients af- ter successful coronary angioplasty显示文摘 | Duded D SiwekM DatkaW | 2007 | Phychiatr Pol2007，41，2： | 1 |
| 19 | International staging system for multiple myeloma显示文摘 | Greipp PR San Miguel J Dude BG | 2005 | J Clin Oncol2005，23，15： | 1 |
| 20 | Myeloma in patients younger than age 50 years presents with more favorable features and shows better survival:an analysis of 10 549 patients from the International Myeloma Working Group显示文摘 | Ludwig H Dude BG Bolejack V | 2008 | Blood2008，111，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员