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| 1 | Titanium dioxide induced inflammation in the small intestine显示文摘AIM:To investigate the effects of titanium dioxide (TiO2) nanoparticles (NPTiO 2 ) and microparticles (MPTiO 2 ) on the inflammatory response in the small intestine of mice. METHODS: Bl 57/6 male mice received distilled water suspensions containing TiO 2 (100 mg/kg body weight) as NPTiO 2 (66 nm), or MPTiO 2 (260 nm) by gavage for 10 d, once a day; the control group received only distilled water. At the end of the treatment the duodenum, jejunum and ileum were extracted for assessment of cytokines, inflammatory cells and titanium content. The cytokines interleukin (IL)-1b, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-17, IL-23, tumor necrosis factor-α (TNF-α), intracellular interferon-γ (IFN-γ) and transforming growth factor-β (TGF-β) were evaluated by enzyme-linked immunosorbent assay in segments of jejunum and ileum (mucosa and underlying muscular tissue). CD4 + and CD8 + T cells, natural killer cells, and dendritic cells were evaluated in duodenum, jejunum and ileum samples fixed in 10% formalin by immuno-histochemistry. The titanium content was determined by inductively coupled plasma atomic emission spectrometry. RESULTS: We found increased levels of T CD4 + cells (cells/mm 2 ) in duodenum:NP 1240 ± 139.4, MP 1070 ± 154.7 vs 458 ± 50.39 (P < 0.01); jejunum:NP 908.4 ± 130.3, MP 813.8 ± 103.8 vs 526.6 ± 61.43 (P < 0.05); and ileum:NP 818.60 ± 123.0, MP 640.1 ± 32.75 vs 466.9 ± 22.4 (P < 0.05). In comparison to the control group, the groups receiving TiO 2 showed a statistically significant increase in the levels of the inflammatory cytokines IL-12, IL-4, IL-23, TNF-α, IFN-γ and TGF-β. The cytokine production was more pronounced in the ileum (mean ± SE):IL-12: NP 33.98 ± 11.76, MP 74.11 ± 25.65 vs 19.06 ± 3.92 (P < 0.05); IL-4: NP 17.36 ± 9.96, MP 22.94 ± 7.47 vs 2.19 ± 0.65 (P < 0.05); IL-23: NP 157.20 ± 75.80, MP 134.50 ± 38.31 vs 22.34 ± 5.81 (P < 0.05); TNFα: NP 3.71 ± 1.33, MP 5.44 ± 1.67 vs 0.99± 019 (P < 0.05); IFNγ: NP 15.85 ± 9.99, MP 34.08 ± 11.44 vs 2.81 ± 0.69 (P < 0.05); and TGF-β: NP 780.70 ± 318.50, MP 1409.00 ± 502.20 vs 205.50 ± 63.93 (P < 0.05). CONCLUSION:Our findings indicate that TiO2 particles induce a Th1-mediated inflammatory response in the small bowel in mice. | Carolina Maciel Nogueira Walter Mendes de Azevedo Maria Lucia Zaidan Dagli Sérgio Hiroshi Toma AndréZonetti de Arruda Leite Maria Laura Lordello Iêda Nishitokukado Carmen Lúcia Ortiz-Agostinho Maria IrmaSeixas Duarte Marcelo Alves Ferreira Aytan Miranda Sipahi | 2012 | World Journal of Gastroenterology2012，18，34： | 8 |
| 2 | Physical activity in primary and secondary prevention of cardiovascular disease:Overview updated显示文摘Although the observed progress in the cardiovascular disease treatment, the incidence of new and recurrent coronary artery disease remains elevated and constitutes the leading cause of death in the developed countries. Three-quarters of deaths due to cardiovascular diseases could be prevented with adequate changes in lifestyle, including increased daily physical activity. New evidence confirms that there is an inverse dose-response relationship between physical activity and cardiovascular disease and mortality risk. However, participation in moderate to vigorous physical activity may not fully attenuate the independent effect of sedentary activities on increased risk for cardiovascular diseases. Physical activity also plays an important role in secondary prevention of cardiovascular diseases by reducing the impact of the disease, slowing its progress and preventing recurrence. Nonetheless, most of eligible cardiovascular patients still do not benefit from secondary prevention/cardiac rehabilitation programs. The present review draws attention to the importance of physical activity in the primary and secondary prevention of cardiovascular diseases. It also addresses the mechanisms by which physical activity and regular exercise can improve cardiovascular health and reduce the burden of the disease. | Alberto J Alves Joao L Viana Suiane L Cavalcante Nórton L Oliveira JoséA Duarte Jorge Mota JoséOliveira Fernando Ribeiro | 2016 | World Journal of Cardiology2016，8，10： | 6 |
| 3 | Extration of ribosomal RNA and genomic DNA from soil for studying the diversity of the indigenous bacterial community 显示文摘 | Duarte G F Rosado A S Seldin L | 1998 | Journal of Microbiological Methods1998，32，： | 2 |
| 4 | The Response of Experimental Rocky Shore Communities to Nutrient Additions 显示文摘 | Bokn T L Duarte C M Pedersen M F | 2003 | Ecosystem2003，6，： | 1 |
| 5 | Three-port triple- half-bridge bidirectional converter with zero-voltage switc- hing 显示文摘 | Tao H Duarte J L Hendrix M A M | 2008 | IEEE Transactions on Power Electronics2008，23，2： | 1 |
| 6 | Three-port bidirectional converter for hybrid fuel cell systems 显示文摘 | Duarte J L Hendrix M Simoes M G | 2007 | Power Electronics IEEE Transactions on2007，22，2： | 1 |
| 7 | Pliant active and reactive power control for grid-interactive converters under unbalanced voltage dips显示文摘 | WANG F DUARTE J L HENDRIX MAM | 2011 | IEEE Transactions on Power Electronics2011，26，5： | 1 |
| 8 | Gdnital mycoplasma in women attending a family planning clinician, Guinea-Bissau and their susceptibility to antimicrobial agents显示文摘 | Domingues D Tavora Tavira L Duarte A | 2003 | Acta Trop2003，86，1： | 1 |
| 9 | Effect offunctionalized carbon as Pt electrocatalyst support on themethanol oxidation reaction显示文摘 | Salgado J R C Duarte D G Ilharco L M | 2011 | Applied Catalysis B: En-vironmental2011，102，： | 1 |
| 10 | Dexamethasone-loaded scaffolds prepared by supercritical-assisted phase inversion显示文摘 | Duarte A R C Mano J F Reis R L | 2009 | Acta Biomaterialia2009，5，6： | 1 |
| 11 | Trans- former-coupled muhiport ZVS bidirectional DC-DC converter with wide input range 显示文摘 | TAO Haimin KOTSOPOULOS A DUARTE J L | 2008 | IEEE Transactions on Power Electronics2008，23，2： | 1 |
| 12 | Dynamic and static simulation tool for PEM fuel cells 显示文摘 | WINGELAAR P J H DUARTE J L HENDRIX M A M | 2006 | IEEE2006，3，： | 1 |
| 13 | Three-port triple half-bridge bidirectional converter with zero-voltage switching显示文摘 | Tao H Duarte J L Hendrix M A M | 2008 | IEEE Transactions on Power Electronics2008，23，2： | 1 |
| 14 | Genital mycoplasmas in women attending a family planning clinician, Guinea Bissau and their susceptibility to antimicrobial agents显示文摘 | Domingues D Tavora Tavira L Duarte A | 2003 | Acta Trop2003，86，1： | 1 |
| 15 | Why is PIN priced显示文摘 | Duarte J Young L | 2009 | Journal of Financial Economics2009，91，2： | 1 |
| 16 | Effect of carbon monoxide on gene expression in cerebrocortical astrocytes:Validation of reference genes for quantitative real-time PCR显示文摘 | OLIVEIRA S R VIEIRA H L DUARTE C B | 2015 | Nitric Oxide2015，49，： | 1 |
| 17 | Evaluation of the detoxification of brewery's spent grain hydrolysate for xylitol production by Debaryomyces hansenii CCMI 941显示文摘 | Carvalheiro F Duarte L C Lopes S | 2005 | Process Biochemistry2005，40，3： | 1 |
| 18 | Rainfall leads toincreased pCO2 in Brazilian coastal lakes 显示文摘 | Morotta H Duarte C M Pinho L | 2010 | Biogeosciences2010，7，5： | 1 |
| 19 | Predictors of post stroke depression: a retrospective study in a rehabilitation unit显示文摘 | Camoes Barbosa A Sequeira Medeiros L Duarte N | 2011 | Acta Med Port2011，24，2： | 1 |
| 20 | The effect Of seminal leukocytes on semen quality in subfertile males with and with-out varicocele 显示文摘 | Tortolero l Duarte Ojeda JM Pamp|ona Casamayor M | 2004 | Arch Esp Urol2004，57，9： | 1 |
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