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| 1 | Titanium dioxide induced inflammation in the small intestine显示文摘AIM:To investigate the effects of titanium dioxide (TiO2) nanoparticles (NPTiO 2 ) and microparticles (MPTiO 2 ) on the inflammatory response in the small intestine of mice. METHODS: Bl 57/6 male mice received distilled water suspensions containing TiO 2 (100 mg/kg body weight) as NPTiO 2 (66 nm), or MPTiO 2 (260 nm) by gavage for 10 d, once a day; the control group received only distilled water. At the end of the treatment the duodenum, jejunum and ileum were extracted for assessment of cytokines, inflammatory cells and titanium content. The cytokines interleukin (IL)-1b, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-17, IL-23, tumor necrosis factor-α (TNF-α), intracellular interferon-γ (IFN-γ) and transforming growth factor-β (TGF-β) were evaluated by enzyme-linked immunosorbent assay in segments of jejunum and ileum (mucosa and underlying muscular tissue). CD4 + and CD8 + T cells, natural killer cells, and dendritic cells were evaluated in duodenum, jejunum and ileum samples fixed in 10% formalin by immuno-histochemistry. The titanium content was determined by inductively coupled plasma atomic emission spectrometry. RESULTS: We found increased levels of T CD4 + cells (cells/mm 2 ) in duodenum:NP 1240 ± 139.4, MP 1070 ± 154.7 vs 458 ± 50.39 (P < 0.01); jejunum:NP 908.4 ± 130.3, MP 813.8 ± 103.8 vs 526.6 ± 61.43 (P < 0.05); and ileum:NP 818.60 ± 123.0, MP 640.1 ± 32.75 vs 466.9 ± 22.4 (P < 0.05). In comparison to the control group, the groups receiving TiO 2 showed a statistically significant increase in the levels of the inflammatory cytokines IL-12, IL-4, IL-23, TNF-α, IFN-γ and TGF-β. The cytokine production was more pronounced in the ileum (mean ± SE):IL-12: NP 33.98 ± 11.76, MP 74.11 ± 25.65 vs 19.06 ± 3.92 (P < 0.05); IL-4: NP 17.36 ± 9.96, MP 22.94 ± 7.47 vs 2.19 ± 0.65 (P < 0.05); IL-23: NP 157.20 ± 75.80, MP 134.50 ± 38.31 vs 22.34 ± 5.81 (P < 0.05); TNFα: NP 3.71 ± 1.33, MP 5.44 ± 1.67 vs 0.99± 019 (P < 0.05); IFNγ: NP 15.85 ± 9.99, MP 34.08 ± 11.44 vs 2.81 ± 0.69 (P < 0.05); and TGF-β: NP 780.70 ± 318.50, MP 1409.00 ± 502.20 vs 205.50 ± 63.93 (P < 0.05). CONCLUSION:Our findings indicate that TiO2 particles induce a Th1-mediated inflammatory response in the small bowel in mice. | Carolina Maciel Nogueira Walter Mendes de Azevedo Maria Lucia Zaidan Dagli Sérgio Hiroshi Toma AndréZonetti de Arruda Leite Maria Laura Lordello Iêda Nishitokukado Carmen Lúcia Ortiz-Agostinho Maria IrmaSeixas Duarte Marcelo Alves Ferreira Aytan Miranda Sipahi | 2012 | World Journal of Gastroenterology2012，18，34： | 8 |
| 2 | 益生菌抑制自发性高血压大鼠的菌群失调和血压升高:短链脂肪酸的作用显示文摘该研究旨在评估益生菌短双歧杆菌CECT7263(BFM)及发酵乳酸杆菌CECT5716(LC40)、短链脂肪酸丁酸盐及醋酸盐对自发性高血压大鼠(spontaneously hypertensive rat,SHR)心血管的作用。方法和结果:5周龄的Wistar Kyoto大鼠(WKY)10只和周龄匹配的SHR 50只随机分为6组:对照WKY、对照SHR、BFM干预的SHR、LC40干预的SHR、丁酸盐干预的SHR和醋酸盐干预的SHR。 | 袁源(译) 练桂丽(审校) Robles-Vera I Toral M de la Visitación N Sánchez M Gómez-Guzmán M Romero M Yang T Izquierdo-Garcia JL Jiménez R Ruiz-Cabello J Guerra-Hernández E Raizada MK Pérez-Vizcaíno F Duarte J | 2020 | 中华高血压杂志2020，28，9： | 2 |
| 3 | A zinc ion controls assembly and stability of the major eapsid protein of rotavirus显示文摘 | Erk I Huet JC Duarte M | 2003 | J Virol2003，77，6： | 1 |
| 4 | Involvement of rat cytochrome 1A1 in the biotransformation of kaempferol to quereetin:relevance to the genotoxicity of kaempferol 显示文摘 | Duarte S I Rodrigues A S Gaspar J | 1997 | Mutagenesis1997，12，5： | 1 |
| 5 | Industrialization of powder compact foaming process显示文摘 | Baumgartner F Duarte I Banhart J | 2000 | Advanced Engineering Materials2000，2，4： | 1 |
| 6 | Nuclear magnetic resonance(NMR)study of the effect of cisplatin on the metabolic profile of MG-63 osteosarcoma cells显示文摘 | Duarte IF Lamego I Marques J | 2010 | J Proteome Res2010，9，11： | 1 |
| 7 | Signetringcell carcinomapresentingin theuterinecervix: re- port of aprinlaryand metastatic cases 显示文摘 | Suglrez Pearanda J M Abdulkader I Bar6n Duarte F J | 2007 | Int J Gynecol Paihol2007，26，3： | 1 |
| 8 | Photo-physical characterization of rhodamine 6G in a 2- hydroxyethyl-methacrylate methyl-methacrylate copolymer 显示文摘 | Holzer W Gratz H Schmitt T Penzkofer A Costela A Gareia-Moreno I Costela A Sastre I R Duarte F J | 2000 | Chemical Physics2000，256，1： | 1 |
| 9 | A study of aluminium foam formation-kinetics and microstructure显示文摘 | Duarte I Banhart J | 2000 | Acta Materialia2000，，48： | 1 |
| 10 | Mechanisms of induction of chromosomal aberrations by hydroquinone inV79 cells显示文摘 | do Ceu Silva M Gaspar J Duarte Silva I | 2003 | Mutagenesis2003，18，6： | 1 |
| 11 | A study of aluminium foam formation kinetics and micro-structure显示文摘 | Duart I Banhart J | 2000 | Acta Materialial2000，48，： | 1 |
| 12 | Ergonomic aspects related to surgeon position in laparoscopic radical prostatectomy显示文摘 | Mitre A I Duarte R J Arap M A | 2009 | J Endourol2009，23，2： | 1 |
| 13 | NMR metabonomics for mammalian cell metabolism studies 显示文摘 | Duarte IF Lamego I Rocha C | 2009 | Bioanalysis2009，1，9： | 1 |
| 14 | Biophysical and biochemical constraints imposed by salt stress: learning from halophytes显示文摘 | Duarte B Sleimi N Cacador I | 2014 | Frontiers in Plant Science2014，5，5： | 1 |
| 15 | Characterization of the aromatic composition of some liquid foods by nuclear magnetic resonance spectrometry and liquid chromatography with nuclear magnetic resonance and mass spectrometric detection 显示文摘 | Gil A M Duarte I F Godejohann M etal | 2003 | Anal Chim Acta2003，488，1： | 1 |
| 16 | Following dynamic biological processes through NMR based metabonomics:A new tool in nanomedicine?显示文摘 | DUARTE I F | 2011 | Journal of Controlled Release2011，153，1： | 1 |
| 17 | Structural and molecular basis of the role of starch and sucrose in Streptococcus mutans biofilm development显示文摘 | KLEIN M I DUARTE S XIAO J | 2009 | Appl Environ Microbiol2009，75，3： | 1 |
| 18 | Advances in management of neurosurgical trauma in different continents 显示文摘 | Basso A Previgliano I Duarte JM | 2001 | World J Surg2001，25，9： | 1 |
| 19 | Generalized finite element methods for three-dimensional structural me-chanics problems显示文摘 | Duarte C A Babuska I Oden J T | 2000 | Computer & Structures2000，77，： | 1 |
| 20 | Proinflammatory cytoRine expression in gastric tissue from children with Helicobacter pylori - associated gastritis显示文摘 | Guiraldes E Duarte I Pena A | 2001 | J Pediatr Gastroenterol Nutr2001，33，2： | 1 |
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