|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric cancer显示文摘AIM: To evaluate the association between polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3Thr241Met and the risk for chronic gastritis and gastric cancer, in a Southeastern Brazilian population.METHODS: Genotyping by PCR-RFLP was carried out on 202 patients with chronic gastritis (CG) and 160 patients with gastric cancer (GC), matched to 202 (C1) and 150(C2) controls, respectively.RESULTS: No differences were observed among the studied grou ps with regard to the genotype distribution of XRCC1 codons 194 and 399 and of XRCC3 codon 241. However, the combined analyses of the three variant alleles (194Trp, 399Gln and 241Met) showed an increased risk for chronic gastritis when compared to the GC group. Moreover, an interaction between the polymorphic alleles and demographic and environmental factors was observed in the CG and GC groups. XRCC1 194Trp was associated with smoking in the CG group,while the variant alleles XRCC1 399Gln and XRCC3241Met were related with gender, smoking, drinking and H pylori infection in the CG and GC groups.CONCLUSION: Our results showed no evidence of a rela-tionship between the polymorphisms XRCC1Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk of chronic gastritis and gastric cancer in the Brazilian population, but the combined effect of these variants may interact to increase the risk for chronic gastritis,considered a premalignant lesion. Our data also indicate a gene-environment interaction in the susceptibility to chronic gastritis and gastric cancer. | Márcia Cristina Duarte Jucimara Colombo Andrea Regina Baptista Rossit Alaor Caetano Aldenis Albaneze Borim Durval Wornrath Ana Elizabete Silva | 2005 | World Journal of Gastroenterology2005，11，42： | 11 |
| 2 | Characterization of proteolipid protein-peptide-specific CD_4^+ T cell of experimental allergic encephalomyelitis in Biozzi AB/H mice | Yong Peng and Chih pin Liu Department of Neurology, The Third Affiliated Hospital, Hunan Medical University , Changsha 410013, China (Peng Y) Division of Immunology, Beckman Research Institute, City of Hope National M edical Center, Duarte, CA 9 | 2002 | Chinese Medical Journal2002，，4： | 3 |
| 3 | Giant hepatic extra-gastrointestinal stromal tumor treated with cytoreductive surgery and adjuvant systemic therapy:A case report and review of literature显示文摘BACKGROUND Primary extra-gastrointestinal stromal tumors(E-GIST)of the liver are rare.The clinical presentation may range from asymptomatic to bleeding or manifestations of mass effect.Oncologic surgery followed by adjuvant therapy with imatinib is the standard of care.However,under specific circumstances,a cytoreductive approach may represent a therapeutic option.We describe herein the case of an 84-year-old woman who presented with a tender,protruding epigastric mass.Abdominal computed tomography scan revealed a large,heterogeneous mass located across segments III,IV,V,and VIII of the liver.The initial approach was transarterial embolization of the tumor,which elicited no appreciable response.Considering the large size and central location of the tumor and the advanced age of the patient,non-anatomic complete resection was indicated.Due to substantial intraoperative bleeding and hemodynamic instability,only a near-complete resection could be achieved.Histopathology and immunohistochemical staining confirmed the diagnosis of primary E-GIST of the liver.Considering the risk/benefit ratio for therapeutic options,debulking surgery may represent a strategy to control pain and prolong survival.CASE SUMMARY Here,we present a case report of a patient diagnosed with E-GIST primary of the liver,which was indicated a cytoreductive surgery and adjuvant therapy with imatinib.CONCLUSION E-GIST primary of the liver is a rare conditional,the treatment is with systemic therapy and total resection surgery.However,a cytoreductive surgery will be necessary when a complete resection is no possible. | Michel Ribeiro Fernandes Caroline Lorenzoni Almeida Ghezzi Tomaz J M Grezzana-Filho Flávia Heinz Feier Ian Leipnitz Aljamir Duarte Chedid Carlos Thadeu Schmidt Cerski Marcio Fernandes Chedid Cléber RositoPinto Kruel | 2021 | World Journal of Gastrointestinal Surgery2021，13，3： | 3 |
| 4 | Assessing the relationship between the rumen microbiota and feed efficiency in Nellore steers显示文摘Background:Ruminants rely upon a complex community of microbes in their rumen to convert host-indigestible feed into nutrients.However,little is known about the association between the rumen microbiota and feed efficiency traits in Nellore(Bos indicus)cattle,a breed of major economic importance to the global beef market.Here,we compare the composition of the bacterial,archaeal and fungal communities in the rumen of Nellore steers with high and low feed efficiency(FE)phenotypes,as measured by residual feed intake(RFI).Results:The Firmicutes to Bacteroidetes ratio was significantly higher(P<0.05)in positive-RFI steers(p-RFI,low feed efficiency)than in negative-RFI(n-RFI,high feed efficiency)steers.The differences in bacterial composition from steers with high and low FE were mainly associated with members of the families Lachnospiraceae,Ruminococcaceae and Christensenellaceae,as well as the genus Prevotella.Archaeal community richness was lower(P<0.05)in p-RFI than in n-RFI steers and the genus Methanobrevibacter was either increased or exclusive of p-RFI steers.The fungal genus Buwchfawromyces was more abundant in the rumen solid fraction of n-RFI steers(P<0.05)and a highly abundant OTU belonging to the genus Piromyces was also increased in the rumen microbiota of highefficiency steers.However,analysis of rumen fermentation variables and functional predictions indicated similar metabolic outputs for the microbiota of distinct FE groups.Conclusions:Our results demonstrate that differences in the ruminal microbiota of high and low FE Nellore steers comprise specific taxa from the bacterial,archaeal and fungal communities.Biomarker OTUs belonging to the genus Piromyces were identified in animals showing high feed efficiency,whereas among archaea,Methanobrevibacter was associated with steers classified as p-RFI.The identification of specific RFI-associated microorganisms in Nellore steers could guide further studies targeting the isolation and functional characterization of rumen microbes potentially important for the energy-harvesting efficiency of ruminants. | Déborah Romaskevis Gomes Lopes Márcio de Souza Duarte Alex J.La Reau Ibrahim Zuniga Chaves Tiago Antônio de Oliveira Mendes Edenio Detmann Cláudia Braga Pereira Bento Maria Eugênia Zerlotti Mercadante Sarah Figueiredo Martins Bonilha Garret Suen Hilário Cuquetto Mantovani | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 3 |
| 5 | 定期运动有助于改善高血压患者蛋白质稳态、炎症和血管活性显示文摘体育锻炼是一种公认的非药物控制血压的策略,除了降低血压外,运动还能对高血压患者的炎症特征、自主功能、内皮功能和抗氧化状态产生积极的影响。但其对高血压患者的蛋白质稳态的影响尚不清楚。已有动物研究表明,运动训练干预可以改善蛋白质质量控制机制,但在动物模型中报告的积极作用仍有待于在人类身上得到证实。本研究旨在根据报告的运动习惯,评估患高血压成年人的蛋白质稳态,生活质量以及炎症、氧化应激和血管活性生物标记物状态。 | Teixeira M Gouveia M Duarte A Ferreira M Simões MI Conceição M Silva G Magalhães S Ferreira R Nunes A Vieira SI Ribeiro F 周卫(译) 叶鹏(审校) | 2020 | 中华高血压杂志2020，28，12： | 2 |
| 6 | 益生菌抑制自发性高血压大鼠的菌群失调和血压升高:短链脂肪酸的作用显示文摘该研究旨在评估益生菌短双歧杆菌CECT7263(BFM)及发酵乳酸杆菌CECT5716(LC40)、短链脂肪酸丁酸盐及醋酸盐对自发性高血压大鼠(spontaneously hypertensive rat,SHR)心血管的作用。方法和结果:5周龄的Wistar Kyoto大鼠(WKY)10只和周龄匹配的SHR 50只随机分为6组:对照WKY、对照SHR、BFM干预的SHR、LC40干预的SHR、丁酸盐干预的SHR和醋酸盐干预的SHR。 | 袁源(译) 练桂丽(审校) Robles-Vera I Toral M de la Visitación N Sánchez M Gómez-Guzmán M Romero M Yang T Izquierdo-Garcia JL Jiménez R Ruiz-Cabello J Guerra-Hernández E Raizada MK Pérez-Vizcaíno F Duarte J | 2020 | 中华高血压杂志2020，28，9： | 2 |
| 7 | The sensitizer 2,4-Dinitrofluorobenzene activates caspase-3 and induces cell death in a skin dendritic cell line显示文摘 | Cruz MT Duarte CB Goncalo M | 2003 | Int J Toxicol2003，22，1： | 2 |
| 8 | Silanes and rare earth salts as chromate replacers for pre-treatments on galvanised steel 显示文摘 | FERREIRA M G S DUARTE R G MONTEMOR M F | 2004 | Electrochimica Acta2004，49，1718： | 1 |
| 9 | Single-pixel imaging via compressive sampling 显示文摘 | DUARTE M F DAVENPORT M A TAKHAR D | 2008 | IEEE Signal Processing Magazine2008，25，2： | 1 |
| 10 | The relationship between phytoplankton diversity and community function in a coastal lagoon显示文摘 | DUARTE P MACEDO M F DAFONSECAL C | 2006 | Hydrobiologia2006，555，： | 1 |
| 11 | The promising role of ^18F-FDG PET in detecting infected lower limb prosthesis implants 显示文摘 | Zhuang H Duarte PS Pourdehnad M | 2001 | J Nucl Med2001，42，1： | 1 |
| 12 | The Response of Experimental Rocky Shore Communities to Nutrient Additions 显示文摘 | Bokn T L Duarte C M Pedersen M F | 2003 | Ecosystem2003，6，： | 1 |
| 13 | Molecularcloning and characterization of a vacuolar classⅢperoxidaseinvolved in the metabolism of anticancer alkaloids in Catha-ranthus roseus显示文摘 | COSTA M M HILLIOU F DUARTE P | 2008 | Plant Physiology2008，146，2： | 1 |
| 14 | Three-port triple- half-bridge bidirectional converter with zero-voltage switc- hing 显示文摘 | Tao H Duarte J L Hendrix M A M | 2008 | IEEE Transactions on Power Electronics2008，23，2： | 1 |
| 15 | Nutrient and temperature control of the contribution of picoplankton to phytoplankton biomass and production显示文摘 | Agawin N S R Duarte C M Agustí S | 2000 | Limnology and Oceanography2000，45，： | 1 |
| 16 | Single pixel imaging via compressive sampling显示文摘 | Duarte M F Davenport M A Takhar D | 2008 | IEEE Signal Pro- cessing Magazine2008，25，2： | 1 |
| 17 | Surgical results and com- plications in a series of 71 consecutive cervical spondylotic corpec- tomies显示文摘 | Bilbao G Duart M Aurrecoechea J J | 2010 | Acta Neurochir(wien)2010，152，7： | 1 |
| 18 | A zinc ion controls assembly and stability of the major eapsid protein of rotavirus显示文摘 | Erk I Huet JC Duarte M | 2003 | J Virol2003，77，6： | 1 |
| 19 | Single-pixel imaging via compressive sampling 显示文摘 | Duarte M Davenport M Takhar D | 2008 | IEEE Signal Processing Maga- zine2008，25，2： | 1 |
| 20 | Three-port bidirectional converter for hybrid fuel cell systems 显示文摘 | Duarte J L Hendrix M Simoes M G | 2007 | Power Electronics IEEE Transactions on2007，22，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员