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| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | 基因对于儿童肥胖的影响在小于胎龄儿童中或不重要显示文摘小于胎龄儿在日后的生活中面临着更高的患肥胖症和代谢性疾病的风险,目前认为这种风险主要与小于胎龄儿出生后生长加速有关。研究人员对奥克兰出生体重协作研究项目中的小于胎龄儿和适于胎龄儿做了研究,测量并计算这些儿童的BMI-Z评分,研究与成人肥胖相关的常见基因变异是否会与小于胎龄儿出生后生长加速有关。研究者将547名欧洲儿童(228名小于胎龄儿和319名适于胎龄儿)进行基因分型,他们被分为共计37个单核苷酸多态性(SNPs)候选基因。重复测量儿童的BMI,并以Z评分法评估肥胖程度。 | Dug Yeo Han Rinki Murphy Angharad R Morgan 郭婧 张帆 | 2013 | 营养健康新观察2013，0，1： | 2 |
| 3 | Role of β-microseminoprotein from prostate cancer initiationto recurrence: A mini-review显示文摘Medline/Pubmed articles relevant to this topic were considered using the search terms ?-microseminoprotein, MSMB, prostate secretory protein of 94 amino acids and PSP94. Full articles were retrieved when the abstract was considered relevant. In addition, other data related to this topic including our own are discussed. Summary of fi ndings-?-microseminoprotein(MSMB) is increasingly being considered as a marker for prostatecancer, as reduced levels have been associated with the disease. Here we review various aspects of this protein including its biological and physiological variants, binding proteins and immune modulation; its importance as a marker for biochemical recurrence of prostate cancer; prostate cancer related splice variants and its therapeutic utility. Two of the most important properties of MSMB are related to anticancer functions and immune modulation. Predominant expression of two(short and full-length) splice variants of MSMB has been observed from normal prostate and several other tissues. In benign prostate hyperplasia the short isoform is dominant, constituting 98% of this isoform, whereas in prostate cancer 96% constitute the fulllength isoform. The MSMB promoter single nucleotide polymorphism rs10993994 with the C allele functions as an activated cyclic adenosine monophosphate response element binding protein binding site. This C variant of rs10993994 could be responsible for the production of splice variants under variable conditions. MSMB has binding motifs to a few known proteins including immunoglobulin G and several Cysteine-rich secretory proteins family proteins. MSMB bound to these proteins is considered as immune modulating. Use of MSMB as a urinary marker for detecting aggressive prostate cancers that could resist radiation and surgical treatments, seems possible, but needs further investigation. The ratio of MSMB splice variants could also be a possible approach in understanding prostate cancers, with higher ratios indicating severe disease. | Nishi Karunasinghe Karen Bishop Pamela Murray Yuanye Xu Megan Goudie Lance Ng Shuotun Zhu Dug Yeo Han Lynnette R Ferguson Jonathan Masters Benji Benjamin Michael Holmes | 2014 | World Journal of Clinical Urology2014，3，1： | 2 |
| 4 | 汽车工厂Painted Body Storage的仿真研究显示文摘文章是针对于汽车厂PaintedBodyStorage(PBS)的模拟仿真研究。汽车厂装配车间是典型的混流生产方式的车间。在喷漆车间,为了减少颜色频繁变换带来的喷头清洗费用,需要尽量将相同颜色的车辆进行组合。PBS是位于油漆车间和装配车车间之间调配空间,控制投入到装配线的车辆顺序,装配线中要尽量要分散相同配置的车辆。满足车辆的接近禁止和均匀化等约束,一旦不能满足,就需要补助人员的投入。PBS的目标是尽量满足这两种约束条件。文章介绍了汽车工厂的PBS研究。提出了装配线的车辆顺序进场、出场的优化算法,通过模拟仿真证明了该算法的优越性,进行了运营因素中的灵敏度分析。 | 宋成 Dug Hee Moon | 2006 | 计算机工程与应用2006，42，12： | 2 |
| 5 | A note on similarity measures between vague sets and between elements显示文摘 | Dug Hun Hong Chul kim | 1999 | Information Sciences1999，115，1： | 1 |
| 6 | Multi-criteria fuzzy decision-making problems based on vague set theory 显示文摘 | Dug Hun Hong Chang-Hwan Choi | 2000 | Fuzzy Sets and Systems2000，114，1： | 1 |
| 7 | Influenee of nanoelay on phenol- formaldehyde and phenol- urea- formaldehyde resins for wood adhesives显示文摘 | LEI H DUG B PIZZI A | 2010 | Journal of Adhesion Science & Technology2010，24，810： | 1 |
| 8 | A note on correlation of interval-valued intuitionistic fuzzy sets显示文摘 | Dug Hun Hong | 1998 | Fuzzy Sets and Systems1998，，： | 1 |
| 9 | Baicalin suppresses lung carcinoma and lung metastasis by SOD mimic and HIF-ltx inhibition 显示文摘 | DUG J HAN G ZHANG S | 2010 | Eur J Pharm Biopharm2010，630，13： | 1 |
| 10 | Montmorillonite reinforced phenol formaldehyde resin: Preparation, characterization, and application in wood bonding显示文摘 | FANG Q cuI H W DUG B | 2014 | International Journal of Adhesion and Adhesives2014，49，： | 1 |
| 11 | Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-d-aspartate显示文摘 | Dug an LL Sensi SL Canzoniero LM et | 1995 | J Neurosci1995，15，10： | 1 |
| 12 | A note on Similarity Measures between Vague Sets and between Elements显示文摘 | Chul Kim | 1999 | Information Sciences1999，，115： | 1 |
| 13 | 显示文摘 | Chen Q Zhou W Z DuG H | 2002 | Advanced Ma terials2002，14，17： | 1 |
| 14 | Effect of fencing and grazing on a Kobresia-dominated meadow in the Qinghai-Tibetan Plateau 显示文摘 | WU G L DUG Z LIU Z H | 2009 | Plant Soil2009，319，： | 1 |
| 15 | Analysis of Multiaxial Warp-knit Performs for Composite Reinforcement 显示文摘 | DUG W KO F | 1996 | Composites Science and Technology1996，56，3： | 1 |
| 16 | An EOQ Model with Quantity Discounts for Both Purchasing Price and Freight Cost显示文摘 | Hwang Hark Moon Dug Hee Shinn Seong Whan | 1990 | Computers & Operations Research1990，17，1： | 1 |
| 17 | A note on similarity measures between vague sets and between elements 显示文摘 | Dug H H Chum K | 1999 | Information Sciences1999，115，1： | 1 |
| 18 | Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells显示文摘 | ZHANG Z WANG C Z DUG J | 2013 | Int J Oncol2013，43，1： | 1 |
| 19 | Perihematomal mitochondrial dysfunction after intracerebral hemorrhage显示文摘 | Kim-Hart JS Kopp SJ Dug an LL | 2006 | Stroke2006，37，10： | 1 |
| 20 | A simple method to synthesise single-crystalline manganese oxide nanowires显示文摘 | YUAN Z Y RENT Z DUG H | 2003 | Chemical Physics Letters2003，378，： | 1 |
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