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| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | Influenee of nanoelay on phenol- formaldehyde and phenol- urea- formaldehyde resins for wood adhesives显示文摘 | LEI H DUG B PIZZI A | 2010 | Journal of Adhesion Science & Technology2010，24，810： | 1 |
| 3 | Montmorillonite reinforced phenol formaldehyde resin: Preparation, characterization, and application in wood bonding显示文摘 | FANG Q cuI H W DUG B | 2014 | International Journal of Adhesion and Adhesives2014，49，： | 1 |
| 4 | Molecular markers for predicting recurrence, progression and outcomes of bladder cancer (do the poster boys need new posters?)显示文摘 | Williamson K | 2004 | Curr Opin Urol2004，14，5： | 1 |
| 5 | FcEpilsonRll/CD23 is expressed in Pakrinson' s disease and induces,in vitro,production of nitric oxide and tumor necrosis factor-alpha in glia cells显示文摘 | Hunot S Dug as N Faucheux B | 1999 | J Neurosci1999，19，： | 1 |
| 6 | An optical microscopy study of dislocations in multicrystalline silicon grown by directional solidification method 显示文摘 | CHEN N QIU S Y LIU B F DUG P LIU G H SUN W | 2010 | Mat Sci Semicond Process2010，13，4： | 1 |
| 7 | Modeling coagulation kinetics incorporating fractal theories:a fractaX rectilinear approach 显示文摘 | DUG L JAMES S B LAURIE S G | 2000 | Wat Res2000，34，7： | 1 |
| 8 | A new strategy to enhance glu- tathione production by multiple H202-induced oxidative stress in Candi- da utilis显示文摘 | LIANG G B LIAO X Y DUG C | 2009 | Bioresource Teclmol2009，100，1： | 1 |
| 9 | In situ synthesis of ultra-fine, porous, tin oxide-carbon nano composites via a molten salt method for lithium-ion batteries 显示文摘 | LIU B GUO Z P DUG D | 2010 | J Power Sources2010，195，16： | 1 |
| 10 | Dissociating intentional learning from relative novelty responses in the medial temporal lobe 显示文摘 | Strang B'A Hurlemann R Dug gins A | 2005 | Neuroimage2005，25，： | 1 |
| 11 | Nanostructured sheets of Ti-O nanobehs for gas sensing and antibacterial applications 显示文摘 | Wang Y M DuG J LiuH LiuD Qin S B Wang N HuCQ Tao X T Jiao J Wang J Y Wang Z L | 2008 | Advanced Functional Materials2008，18，： | 1 |
| 12 | Short-term Load Forecasting for the Holidays Using Fuzzy Liner Regression Method显示文摘 | KYUNG B S YOUNG S B DUG H H | 2005 | IEEE Transactions Power Systems2005，20，1： | 1 |
| 13 | Influence of nanoclay on urea-formaldehyde resins for wood adhesives and its model显示文摘 | LEI H DUG B PIZZI A | 2008 | Journal of Applied Polymer Science2008，109，4： | 1 |
| 14 | Influence of nanoclay on phenol-formaldehyde and phenol-urea-formaldehyde resins for wood adhesives显示文摘 | LEI H DUG B PIZZI A | 2010 | Journal of Adhesion Science and Tech- nology2010，24，810： | 1 |
| 15 | Performance and reaction mechanism of zero formaldehyde-emission urea- glyoxal (UG) resin显示文摘 | DENG S D DUG B LI X H | 2014 | Journal of Taiwan Institute of Chemical Engineers2014，45，4： | 1 |
| 16 | Performance, reaction mechanism and characterization of glyoxal-monomethylol urea (G-MMU) resin显示文摘 | DENG S D DUG B LI X H | 2014 | Industrial & Engineering Chemistry Research2014，53，13： | 1 |
| 17 | Synthesis, structure and characterization of glyoxal-urea-formaldehyde cocon'- densed resins显示文摘 | DENG S D PIZZI A DUG B | 2014 | Journal of Applied Polymer Science2014，131，21： | 1 |
| 18 | Synthesis-structure- performance relationship of cocondensed phenol-urea- formaldehyde resins by MALDI-ToF and 'C-NMR显示文摘 | DUG B LEI H PIZZI A | 2008 | Journal of Applied Polymer Science2008，110，2： | 1 |
| 19 | Influence of nanoclay on urea-formaldehyde resins for wood adhesives and its model显示文摘 | LEI H DUG B PIZZI A | 2008 | Journal of Applied Polymer Science2008，109，4： | 1 |
| 20 | Disruption of soy-based adhesive treated by Ca(OH)2 and NaOH显示文摘 | WU Z G LEI H DUG B | 2013 | Journal of Adhesion Science and Technology2013，27，20： | 1 |
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