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| 1 | Long-term stability of gentamicin sulfate-ethylenediaminetetraacetic acid disodium salt (EDTA-Na_2) solution for catheter locks显示文摘A lock solution composed of gentamicin sulfate(5 mg/mL) and ethylenediaminetetraacetic acid disodium salt(EDTA-Na2, 30 mg/mL) could fully eradicate in vivo bacterial biofilms in totally implantable venous access ports(TIVAP). In this study, fabrication, conditioning and sterilization processes of antimicrobial lock solution(ALS) were detailed and completed by a stability study. Stability of ALS was conducted for12 months in vial(25 °C 7 2 °C, 60% 7 5% relative humidity(RH), and at 40 °C 7 2 °C, RH 75% 7 5%)and for 24 h and 72 h in TIVAP(40 °C 7 2 °C, RH 75% 7 5%). A stability indicating HPLC assay with UV detection for simultaneous quantification of gentamicin sulfate and EDTA-Na2 was developed. ALS was assayed by ion-pairing high performance liquid chromatography(HPLC) needing gentamicin derivatization, EDTA-Na2 metallocomplexation of samples and gradient mobile phase. HPLC methods to separate four gentamicin components and EDTA-Na2 were validated. Efficiency of sterility procedure and conditioning of ALS was confirmed by bacterial endotoxins and sterility tests. Physicochemical stability of ALS was determined by visual inspection, osmolality, pH, and sub-visible particle counting. Results confirmed that the stability of ALS in vials was maintained for 12 months and 24 h and 72 h in TIVAP. | Anne-Sophie Fiolet Elise Jandot Pauline Doucey Coralie Crétet Célia Brunel Christine Pivot Jean-Marc Ghigo Christophe Beloin David Lebeaux Fabrice Pirot | 2018 | Journal of Pharmaceutical Analysis2018，8，6： | 2 |
| 2 | Recruitment of TNF receptor 1 to lipid rafts is essential for TNF alpha-mediated NF-kappaB activation 显示文摘 | Legler DF Micheau O Doucey MA | 2003 | Immunity2003，18，5： | 1 |
| 3 | 查看详情显示文摘 | Doucey L Revault M Lautie A | | 0，，14： | 1 |
| 4 | SiCN nanocoposite: creep behaviour 显示文摘 | BESSON J L DOUCEY B LUCAS S | 2001 | Journal of the European Ceramic Society2001，21，： | 1 |
| 5 | Optical properties and local atomic order in non hydrogenated amorphous silicon carbonitride films显示文摘 | Doucey B Cuniot M Moudni R | 2002 | J Mater Sci2002，37，： | 1 |
| 6 | The betal and beta3 integrins promote T cell receptor-mediated cytotoxic rF lymphocyte activation显示文摘 | Doucey MA Legler DF Faroudi M etal | 2003 | J Biol Chem2003，278，26： | 1 |
| 7 | Recruitment of TNF receptor 1 to lipid rafts is essential for TNFα-mediated NF-κB activation显示文摘 | Legler DF Micheau O Doucey MA | | 0，，05： | 1 |
| 8 | Functional avidity of tumor antigen-specific CTL recognition directly correlates with the stability of MHC/peptide multimer binding to TCR显示文摘 | Dutoit V Rubio-Godoy V Doucey MA | 2002 | J Immunol2002，168，3： | 1 |
| 9 | Recruitment of TNF receptor 1 to lipid rafts is essential for TNF alpha-mediated NF-kappa B activation 显示文摘 | Legler DF Micheau O Doucey M | 2003 | Immunity2003，18，5： | 1 |
| 10 | Recruitment of TNF Receptor 1 to lipid rafts is essential for TNFa-mediated NF-kB activation显示文摘 | Legler DF Micheau O Doucey M | 2003 | Immunity2003，18，： | 1 |
| 11 | SiCN nanocomposite: creep behaviour 显示文摘 | BESSON J L DOUCEY B LUCAS S | 2001 | J Eur Ceram Soc2001，21，： | 1 |
| 12 | SiCN nanocomposite: creep behavior 显示文摘 | BESSON J-L DOUCEY B LUCAS S | 2001 | J Eur Cerarn Soc2001，21，： | 1 |
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