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| 1 | Management of carbon tetrachloride-induced acute liver injury in rats by syngeneic hepatocyte transplantation in spleen and peritoneal cavity显示文摘AIM: Acute hepatitis may seldom have a fulminant course.In the treatment of this medical emergency, potential liver support measure must provide immediate and sufficient assistance to the hepatic function. The goal of our study was to study the adequacy of hepatocyte transplantation (HCTx) in two different anatomical sites, splenic parenchyma and peritoneal cavity, in a rat model of reversible acute hepatitis induced by carbon tetrachloride (CCl4).METHODS: After CCl4 intoxication, 84 male Wistar rats used as recipients were divided in to four experimental groups accordingly to their treatment: Group A (n=24): intrasplenic transplantation of 10±10^6 isolated hepatoo/tes, Group B (n=24):intrapedtoneal transplantation of 20×10^6 isolated hepatocytes attached on plastic microcarriers, Group C (n= 18): intrasplenic injection of 1 mL normal saline (sham-operated controls),Group D (n=18): intraperitoneal injection of 2.5 mL normal saline (sham-operated controls). Survival, liver function tests (LIT) and histology were studied in all four groups, on d 2,5 and 10 post-HCTx.RESULTS: The ten-day survival (and mean survival) in the 4 groups was 72.2% (8.1±3.1), 33.3% (5.4±3.4), 0%(3.1±1.3) and 33.3% (5.4±3.6) in groups A, B, C, D,respectively (PAB<0.05, PAc<0.05, P80=NS). In the final survivors, LIT (except alkaline phosphatase) and hepatic histology retumed to normal, independently of their previous therapy. Viable hepatocytes were identified within splenic parenchyma (in group A on d 2) and both in the native liver and the fatty tissue of abdominal wall (in group B on d 5).CONCLUSION: A significantly better survival of the intrasplenically transplanted animals has been demonstrated,Intraperitoneal hepatocytes failed to promptly engraft. A different timing between liver injury and intraperitoneal HCTx may give better results and merits further investigation. | Charalampos Pilichos Despina Perrea Maria Demonakou Athena Preza Ismini Donta | 2004 | World Journal of Gastroenterology2004，10，14： | 2 |
| 2 | Quantitative ultrasound is better correlated with bone mineral density and biochemical bone markers in elderly women 显示文摘 | Lappa V Dontas IA Trovas G | 2007 | Clin Rheumatol2007，26，7： | 1 |
| 3 | Cytotoxic activity of Aeromonas hydrophila 显示文摘 | Donta S T Haddow A D | 1978 | Infecl Immun1978，21，： | 1 |
| 4 | The effects of mild hypothermia on coagulation tests and haemodynamic variables in anaesthetized rabbits显示文摘 | Staikou C Donta I Theodossopoulos T | 2011 | West Indian Medical Journal2011，60，5： | 1 |
| 5 | The influence of indomethacin co-administration on ofloxacin levels in plasma and cerebrospinal fluid in rats显示文摘 | DONTAS I SOKOLIS DP GIAMARELLOS-BOURBOULIS EJ | 2004 | Int J Antimicrob Agents2004，23，4： | 1 |
| 6 | Immunoprophylaxis against Klebsiella and Pseudomonas aeruginosa infections显示文摘 | Donta ST Peduzzi P Cross AS | 1996 | J Infect Dis1996，174，： | 1 |
| 7 | Risk factors and prevention of os- teoporosis related fractures显示文摘 | Dontas IA Yiannakopoulos CK | 2007 | Museuloskelet2007，7，3： | 1 |
| 8 | The laboratory rat as an animal model for osteoporosis research显示文摘 | Lelovas PP Xanthos TT Thoma SE Lyritis GP Dontas IA | 2008 | Comp Med2008，58，5： | 1 |
| 9 | Risk factors and preventionof osteoporosis-related fractures 显示文摘 | Dontas IA Yiannakopoulos CK | 2007 | J MusculoskeletNeuronal Interact2007，7，3： | 1 |
| 10 | Pharmacological aspects and potential new clinical applications of ketamine: reevaluation of an old drug显示文摘 | Aroni F Iacovidou N Dontas I | 2009 | J Clin Pharmacol2009，49，8： | 1 |
| 11 | Risk factors and prevention of osteoporosis-related fractures显示文摘 | Dontas IA Yiannakopoulos CK | 2007 | J Musculoskelet Neuronal Interact2007，7，3： | 1 |
| 12 | Abdominal compres- sions do not achieve similar survival rates compared with chest compressions: an experimental study 显示文摘 | Xanthos T Bassiakou E Dontas I | 2011 | Am J Emerg Med2011，29，6： | 1 |
| 13 | Dietary Saturated and trans Fatty Acids and Cholesterol and 25-Year Mortality from Coronary Heart Disease: The Seven Countries Study显示文摘 | D. Kromhout A. Menotti B. Bloemberg C. Aravanis H. Blackburn R. Buzina A.S. Dontas F. Fidanza S. Giaipaoli A. Jansen M. Karvonen M. Katan A. Nissinen S. Nedeljkovic J. Pekkanen M. Pekkarinen S. Punsar L. Rasanen B. Simic H. Toshima | 1995 | Preventive Medicine1995，，3： | 1 |
| 14 | Cyto toxic activity of a erom onas hydrophila显示文摘 | Donta S T | 1978 | Infect Immun1978，21，： | 1 |
| 15 | The interfacial properties of erbium films on the two polar faces of 6H-SiC (001)显示文摘 | DONTAS I KENNOU S | 2001 | Diamond and Related Materials2001，10，： | 1 |
| 16 | Growing male rats in individually ventilated and open-top cages显示文摘 | Kostomitsopoulos N Dontas Alexakos P | 2011 | J Am Assoc Lab Anita Sci2011，50，6： | 1 |
| 17 | Survey on recent advances in IoT application layer protocols and machine learning scope for research directions显示文摘The Internet of Things(IoT)has been growing over the past few years due to its flexibility and ease of use in real-time applications.The IoT's foremost task is ensuring that there is proper communication among different types of applications and devices,and that the application layer protocols fulfill this necessity.However,as the number of applications grows,it is necessary to modify or enhance the application layer protocols according to specific IoT applications,allowing specific issues to be addressed,such as dynamic adaption to network conditions and interoperability.Recently,several IoT application layer protocols have been enhanced and modified according to application requirements.However,no existing survey articles focus on these protocols.In this article,we survey traditional and recent advances in IoT application layer protocols,as well as relevant real-time applications and their adapted application layer protocols for improving performance.As changing the nature of protocols for each application is unrealistic,machine learning offers means of making protocols intelligent and is able to adapt dynamically.In this context,we focus on providing open challenges to drive IoT application layer protocols in such a direction. | Praveen Kumar Donta Satish Narayana Srirama Tarachand Amgoth Chandra Sekhara Rao Annavarapu | 2022 | Digital Communications and Networks2022，8，5： | 1 |
| 18 | Differential effects of Clostridiurn difficile toxins on tissue-cultured cells 显示文摘 | Donta ST Sullivan N Wilkins TD | 1982 | J Clin Microbiol1982，15，6： | 1 |
| 19 | The seven countries study: 2 289 deaths in 15 years显示文摘 | Keys A Menotti A Aravanis C Blackburn H Djordevic BS Buzina R Dontas AS Fidanza F Karvonen MJ Kimura N | 1984 | Prev Med1984，13，2： | 1 |
| 20 | Abdominal compressions do not achieve similar survival rates compared with chest compressions: an experimental study 显示文摘 | Xanthos T Bassiakou E Dontas I | 2011 | Am J Emerg Med2011，29，6： | 1 |
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