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| 1 | ALDH2 protects against stroke by clearing 4-HNE显示文摘(ALDH2 ) 醛脱氢酶 2 是使象 4-hydroxy-2-nonenal (4-HNE ) 那样的乙醇和有毒的醛产生代射变化的 mitochondrial 酶。用不偏的 proteomic 搜索,我们作为与自发地高血压的老鼠(SHR ) 相比在击容易的自发地高血压的老鼠(SHR-SP ) 识别了 ALDH2 缺乏。我们作为 overexpression 在 neuronal 损害结束了 ALDH2 缺乏的原因的角色或 ALDH2 的激活由清除 4-HNE 在授与 neuroprotection 在 vitro 研究。进一步, ALDH2 击倒的老鼠揭示了 PKCε 的 neuroprotective 效果的缺席;。被知道对击施加保护的中等乙醇管理被显示提高 4-HNE 的 detoxification,并且免于 ischemic 通过 PKCε 的服的损害; -ALDH2 小径。在 SHR-SP,浆液 4-HNE 水平固执地与 lifespan 相反地被提高并且相关。在在人的击的 4-HNE 的角色被它的血浆层次的坚持的举起也在击以后建议至少 6 个月。最后,我们观察到发展了的跟随 8 年的 1 242 个题目中的 21 个比没得中风的那些摸有的更高起始的血浆 4-HNE 层次。这些调查结果建议 ALDH2 小径的激活可以在击容易的题目的鉴定用作一个有用索引,并且 ALDH2 小径可以是在击的治疗学的干预的一个潜在的目标。 | Jin-Min Guo Ai-Jun Liu Pu Zang Wen-Zhe Dong Li Ying Wei W ang Pu Xu Xu-Rui Song Jun Cai She-Qing Zhang Jun-Li Duan Jawahar L Mehta Ding-Feng Su | 2013 | Cell Research2013，23，7： | 19 |
| 2 | Adsorption of Pb and Cd onto metal oxides and organic material in natural surface coatings as determined by selective extractions:New evidence for the Importance of Mn and Fe Oxides显示文摘 | Dong D Nelson Y M Lion L W | 2000 | Water Research2000，34，2： | 2 |
| 3 | Effect of Interracial Free Energy on Hydriding Reaction of Mg-Ni Thin Films 显示文摘 | Ouyang L Z Ye SY Dong H W | 2007 | ApplPhysLett2007，90，02： | 1 |
| 4 | A very simple and low cost route to Bi2 S3 nanorods bundles and dandelion-like nanostructures显示文摘 | Dong L H Chu Y Zhang W | 2008 | Mater Lett2008，62，27： | 1 |
| 5 | Studies on Lanthanide Complexes with A New Schiff Base Macrocyclic Ligand显示文摘 | Dong W K Yang R D Yan L | 2001 | Journal of Lanzhou University(Science) (English)2001，37，1： | 1 |
| 6 | High-strength reinforced concrete deep and short beams:shear design equations in North America and UK practice显示文摘 | Tan K H Dong F K Weng L W | 1998 | ACI Structural Journal1998，95，3： | 1 |
| 7 | Study on macrophage ac- tivation and structural characteristics of purified polysaccharide from the liquid culture broth of Cordyceps militaris显示文摘 | JONG S L JEONG S K DONG P W | 2010 | Carbohydrate Pol- ymers2010，，82： | 1 |
| 8 | Zinc oxide nanodisk 显示文摘 | Xu C X Sun X W Dong Z L | 2004 | Appl Phys Lett2004，85，17： | 1 |
| 9 | Determination of polystyrene-carbon dioxide- decahydronaphthalene solution properties by high pressure dynamic light scattering显示文摘 | Dong L B Carbonell R G Roberts G W | 2009 | Polymer2009，50，24： | 1 |
| 10 | 查看详情显示文摘 | I Ren F M Wang X L Dong W J Bai L N | | 0，，： | 1 |
| 11 | Geometric and compositional appearance of atheroma in an angiographically normal carotid artery in patients with atherosclerosis显示文摘 | Dong L Underhill HR Yu W | 2010 | AJNR Am J Neuroradinl2010，31，： | 1 |
| 12 | Sediment trans-port in the Yellow Sea and East China Sea显示文摘 | Dong L X Guan W B Chen Q | 2011 | Estuarine Coastal and Shelf Science2011，93，3： | 1 |
| 13 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 14 | Helical conjugated polymers:Synthesis,stability,and chiroptical properties of poly(alkyl phenylpropiolate)s bearing stereogenic pendants显示文摘 | Jacky W Y Lam Dong Yuping Kevin K L Cheuk | 2004 | Macromolecules2004，37，18： | 1 |
| 15 | cDNA cloning and ex- pression of a novel estrogen receptor β-subtype in goldfish (Carassius auratus) 显示文摘 | Ma C H Dong K W Yu K L | 2000 | Biochim Biophys Acta2000，1490，： | 1 |
| 16 | Molecular characterization of two pheromone binding proteins and quantitative analysis of their expression in the beet armyworm, Spodoptera exigua Hubner显示文摘 | Xiu W M Dong S L | 2007 | J Chem Ecol2007，33，： | 1 |
| 17 | Abnormal organic matter maturation in the Yinggehai Basin,offshore South China Sea:Implications for hydrocarbon expulsion and fluid migration from overpressured systems显示文摘 | Hao F Li S T Dong W L | 1998 | Journal of Petroleum Geology1998，21，4： | 1 |
| 18 | Adsorption of Pb and Cd ontometal oxides and organic material in natural surface coatings as deter-mined by selective extractions : New evidence for the importance of Mnand Fe oxides显示文摘 | Dong D Nelson Y M Lion L W | 2000 | Water Research2000，34，2： | 1 |
| 19 | A new differential scheme with multi-time levels 显示文摘 | DONG W J CHOU J F | 2001 | Chinese Physics2001，10，11： | 1 |
| 20 | Study on preparation and fire retardant mechanism analysis of intumescent flame-retardant coatings 显示文摘 | GU J W ZHANG G C DONGS L | 2007 | Surf Coat Technol2007，201，： | 1 |
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