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| 1 | Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids:A randomized controlled trial显示文摘AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) vs hydrocortisone acetate-based suppositories in acute hemorrhoidal disease.METHODS: A multicenter(11 sites), randomized(1:1:1), open, controlled trial with parallel groups was performed. All participating patients gave their written,informed consent. After inclusion, patients with acute symptoms of hemorrhoids were centrally randomized to receive, as outpatients, by the rectal route, suppositories of rSK 200000 IU of one unit every 8 h(first 3 units)and afterwards every 12 h until 8 administrations were completed(schedule A), one unit every 8 h until 6 units were completed(schedule B), or 25 mg hydrocortisone acetate once every 8 h up to a maximum of 24 administrations. Evaluations were performed at 3, 5,and 10 d post-inclusion. The main end-point was the 5thday response(disappearance of pain and bleeding, and≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were also evaluated.RESULTS: Groups were homogeneous with regards to demographic and baseline characteristics. Fifth day complete response rates were 156/170(91.8%; 95%CI:87.3-96.2), 155/170(91.2%; 95%CI: 86.6%-95.7%),and 46/170(27.1%; 95%CI: 20.1%-34.0%) with rSK(schedule A and B) and hydrocortisone acetate suppositories, respectively. These 64.6% and 63.9%differences(95%CI: 56.7%-72.2% and 55.7%-72.0%)were highly significant(P < 0.001). This advantage was detected since the early 3rd day evaluation(68.8% and64.1% vs 7.1% for the rSK and active control groups,respectively; P < 0.001) and was maintained even at the late 10 th day assessment(97.1% and 93.5% vs67.1% for rSK and hydrocortisone acetate, respectively;P < 0.001). Time to response was 3 d(95%CI: 2.9-3.1)for both rSK groups and 10 d(95%CI: 9.3-10.7) in the hydrocortisone acetate group. This difference was highly significant(P < 0.001). All subgroup stratified analyses(with or without thrombosis and hemorrhoid classification) showed a statistically significant advantage for the rSK groups. Thrombectomy was necessary in4/251 and 14/133 patients with baseline thrombosis in the rSK and hydrocortisone acetate groups, respectively(P < 0.001). There were no adverse events attributable to the experimental treatment.CONCLUSION: rSK suppositories showed a significant advantage over a widely-used over-the-counter hydrocortisone acetate preparation for the treatment of acute hemorrhoidal illness, as well as having an adequate safety profile. | Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-Alvarez Osmany Martínez-Serrano Odalys C Lazo-Diago Cimara H Bermúdez-Badell José R Causa-García Juan E Domínguez-Suárez Pedro A López-Saura 无 | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Motor cortical hyperexcitability in idiopathic scoliosis:could focal dystonia be a subclinical etiological factor显示文摘 | Doménech J Tormos JM Barrios C | 2010 | Eur Spine J2010，19，2： | 1 |
| 4 | Manufacture of pizza cheese显示文摘 | Breene W M Price W V Ernstr Dom C A | 1994 | Dairy Sci1994，47，： | 1 |
| 5 | HIV vaccine design and the neutralizing antibody problem显示文摘 | Burton D R Desrosiers R C Doms R W | 2004 | Nat Med2004，5，3： | 1 |
| 6 | Human endometrial CD98 is essential for blastocyst adhesion显示文摘 | Domínguez F Simón C Qui(n)onero A | | 0，，10： | 1 |
| 7 | Analysis of factors for conversion of laparoscopic to open cholecystectomy: a prospective study of 703 patients with acute cholecystitis显示文摘 | Domínguez LC Rivera A Bermúdez C | 2011 | Cir Esp2011，89，5： | 1 |
| 8 | Lactic acid production from corn cobs by simultaneous saccharification and fermentation:a mathematical interpretation 显示文摘 | Rivas B Moldes A B Domínguez J M Parajó J C | 2004 | Enzyme and Microbial Technology2004，34，7： | 1 |
| 9 | A two-stage distributed architecture for voltage control in power distribution systems显示文摘 | ROBBINS B A HADJICOSTIS C N DOM~NGUEZ- GARCIA A D | 2013 | IEEE Trans on Power Systems2013，28，2： | 1 |
| 10 | The R33 G protein-coupled receptor gene of rat cytomegalovirus plays an essential role in the pathogenesis of viral infection 显示文摘 | Vink C Van Dom J G | 1998 | J Virol1998，72，： | 1 |
| 11 | HIV vaccine design andthe neutralizing antibody problem显示文摘 | Burton D R Desrosiers R C Doms R W | 2004 | Nature Immunology2004，5，3： | 1 |
| 12 | Endometrial receptivity in an in vitro fertilization program as assessed by spiral artery blood flow,endometrial thiekness,endometrial volume,and uterine artery blood flow 显示文摘 | Sehild RL Knobloch C Dom C | 2001 | Fertil Steril2001，75，2： | 1 |
| 13 | Unwelcomed guests with master keys: How HIV uses chemokine receptors for cellular entry显示文摘 | Doms R W Peiper S C | 1997 | Virology1997，235，2： | 1 |
| 14 | Alkali treatment of viscose cellulosic fibers from eucalyptus wood:Structural,morphological,and thermal analysis显示文摘 | Rojo E Alonso M Domínguez J C | 2013 | Journal of Applied Polymer Science2013，130，3： | 1 |
| 15 | Hypertension and mild cognitive impairment显示文摘 | Sierra C Dom nech M Camafort M | | 0，，06： | 1 |
| 16 | A review of the environmental fate, effects and exposures of Bisphenol A 显示文摘 | Staples C A Dom P B Klecka G M | 1998 | Chemosphere1998，36，10： | 1 |
| 17 | Disruption of srtA gene in Streptococcus suis results in decreased interactions with endothelial cells and extraeellular matrix proteins 显示文摘 | Vanier G Sekizaki T Dom nguez-Punaro M C | 2008 | Vet Microbiol2008，12，： | 1 |
| 18 | Vermicomposting of sewage sludge:Effect of bulking materials on the growth and reproduction of the earthworm Eisenia andrei显示文摘 | Domínguez J Edwards C A Webster M | 2000 | Pedobiologia2000，44，1： | 1 |
| 19 | Relationships between leaf morphological traits,nutrient concentrations and isotopic signatures for Mediterranean woody plant species and communities显示文摘 | Domínguez MT Aponte C Pérez-Ramos IM | | 0，，： | 1 |
| 20 | Baseline toxic mixtures of non-toxic chemicals: 'Solubility addition' increases exposure for solid hydrophobic chemicals 显示文摘 | Smith K E C Schmicdt S N Dom N | 2013 | Environmental Science & Technology2013，47，4： | 1 |
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