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| 1 | 肝脏转移性消化道肝样腺癌:一种易与原发性肝细胞肝癌混淆的高级别癌显示文摘目的:探讨肝脏转移性消化道肝样腺癌(hepatoid adenocarcinoma)病例的临床病理学和免疫表型特征。方法:回顾性分析2009年1月至2019年1月在鼓楼医院诊治的8例肝脏转移性消化道肝样腺癌患者的临床资料、病理组织学形态以及免疫组织化学(EnVision法)表达特点。结果:患者男性5例,女性3例,平均年龄66岁。原发于远端食管1例,原发于右半结肠1例,其余6例均原发于胃。4例患者治疗前血清甲胎蛋白(AFP)升高,2例血清AFP水平正常,2例结果不详。8例患者初诊时均有肝转移。镜下观察:原发部位肿瘤组织由肝样分化区构成,伴或不伴普通腺癌成分,肝样分化区组织学特点似典型肝细胞肝癌(hepatocellular carcinoma,HCC)。而肝脏转移灶组织学形态以肝样分化为主,与HCC难以鉴别。免疫表型上,原发灶与转移灶肝样分化区域不同程度表达HCC的标志物如Glypican 3、AFP、SALL4和HepPar-1;同时也表达消化道腺癌的标志物,如细胞角蛋白(CK)19、CDX-2和Villin等。结论:消化道肝样腺癌临床症状不特异,有较强的侵袭和转移能力。当以肝脏转移灶为首发症状时,仅根据组织病理学特征很难与肝脏原发性HCC相鉴别。肝脏转移性肝样腺癌需要综合临床、影像学、组织病理学以及免疫组织化学检查等结果才能够得出准确诊断。 | 娄可心 付尧 吴鸿雁 王婷 Attigah Samuel Doe Kwasi 樊祥山 | 2020 | 中华病理学杂志2020，49，7： | 7 |
| 2 | 聚乙烯基撑碳酸酯和聚羟基甲撑的合成与表征显示文摘通过乙烯基撑碳酸酯的聚合制得了无色透明的高分子量的聚合物.再经水解制得了聚羟基甲撑膜和粉状物.研究了在丙酮和二甲基甲酰胺中聚乙烯基撑碳酸酯的降解机理. | 黄家贤 Adriaan Bantjes Leen van der Does | 1989 | 高等学校化学学报1989，10，8： | 6 |
| 3 | A small, cysteine‐rich protein secreted by Fusarium oxysporum during colonization of xylem vessels is required for I‐3‐mediated resistance in tomato显示文摘 | MartijnRep H. CharlotteVan Der Does MichielMeijer RingoVan Wijk Petra M.Houterman Henk L.Dekker Chris G.De Koster Ben J. C.Cornelissen | 2004 | Molecular Microbiology2004，，5： | 2 |
| 4 | 显示文摘 | CLAESSENS S DEMIRGUC-KUNT A HUIZINGA H: How does Foreign Entry Affect the Domestic Banking Market? | 2001 | Journal of Banking and Finance2001，25，： | 1 |
| 5 | The bacterial translocase: a dynamic protein channel complex显示文摘 | de Keyzer J van der Does C Driessen A J | 2003 | Cell Mol Life Sci2003，60，： | 1 |
| 6 | A report of the International Study of Kidney Disease in Children 显示文摘 | Tarshish P Tobin J N Bemstein J Cyclophosphamide does not benefit patients with focal segmental glomerulosclerosis | 1996 | Pediatr Nephrol1996，10，5： | 1 |
| 7 | Dutch hospital implements six sigma 显示文摘 | Heuvel J V D Does R J M M | 2005 | Six Sigma Forum Magazine2005，4，2： | 1 |
| 8 | Immunotherapy in allergic fungal sinusitis :The controversy continues : A recent review of literature显示文摘 | Doe|lman MS Dion GR Weitzel EK | 2013 | Allergy Rhinol (Providence)2013，4，1： | 1 |
| 9 | Asymmetric cell division: fly neuroblast meets worm zygote 显示文摘 | Doe CQ Bowerman B | 2001 | Curr Opin Cell Biol2001，13，1： | 1 |
| 10 | Novel Rho Kinase inhibitors with anti-inflammatory and vasodilatory activities显示文摘 | Doe C Bentley R Behm DJ | 2007 | J Pharmacol Exp Ther2007，320，1： | 1 |
| 11 | Plumbotectonics-the model显示文摘 | Zartman R E Doe B R | 1981 | Tectonophysics1981，75，： | 1 |
| 12 | Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities 显示文摘 | Doe C Beatley R Behm D J | 2007 | J Pharmacol Exp % her2007，320，1： | 1 |
| 13 | 显示文摘 | Simpson SH Gamble JM Mereu L etal Effect of aspirin does on mortality and cardiovascular events in people with diabetes:a meta- analysis | 2011 | J Gen Inter Med2011，26，11： | 1 |
| 14 | Biodiversity and stability in grasslands显示文摘 | TILNAN D DOEING J A | 1994 | Nat1994，367，： | 1 |
| 15 | Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation 显示文摘 | Lee CY Robinson KJ Doe CQ | 2006 | Nature2006，439，7076： | 1 |
| 16 | Symptoms and well-being in relation to glyce mic control in type Ⅱ diabetes显示文摘 | Ferdinand EE Does VD Grootenhuis PA | 1996 | Diabetes Care1996，19，： | 1 |
| 17 | Circadian expression and induction by wounding of tobacco genes for cysteine proteinase显示文摘 | Linthorst H J van der Does C Brederode F T | 1993 | Plant Molecular Biology1993，21，： | 1 |
| 18 | Lake Restoration with and Without Dredging of Phosphorus Enriched Upper Sediment Layers显示文摘 | VAN DER DOES J VVRSTRAELEN P BOERS P | 1992 | Hydrobiologia1992，233，： | 1 |
| 19 | Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities 显示文摘 | Doe C Bentley R Behm DJ | 2007 | J Pharmacol Exp Ther2007，320，1： | 1 |
| 20 | Exposure to electrical contact currents and the risk of childhood leukemia 显示文摘 | Does M Sclo G Metayer C | 2011 | Radiat Res2011，175，： | 1 |
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