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| 1 | Influence of irritable bowel syndrome on treatment outcome in gastroesophageal reflux disease显示文摘AIM: To investigate the influence of irritable bowel syndrome (IBS)-like symptoms on treatment outcomes with pantoprazole in gastroesophageal reflux disease (GERD) in a real life setting. METHODS: For this prospective, open-label, multinational, multicentre study, 1888 patients assessed by the investigators as suffering from GERD were recruited. The patients were additionally classified as with or without IBS-like symptoms at baseline. They were treated with pantoprazole 40 mg once daily and completed the Reflux Questionnaire (ReQuest) short version daily. Response rates and symptom scores were compared after 4 and 8 wk of treatment for subgroups defined by the subclasses of GERD [erosive(ERD) and non-erosive reflux disease (NERD)] and the presence of IBS-like symptoms. RESULTS: IBS-like symptoms were more prevalent in NERD than in ERD (18.3% vs 12.7%, P = 0.0015). Response rates after 4 and/or 8 wk of treatment were lower in patients with IBS-like symptoms than in patients without IBS-like symptoms in both ERD (Week 4: P < 0.0001, Week 8: P < 0.0339) and NERD (Week 8: P = 0.0088). At baseline, ReQuest 'lower abdominal com- plaints' symptom scores were highest in NERD patients with IBS-like symptoms. Additionally, these patients had the strongest symptom improvement after treatment compared with all other subgroups. CONCLUSION: IBS-like symptoms influence treatment outcome and symptom burden in GERD and should be considered in management. Proton pump inhibitors can improve IBS-like symptoms, particularly in NERD. | Hubert Mnnikes Robert C Heading Holger Schmitt Hubert Doerfler | 2011 | World Journal of Gastroenterology2011，17，27： | 4 |
| 2 | Elimination Diet Effectively Treats Eosinophilic Esophagitis in Adults; Food Reintroduction Identifies Causative Factors显示文摘 | Nirmala Gonsalves Guang–Yu Yang Bethany Doerfler Sally Ritz Anne M. Ditto Ikuo Hirano | 2012 | Gastroenterology2012，，： | 3 |
| 3 | Gilmour ML Kinetic profile of in- fluenza virus infection in three rat strains显示文摘 | Daniels MJ Selgrade MK Doerfler D | 2003 | Comp Med2003，53，3： | 1 |
| 4 | Imaging of SeIlar and Parasellar Lesions 显示文摘 | Rennert J Doerfler A | 2007 | Clin Neurol Neurosurg2007，109，2： | 1 |
| 5 | Perfusion and disperfusion-weighted magnetic resonance imaging for monitoring decompressive craniectomy in animals with experimental hemispheric stroke显示文摘 | Doerfler A Engelhom F Heiland S | 2002 | Neuro-surgery2002，96，5： | 1 |
| 6 | Elimination Diet Effectively Treats Eosinophilic Esophagitis in Adults; Food Reintroduction Identifies Causative Factors显示文摘 | Nirmala Gonsalves Guang–Yu Yang Bethany Doerfler Sally Ritz Anne M. Ditto Ikuo Hirano | 2012 | Gastroenterology2012，，7： | 1 |
| 7 | Treatment of wide- necked intracranial aneurysms with a self-expanding stent system: initial clinical experience 显示文摘 | Wanke I Doerfler A Schoch B | 2003 | Am J Neuroradiol2003，24，6： | 1 |
| 8 | Post-traumatic stress disorder in patients with coronary artery disease: screening and management implica- tions显示文摘 | Doerfler LA Paraskos JA | 2005 | Can J Cardiol2005，21，8： | 1 |
| 9 | Antiendotoxin activity of lipid A analogues: requirements of the chemical structure显示文摘 | Danner Rl van Dervort AL Doerfler ME | 1990 | Pharm res1990，7，3： | 1 |
| 10 | Treatment of wideneeked in- traeranial aneurysms with a self - expanding stent system: initial clinical experience 显示文摘 | Wanke I Doerfler A Sehoch B | 2003 | AJNR2003，24，6： | 1 |
| 11 | Central venous catheter placement in patients with disorders of hemostasis显示文摘 | Doerfler M E Kaufman B Goldenberg A S | 1996 | Chest1996，110，1： | 1 |
| 12 | Clinical outcome and neu- ropsychological deficits after right ecompressive hemicraniectomy in MCA infarction显示文摘 | Leonhardt G Wilhelm H Doerfler A | 2002 | Neuro12002，249，： | 1 |
| 13 | Dynamic Testing of a Slow Sample Rate,High-Resolution Data Acquisition Systems 显示文摘 | Doerfler D W | 1986 | IEEE Transactions on Instrumentation and Measurement1986，35，4： | 1 |
| 14 | PattemsofDNAmethylation-evolutional vestiges of foreign DNA inactivation as a host defense mechanism显示文摘 | | 1991 | Biol Chem Hoppe-Seyler1991，372，： | 1 |
| 15 | Endovascular treatment of cerebrovascular disease显示文摘 | Doerfler A Becker W Wanke I | 2004 | Curt Opin Neurol2004，17，4： | 1 |
| 16 | Ingested foreign (phageM13)DNA survives transiently in the gastrointestinal tract and enters the bloodstream of mice显示文摘 | Schubbert R Lettmann C Doerfler W | 1994 | Mol General Genetics1994，242，： | 1 |
| 17 | Decompressive craniecto- my, reperfusion or a combination for early treatment of acute ' malig- nant' cerebral hemispheric stroke in rats Potential mechanism studied by MRI 显示文摘 | Engelhom T Doerfler A Kastrup A | 1999 | Stroke1999，30，7： | 1 |
| 18 | Granger causality in integrated GC-MS and LC-MS metabolomics data reveals the interface of primary and secondary metabolism 显示文摘 | Doerfler H Lyon D Naegele T | 2013 | Metabolo- mics2013，9，3： | 1 |
| 19 | Treat- ment of Wide - Necked Intracranial Aneurysms with a Self- Expanding Stent System: Initial Clinical Experi- ence 显示文摘 | Isabel Wanke Arnd Doerfler Beate Schoch | 2003 | American Journal of Neuroradiology2003，24，： | 1 |
| 20 | Treatment of wide- necked intracranial aneurysms with a self - expanding stent system: initial clinical experience显示文摘 | Wanke I Doerfler A Schoch B | 2003 | AJNR Am J Neuroradiol2003，24，6： | 1 |
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