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| 1 | Effect of Alstonia scholaris bark extract on testicular function of Wistar rats显示文摘Aim:To evaluate the antifertility effect of Alstonia scholaris bark extract in male rats.Methods:In male Wistar rats Alstonia scholaris bark extract was given by oral route at a dose of 200mg/day for60days,The fertility and testicular function were assessed by mating tests,sperm motility,sperm concentration,biochemical indices and testicular cell population dynamics.Results:Oral feeding with the extract at a dose of 200mg/day for the period of 60days did not cause body weight loss,while the weights of testes,epididymides,seminal vesicle and ventral prostate were significantly reduced.The production of step-19 spermatids was reduced by 79.6%in treated rats.The popu-lation of preleptotene and pachytene spermatocytes were decrased by61.9%and60.1%,respectively.Spematogo-nia and Sertoli cell population were also affected.The seminiferous tubule and Leydig cell nuclear area were reduced significantly(P<0.01)when compared to the controls..Reduced sperm count and motility yesulted in a total supprs-sion of fertility.A significant fall in the protein and sialic acid content of the testes,epididymides,seminal vesicle and ventral prostate as well as glycogen content of testes were also noticed.The fructose content in the seminal vesicle was lowered whereas the testicular cholesterol was elevated as compared with the controls.The following com-pounds were obtained from the extract with chromatographic separation over Si-gel column;α-amyrin,β-amyrin,lupiol acetate,venenative,rhazine and yohimbine,Conclusion:At the dose level employed,Alstonia scholaris bark extract has a significant antifertility effect in male rast;the primary site of action may be post meiotic germ cells(Step19spermatids). | R. S. Gupta Rakhi Sharma Aruna Sharma A.K. Bhatnager M.P. Dobhal Y.C. Joshi M.C. Sharma | 2002 | Asian Journal of Andrology2002，4，3： | 3 |
| 2 | Deposition of atmospheric pollutant and their chemical characterization in snow pit profile at Dokriani Glacier,Central Himalaya显示文摘The uncertainty in assessing the numerous atmospheric pollutants transported via wind from arid and semi-arid regions is affecting the glacial ecosystem. In our study area due to the complexity of the system, a prominent seasonal difference noticed among major ions(Ca^(2+), Mg^(2+), SO_4^(2-), and NO_3^-). There is a need for understanding the ions cycling as a whole and the directionality of the feedback loops in the system. Therefore, we provide an appraisal of our current hypothesis for seasonal difference in major ion concentration from snow samples for two corresponding years(2013 and 2015) at Dokriani Glacier. A systematic study of chemical compositionsin the shallow snow pit from Dokriani Glacier was undertaken for the pre-monsoon season to understand the cycling of major ions from atmosphere to solute acquisition process. The intimating connections of ions cycling in snow and its temporal behavior was observed and analyzed through various statistical tests. Among major ions, the SO_4^(2-)has the highest concentration among anions on an average considered as 14.21% in 2013 and 29.46% in 2015. On the other side Ca^(2+) is the dominant cation contributing 28.22% in 2013 and 15.3% in 2015 on average. The average ratio of Na+/Cl-was higher in 2013 whereas lower in 2015. The backward trajectory analysis suggests the possible sources of the ions transported from Central Asia through the Western Disturbance(WD) as a prominent source of winter precipitation mainly in the Central Himalaya. Ionicconcentration of Ca^(2+) in cations was highly dominated while in anion SO_4^(2-)played the major role. Factor analysis and correlation matrix suggested that, the precipitation chemistry is mostly influenced by anthropogenic, crustal, and sea salt sources over the studied region. The elemental cycling through ocean, atmosphere and biosphere opens up new ways to understand the geochemical processes operating at the glacierized catchments of the Himalaya. Moreover, increasing the field-based studies in the coming decades would also have the certain advantage in overcoming the conceptual and computational geochemical modelling difficulties. | Shipika SUNDRIYAL Tanuj SHUKLA Lekhendra TRIPATHEE Dwarika Prashad DOBHAL Sameer Kumar TIWARI Uday BHAN | 2018 | Journal of Mountain Science2018，15，10： | 2 |
| 3 | Evaluation of antidiabetic and antioxidant potential of lupeol in experimental hyperglycaemia显示文摘 | Rajnish Gupta AnilKumar Sharma M.C. Sharma M.P. Dobhal R.S. Gupta | 2012 | Natural Product Research2012，，12： | 1 |
| 4 | Phytochemical evaluation and antispermatogenic activity of Thevetia peruviana methanol extract in male albino rats显示文摘 | Rajnish Gupta Jai B. S. Kachhawa R. S. Gupta Anil Kumar Sharma M. C. Sharma M. P. Dobhal | 2011 | Human Fertility2011，，1： | 1 |
| 5 | New flavanone triglycoside from Moringa oleifera 显示文摘 | Jangwan JS Dobhal M | 2008 | Int J Chem Sci2008，6，1： | 1 |
| 6 | Highly ef- ficient plant regeneration through somatic embryogenesis in Sapin- dus mukorossi 显示文摘 | Upma Dobhal Snehlata Bhandari Shivani Bisht | 2009 | Plant Archives2009，2，6： | 1 |
| 7 | Effect of Saponins of Albizia lebbeck (L.) Benth bark on the reproductive system of male albino rats显示文摘 | R.S. Gupta Rakesh Chaudhary Rajesh K. Yadav Suresh K. Verma M.P. Dobhal | 2004 | Journal of Ethnopharmacology2004，，1： | 1 |
| 8 | Butanolides from Methanolic Extract of Litsea glutinosa显示文摘 | Agrawal N Pareek D Dobhal S | 2013 | Chem Biodivers2013，10，3： | 1 |
| 9 | Ferulic acid esters from Plumeria bicolor 显示文摘 | Dobhal M Hasan A M Sharma M | 1999 | Phytochemistry1999，51，2： | 1 |
| 10 | Remarkable features of McMurry reaction condition in dimerization of formyl-and 2-formylvinylpurpurinmides 显示文摘 | Goswami L N Ethiraian M Dobhal M P | 2009 | J Org Chem2009，74，2： | 1 |
| 11 | Ferulic acid esters from Plumeria bicolor显示文摘 | Dobhal M Hasan A M Sharma M | 1999 | Phytochemistry1999，51，2： | 1 |
| 12 | Genetic analysis of growth and wood variations in Leucaena leucocephala (Lam.) de Wit.显示文摘We selected 28 populations of Leucaena leucocephala from different geographical locations in the states of Andhra Pradesh, Tamil Nadu and Orissa of India on the basis of height and girth at breast height (GBH). We evaluated fiber length, optical density, wall thickness, vessel element length, vessel element diameter, specific gravity and lignin of these populations of L. leucocephala in different sites. Populations had significant variations for all growth, wood and paper parameters. Girth at breast height (GBH) and specific gravity were the most important parameters for heritability and genetic gain, respectively. The minimum heritability was reported for vessel element length and genetic gain for fiber length. The populations were grouped into six clusters, cluster II had maximum number of populations (14) and clusters IV and VI had one population each. GBH contributed maximum of 34.39 % towards total divergence followed by specific gravity (14.02%). An economic technique to produce quality seed by establishing seed orchards with genetically divergent parents was suggested. The hybridization among the populations selected from diverse clusters could produce greater heterosis needed for higher growth and suitable wood and paper manufacturing parameters. | E K. Pande A. Kumar S. Ravichandran S. Naithani V. Kothiyal E B. K. Kishore A. Raturi E Gautam S. Dobhal S. Sharma | 2013 | Journal of Forestry Research2013，24，3： | 1 |
| 13 | Re- markable features of McMurry reaction condition in dimeriza- tion of formyl-and 2-formylvinylpurpurinmides 显示文摘 | Goswami L N Ethiraian M Dobhal M P | 2009 | J Org Chem2009，74，2： | 1 |
| 14 | Recession and morphogeometrical change of Dokriani glacier (1962--1995) Garhwal Himalaya, India 显示文摘 | Dobhal D P Gergan J T Thayyen R J | 2004 | Current Science2004，86，5： | 1 |
| 15 | Flavonoids:A versa-tile source of anticancer drugs显示文摘 | Chahar MK Sharma N Dobhal MP | 2011 | Pharmacogn Rev2011，5，9： | 1 |
| 16 | Population genetic study of Fagopyrum tataricum from Western Himalaya using ISSR markers显示文摘 | Kishore G Pandey A Dobhal R | 2013 | Biochemical Genetics2013，51，910： | 1 |
| 17 | Methyl pyropheophorbide-a analogues, Potential fluorescent probes for the peripheral-type benzo-diazepine receptor effect of central metal in pho- tosensitizing efficacy 显示文摘 | CHEN Y H ZHENG X DOBHAL M P | 2005 | J Med Chem2005，48，： | 1 |
| 18 | Genetic analysis of fruit firmness and related traits in tomato显示文摘 | DOBHAL VK KOHLI UK MEHTA D | 1999 | Joumal of Hill Research1999，12，： | 1 |
| 19 | Phytochemical Constitu-ents ,Traditional Uses, and Pharma- cological Properties of theGenus Plumeria显示文摘 | SharmaG Chahar M K’Dobhal S | 2011 | Chemistry & Biodiversity2011，8，8： | 1 |
| 20 | Remark- able features of McMurry reaction condition in dimerization of formyl-and 2-formylvinylpurpurinmides 显示文摘 | Goswami L N Ethiraian M Dobhal M P | 2009 | J Org Chem2009，74，2： | 1 |
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