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| 1 | Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound显示文摘AIM:To evaluate whether contrast enhanced ultrasound(CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer.METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal cancer underwent CEUS before treatment(CEUS date 1) and before the second(CEUS date 2) and fourth(CEUS date 3) cycle of bevacizumab based chemotherapy.Three parameters [PEAK,Time to peak(TTP) and RISE RATE]were correlated with radiological response.RESULTS:For neoadjuvant purpose a reduction of tumour mass was required to assume clinical response.Based on these response criteria there was a significant(P < 0.001) correlation in TTP between metastases of responders(9.08 s) and non-responders(14.76 s) archived on CEUS date 1.By calculating a standardized quotient(metastases divided by normal liver tissue) we were able to define a cut off,predicting response with a sensitivity of 92.3 % and a specificity of 100 %.To reflect a palliative intention only those patients with progressive disease were classified as non-responders.In this stetting TTP was also significantly(P < 0.01) different between responders and non-responders.In contrast,Peak and Rise rate did not show any significant difference between responder and non-responder.CONCLUSION:CEUS might serve as a surrogate marker to predict treatment response in patients with metastasized colorectal cancer who receive antiangiogenic therapy. | Ramin Schirin-Sokhan Ron Winograd Christoph Roderburg Jhenee Bubenzer Nicole Cabral do ó Dorothee Guggenberger Hartmut Hecker Christian Trautwein Jens J W Tischendorf | 2012 | World Journal of Gastroenterology2012，18，6： | 16 |
| 2 | Quantitative Study on Nonmetallic Inclusion Particles in Steels by Automatic Image Analysis With Extreme Values Method显示文摘The presence of nonmetallic inclusion particles which appear during steelmaking process is harmful to the properties of steels,which is mainly as a function of some aspects such as size,volume fraction,shape,and distribution of these particles.The automatic image analysis technique is one of the most important tools for the quantitative determination of these parameters.The classical Student approach and the Extreme Values Method(EVM) were used for the inclusion size and shape determination and the evaluation of distance between the inclusion particles.The results thus obtained indicated that there were significant differences in the characteristics of the inclusion particles in the analyzed products.Both methods achieved results with some differences,indicating that EVM could be used as a faster and more reliable statistical methodology. | Cássio Barbosa José Brant de Campos Jneo Lopes do Nascimento Iêda Maria Vieira Caminha | 2009 | Journal of Iron and Steel Research(International)2009，16，4： | 7 |
| 3 | 血管紧张素Ⅱ2型受体的基因多态性(+1675G/A)对已接受治疗高血压患者的左心室肥大和左心室构型的作用显示文摘已有报道显示血管紧张素Ⅱ2型受体的基因多态性(AGTR2+1675G/A)与左心室肥大(left ventric-ular hypertrophy,LVH)相关。研究者检验这种基因多态性是否影响已按高血压治疗指南治疗的原发性高血压和心血管疾病患者的LVH和左心室构型参数。 | 张玲玉 叶鹏 Huber M V ller H Jakob S Reibis R Do V Bol-brinker J Zergibel I Schmieder RE Treszl A Wegscheider K Kreutz R | 2010 | 中华高血压杂志2010，18，12： | 6 |
| 4 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 5 | Standardized measurement of the future liver remnant prior to extended liver resection: Methodology and clinical associations显示文摘 | Jean-Nicolas Vauthey Amin Chaoui Kim-Anh Do Malcolm M Bilimoria Marc J Fenstermacher Chuslip Charnsangavej Marshall Hicks Guido Alsfasser Gregory Lauwers Irvin F Hawkins James Caridi | 2000 | Surgery2000，，5： | 2 |
| 6 | Fingerprinting the circulating repertoire of antibodies from cancer patients显示文摘 | Kim J Do KA | 2003 | Nat Biotechnol2003，21，1： | 1 |
| 7 | The nonsubsampled Contourlet transform: theory, design, and applications 显示文摘 | Cunha A L Zhou J Do M N | 2006 | IEEE Transactions on Image Process2006，15，10： | 1 |
| 8 | Skin color detection through estimation and conversion of illuminant color under various illuminations 显示文摘 | Do H C You J Y Chien S | 2007 | IEEE Transactions on Consumer Electronics2007，53，3： | 1 |
| 9 | Association of interleukin-5 and eotaxin with acute exacerbation of asthma显示文摘 | Park SW Kim do J Chang HS | 2003 | Int Arch Allergy Immunol2003，131，4： | 1 |
| 10 | Comparison between in vivo dosimetry and barium contrast technique for prediction of rectal complications in high - dose - rate intracavitary radiotherapy in cervix cancer patients 显示文摘 | Huh S J Lim do H Ahn YC | 2003 | Strahlenther Onkol2003，179，3： | 1 |
| 11 | Indigofera suffruticosa: An Alternative Anticancer Therapy 显示文摘 | Vieira J R de Souza I A do Nascimento S C | 2007 | Evid Based Complement Alternat Med2007，4，3： | 1 |
| 12 | PSA performances and viscoelastic properties of SIS-based PSA blends with H-DCPD tackifiers 显示文摘 | Lim DH Do HS Kim H J | 2006 | JAppl Polym Sci2006，102，3： | 1 |
| 13 | Nleumaeic dilatation in effective long - term treatment for achalasia 显示文摘 | Kak PO Gilben J CastelI DO | 2011 | Digest Dis Sci2011，43，9： | 1 |
| 14 | Distribution of antibody ti-ters to mycoplasma pneumoniae in korean children in2000-2003显示文摘 | Yu J Yoo Y Kim do K | 2005 | J Korean Med Sci2005，20，4： | 1 |
| 15 | Unruptured intracranial aneurysms: natu- ral history, clinical outcome, and risks of surgical and endovascular treatment 显示文摘 | Wiebers DO Whisnant JP Huston J | 2003 | Lancet2003，362，： | 1 |
| 16 | Classification of oesophageal motility abnormalities 显示文摘 | Spechler S J Castell DO | 2001 | Gut2001，49，： | 1 |
| 17 | Long-term outcomes after lapa- roscopy-assisted gastrectomy for advanced gastric cancer: a large- scale muhicenter retrospective study 显示文摘 | do Park J Han SU Hyung WJ | 2012 | Surg Endosc2012，26，6： | 1 |
| 18 | Tumor necrosis factor α-induced interleukin-32 is positively regulated via the Syk/protein kinase Cδ/JNK pathway in rheumatoid synovial fibroblasts显示文摘 | Mun S H Kim J W Nah S S Ko N Y Lee J H Kim J D Kim do K Kim H S Choi J D Kim S H Lee C K Park S H Kim B K Kim H S Kim Y M and Choi W S | | 0，，03： | 1 |
| 19 | Non-steady-state Subduction and Trench- parallel Flow Induced by Overriding Plate Structure 显示文摘 | RODRIGUEZ-GONZALEZ J BILLEN M I NEGRE- DO A M | 2014 | Earth and Planetary Science Letters2014，401，： | 1 |
| 20 | Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis显示文摘 | Clegg DO Reda D J Harris CL | 2006 | N Engl J Med2006，354，8： | 1 |
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