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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | 血管紧张素Ⅱ2型受体的基因多态性(+1675G/A)对已接受治疗高血压患者的左心室肥大和左心室构型的作用显示文摘已有报道显示血管紧张素Ⅱ2型受体的基因多态性(AGTR2+1675G/A)与左心室肥大(left ventric-ular hypertrophy,LVH)相关。研究者检验这种基因多态性是否影响已按高血压治疗指南治疗的原发性高血压和心血管疾病患者的LVH和左心室构型参数。 | 张玲玉 叶鹏 Huber M V ller H Jakob S Reibis R Do V Bol-brinker J Zergibel I Schmieder RE Treszl A Wegscheider K Kreutz R | 2010 | 中华高血压杂志2010，18，12： | 6 |
| 3 | Hypersurfaces with constant mean curvature in sphere显示文摘 | Alencar H Carmo M P do | 1994 | Proc Amer Math Soc Vol1994，120，4： | 2 |
| 4 | Mycorrhiza and Phosphate Solubilizing Bacteria:Potential Bioagents for Sustainable Phosphorus Management in Agriculture显示文摘Phosphorus(P)is a critical nutrient that plays an essential role in improving soil fertility for optimum plant growth and productivity.It is one of the most deficient macro-nutrients in agricultural soils after nitrogen and is considered inadequate for plant growth and production.To P availability in soils,the farmers are applying huge amounts of synthetic P fertilizers that adversely affect the wider environment,groundwater,soil fertility and microbial population.Many beneficial microbes are known to release and supply soluble P for improving growth and yield of a variety of plants in a sustainable manner in P deficient soils.Thus,inoculation of these microbes,including arbuscular mycorrhizal fungi(AMF)and phosphate solubilizing bacteria(PSB)to soil to enhance crop production without harming the environment,is an alternative approach to chemical fertilizers.The combined role of AMF and PSB in P solubilization is not well understood and the application and mode of action of these microbial groups are often naive due to variation in the environment.Therefore,the current review article would develop a better understanding of the interactive role and mechanisms of AMF and PSB in improving P availability from both organic and inorganic sources in a sustainable crop production system.Finally,the current review would loop out further avenues for researchers interested to commercially produce effective AMF and PSB-based biofertilizers for sustainable management of phosphorus over a wide range of agricultural crops worldwide. | Fazli Wahid Muhammad Sharif Shah Fahad Amjad Ali Muhammad Adnan Rafiullah Shah Saud Subhan Danish Muhammad Arif Ali Niaz Ahmed Hüseyin Arslan Doğan Arslan Murat Erman Ayman EL Sabagh Fatemeh Gholizadeh Rahul Datta | 2022 | Phyton-International Journal of Experimental Botany2022，91，2： | 2 |
| 5 | Data cleaning: problems and current approaches显示文摘 | Rahm E Do H H | 2000 | IEEE Data Engineer Bulletin2000，23，4： | 2 |
| 6 | Skin color detection through estimation and conversion of illuminant color under various illuminations 显示文摘 | Do H C You J Y Chien S | 2007 | IEEE Transactions on Consumer Electronics2007，53，3： | 1 |
| 7 | Comparison between in vivo dosimetry and barium contrast technique for prediction of rectal complications in high - dose - rate intracavitary radiotherapy in cervix cancer patients 显示文摘 | Huh S J Lim do H Ahn YC | 2003 | Strahlenther Onkol2003，179，3： | 1 |
| 8 | PSA performances and viscoelastic properties of SIS-based PSA blends with H-DCPD tackifiers 显示文摘 | Lim DH Do HS Kim H J | 2006 | JAppl Polym Sci2006，102，3： | 1 |
| 9 | Microsomal prosta- glandin E synthase is regulated by proinflammatory crtokines and glucocorticoids in primary rheumatoid synovial cells显示文摘 | Stichtenoth DO Thoren S Bian H | 2001 | J Immu- nol2001，167，1： | 1 |
| 10 | Appropriate volumes for adsorption isotherm studies:The absolute void volume,accessible pore volume and enclosing particle volume显示文摘 | DO D D DO H D | 2007 | Journal of Colloid and Interface Science2007，316，2： | 1 |
| 11 | Diagnosis of liver fi brosis and cirrhosis with diffusion-weighted imaging: value of normalized apparent diffusion coefficient using the spleen as reference organ 显示文摘 | Do RK Cbandarana H Felker E | 2010 | AJR2010，195，： | 1 |
| 12 | Slump loss control of cement paste by adding polycarboxylic type slump-releasing dispersant 显示文摘 | GYE G SEONG S H DO S K | 1999 | Cem Concr Res1999，29，2： | 1 |
| 13 | Multiple primary cancers in patients with non-Uodgkin's lymphoma显示文摘 | Song H Do Y Lee W | 2006 | J Clin Oncol2006，，17： | 1 |
| 14 | Application of G1S - Based Multi - Criteria Analysis for Site Selection of Aquifer Recharge with Re- claimed water 显示文摘 | Pedrero F Albuquerque A Marecos do Monte H | 2011 | Resources Conservation and Recycling2011，56，1： | 1 |
| 15 | A long reset-time power-on re- set circuit with brown-out detection capability 显示文摘 | Le H B Do X D Lee S G | 2011 | Circuits and Systems II: Express Briefs IEEE Transactions on2011，58，： | 1 |
| 16 | Corrective osteotomy for cubitus varus in middle - aged patients 显示文摘 | LIM T K KOH K H LEE DO K | 2011 | Shoulder Elbow Surg2011，20，3： | 1 |
| 17 | Tumor necrosis factor α-induced interleukin-32 is positively regulated via the Syk/protein kinase Cδ/JNK pathway in rheumatoid synovial fibroblasts显示文摘 | Mun S H Kim J W Nah S S Ko N Y Lee J H Kim J D Kim do K Kim H S Choi J D Kim S H Lee C K Park S H Kim B K Kim H S Kim Y M and Choi W S | | 0，，03： | 1 |
| 18 | Data cleaning:problems and current approaches显示文摘 | RAHM E DO H H | | 0，，04： | 1 |
| 19 | Physicochemical properties of native and partially gelatinized high-amylose jackfruit (Artocarpus heterophyllus Lain)seed starch显示文摘 | Tran P L Dang H D N Do V H | 2015 | Lebensmittel- Wissenschaft und-Technologie2015，62，2： | 1 |
| 20 | Fuzzy system reliability analysis by the use of Tw (the weakest t-norm) on fuzzy number arithmetric operation显示文摘 | Do H Y | 1997 | Fuzzy sets and systems1997，90，： | 1 |
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