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| 1 | Histopathological characteristics and causes of kidney graft failure in the current era of immunosuppression显示文摘BACKGROUND The histopathological findings on the failing kidney allograft in the modern era is not well studied. In this study, we present our experience working with kidney transplant recipients with graft failure within one year of the biopsy.AIM To report the histopathological characteristics of failed kidney allografts in the current era of immunosuppression based on the time after transplant, cause of the end-stage renal disease and induction immunosuppressive medications.METHODS In a single-center observational study, we characterized the histopathological findings of allograft biopsies in kidney transplant recipients with graft failure within one year after the biopsy.RESULTS We identified 329 patients with graft failure that met the selection criteria between January 1, 2006 and December 31, 2016. The three most common biopsy findings were interstitial fibrosis and tubular atrophy(IFTA, 53%), acute rejection (AR, 43%) and transplant glomerulopathy(TG, 33%). Similarly, the three most common causes of graft failure based on the primary diagnosis were AR(40%),TG(17%), and IFTA(13%). Most grafts failed within two years of post-transplant(36%). Subsequently, approximately 10%-15% of grafts failed every two years: >2-4 years(16%), > 4-6 years(13%), > 6-8 years(11%), > 8-10 years(9%) and > 10 years(16%). AR was the most common cause of graft failure in the first six years(48%), whereas TG was the most prevalent cause of graft failure after 6 years(32%) of transplant.CONCLUSION In the current era of immunosuppression, AR is still the most common cause of early graft failure, while TG is the most prevalent cause of late graft failure. | Sandesh Parajuli Fahad Aziz Neetika Garg Sarah E Panzer Emily Joachim Brenda Muth Maha Mohamed Justin Blazel Weixiong Zhong Brad C Astor Didier A Mandelbrot Arjang Djamali | 2019 | World Journal of Transplantation2019，9，6： | 2 |
| 2 | Blood oxygen level-dependent and pufusion magnetic resonance imaging: detecting differences in oxygen bioavailability and blood flow in transplanted kidneys 显示文摘 | Sadowski E A Djamali A Wentland A L | 2010 | Magn Reson Imaging2010，28，1： | 1 |
| 3 | Epithelial-to-mesenchymal transition and chronic allograft tubulointerstitial fibrosis显示文摘 | Bedi S Vidyasagar A Djamali A | 2008 | Transplant Rev (Orlando)2008，22，1： | 1 |
| 4 | Differentiation of endoderm derivatives, pancreas and intestine,from rhesus embryonic stem cells显示文摘 | Jacobson L Kahan B Djamali A | 2001 | Transplant Proc2001，33，12： | 1 |
| 5 | Background fluctuation of kidney function versus contrast-induced nephrotoxicity显示文摘 | Bruce RJ Djamali A Shinki K | 2009 | AJR Am J Roentgenol2009，192，： | 1 |
| 6 | Background fluctuation of kidney function versus contrast-induced nephrotoxicity显示文摘 | Bruce RJ Djamali A Shinki K | 2009 | AJR Am J Roentgenol2009，192，3： | 1 |
| 7 | Do statins delay the incidence of ESRD in diabetic patients with moderate CKD?显示文摘 | CONLEY J OLAFSSON A DJAMALI A | 2010 | J Nephrol2010，23，： | 1 |
| 8 | The impact of hepatitis C virus donor and recipient status on long‐term kidney transplant outcomes: University of Wisconsin experience显示文摘 | Neeraj Singh Nikole Neidlinger Arjang Djamali Glen Leverson Barbara Voss Hans W. Sollinger John D. Pirsch | 2012 | Clinical Transplantation2012，，5： | 1 |
| 9 | A, Some biological aspects of lemuru, Sardinella sirm (Walbaum), around Panggang Island 显示文摘 | Burhanuddin M Hutomo S Mar:osewojo Djamali | 1974 | Oseanol Indones1974，，2： | 1 |
| 10 | Differentiation of endoderm derivatives, pancreas and intestine, from rhesus embryonic stem cells显示文摘 | Jacobson L Kahan B Djamali A | 2001 | Transplant Pmc2001，33，12： | 1 |
| 11 | Mycophenolic acid may delay allograft fibrosis by inhibiting TGF-β1-induced activation of Nox-2 via the NF-κB pathway显示文摘 | DJAMALI A VIDYASAGAR A YAGCI G | 2010 | Transplantation2010，90，4： | 1 |
| 12 | Oxidative stress as a common pathway to chronic tubulointerstitial injury in kidney allografts显示文摘 | Djamali A | 2007 | Am J Physiol Renal Physiol2007，293，2： | 1 |
| 13 | Noninva- sive assessment of early kidney allograft dysfunction by blood oxygen level-dependent magnetic resonance imaging 显示文摘 | Djamali A Sadowski EA Samaniego-Picota M | 2006 | Transplantation2006，82，5： | 1 |
| 14 | Diagnosis and management of antibody-mediated rejection: current status and novel approaches显示文摘 | Djamali A Kaufman DB Ellis TM | 2014 | Am J Transplant2014，14，2： | 1 |
| 15 | Increase in proteinu- ria > 200 mg,/g after late rejection is associated with poor graft survival 显示文摘 | Djamali A Samaniego M TorrealbaJ | 2010 | Nephrology Dialysis Transplantation2010，25，4： | 1 |
| 16 | Noninvasive assessment of early kidney allograft dysfunction by blood oxygen level-dependent magnetic resonance imaging 显示文摘 | Djamali A Sadowski EA Samaniego-Picota M | 2006 | Transplantation2006，82，5： | 1 |
| 17 | Noninvasive assessment of early kidney allograft dysfunction by blood oxygen level-dependent magnetic resonance imaging显示文摘 | Sadowski EA Samaniego-Picota M | 2006 | Transplantation2006，82，5： | 1 |
| 18 | Oxidative stress as a common pathway to chronic tubulointetitial injury in kidney allografts显示文摘 | DJAMALI A | 2007 | Am J Physiol Re- nal Physiol2007，293，2： | 1 |
| 19 | Blood oxygen-level -dependent and perfusion magnetic resonance imaging: detecting differences in oxygen bioavailability and blood flow in transplanted kidneys 显示文摘 | Sadowski EA Djamali A Wentland AL | 2010 | Magn Reson Imaging2010，28，1： | 1 |
| 20 | Contributing factors to complications and surgical success in mouse kidney transplantation显示文摘 | Huang LJ Reese S Djamali A | 2012 | Int BrazJ Urol2012，38，3： | 1 |
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