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| 1 | Micro RNAs in the development of non-alcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease or nonalcoholic fatty liver disease(NAFLD) refers to a group of disorders that arise from the accrual of fat in hepatocytes. Although various factors have been associated with the development of NAFLD, including genetic predisposition and environmental exposures, little is known aboutthe underlying pathogenesis of the disease. Research efforts are ongoing to identify biological targets and signaling pathways that mediate NAFLD. Emerging evidence has implicated a role for micro RNAs(mi RNAs), short single-stranded molecules that regulate gene expression either transcriptionally, through targeting of promoter regions, or post-transcriptionally, by blocking translation or promoting cleavage of specific target m RNAs. Several mi RNAs have been associated with NAFLD, although our understanding of the biology underlying their role is still emerging. The goal of this review is to present an overview of the current state of knowledge of mi RNAs involved in the development of NAFLD across a range of in vitro and in vivo models, including mi RNAs that contribute to pathological mechanisms related to fatty liver in humans. Much less is known about the specific targets of mi RNAs in cells, nor the molecular mechanisms involved in the development and progression NAFLD and related outcomes. More recently, the identification and validation of mi RNA signatures in serum may facilitate the development of improved methods for diagnosis and clinical monitoring of disease progression. | Glenn S Gerhard Johanna K DiStefano | 2015 | World Journal of Hepatology2015，7，2： | 5 |
| 2 | Neoadjuvant treatment of locally advanced carcinoma of the uterine cervix with epirubicin,paclitaxel and cisplatin显示文摘 | D'Agostino G Distefano M Greggi S | 2002 | Cancer Chemother Pharmacol2002，49，3： | 1 |
| 3 | Histological and molecular analysis of pollerrpistil interaction in demenfine显示文摘 | DISTEFANO G CARUSO M LA MALFA S | 2009 | Plant Cell Reports2009，28，9： | 1 |
| 4 | Clinico-pathologic, immunohistochemical, and TUNEL study in early cardiac allograft failure显示文摘 | Panizo-Santos A Lozano MD Distefano S | 2000 | Cardiovasc Pathol2000，9，3： | 1 |
| 5 | Elsevier reliability and availability analysis of dependent dynamic systems with DRBDs 显示文摘 | Distefano S Puliafito A | 2009 | Relia bility Engineering - System Safety2009，94，13： | 1 |
| 6 | Beta-estradiol stimulation of DNA synthesis requires different PKC isoforms in HepG2 and MCF7 cells显示文摘 | Marino M Distefano E Caporali S | 2001 | J Cell Physiol2001，188，2： | 1 |
| 7 | Ouality of life and psychological distress in locally advanced cervical cancer patients administered pre-operative ehemoradiotherapy 显示文摘 | Distefano M Riccardi S Capelli G | 2008 | Gyneeol Oneol2008，111，1： | 1 |
| 8 | Dependability evaluat-ion with dynamic reliability block diagrams and dynamic fault trees显示文摘 | Distefano S Puliafito A | 2009 | IEEE Dependable and Secure Computing2009，6，： | 1 |
| 9 | Quality of life and psycholog- ical distress in locally advanced cervical cancer patients administered pre - operative chemoradiotherapy 显示文摘 | Distefano M Riccardi S Capelli G | 2008 | Gynecologic Oncology2008，，1： | 1 |
| 10 | Neoadjuvant treatment of locally advanced carcinoma of the uterine cervix with epirubicin, pa- clitaxel and cisplatin 显示文摘 | D'Agostino G Distefano M Greggi S | 2002 | Cancer Chemother Pharmacol2002，49，3： | 1 |
| 11 | Hydrogen as an electron donor for dechlorination of tetrachloroethene by an anaerobic mixed culture显示文摘 | Distefano T D Gossett J M Zinder S H | 1992 | Applied & Environmental Micro- biology1992，58，11： | 1 |
| 12 | Photothermal degradation of ethylene-vinyl acetate copolymer显示文摘 | Liang R H Clayton A DiStefano S | 1983 | Polymer Science and Technology1983，，20： | 1 |
| 13 | Neoadjuvant treatment of locally advanced carcinoma of the uterine cervix with epirubicin, paclitaxel and cisplatin 显示文摘 | D' Agostino G Distefano M Greggi S | 2002 | Cancer Chemother Pharmacol2002，49，3： | 1 |
| 14 | The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vi- vo 显示文摘 | DeChiara TM Bowen DC Valenzuela DM Simmons MV Poueymirou WT Thomas S Kinetz E Compton DL Ro- jas E Park JS Smith C DiStefano PS Glass DJ Bur- den SJ Yancopoulos GD | 1996 | Cell1996，85，4： | 1 |
| 15 | Neoadjuvant treatment of locally advanced carcinoma of the uterine cervix with epirubicin,paclitaxel and cisplatin显示文摘 | D'Agostino G Distefano M Greggi S | 2002 | Cancer Chemother Pharmacol2002，49，3： | 1 |
| 16 | Dynamic reliability block diagrams VS dynamic fault trees 显示文摘 | Distefano S Puliafito A | 2007 | IEEE2007，，1： | 1 |
| 17 | Modeling distributed computing system reliability with DRBD 显示文摘 | Distefano S Scarpa M Puliafito A | 2006 | IEEE2006，，10： | 1 |
| 18 | Neurotrophic factors: from molecules to man 显示文摘 | Lindsay R M Wiegand S J Altar C A DiStefano P S | 1994 | Trends Neurosci1994，17，： | 1 |
| 19 | Ciliary neurotrophic factor induces down-regulation of its receptor and desensitization of signal transduction pathway in vivo:non-equivalence with pharmacological activity显示文摘 | Distefano P S Boulton T G Stark J L | 1996 | J Biol Chem1996，271，22： | 1 |
| 20 | Insulin resistance, glycemic control and adiposity: key determinants of healthy lifes- pan显示文摘 | DISTEFANO P S CURTIS R GEDDES B J | 2007 | Cun' Alzheimer Res2007，4，2： | 1 |
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