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| 1 | Health-related quality of life in high-grade glioma patients显示文摘Gliomas are malignant primary brain tumors and yet incurable. Palliation and the maintenance or improvement of the patient's quality of life is therefore of main importance. For that reason, health-related quality of life(HRQoL) has become an important outcome measure in clinical trials, next to traditional outcome measures such as overall and progression-free survivals, and radiological response to treatment. HRQoL is a multidimensional concept covering physical, psychological, and social domains, as well as symptoms induced by the disease and its treatment. HRQoL is assessed by using self-reported, validated questionnaires. Various generic HRQoL questionnaires, which can be supplemented with a brain tumor- specific module, are available. Both the tumor and its treatment can have a negative effect on HRQoL. However, treatment with surgery, radiotherapy, chemotherapy, and supportive treatment may also improve patients' HRQoL, in addition to extending survival. It is expected that the impact of HRQoL measurements in both clinical trials and clinical practice will increase. Hence, it is important that HRQoL data are collected, analyzed, and interpreted correctly. Methodological issues such as selection bias and missing data may hamper the interpretation of HRQoL data and should therefore be accounted. In clinical trials, HRQoL can be used to assess the benefits of a new treatment strategy, which should be weighed carefully against the adverse effects of that treatment. In daily clinical practice, HRQoL assessments of an individual patient can be used to inform physicians about the impact of a specific treatment strategy, and it may facilitate the communication between the physicians and the patients. | Linda Dirven Neil K.Aaronson Jan J.Heimans Martin J.B.Taphoorn | 2014 | Chinese Journal of Cancer2014，33，1： | 4 |
| 2 | What is the role of quality circles in strategies to optimise antibiotic pre- scribing A pragmatic cluster-randomised controlled trial in primary care显示文摘 | Van Driel ML Coenen S Dirven K | 2007 | Qual Saf Health Care2007，16，3： | 1 |
| 3 | Feasibility of a branched stent-graft in common iliac artery aneurysms显示文摘 | Malina M Dirven M Sonesson B | 2006 | J Endovasc Ther2006，13，4： | 1 |
| 4 | Evaluation of 12 commercial tests and the complement fixation test for Mycoplasma prreumon/ae-specific immunoglobulin G (IgG) and IgM antibodies, with PCR used as the 'Gold Standard' 显示文摘 | BEERSMA M F C DIRVEN K van DAM A P | 2005 | J Clin Microbiol2005，43，5： | 1 |
| 5 | The assessment of pharyngo- cutaneous fistula rate in patients treated primarily with definitive radiotherapy followed by salvage surgery of the larynx and hypo- pharynx 显示文摘 | Dirven R Swinson B D Gao K | 2009 | Laryngoscope2009，119，9： | 1 |
| 6 | Repeated surgery for glioblastoma mnltiforme: only in combination with other salvage therapy显示文摘 | Mandl ES Dirven CM Buis RD | 2008 | Surg Neurol2008，69，5： | 1 |
| 7 | Repeated surgery for glioblas- toma muhiforme: only in combination with other salvage therapy 显示文摘 | Mandl ES Dirven C Buis DR | 2008 | Surg Neurol2008，69，： | 1 |
| 8 | The risk of rebleeding after external lumbar drainage in patients with untreated ruptured cerebral aneurysms显示文摘 | Dirven CM Algra A | 2005 | Acta Neurochir(Wien)2005，147，： | 1 |
| 9 | Radiosurgery of brain arteriovenous malformations in children显示文摘 | Buis DR Dirven CM Lagerwaard FJ | 2008 | J Neurol2008，255，4： | 1 |
| 10 | Evaluation of 12 commercial test and the complement fixation test for Mycoplasma pneumoniae-specific immunoglobulin G( IgG )and IgM anfibodis, with PCR used as the 'gold standard' 显示文摘 | Beersma MF Dirven K van Dam AP | 2005 | Clin Microbiol2005，43，5： | 1 |
| 11 | Intercultural Communication显示文摘 | Dirven R Putz M | | 0，，05： | 1 |
| 12 | Quality indicators for type -2 diabetes care in practice guidelines: an example from six European countries显示文摘 | Wens J Dirven K Mathieu C | 2007 | Prim Care Diabetes2007，1，1： | 1 |
| 13 | Repeated surgery for glio- blastoma multiforme: only in combination with other salvage thera- py 显示文摘 | Mandl ES Dirven CM Buis DR | 2008 | Snrg Neurol2008，69，5： | 1 |
| 14 | Clinical and radiological outcomes of four disease activity driven treatment strategies:8-year results of the Best study显示文摘 | van den Broek M Dirven L Klarenbeek N | | 0，，3： | 1 |
| 15 | The role of corticosteroids in the management of chronic sub- dural hematoma:a systematic review显示文摘 | Berghauser Pont LM Dirven CM Dippel DW et a/ | 2012 | Eur J Neurol2012，19，11： | 1 |
| 16 | Long-term cost-utility analysis of treatment strategies in patients with recent-onset rheumatoid arthritis-5 year follow-up data from the best study显示文摘 | van den Hout W Klarenbeek N Dirven L | | 0，，3： | 1 |
| 17 | Discontinuation of infliximab and potential predictors of persistent low disease activity in patients with early rheumatoid arthritis and disease activity score-steered therapy: subanalysis of the BeSt study显示文摘 | VAN DEN BROEK M KLARENBEEK NB DIRVEN L | 2011 | Ann Rheum Dis2011，70，8： | 1 |
| 18 | Metonymy and Metaphor: Differentmental Strategies of Conceptualisation 显示文摘 | DIRVEN R | 1993 | Leuvense Bijdragen1993，8，2： | 1 |
| 19 | Shunting normal pressure hydrocephalus:Do the benefits outweigh the risk A multicenter study and literature review显示文摘 | Vanneste J Augustjin P Dirven C | 1992 | Neurology1992，42，1： | 1 |
| 20 | Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy显示文摘 | Lamfers ML Grill J Dirven CM | 2002 | Cancer Res2002，62，20： | 1 |
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