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| 1 | A randomized controlled clinical trial on the treatment of Thymosin-a1 versus interferon-α in patients with hepatitis B显示文摘INTRODUCTIONChronic hepatitis B virus (HBV) infection is a serious problem because of its world wide distribution and possible adverse sequelae ,such as cirrhosis and hepatocellular carcinoma .The World Health Organization estimates that HBV has infected mord than 350 million people worldwide ,and up to 20% of them will become chromic carricrs and will be at significant risk for cirrhosis and HCC .The ultimate goal of the therapy for chronic hepatitis B is to prevent progression to cirrhosis and to prevent development of HCC. | Jing You Lin Zhuang Bao Zhang Tang Wei Bo Yang Su Ying Ding Wu Li Rong Xue Wu Hong Li Zhang Yan Mei Zhang Shao Ming Yan Lu Zhang ~1Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China ~2Departrnent of Hepatology,Kunming Third Municipal People’s Hospital,Kunming 650041,Yunnan Province,China | 2001 | World Journal of Gastroenterology2001，7，3： | 48 |
| 2 | On the Application of PCA Technique to Fault Diagnosis显示文摘In this paper, we briefly address the application of the standard principal component analysis (PCA) technique to fault detection and identification. Based on an analysis of the existing test statistic, we propose a new test statistic, which is similar to the Hawkin’s TH 2 statistic but without the numerical drawback. In comparison with the SPE index, the threshold setting associated with the new statistic is computationally simpler. Our further study is dedicated to the analysis of fault sensitivity. We consider the off-set and scaling faults, and evaluate the test statistic by viewing its sensitivity to the faults. Our final study focuses on identifying off-set and scaling faults. To this end, two algorithms are proposed. This paper also includes some critical remarks on the application of the PCA technique to fault diagnosis. | DING S ZHANG P DING E YIN S Naik A DENG P GUI W | 2010 | Tsinghua Science and Technology2010，15，2： | 31 |
| 3 | Pharmacokinetic Studies of Factor VIII in Chinese Boys with Severe Hemophilia A: A Single-Center Study显示文摘 | Zhen-Ping Chen Pei-jing Li Gang Li Ling Tang Ying-Zi Zhen Xin-Yi Wu Xiao-Ling Cheng Koon Hung Luke Victor S Blanchette Man-Chiu Poon Qiu-Lan Ding Run-Hui Wu | 2018 | Chinese Medical Journal2018，，15： | 11 |
| 4 | Performance of the Prostate Health Index in predicting prostate biopsy outcomes among men with a negative digital rectal examination and transrectal ultrasonography显示文摘[-2]proPSA (p2PSA ) 和它的衍生物, p2PSA-to-free PSA 比率(% p2PSA ) ,和前列腺健康索引(PHI ) 极大地在前列腺活体检视有或没有前列腺癌症(PCa ) 改进了在人之间的辨别。然而,很少在数字直肠的考试(DRE ) 和 transrectal ultrasonography (TRUS ) 是否定的情况中对他们的表演被知道。在有否定 DRE 和 TRUS 的中国的 261 个连续病人的一个未来的队被招募并且经历前列腺活体检视。在活体检视被用来测量各种各样的 PSA 衍生物以前,一件浆液样品收集了,包括总数前列腺特定的抗原(tPSA ) ,免费 PSA,和 p2PSA。为每个病人, free-to-total PSA 比率(% fPSA ) , PSA 密度(PSAD ) , p2PSA-to-free PSA 比率(% p2PSA ) ,和 PHI 是计算的。歧视的性能在在 91% 敏感操作典型曲线(AUC ) 和活体检视率的接收装置下面用区域被估计。在关于年龄, tPSA, % fPSA, PSAD, p2PSA, % p2PSA,和 PHI 的全部队以内的 AUC 分数分别地是 0.598, 0.751, 0.646, 0.789, 0.814, 0.808,和 0.853。PHI 是前列腺活体检视结果的最好的预言者,特别在有 10.1-20 ng ml −1 的 tPSA 的病人。与另外的标记相比,在 91% 的敏感, PHI 为决定哪个人不需要经历活体检视是最有用的,从而避免不必要的过程。PHI 的使用能由在中国与否定 DRE 和 TRUS 在人之中预言前列腺活体检视结果改进 PCa 察觉的精确性。 | Guo-Peng Yu Rong Na Ding-Wei Ye Jun Qi Fang Liu Hai-Tao Chen Yi-Shuo Wu Gui-Ming Zhang Jie-Lin Sun Yao Zhu Li-Qun Huang Shan-Cheng Ren De-Ke Jiang S Lilly Zheng Hao-WenJiang Ying-Hao Sun Qiang Ding Jianfeng Xu | 2016 | Asian Journal of Andrology2016，18，4： | 10 |
| 5 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 6 | Regulating effect of Chinese herbal medicine on the peritoneal lymphatic stomata in enhancing ascites absorption of experimental hepatofibrotic mice显示文摘AIM: To observe the regulatory effect of Chinese herbalmedicine on peritoneal lymphatic stomata and itssignificance in treating ascites in liver fibrosis model mice.METHODS: Two Chinese herbal composite prescriptionswere used separately to treat the carbon tetrachloride-induced mouse model of liver fibrosis. The histo-pathologicchanges of the liver sections (HE and VG stainings) wereobserved. The peritoneal lymphatic stomata was detected byscanning electron microscopy and computer imageprocessing. The changes of urinary volume and sodium ionconcentration were measured.RESULTS: In the model group, lots of fibrous tissue formedin liver and extended into the hepatic Iobulss to separatethem incompletely. In the treated and prevention groups,the histo-pathologic changes of liver was rather milder, onlyshowed much less fibrous tissue proliferation in the hepaticIobules. The peritoneal lymphatic stomata enlarged withincreased density in the experimental groups (diameter:PA, 3.07±0.69μm; PB, 2.82±0.37μm; TA, 3.25±0.82μmand TB, 2.82±0.56μm; density: PA, 7.11± 1.90 stomata@1000μm-2; PB, 8.76± 1.45 stomata@ 1000μm-2; TA, 6.55± 1.44 stomata@ 1000μm-2 and TB, 8.76 ± 1. 79 stomata@ 1000μm-2), as compared with the model group (diameter: 2.00 ±0.52μm; density: 4.45 ± 1. 05 stomata@ 1000 μm-2 ). Aftertreatment, the urinary volume and sodium ion excretionincreased in the experimental groupe ( PA, 231.28 ± 41. 09mmol@L-1; PB, 171.69± 27.48 mmol@L-1 and TA, 231.44±34.12 retool@ L-1 ), which were significantly different with thosein the model group (129.33 ± 36.75 rnmol@ L-1 ).CONCLUSION: Chinese herbal medicine has marked effectsin alleviating liver fibrosis, regulating peritoneal lymphaticstomata, improving the drainage of ascites from peritonealcavity and causing increase of urinary volume and sodiumion excretion to reduce the water and sodium retention, andthus have favorable therapeutic effect in treating ascites. | Ji-Cheng Li Shi-Ping Ding,Department of Lymphology,Department of Histology and Embryology, Medical College of Zhejiang University,Hangzhou 310031,Zhejiang Province,China Jian Xu,Hangzhou First People’ s Hospital,Hangzhou 310006,Zhejiang Province,China | 2002 | World Journal of Gastroenterology2002，8，2： | 10 |
| 7 | Case Report:Lance-Adams syndrome:a report of two cases显示文摘Chronic post-hypoxic myoclonus, also known as Lance-Adams syndrome (LAS), is a rare complication of successful cardiopulmanry resuscitation often accompanied by action myoclonus and cerebellar ataxia. It is seen in patients who have un-dergone a cardiorespiratory arrest, regained consciousness afterwards, and then developed myoclonus days or weeks after the event. Worldwide, 122 cases have been reported in the literature so far, including 1 case of Chinese. Here we report 2 Chinese LAS patients with detailed neuroimagings. Cranial single photon emission computed tomography (SPECT) of patient 1, a 52-year-old woman, showed a mild hypoperfusion in her left temporal lobe, whereas patient 2, a 54-year-old woman, manifested a mild bilateral decrease of glucose metabolism in the frontal lobes and a mild to moderate decrease of the N-acetyl aspartate (NAA) peak in the bilateral hippocampi by cranial [18F]-fluorodeoxyglucose positron emission tomographic (PET) scan and cranial magnetic resonance spectroscopy (MRS), respectively. We also review the literature on the neuroimaging, pathogenesis, and treatment of LAS. | ZHANG Yan-xing1,2, LIU Jian-ren1, JIANG biao3, LIU Hui-qin1, DING Mei-ping1, SONG Shui-jiang1, ZHANG Bao-rong1, ZHANG Hong4, XU Bin5, CHEN Huai-hong6, WANG Zhong-jin1, HUANG Jian-zheng1 (1Department of Neurology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China) (2Department of Neurology, Shaoxing People’s Hospital, Shaoxing 312000, China) (3Department of Radiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China) (4Department of Nuclear Medicine, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China) (5Department of Neurology, the Second Affiliated Hospital, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310005, China) (6Department of Geratology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China) | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，10： | 6 |
| 8 | Priorities for research and control of cestode zoonoses in Asia显示文摘Globally,cestode zoonoses cause serious public health problems,particularly in Asia.Among all neglected zoonotic diseases,cestode zoonoses account for over 75%of global disability adjusted life years(DALYs)lost.An international symposium on cestode zoonoses research and control was held in Shanghai,China between 28th and 30th October 2012 in order to establish joint efforts to study and research effective approaches to control these zoonoses.It brought together 96 scientists from the Asian region and beyond to exchange ideas,report on progress,make a gap analysis,and distill prioritizing settings with a focus on the Asian region.Key objectives of this international symposium were to agree on solutions to accelerate progress towards decreasing transmission,and human mortality and morbidity caused by the three major cestode zoonoses(cystic echinococcosis,alveolar echinococcosis,and cysticercosis);to critically assess the potential to control these diseases;to establish a research and validation agenda on existing and new approaches;and to report on novel tools for the study and control of cestode zoonoses. | Ning Xiao Jia-Wen Yao Wei Ding Patrick Giraudoux Philip S Craig Akira Ito | 2013 | Infectious Diseases of Poverty2013，2，1： | 6 |
| 9 | Clinical Observation of Pregnancy with Chlamydia Trachomatis Infection.显示文摘From 1992 to 1993, 1 389 cases of pregnancy at 12-20 gestational weeks were investigated. At first antenatal visit the samples of cervical secretion were taken for chlamydia trachomatis antigen test and blood samples were tested for antidody simultaneously. Micro immunofluorescence | Ding Ying et al. Shanghai Changning District Women’s Hospital, Shanghai 200052 | 1995 | Chinese Medical Journal1995，，7： | 6 |
| 10 | Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial显示文摘 | Eric Lawitz Fred F Poordad Phillip S Pang Robert H Hyland Xiao Ding Hongmei Mo William T Symonds John G McHutchison Fernando E Membreno | 2013 | The Lancet2013，，： | 5 |
| 11 | 模型不确定性线性系统的鲁棒故障检测滤波器设计(英文)显示文摘基于给定的性能指标函数 ,将受模型不确定性和范数有界未知输入影响的线性不确定系统的基于观测器的鲁棒故障检测滤波器设计问题归结为H∞ 优化问题 ,并通过选取适当的后置滤波器和观测器增益矩阵 ,使产生的残差达到对于未知输入和模型不确定性的鲁棒性与对于故障的灵敏度的最佳均衡 .简例验证了本文提出算法的有效性 . | 钟麦英 张承慧 DING S X | 2003 | 控制理论与应用2003，20，5： | 4 |
| 12 | JWA regulates melanoma metastasis by integrin alpha(V)beta(3) signaling(摘要)显示文摘 | Bai, J Zhang, J Wu, J Shen, L Zeng, J Ding, J Wu, Y Gong, Z Li, A Xu, S Zhou, J Li, G | 2010 | 南京医科大学学报(自然科学版)2010，30，8： | 4 |
| 13 | A novel orthotopic and metastatic mouse model of breast cancer in human mammary microenvironment(摘要)显示文摘 | Wang, J Xia, TS Liu, XA Ding, Q Du, Q Yin, H Wang, S | 2010 | 南京医科大学学报(自然科学版)2010，30，8： | 4 |
| 14 | 采样数据系统故障检测的H_∞方法显示文摘提出一种对采样数据系统进行故障检测的H_∞方法。首先构造离散时间故障检测系统,分析残差产生器的动态特性。然后从故障检测的角度引入算子,定量考察连续时间未知输入信号和故障信号对离散时间残差信号的影响。最后优化残差产生器的参数,使得故障检测系统对未知输入具有较强的鲁棒性,同时对故障具有较高的灵敏度。 | 张萍 DING S X 王桂增 周东华 | 2003 | 控制理论与应用2003，20，3： | 4 |
| 15 | 一种故障检测滤波器的多目标优化设计方法显示文摘提出一种基于观测器的故障检测滤波器的非凸多目标优化设计方法.针对线性时不变动态系统,构建一个由输出观测器和后滤波器组成的故障检测滤波器,将其残差动态特性描述为非凸的双线性矩阵不等式形式.利用双线性矩阵不等式中可完全平方非正定项的上界替代原非正定项,将双线性矩阵不等式转化为一组线性矩阵不等式,进而获得多目标优化问题的可解条件以及观测器增益与后滤波器矩阵的求解方法.仿真算例说明了算法的有效性. | 彭涛 桂卫华 Ding S X 谢勇 | 2005 | 控制与决策2005，20，7： | 4 |
| 16 | A Remark on the Mallat Pyramidal Algorithm of Wavelet Analysis显示文摘The exact relationships between the lenthgs of scale sequences and wavelet sequences in the Mallat pyramidal algorithm for computing wavelet trans- form coefficients are obtained,and the maximum possible scale of arbitrary discrete signal is derived. | Xianbin LI &1 Houqiang LI &2 Fuquan WANG &3Jing DING 1 (Dept.of Physics,Sichuan Union University,Chengdu6 1 0 0 6 4,P.R.China) 2 (Dept.of Math.Sichuan teacher’s College,Nanchong6 370 0 2 P.R.China) 3(Dept.of Hydrology,Sichuan Union University.Chengdu6 | 1997 | Communications in Nonlinear Science and Numerical Simulation1997，2，4： | 3 |
| 17 | Impedance spectra of hot, dry gabbro at high temperature and pressure显示文摘Impedance spectra of hot, dry gabbro have been studied at 1.0~2.0 Gpa and 593~1173 K.The experimental results indicate that complex impedance depends on frequency of altering current. Impedance arcs representing grain interiors and grain boundaries conduction mechanism are displayed in the complex impedance plane. The impedance arc corresponding to grain interiors occurs over the range of 102~105 Hz, and the impedance arc corresponding to grain boundaries occurs over the range of 12~102 Hz. Each element of equivalent circuit corresponding to grain interiors is fit for complex nonlinear least square program. When garnet occurs in gabbro, the electrical conductivity of gabbro abruptly changes. | WANG Duojun, LIU Congqiang, LI Heping, YI Li, SU Genli and DING Dongye( Laboratory for Study of the Earth’s Interior and Geofluids, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China) | 2002 | Progress in Natural Science:Materials International2002，12，5： | 3 |
| 18 | Effects of systemic administration of iptakalim on extracellular neurotransmitter levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats显示文摘 | Wang S Hu LF Zhang Y Sun T Sun YH Liu SY Ding JH Wu J Hu G | 2006 | 中国生物学文摘2006，20，10： | 3 |
| 19 | Numerical simulations of morphological changes in barrier islands induced by storm surges and waves using a supercritical flow model显示文摘在这份报纸,一个先进明确的有限体积流动模型在二尺寸为模仿 supercritical 被介绍在一个潮汐 / 沿海的入口和障碍岛的沿海的流动和词法变化由于暴风雨巨浪和波浪。这个流动模型被结合存在波浪行动模型和沉积运输模型。结果综合沿海的过程模型能够模仿象快速的沿海的水流导致的波浪和波浪那样的极端条件导致的流动。这个发达 supercritical 流动模型与 Coriolis 力量,不平的深测术,风压力,和波浪放射压力的效果基于非线性的浅水方程的保守形式的答案。前面的 Euler 计划被用于不稳定的条款;并且对流条款是用与不一致的直线格子上的 HLL Riemann 解答者一起的 Godunov 类型 shockcapturing 计划的 discretized。发达模型的精确性被解决一个试验性的水坝裂缝测试用例调查。由于严重暴风雨攻击的突破的障碍岛,溢出和冲洗被模仿,联系到事件的预言的词法变化被分析在所有物理力量是在场的海岸调查模型的适用性。 | Soumendra Nath KUIRY Yan DING Sam S Y WANG | 2014 | Frontiers of Structural and Civil Engineering2014，8，1： | 2 |
| 20 | Enhancement of surface wettability via micro-and nanostructures by single point diamond turning显示文摘Studies on surface wettability have received tremendous interest due to their potential applications in research and industrial processes. One of the strategies to tune surface wettability is modifying surface topography at micro-and nanoscales. In this research, periodic micro-and nanostructures were patterned on several polymer surfaces by ultra-precision single point diamond turning to investigate the relationships between surface topographies at the micro-and nanoscales and their surface wettability. This research revealed that single-point diamond turning could be used to enhance the wettability of a variety of polymers, including polyvinyl chloride(PVC), polyethylene 1000(PE1000), polypropylene copolymer(PP) and polytetrafluoroethylene(PFTE), which cannot be processed by conventional semiconductor-based manufacturing processes. Materials exhibiting common wettability properties(θ≈ 90°) changed to exhibit 'superhydrophobic' behavior(θ > 150°). Compared with the size of the structures, the aspect ratio of the void space between micro-and nanostructures has a strong impact on surface wettability. | Nicolás Cabezudo Jining Sun Behnam Andi Fei Ding Ding Wang Wenlong Chang Xichun Luo Ben B.Xu | 2019 | Nanotechnology and Precision Engineering2019，2，1： | 2 |
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