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| 1 | 功率IGBT模块的寿命预测显示文摘介绍了功率循环试验数据的威布尔分析方法,分析了现有的典型模块寿命模型,论述了寿命预测的方法:将任务曲线转化成温度曲线,利用雨流计数法,根据线性疲劳损伤积累理论和寿命模型计算功率循环寿命。最后,预测了应用于HXD1C电力机车的株洲南车时代电气股份有限公司3300V/1200A IGBT模块的功率循环寿命。 | 王彦刚 Chamund Dinesh 李世平 Jones Steve 窦泽春 忻兰苑 刘国友 | 2013 | 机车电传动2013，，2： | 27 |
| 2 | A Review on Pharmacological and Analytical Aspects of Naringenin显示文摘Flavonoids are a widely distributed group of phytochemicals having benzo-pyrone nucleus, and more than 4,000 different flavonoids have been described and categorized into flavonols, flavones, flavanones, isoflavones, catechins and anthocyanidins. Flavonoids occurs naturally in fruits, vegetables, nuts, and beverages such as coffee, tea, and red wine, as well as in medical herbs. Flavonoids are responsible for the different colors of plant parts and are important constituents of the human diet. Flavanoids have different pharmacological activities, such as antioxidant, anti-allergic, antibacterial, anti-inflammatory, antimutagenic and anticancer activity. Naringenin belongs to the flavanones and is mainly found in fruits(grapefruit and oranges) and vegetables. Pharmacologically, it has anticancer, antimutagenic, anti-inflammatory, antioxidant, antiproliferative and antiatherogenic activities. Naringenin is used for the treatments of osteoporosis, cancer and cardiovascular diseases, and showed lipid-lowering and insulin-like properties. In the present review, detailed pharmacological and analytical aspects of naringenin have been presented, which revealed the impressive pharmacological profile and the possible usefulness in the treatment of different types of diseases in the future. The information provided in this communication will act as an important source for development of effective medicines for the treatment of various disorders. | Kanika Patel Gireesh Kumar Singh Dinesh Kumar Patel | 2018 | Chinese Journal of Integrative Medicine2018，24，7： | 28 |
| 3 | Nuclear factor kappa B role in inflammation associated gastrointestinal malignancies显示文摘Nuclear factor kappa B(NF-κB) has an established role in the regulation of innate immunity and inflammation.NF-κB is also involved in critical mechanisms connecting inflammation and cancer development.Recent investigations suggest that the NF-κB signaling cascade may be the central mediator of gastrointestinal malignancies including esophageal,gastric and colorectal cancers.This review will explore NF-κB's function in inflammation-associated gastrointestinal malignancies,highlighting its oncogenic contribution to each step of carcinogenesis.NF-κB's role in the inflammation-to-carcinoma sequence in gastrointestinal malignancies warrants stronger emphasis upon targeting this pathway in achieving greater therapeutic efficacy. | Sahil Gambhir Dinesh Vyas Michael Hollis Apporva Aekka Arpita Vyas | 2015 | World Journal of Gastroenterology2015，21，11： | 24 |
| 4 | Heteromeric and Homomeric Geranyl Diphosphate Synthases from Catharanthus roseus and Their Role in Monoterpene Indole Alkaloid Biosynthesis显示文摘Catharanthus roseus 是二很重要的 monoterpene 吲哚碱(MIA ) 的唯一的来源反癌症代理人:vinblastine 和长春新碱。MIA 拥有萜烯和分别地从 terpenoid 和 shikimate 小径导出的吲哚一半。Geranyl diphosphate (GPP ) ,入口点到萜烯一半的形成,由 GPP synthase (GPPS ) 是 isopentenyl diphosphate (IPP ) 和 dimethylallyl diphosphate (DMAPP ) 的冷凝作用的一个产品。这里,我们报导与顺序类似编码蛋白质到大子单元(CrGPPS.LSU ) 和 heteromeric GPPS,和 homomeric 的小子单元(CrGPPS.SSU ) 的三基因 GPPS。CrGPPS.LSU 是生产 GPP 和 geranyl geranyl diphosphate (GGPP ) 的 bifunctional 酶, CrGPPS.SSU 是不活跃的,而 CrGPPS 是形成 GPP 的 homomeric 酶。在 Escherichia coli 的两个子单元的合作表示与生产仅仅 GPP 的提高的活动导致了 heteromeric 酶。当 CrGPPS.LSU 和 CrGPPS 在更旧、更年轻的叶子显示出更高的表示时,分别地, CrGPPS.SSU 显示出一个增加的趋势并且逐渐地减少了。叶子的甲基 jasmonate (MeJA ) 处理显著地导致了仅仅 CrGPPS.SSU 的表示。而 CrGPPS 是 mitochondrial, GFP 本地化显示 CrGPPS.SSU 是 plastidial。在 C 的 AmGPPS.SSU 的短暂 overexpression。roseus 叶子导致了增加的 vindoline, vinblastine 和长春新碱的立即的 monomeric 先锋。尽管 C。roseus 有 heteromeric 和 homomeric GPPS 酶,我们的结果含有有为 MIA 生合成调整 GPP 流动的 CrGPPS.SSU 的仅仅 heteromeric GPPS 的参与。 | Avanish Rai Shachi S. Smita Anup Kumar Singh Karuna Shanker Dinesh A. Nagegowda | 2013 | Molecular Plant2013，6，5： | 20 |
| 5 | 舒芬太尼复合罗哌卡因用于硬膜外无痛分娩的临床观察显示文摘目的探讨舒芬太尼复合罗哌卡因用于连续硬膜外无痛分娩的效果和安全程度。方法将2018年12月至2019年4月期间昆明医科大学附属延安医院100例在产房正常待产的初产妇随机分为2组(n=50例),实验组常规于L2~3间隙行连续硬膜外穿刺,试验量后头侧置硬膜外管4cm接PCEA泵,协助产妇平卧位后给予舒芬太尼复合罗哌卡因的首剂量和维持剂量,对照组产妇实施常规阴道分娩。观察2组产妇硬膜外自控镇痛效果、产程时间、出血量和新生儿Apgar评分情况,记录是否需要助产和紧急更改剖宫产,是否出现产后出血和胎儿窘迫等不良事件。结果 2组产妇的年龄、身高、体重、孕周值比较差异无统计学意义(P>0.05),实验组产妇分娩镇痛效果的优良率明显高于对照组(P<0.05),2组产妇出血量和新生儿Apgar评分比较差异无统计学意义(P>0.05),实验组产妇第一产程和第二产程时间明显短于对照组(P<0.05),实验组产妇出现需要阴道助产、紧急更改剖宫产和产后出血的比例明显低于对照组(P<0.05)。结论舒芬太尼复合罗哌卡因用于连续硬膜外无痛分娩,镇痛效果显著,能够显著缩短产程时间,提高产妇自然分娩率,降低分娩过程中不良事件的发生率,可以安全有效地应用于临床。 | Dinesh Kumar Shrestha 刘萍 张富荣 | 2019 | 昆明医科大学学报2019，40，10： | 20 |
| 6 | Micro RNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity显示文摘Over the past decade, research has shown that aberrant expression of micro RNA(mi RNA) is involved in colorectal cancer development and progression. Micro RNAs are small sequences of non-coding RNA that regulate expression of genes involved in important cellular functions, such as cell differentiation, multiplication, and apoptosis. A specific mi RNA may display the effects of a tumor suppressor or oncogene. Altered mi RNA expression is found in colorectal cancer(CRC) and patterns of mi RNA expression correlate with CRC detection and outcome. Studies also have examined the use of circulating serum mi RNA and fecal mi RNA expression as non-invasive markers for early detection. Here, we review recent evidence demonstrating the potential role of mi RNA in CRC and the implications of its use in the diagnosis, prognosis, and management of CRC. | Michael Hollis Kavitha Nair Arpita Vyas Lakshmi Shankar Chaturvedi Sahil Gambhir Dinesh Vyas | 2015 | World Journal of Gastroenterology2015，21，27： | 19 |
| 7 | A review on medicinal importance,pharmacological activity and bioanalytical aspects of beta-carboline alkaloid 'Harmine'显示文摘Harmine,a beta-carboline alkaloid,is widely distributed in the plants,marine creatures,insects, mammalians as well as in human tissues and body fluids.Harmine was originally isolated from seeds of Peganum harmal in 1847 having a core indole structure and a pyridine ring.Harmine has various types of pharmacological activities such as antimicrobial,antifungal,antitumor,cytotoxic, antiplasmodial,antioxidaant,antimutagenic,antigenotoxic and hallucinogenic properties.It acts on gamma-aminobutyric acid type A and monoamine oxidase A or B receptor,enhances insulin sensitivity and also produces vasorelaxant effect.Harmine prevents bone loss by suppressing osteoclastogenesis.The current review gives an overview on pharmacological activity and analytical techniques of harmine,which may be useful for researcheres to explore the hidden potential of harmine and and will also help in developing new drugs for the treatment of various diseases. | K Patel M Gadewar R Tripathi SK Prasad Dinesh Kumar Patel | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，8： | 17 |
| 8 | Sensitivity of Labile Soil Organic Carbon Pools to Long-Term Fertilizer, Straw and Manure Management in Rice-Wheat System显示文摘Labile soil organic carbon(SOC) pools, estimated through chemical fractionation techniques, are considered sensitive indicators of management-induced changes in quality and composition of soil organic matter. Although the impacts of organic manure and crop residue applications on C sequestration in rice-wheat system are fairly well documented, their influence on labile SOC pools is relatively less known. Impacts of organic manure, rice straw, and inorganic fertilizer nitrogen(N) applications on soil total organic carbon(TOC)and SOC pools including water-extractable organic C(WEOC), hot water-soluble organic C(HWOC), potassium permanganateoxidizable organic C(KMnO 4-C), microbial biomass C(MBC), mineralizable organic C(Cmin), and the oxidizable fractions of decreasing oxidizability(easily-oxidizable, oxidizable, and weakly-oxidizable) were investigated in an 11-year field experiment under rice-wheat system. The field experiment included treatments of different combinations of farmyard manure, rice straw, and fertilizer N application rates, with C inputs estimated to be in the range from 23 to 127 Mg ha-1. After 11 years of experiment, WEOC,HWOC, and KMnO 4-C were 0.32%–0.50%, 2.2%–3.3%, and 15.0%–20.6% of TOC, respectively. The easily-oxidizable, oxidizable,and weakly-oxidizable fractions were 43%–57%, 22%–27%, and 10%–19% of TOC, respectively. The applications of farmyard manure and rice straw improved WEOC, HWOC, KMnO 4-C, easily-oxidizable fraction, Cmin, and MBC, though the rates of change varied considerably from-14% to 145% and-11% to 83% of TOC, respectively. At the C input levels between 29 and 78 Mg C ha-1during the 11-year period, the greatest increase was observed in WEOC and the minimum in KMnO 4-C. Water-extractable organic C exhibited a relatively greater sensitivity to management than TOC, suggesting that it may be used as a sensitive indicator of management-induced changes in soil organic matter under rice-wheat system. All the other labile SOC pools exhibited almost the same sensitivity to management as TOC. Most of the SOC pools investigated were positively correlated to each other though their amounts differed considerably. Long-term applications of farmyard manure and rice straw resulted in build-up of not only the labile but also the recalcitrant pool of SOC, emphasizing the need for continued application of organic amendments for permanence of the accrued C under the experimental conditions. | Dinesh K.BENBI Kiranvir BRAR Amardeep S.TOOR Shivani SHARMA | 2015 | Pedosphere2015，25，4： | 16 |
| 9 | 唑类超分子药物研究与应用显示文摘基于非共价键力的超分子化学发展非常迅猛,在化学、物理、材料科学、信息科学以及医药等领域显示出广泛的应用前景和巨大的开发价值.唑类化合物如咪唑、噻唑、噁唑、吡唑、三唑、四唑和咔唑等具有特殊的含氮芳杂环结构,可通过非共价键力与无机物和/或有机物形成络合物超分子,表现出广泛的生物活性.近些年来,唑类超分子在医药领域发展迅速,已成为研究热点领域之一.结合本课题组相关研究工作,参考国内外近五年文献,系统地综述了唑类超分子作为药物在抗癌、抗细菌、抗真菌、杀虫、抗糖尿病、降血压、消炎等方面的研究与应用,并展望了其未来可能的发展趋势. | 程宇 王辉 Dinesh Addla 周成合 | 2016 | 有机化学2016，36，1： | 16 |
| 10 | 基于SIMD指令的柔性物体并行碰撞检测显示文摘复杂场景中柔性物体间的碰撞检测依然难以满足交互设计的要求.为了提高处理速度,文中给出了一种充分利用现代CPU的并行处理能力的碰撞检测算法.算法基于两方面的并行处理:即基于SIMD指令的指令级并行处理和基于多线程的任务级并行处理.算法给出了一种针对SIMD指令特别优化的k-DOP模型——SIMD-DOP,从理论上分析了该包围盒的高效性,并与常规的16-DOP和24-DOP进行了运行效率对比.通过使用SIMD-DOP同时在多核间进行负载均衡,算法获得了优化的并行加速.文中算法已经在一台16核工作站上针对一组复杂测试场景进行了验证. | 唐敏 MANOCHA Dinesh 童若锋 | 2009 | 计算机学报2009，32，10： | 13 |
| 11 | A review on synthesis of graphene,h-BN and MoS2 for energy storage applications:Recent progress and perspectives显示文摘The significance of graphene and its two-dimensional(2D)analogous inorganic layered materials especially as hexagonal boron nitride(h-BN)and molybdenum disulphide(MoS2)for“clean energy”applications became apparent over the last few years due to their extraordinary properties.In this review article we study the current progress and selected challenges in the syntheses of graphene,h-BN and MoS2 including energy storage applications as supercapacitors and batteries.Various substrates/catalysts(metals/insulator/semiconducting)have been used to obtain graphene,h-BN and MoS2 using different kinds of precursors.The most widespread methods for synthesis of graphene,h-BN and MoS2 layers are chemical vapor deposition(CVD),plasma-enhanced CVD,hydro/solvothermal methods,liquid phase exfoliation,physical methods etc.Current research has shown that graphene,h-BN and MoS2 layered materials modified with metal oxide can have an insightful influence on the performance of energy storage devices as supercapacitors and batteries.This review article also contains the discussion on the opportunities and perspectives of these materials(graphene,h-BN and MoS2)in the energy storage fields.We expect that this witen review article including recent research on energy storage will help in generating new insights for further development and practical applications of graphene,h-BN and MoS2 layers based materials. | Rajesh Kumar Sumanta Sahoo Ednan Joanni Rajesh Kumar Singh Ram Manohar Yadav Rajiv Kumar Verma Dinesh Pratap Singh Wai Kian Tan Angel Perez del Pino Stanislav A.Moshkalev Atsunori Matsuda | 2019 | Nano Research2019，12，11： | 12 |
| 12 | A Review on Pharmacological and Analytical Aspects of Diosmetin:A Concise Report显示文摘Plants have been used as a source for food material and natural remedies for the treatment of vast range of diseases.Nature provides us remedies for the treatment of various types of disorders ranging from simple ailments to complicated diseases.Plants are known to possess different pharmacological activities due to the presence of various phytoconstituents.Flavonoids are one of the main active phytoconstituents found in fruits,vegetables,wines,tea and cocoa.Flavonoids exhibit various pharmacological activities such as antioxidant,anti-inflammatory,anti-allergic,antibacterial,oestrogenic,cytotoxic antitumoural,hepatoprotective,antithrombotic and antiviral activity.Diosmetin(3',5,7-trihydroxy-4'-methoxyflavone),the aglycone part of the flavonoid glycosides diosmin occurs naturally in citrus fruit.Although it is found in herbal medicines and plays an important role in the treatment of various ailments,only limited scientific researches have been conducted.The aim of this review is to collect all available scientific literature published on diosmetin and combine it into this paper.This review contains an overview of pharmacological activities,isolation techniques and analytical techniques for diosmetin.Thus,valuable information provided in the present review will help researchers in developing alternative methods for the treatment of diseases from diosmetin. | Kanika Patel Manoj Gadewar Vijay Tahilyani Dinesh Kumar Patel | 2013 | Chinese Journal of Integrative Medicine2013，19，10： | 11 |
| 13 | One-pot synthesis of 2-aminothiazoles in PEG-400显示文摘A facile one-pot synthesis of 2-aminothiazoles has been carried in PEG-400 as a greener medium at room temperature.This method avoids the use of lachrymatric a-bromoketones as well as the volatile,toxic organic solvents. | Dhanaji V.Jawale Dinesh L.Lingampalle Umesh R.Pratap Ramrao A.Mane | 2010 | Chinese Chemical Letters2010，21，4： | 8 |
| 14 | Antidiabetic activity of alcoholic leaves extract of Alangium lamarckii Thwaites on streptozotocin-nicotinamide induced type 2 diabetic rats显示文摘Objective:To investigate antidiabetic potential of alcoholic leaves extract of Alangium lamarekii (A.lamarckii) on streptozotocin-nicotinamide induced type 2 diabetic rats.Methods:Oral glucose tolerance test was done by inducing hyperglycemic state via administration of glucose in water(2 g/kg).Single dose of alcoholic leaves extract of.4.lamarckii(250 and 500 mg/kg,p.o.) were administered to normoglycemic,hyperglycemic rats.Type 2 diabetes was induced by single intraperitoneal injection of nicotinamide(110 mg/kg) followed by streptozotocin(65 mg/kg).The study also included estimations of blood plasma glucose,lipid profile,liver glycogen,body weight and antioxidant status in normal and diabetic rats.Results:Admistration of alcoholic extract of A.lamarekii at two dosage 250 and 500 rag/kg,p.o.did not showed any significant change in blood glucose level of normoglycemic rats(P>0.05).whereas,oral glucose tolerance test depicted reduction in blood glucose level(P<0.05).The streptozotocin-nicotinamide induced diabetic rats, significantly decreased the blood plasma glucose level(P<0.001) comparable to glibenclamide (10 mg/kg),restored the lipid profile and showed improvement in liver glycogen,body weight and antioxidant status in diabetic rats.Conclusions:Present finding demonstrated the significant antidiabetic activity of alcoholic leaves extract of.4.lamarekii. | Rajesh Kumar Dinesh Kumar Pate Satyendra Kuldip Prasad Kirshnamurthy Sairam Siva Hemalatha | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 8 |
| 15 | 植物中的生物活性多糖显示文摘多糖是由糖甙键连接起来的醛糖或酮糖组成的天然大分子。仅由一种单糖组成的多糖称为同聚糖,而由一种以上单糖组成的多糖称为杂聚糖。多糖是所有生命有机体的重要组成成分并与维持生命所必需的多种功能有关,大量存在于藻类、真菌、高等陆生植物中。近年来植物来源多糖已成为一类重要的具有生物活性的天然产物。很多多糖都具有抗肿瘤、免疫、抗补体、抗炎症、抗凝血、降血糖和抗病毒活性。本文综述了美国化学文摘自1977年1月至1988年12月所摘录的具有生物活性的植物多糖。 | Rashmi Srivastava Dinesh K.Kulshreshtha 孔振武 | 1991 | 药学进展1991，15，1： | 8 |
| 16 | 快速眼动睡眠产生的神经机制:蓝斑核神经元停止发放是一个必要的条件(英文)显示文摘两种类型的神经元参与了快速眼动(rapideyemovement,REM)睡眠的调节:快速眼动-发放(REM-ON)神经元和快速眼动-沉寂神经元(REM-OFF)。快速眼动-沉寂神经元属去甲肾上腺素能神经元,正如名字表示的那样——在快速眼动睡眠期间停止发放。已有研究表明,这些神经元放电活动的停止是导致快速眼动睡眠的前提条件,γ-氨基丁酸(γ-aminobutyricacid,GABA)可使它们停止发放。如果这些神经元不停止发放,脑中的去甲肾上腺素水平将升高,不出现快速眼动睡眠。剥夺快速眼动睡眠所引起的去甲肾上腺素增加,至少是快速眼动睡眠丧失引起Na+-K+ATP酶活性增加的原因,而这可能是导致快速眼动睡眠剥夺所引发的各种效应的主要因素。 | Dinesh Pal Vibha Madan Birendra Nath Mallick | 2005 | 生理学报2005，57，4： | 8 |
| 17 | Antidiabetic activity of methanolic bark extract of Alhizia odoratissima Benth.in alloxan induced diabetic albino mice显示文摘Objective:To evaluate the antidiabetic potential of methanolic extract of Albizia odoratissima Benth.bark in alloxan induced diabetic mice.Methods:Group-Ⅰ(normal control) mice received only basal diet without any treatment.In Group-Ⅱ(Diabetic control) mice,diabetes was induced by alloxan(150 mg/kg i.p.) and received only Tween 80.5%v/v in normal saline. Group-Ⅲand Group-Ⅳmice received metformin(10 mg/kg) and gliclazide(10 mg/kg) as standard drugs.Group-ⅤandⅥmice received methanolic bark extract of Albizia odoratissima at doses of 250 and 500 mg/kg body weight p.o.,respectively.Results:The results of the study indicates that Albizia odoratissima bark extract significantly(P<0.01) reduced the blood sugar level.The bark extract also significantly reduced the levels of serum cholesterol,triglycerides, serum glutamic-oxaloacetic transaminase,serum glutamic-pyruvic transaminase,alkaline phosphatase and decreases level of total proteins in alloxan induced diabetic mice.Conclusions: Methanolic extract of Albizia odoratissima has protective effects on the protection of vital tissues(pancreas,kidney,liver,heart and spleen),thereby reducing the causation of diabetes in experimental animals. | Dinesh Kumar Sunil Kumar Sonia Kohli Renu Arya Jyoti Gupta | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 7 |
| 18 | Evaluation of phytochemical and antioxidant activities of the different fractions of Hybanthus enneaspermus (Linn.) F.Muell. (Violaceae).显示文摘Objective:To investigate the naturally occurring antioxidant for the first time from the different solvent fractions of Hybanthus enneaspermus(H.enneaspermus) Linn F.Muell.family(Violaceae). Methods:Different fractions of H.enneaspermus were tested for total phenolic content,and in vitro antioxidant activity was measured by total antioxidant assay,DPPH assay,reducing power, nitric oxide(NO),hydrogen peroxide(H2O2) scavenging assays.Results:The ethyl acetate(EA) fraction was found to have high levels of phenolic content[(212.15±0.79) mg GAE/g].The EA fraction exhibited higher total antioxidant capacity,higher percentage of DPPH radical scavenging activity[(127.07±2.29) Fg/mL],nitric oxide[(245.16±1.44)μg/mLJ,hydrogen peroxide[(227.38±7.18)μg/mL],deoxyribose[(270.61±8.72)μg/mL]and higher reducing power.There was a significant correlation between total phenolic content and total antioxidant activity(r =0.972). Conclusions:These results reveal that EA fraction of H.enneaspermus has strong antioxidant potential compared with other fractions.Our further study has been extended to the isolation of the possible compound that is responsible for having antioxidant property. | Dinesh Kumar Patel Rajesh Kumar Damiki Laloo Siva Hemalatha | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，5： | 7 |
| 19 | 不同激光表面纹理对轴承材料AISI52100摩擦性能的影响显示文摘铬钢因具有高强度和耐磨性而用于轴承。然而,在实际使用中,因滑动摩擦导致的故障而使寿命缩短。为了提高AISI52100铬钢材料的耐久性,本文分析了激光表面纹理(LST)化的效果。利用圆盘摩擦,对不同形状,如椭圆和圆,与未纹理化处理试样的磨损行为进行了对比研究。用于磨损分析的润滑剂是SKFNLGI-3半固体锂基润滑脂。在10、30和50 N的不同载荷下,用750 r/min和1400 r/min 2种滑动速度进行滑动磨损分析。用扫描电子显微镜(SEM)对磨损形貌进行了分析。样品的粗糙度用白光干涉仪测量。与未纹理化处理试样相比,观察到不同形状如圆和椭圆对铬合金摩擦磨损性能的影响。由于磨损碎片和润滑剂被捕获,激光表面纹理显示椭圆的摩擦和磨损与圆形图案相比,明显减少。 | PAUL JOSHUA S DINESH BABU P | 2020 | Journal of Central South University2020，27，8： | 6 |
| 20 | Assessment of tumor markers CA 19-9,CEA,CA 125,and CA 242 for the early diagnosis and prognosis prediction of gallbladder cancer显示文摘BACKGROUND Gallbladder cancer(GBC)is one of the leading and aggressive cancers in this region of India.It is very difficult to diagnose in the early stage,as it lacks typical early signs and symptoms;thus,the diagnosis is often in the advanced stage,which ultimately leads to a poor 5-year survival outcome.Tumor markers including carbohydrate antigen 19-9(CA 19-9),carcinoembryonic antigen(CEA),CA 125,CA 242,and alpha fetoprotein are used as indicators in the diagnosis and prognosis of GBC.AIM To compare tumor marker levels between GBC and benign GB diseases(GBDs)and to assess the combined use of tumor markers to increase the diagnostic accuracy for GBC.METHODS Patients of either sex aged≥18 years,with suspected GBC(GB polyp,irregular thick GB wall,GB mass,porcelain GB)on the basis of radiological imaging were included in this study.GB wall thickness using ultrasonography and tumor markers CEA,CA 125,CA 19-9,and CA 242 in all patients were recorded.All cases after surgical intervention were divided into two groups,GBC and benign GBD,according to histopathological examination findings.The cases were followed up and clinical findings,radiological findings,and levels of tumor markers were assessed.RESULTS A total of 200 patients were included in this study,of whom 80 patients had GBC and 120 patients had benign GBD.The median(interquartile range)age was 52.0(41.0-60.0)years and the majority of patients(132,66.0%)were women.Tumor markers including CA 19-9,CA 125,CEA,and CA 242 were significantly elevated in patients with GBC(P<0.001).There was a significant reduction in tumor markers at 3 and 6 mo from baseline(P<0.001).The mean survival of patients with normal and elevated levels of tumor markers CA 125,CA 19-9,and CEA was comparable;however lymph node metastasis and CA 242 expression level were independent prognostic factors.CONCLUSION Serum levels of tumor markers including CA 19-9,CA 125,CEA,and CA 242 were significantly associated with GBC.However,no significant association was observed between the presence of elevated levels of any tumor marker with respect to survival.Tumor marker assessment during follow-up may represent a treatment response. | Seema Rani Sinha Prem Prakash Rakesh Kumar Singh Dinesh Kumar Sinha | 2022 | World Journal of Gastrointestinal Surgery2022，14，11： | 5 |
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