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| 1 | Red blood cell distribution width in elderly hospitalized patients with cardiovascular disease显示文摘BACKGROUND Red blood cell distribution width(RDW)is elevated in patients with cardiovascular disease(CVD).AIM To determine RDW values and impact of CV and non-CV coexisting morbidities in elderly patients hospitalized with chronic CVD.METHODS This prospective study included 204 consecutive elderly patients(age 77.5[7.41]years,female 94[46%],left ventricular ejection fraction 53.00%[37.50,55.00])hospitalized with chronic CVD at the Cardiology Department of Larissa University General Hospital(Larissa,Greece)from January 2019 to April 2019.Elderly patients were selected due to the high prevalence of coexisting morbidities in this patient population.Hospitalized patients with acute CVD(acute coronary syndromes,new-onset heart failure[HF],and acute pericarditis/myocarditis),primary isolated valvular heart disease,sepsis,and those with a history of blood transfusions or cancer were excluded.The evaluation of the patients within 24 h from admission included clinical examination,laboratory blood tests,and echocardiography.RESULTS The most common cardiac morbidities were hypertension and coronary artery disease,with acutely decompensated chronic heart failure(ADCHF)and atrial fibrillation(AF)also frequently being present.The most common non-cardiac morbidities were anemia and chronic kidney disease followed by diabetes mellitus,chronic obstructive pulmonary disease,and sleep apnea.RDW was significantly elevated 15.48(2.15);121(59.3%)of patients had RDW>14.5%which represents the upper limit of normal in our institution.Factors associated with RDW in stepwise regression analysis were ADCHF(coefficient:1.406;95%confidence interval[CI]:0.830-1.981;P<0.001),AF(1.192;0.673 to 1.711;P<0.001),and anemia(0.806;0.256 to 1.355;P=0.004).ADCHF was the most significant factor associated with RDW.RDW was on average 1.41 higher for patients with than without ADCHF,1.19 higher for patients with than without AF,and 0.81 higher for patients with than without anemia.When patients were grouped based on the presence or absence of anemia,ADCHF and AF,heart rate was not increased in those with anemia but was significantly increased in those with ADCHF or AF.CONCLUSION RDW was elevated in elderly hospitalized patients with chronic CVD.Factors associated with RDW were anemia and CV factors associated with elevated heart rate(ADCHF,AF),suggesting sympathetic overactivity. | Andrew Xanthopoulos Konstantinos Tryposkiadis Apostolos Dimos Angeliki Bourazana Alexandros Zagouras Nikolaos Iakovis Michail Papamichalis Grigorios Giamouzis George Vassilopoulos John Skoularigis Filippos Triposkiadis | 2021 | World Journal of Cardiology2021，13，9： | 13 |
| 2 | Small bowel parasitosis as cause of obscure gastrointestinal bleeding diagnosed by capsule endoscopy显示文摘Hookworm infection is a relatively common cause of anemia in endemic areas.However,it is rarely encountered in Europe.In this report we describe the case of a 24-year old patient originating from an endemic area who was admitted due to severe anemia,with an Hct of 15.6%and eosinophilia(Eosinophils:22.4%).While both esophagogastroduodenoscopy and colonoscopy were non-diagnostic,capsule endoscopy revealed a large number of hookworms infesting his small bowel and withdrawing blood.The patient was successfully treated with Albendazole.Capsule endoscopy was proven an important tool in diagnosing intestinal parasitosis. | Dimitrios K Christodoulou Dimitrios E Sigounas Konstantinos H Katsanos Georgios Dimos Epameinondas VTsianos | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 7 |
| 3 | Hypolipidemic,antioxidant and anti-atherosclerogenic effects of aqueous extract of Zanthoxylum heitzii stem bark in diet-induced hypercholesterolemic rats显示文摘Objective:To evaluate anti-dyslipidemic,antioxidant and anti-atherosclerogenic properties of this extract in diet-induced hypercholesterolemic rat.a model of metabolic syndrome-induced atherosclerosis and associated cardiovascular diseases.Methods:Normocholeslerolemic(NC) male rats were divided into six groups(n=10) and fed a high-cholesterol(HC) diet for 30 days(5 groups),or normal rat chow(normal control group).Rats given a HC diet also received distilled water(disease control),the potent hypocholcsterolcmic agent with antiatherosclerotic activity atorvastatin(2 mg/kg,positive control),or one of the three doses of Zanthoxylum heitzii stem bark aqueous extract tested(225,300 and 375 mg/kg) concomitantly for four months.Signs of general toxicity,body temperature and weight,and water and food intake were monitored in live animals.After sacrifice,lipid profiles and oxidative stress markers were assessed in the blood and liver,aorta,and feces,and histopathological analysis of aorta was performed.Results:Plant extract prevented the elevation of aortic total cholesterol and triglycerides,and hepatic low density lipoprotein,very low density lipoprotein,and total cholesterol.Lipid peroxidation(TBARS) was decreased and aortic atherosclerotic plaque formation prevented.Conclusions:These observations strongly suggest that stem bark aqueous extract of Zanthoxylum heitzii has anti-atherosclerogenic properties,at least partly mediated by antioxidant and hypolipidemic effects. | Fidele Ntchapda Kakesse Maguirgue Hamadjida Adjia Paul Faustin Seke Etet Théophile Dimo | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，5： | 3 |
| 4 | Diuretic and antioxidant activities of the aqueous extract of leaves of Cassia occidentalis(Linn.) in rats显示文摘Objective: To assess the putative diuretic and antioxidant properties of Cassia occidentalis(C. occidentalis) leaves' aqueous extract. Methods: Adult rats were administered with C. occidentalis leaves aqueous extract acutely(24-h) and subchronically(7 d), at doses 80, 160, 240, 320, and 400 mg/kg(per os). Negative control group received only an equivalent volume of distilled water, while the two positive control groups received the diuretic drugs furosemide(20 mg/kg, i.p.) and hydrochlorothiazide(HCTZ, 20 mg/kg, i.p.). Urinary elimination of electrolytes in response to treatments was evaluated, together with changes in concentrations of creatinine, urea, aldosterone, glucose, and albumin in urine and plasma. Various urinary indicators of kidney function and plasmatic markers of oxidative stress were also assessed. Results: The acute administration of C. occidentalis increased the urinary excretion of 107.58% at the higher dose tested, compared to negative control. The reference drugs furosemide and HCTZ induced increases of 84.27 % and 48.05 %, respectively. Acutely, the extract induced Na+ and Cl- elimination, whereas subchronically an increase in K+ elimination was also observed. The extract also improved the kidney function indexes and oxidative stress markers. These effects were dose-dependent and comparable with positive control observations. Conclusions: Our i ndings strongly suggest that C. occidentalis aqueous extract has diuretic and antioxidant activities, and deserves further studies considering the potential for the treatment of hypertension. | Théophile Dimo Fidèle Ntchapda Joseph Barama David Romain Kemeta Azambou Paul Faustin Seke Etet | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，9： | 2 |
| 5 | Evolving concepts of stability and intramedullary fixation of intertrochanteric fractures—A review显示文摘 | Constantine Kokoroghiannis Ioannis Aktselis Anastasios Deligeorgis Evaggelos Fragkomichalos Dimos Papadimas Ioannis Pappadas | 2011 | Injury2011，，6： | 2 |
| 6 | Leader–follower cooperative attitude control of multiple rigid bodies显示文摘 | Dimos V. Dimarogonas Panagiotis Tsiotras Kostas J. Kyriakopoulos | 2009 | Systems & Control Letters2009，，6： | 2 |
| 7 | Hypolipidemic and anti-atherosclerogenic effects of aqueous extract of Ipomoea batatas leaves in diet-induced hypercholesterolemic rats显示文摘Objective:Ipomoea batatas(L.)Lam.is a food plant used in African traditional medicine to treat cardiovascular diseases and related conditions.We assessed the hypolipidemic and anti-atherosclerogenic properties of the aqueous extract of I.batatas leaves in a rat model of diet-induced hypercholesterolemia.Methods:Hypercholesterolemia was induced in male Wistar rats by exclusive feeding with a cholesterolenriched(1%)standard diet for four weeks.Then,rats were treated once daily(per os)with I.batatas extract at doses of 400,500 and 600 mg/kg or with atorvastatin(2 mg/kg),for four weeks.Following treatment,animals were observed for another four weeks and then sacrificed.Aortas were excised and processed for histopathological studies,and blood glucose level and lipid profile were measured.Results:Hypercholesterolemic animals experienced a 21.5%faster increase in body weight,significant increases in blood glucose and blood lipids(148.94%triglycerides,196.97%high-density lipoprotein cholesterol,773.04%low-density lipoprotein cholesterol,148.93%very low-density lipoprotein cholesterol and 210.42%total cholesterol),and increases in aorta thickness and atherosclerotic plaque sizes compared to rats fed standard diet.Treatment of hypercholesterolemic rats with the extract mitigated these alterations and restored blood glucose and blood lipid levels to normocholesterolemic values.Conclusion:Our findings suggest that I.batatas leaves have hypolipidemic and anti-atherosclerogenic properties and justify their use in traditional medicine. | Fidele Ntchapda Fernand C.Tchatchouang David Miaffo Barthelemy Maidadi Lorella Vecchio Rodrigue E.Talla Christian Bonabe Paul F.Seke Etet Theophile Dimo | 2021 | Journal of Integrative Medicine2021，19，3： | 2 |
| 8 | Antidiabetic and antioxidant effects of Annona muricata (Annonaceae), aqueous extract on streptozotocin-induced diabetic rats显示文摘 | Ngueguim Tsofack Florence Massa Zibi Benoit Kouamouo Jonas Tchuidjang Alexandra Dzeufiet Djomeni Paul Désiré Kamtchouing Pierre Dimo Théophile | 2014 | Journal of Ethnopharmacology2014，，2： | 2 |
| 9 | Experimental and analytical study of latticed structures made from FRP composite materials显示文摘 | Dimos J. Polyzois Ioannis G. Raftoyiannis Andrew Ochonski | 2013 | Composite Structures2013，，： | 1 |
| 10 | Induced pluripatent stem ceils generated from patients with ALS can be differentiated into motor neurons显示文摘 | Dimos JT Rodolfa KT Niakan KK | 2008 | Science2008，321，5893： | 1 |
| 11 | Fabrication of multilayer passive and active electric components on polymer using inkjet printing and low temperature laser processing显示文摘 | Seung Hwan Ko Jaewon Chung Heng Pan Costas P. Grigoropoulos Dimos Poulikakos | 2006 | Sensors & Actuators: A Physical2006，，1： | 1 |
| 12 | From opportunity insight to opportunity intention: The importance of person-situation learning match显示文摘 | Dimo Dimov | 2007 | Entrepreneurship Theory and Practice2007，31，4： | 1 |
| 13 | Choosing the optimal wall shear parameter for the prediction of plaque location—A patient-specific computational study in human left coronary arteries显示文摘 | Farhad Rikhtegar Joseph A. Knight Ufuk Olgac Stefan C. Saur Dimos Poulikakos William Marshall Philippe C. Cattin Hatem Alkadhi Vartan Kurtcuoglu | 2012 | Atherosclerosis2012，，2： | 1 |
| 14 | Polarization Suppres- sion In Pb ( Zr, Ti ) 0-3 Thin-Films 显示文摘 | Warren WL Dimos D Tuttle BA | 1995 | Journal of Applied Physics1995，77，： | 1 |
| 15 | Induced pluripotent stem cells generated from patients with ALS can be differentiated into mo- tor neurons显示文摘 | Dimos JT Rodolfa KT Niakan KK | 2008 | Science2008，321，： | 1 |
| 16 | A stem cell molecular signature显示文摘 | Ivanova NB Dimos JT Schaniel C | 2002 | Science2002，298，： | 1 |
| 17 | shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development显示文摘 | Fasano CA Dimos JT Ivanova NB | 2007 | Stem Cells2007，1，1： | 1 |
| 18 | 显示文摘 | Warren W L Dimos D Tuttle B A | 1995 | J Appl Phys1995，77，： | 1 |
| 19 | Nonrandom percolation behavior of grain boundary networks in high-Tc superconductors显示文摘 | DIMOS D CHAUDAHARI P MANNHART J | 1990 | Phys Rev1990，41，： | 1 |
| 20 | Choosing the optimal wall shear parameter for the prediction of plaque location—A patient-specific computational study in human right coronary arteries显示文摘 | Joseph Knight Ufuk Olgac Stefan C. Saur Dimos Poulikakos William Marshall Philippe C. Cattin Hatem Alkadhi Vartan Kurtcuoglu | 2010 | Atherosclerosis2010，，2： | 1 |
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