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| 1 | Cardiac autonomic neuropathy in patients with diabetes mellitus显示文摘Cardiac autonomic neuropathy(CAN)is an often overlooked and common complication of diabetes mellitus.CAN is associated with increased cardiovascular morbidity and mortality.The pathogenesis of CAN is complex and involves a cascade of pathways activated by hyperglycaemia resulting in neuronal ischaemia and cellular death.In addition,autoimmune and genetic factors are involved in the development of CAN.CAN might be subclinical for several years until the patient develops resting tachycardia,exercise intolerance,postural hypotension,cardiac dysfunction and diabetic cardiomyopathy.During its sub-clinical phase,heart rate variability that is influenced by the balance between parasympathetic and sympathetic tones can help in detecting CAN before the disease is symptomatic.Newer imaging techniques(such as scintigraphy)have allowed earlier detection of CAN in the pre-clinical phase and allowed better assessment of the sympathetic nervous system.One of the main difficulties in CAN research is the lack of a universally accepted definition of CAN;however,the Toronto Consensus Panel on Diabetic Neuropathy has recently issued guidance for the diagnosis and staging of CAN,and also proposed screening for CAN in patients with diabetes mellitus.A major challenge,however,is the lack of specific treatment to slow the progression or prevent the development of CAN.Lifestyle changes,improved metabolic control might prevent or slow the progression of CAN.Reversal will require combination of these treatments with new targeted therapeutic approaches.The aim of this article is to review the latest evidence regarding the epidemiology,pathogenesis,manifestations,diagnosis and treatment for CAN. | Gerasimos Dimitropoulos Abd A Tahrani Martin J Stevens | 2014 | World Journal of Diabetes2014,5,1: | 48 |
| 2 | Global initia- tive for chronic obstructive lung disease for chronic obstructive pulmonary disease: GOLD opportunity for lung disorders 显示文摘 | Minas M Dimitropoulos K Pastaka Ch | 2005 | Prey Med2005,40,3: | 1 |
| 3 | Prasugrel overcomes high on clopidogrel platelet reactivity post-stenting more effectively than high-dose(150mg)clopidogrel:the importance of CYP2C19*2 genotyping显示文摘 | Alexopoulos D Dimitropoulos G Davlouros P | | 0,,04: | 1 |
| 4 | Histogrambased traffic anomaly detection 显示文摘 | Kind A Stoecklin M P Dimitropoulos X | 2009 | IEEE Transactions on Network Service Management2009,6,2: | 1 |
| 5 | Multi-scaled morphological features for the characterization of mammographie masses using statistical classification schemes显示文摘 | Harris Georgiou Michael Mavroforakis Nikos Dimitropoulos | 2007 | Journal of Artificial Intelligence in Medicine2007,41,8: | 1 |
| 6 | Children with congenital hy- pothyroidism:Long - term intellectual outcome after early high - dose treatment 显示文摘 | Dimitropoulos A Molinari L Etter K | 2009 | Pediatr Res2009,65,2: | 1 |
| 7 | AS relationships: inference and validation显示文摘 | Dimitropoulos X Krioukov D Fomenkov M | 2007 | SIGCOMM Computer Communications Review2007,37,1: | 1 |
| 8 | Single ventricle anatomy predicts delayed microstruetural brain development 显示文摘 | Sethi V Tabbutt S Dimitropoulos A | 2013 | Pediatr Res2013,73,5: | 1 |
| 9 | Anomalyextraction in backbone networks using association rules显示文摘 | Brauckhoff D Dimitropoulos X Wagner A | 2012 | IEEE/ACM Transactions on Networking(TON)2012,20,6: | 1 |
| 10 | Assessing the determinants of local acceptability of wind-farm investment: A choice experiment in the Greek Aegean Islands显示文摘 | Alexandros Dimitropoulos Andreas Kontoleon | 2009 | Energy Policy2009,,5: | 1 |
| 11 | Clopidogrel resistance: cur- rent aspects and future directions 显示文摘 | Vlachojannis GJ Dimitropoulos G Alexpoulos D | 2011 | Hellenic J Cardiol2011,52,: | 1 |
| 12 | Automating root-cause analysis of network anomalies using {requent itemset mining显示文摘 | PAREDES-OLIVA I DIMITROPOULOS X MO- LINA M | 2010 | ACM SIGCOMM Computer Communication Review2010,41,4: | 1 |
| 13 | Clop-idogrel resistance: current aspects and future directions显示文摘 | Vlachojannis GJ Dimitropoulos G Alexopoulos D | 2011 | Hellenic J Cardiol2011,52,3: | 1 |
| 14 | Prophylactic cranial irradiation in non-small cell lung cancer patients:who might be the candidates显示文摘 | Dimitropoulos C Hillas G Nikolakopoulou S | | 0,,: | 1 |
| 15 | Graph annotations in modeling complex network topologies显示文摘 | Dimitropoulos X Krioukov D Vahdat A | 2009 | ACM Transactions on Modeling and Computer Simulation2009,19,4: | 1 |
| 16 | Empirical Estimates of the Direct Rebound Effect : A Review 显示文摘 | Sorrell S Dimitropoulos J Sommerville M | 2009 | Energy Policy2009,37,4: | 1 |
| 17 | Subjective and ob- jective evaluation of risk on roadway curves 显示文摘 | Kanellaidis G Dimitropoulos I | 1994 | Traffic Engineering and Control1994,35,78: | 1 |
| 18 | A 2-D ferrous object imaging technique based on magnetic field sensor arrays显示文摘 | Dimitropoulos P D Avaritsioris J N | 2003 | Sensors and Actuators A:Physical2003,106,13: | 1 |
| 19 | Prophylactic cranial irradiation in non-small cell lung cancer patients:who might be the candidates显示文摘 | Dimitropoulos C Hillas G Nikolakopoulou S | 2011 | Cancer Manag Res2011,,3: | 1 |
| 20 | Clopidogrel resistance: current aspects and future direction 显示文摘 | Vlachojannis GJ Dimitropoulos G Alexopoulos D | 2011 | Hellenic J Cardiol2011,52,3: | 1 |