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| 1 | Gut microbiota and non-alcoholic fatty liver disease显示文摘BACKGROUND: Non-alcoholic fatty liver disease(NAFLD) is a common disorder with poorly understood pathogenesis. Beyond environmental and genetic factors,cumulative data support the causative role of gut microbiota in disease development and progression.DATA SOURCE: We performed a Pub Med literature search with the following key words: 'non-alcoholic fatty liver disease','non-alcoholic steatohepatitis','fatty liver','gut microbiota' and 'microbiome',to review the data implicating gut microbiota in NAFLD development and progression.RESULTS: Recent metagenomic studies revealed differences in the phylum and genus levels between patients with fatty liver and healthy controls. While bacteroidetes and firmicutes remain the dominant phyla among NAFLD patients,their proportional abundance and genera detection vary among different studies. New techniques indicate a correlation between the methanogenic archaeon(methanobrevibacter smithii) and obesity,while the bacterium akkermanshia municiphila protects against metabolic syndrome. Among NAFLD patients,small intestinal bacterial overgrowth detected by breath tests might induce gut microbiota and host interactions,facilitating disease development.CONCLUSIONS: There is evidence that gut microbiota participates in NAFLD development through,among others,obesity induction,endogenous ethanol production,inflammatory response triggering and alterations in choline metabolism. Further studies with emerging techniques are needed to further elucidate the microbiome and host crosstalk in NAFLD pathogenesis. | Paraskevas Gkolfakis George Dimitriadis Konstantinos Triantafyllou | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，6： | 22 |
| 2 | Effects of phosphodiesterase 5 inhibitors on sperm parameters and fertilizing capacity显示文摘这评论研究的目的是阐明效果那磷酸二酯酶 5 (PDE5 ) 禁止者在精子上施加活动性, capacitation 过程并且在他们使肥沃的能力上卵母细胞。第二个送信人系统象 cAMP/adenylate cyclase (交流) 那样系统和 cGMP/guanylate cyclase (GC ) 系统看起来调整精子功能。intracytosolic 营地的增加的层次导致精子活动性和生存能力的改进。由氮的氧化物的低剂量的 GC 的刺激(没有) 导致精子活动性的改进或维护,而更高的集中在精子参数上有不利效果。几在活体内和在试管内研究被执行了以便检验 PDE5 禁止者是否断然或否定地影响精子参数和精子使肥沃能力。这些研究的结果是争论的。一些这些研究不在从与 PDE5 禁止者被对待的人收集的精子的活动性,生存能力,和形态学上表明 PDE5 禁止者的重要效果。在另一方面,几研究在精子活动性上表明 PDE5 禁止者的积极效果在活体内和在试管内。sildenafil 柠檬酸盐的在试管内研究随在除 PDE5 以外的 PDE 对碘氧基苯甲醚上建议 sildenafil 柠檬酸盐的一个禁止的行动的细胞内部的营地的增加在精子活动性上表明 stimulatory 效果。在另一方面, tadalafil 的行动看起来在 PDE11 上与这混合物的禁止的效果被联系。在在一个每日的基础与 vardenafil 对待的人的在活体内研究每精液,量的精子活动性,和质的精子活动性表明了精子的一个显著地更大的全部的数字;vardenafil 管理提高前列腺的能分泌的功能并且随后增加精子的质、量的活动性,这被建议了。PDE5 禁止者在精子参数上施加的效果可以导致帮助繁殖技术(艺术) 的结果的改进程序。在未来 PDE5,禁止者可能为男不孕的缓和用作附属物 therapeutical 代理人。 | F. Dimitriadis D. Giannakis N. Pardalidis K. Zikopoulos E. Paraskevaidis N. Giotitsas V. Kalaboki P.Tsounapi D. Baltogiannis Georgiou M.Saito T.Watanabe I. Miyagawa N.Sofildtis | 2008 | Asian Journal of Andrology2008，10，1： | 11 |
| 3 | Genetic and epigenetic risks of intracytoplasmic sperm injection method显示文摘怀孕由帮助繁殖技术完成了,特别地由胞质内精子注射(ICSI ) 过程,产生对与 ICSI 对待的男人口固有的基因风险和对这个创新过程固有的另外的风险。记录,以及理论,风险在现在的评论学习被讨论。这些风险主要表示位于男性下面的基因畸形的后果代替生育力(或不孕) 并且可能在不孕的治疗为新奇途径和应用的发展成为激发器。另外,冒的风险,当先天的异例和另外的理论或随机的风险被讨论,一个复合基因背景出现在出生。最近的数据建议那种帮助繁殖技术可能也影响雄配子,雌配子,或力量的渐成说特征影响早胚胎开始。它可能也为印畸形的 genomic 与增加的风险被联系。 | Ioannis Georgiou Maria Syrrou Nicolaos Pardalidis Konstantinos Karakitsios Themis Mantzavinos Nikolaos Giotitsas Dimitrios Loutradis Fotis Dimitriadis Motoaki Saito Ikuo Miyagawa Pavlos Tzoumis Anastasios Sylakos Nikolaos Kanakas Theodoros Moustakareas Dimitrios Baltogiannis Stavros Touloupides Dimitrios Giannakis Michael Fatouros Nikolaos Sofikitis | 2006 | Asian Journal of Andrology2006，8，6： | 9 |
| 4 | Gene polymorphisms associated with functional dyspepsia显示文摘Functional dyspepsia(FD) is a constellation of functional upper abdominal complaints with poorly elucidated pathophysiology. However, there is increasing evidence that susceptibility to FD is influenced by hereditary factors. Genetic association studies in FD have examined genotypes related to gastrointestinal motility or sensation, as well as those related to inflammation or immune response. G-protein b3 subunit gene polymorphisms were first reported as being associated with FD. Thereafter, several gene polymorphisms including serotonin transporter promoter, interlukin-17 F, migration inhibitory factor, cholecystocynine-1 intron 1, cyclooxygenase-1, catechol-o-methyltransferase, transient receptor potential vanilloid 1 receptor, regulated upon activation normal T cell expressed and secreted, p22 PHOX, Toll like receptor 2, SCN10 A, CD14 and adrenoreceptors have been investigated in relation to FD; however, the results are contradictory. Several limitations underscore the value of current studies. Among others, inconsistencies in the definitions of FD and controls, subject composition differences regarding FD subtypes, inadequate samples, geographical and ethnical differences, as well as unadjusted environmental factors. Further well-designed studies are necessary to determine how targeted genes polymorphisms, influence the clinical manifestations and potentially the therapeutic response in FD. | Anastasia Kourikou George P Karamanolis George D Dimitriadis Konstantinos Triantafyllou | 2015 | World Journal of Gastroenterology2015，21，25： | 8 |
| 5 | Virtual reality simulators for gastrointestinal endoscopy training显示文摘The use of simulators as educational tools for medical procedures is spreading rapidly and many efforts have been made for their implementation in gastrointestinal endoscopy training. Endoscopy simulation training has been suggested for ascertaining patient safety while positively influencing the trainees' learning curve. Virtual simulators are the most promising tool among all available types of simulators. These integrated modalities offer a human-like endoscopy experience by combining virtual images of the gastrointestinal tract and haptic realism with using a customized endoscope. From their first steps in the 1980s until today, research involving virtual endoscopic simulators can be divided in two categories: investigation of the impact of virtual simulator training in acquiring endoscopy skills and measuring competence. Emphasis should also be given to the financial impact of their implementation in endoscopy, including the cost of these state-of-theart simulators and the potential economic benefits from their usage. Advances in technology will contribute to the upgrade of existing models and the development of new ones; while further research should be carried out to discover new fields of application. | Konstantinos Triantafyllou Lazaros Dimitrios Lazaridis George D Dimitriadis | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，1： | 7 |
| 6 | Insulin action in muscle and adipose tissue in type 2 diabetes:The significance of blood flow显示文摘Under normal metabolic conditions insulin stimulates microvascular perfusion(capillary recruitment) of skeletal muscle and subcutaneous adipose tissue and thus increases blood flow mainly after meal ingestion or physical exercise.This helps the delivery of insulinitself but also that of substrates and of other signalling molecules to multiple tissues beds and facilitates glucose disposal and lipid kinetics.This effect is impaired in insulin resistance and type 2 diabetes early in the development of metabolic dysregulation and reflects early-onset endothelial dysfunction.Failure of insulin to increase muscle and adipose tissue blood flow results in decreased glucose handling.In fat depots,a blunted postprandial blood flow response will result in an insufficient suppression of lipolysis and an increased spill over of fatty acids in the circulation,leading to a more pronounced insulin resistant state in skeletal muscle.This defect in blood flow response is apparent even in the prediabetic state,implying that it is a facet of insulin resistance and exists long before overt hyperglycaemia develops.The following review intends to summarize the contribution of blood flow impairment to the development of the atherogenic dysglycemia and dyslipidaemia. | Vaia Lambadiari Konstantinos Triantafyllou George D Dimitriadis | 2015 | World Journal of Diabetes2015，6，4： | 6 |
| 7 | KIT exon 11 codon 557/558 deletion/insertion mutations define a subset of gastrointestinal stromal tumors with malignant potential显示文摘AIM: To study the association of the frequency and pattern of KIT and PDGFRA mutations and clinicopathological factors in a group of patients with gastrointestinal stromal tumors (GIST). METHODS: Thirty patients with GIST were examined. Exons 9, 11, 13, and 17 of the KIT and exons 12 and 18 of the PDGFRA gene were analyzed for the presence of mutations by PCR amplification and direct sequencing. RESULTS: KIT or PDGFRA mutations were detected in 21 of the 30 patients (70%). Sixteen patients had mutations within KIT exon 11, three within KIT exon 9, and two within PDGFRA exon 18. GISTs with KIT exon 9 mutations were predominantly located in the small intestine, showed a spindle cell phenotype, and were assessed as potentially malignant. GISTs with KIT exon 11 mutations were located in the stomach and intestine, showed mainly a spindle cell phenotype, and were scored as potentially malignant (P < 0.05). Tumors with KIT exon 11 codon 557/558 deletion/insertion mutations were found to be associated with a potentially malignant clinical behaviour (P < 0.003). GISTs with PDGFRA mutations located in stomach showed a mixedcell phenotype and were classified as of very low or low moderate malignant potential. CONCLUSION: Determination of KIT and PDGFRA mutations should be additional parameters for the better prediction of GISTs clinical behaviour. Tumors with deletion/insertion mutations affecting codons 557/558 of the KIT gene seem to represent a distinct subset of malignant GISTs. | Katerina Kontogianni-Katsarou Euthimios Dimitriadis Constantina Lariou Evi Kairi-Vassilatou Nikolaos Pandis Agatha Kondi-Paphiti | 2008 | World Journal of Gastroenterology2008，14，12： | 4 |
| 8 | Endoclipping treatment of life-threatening rectal bleeding after prostate biopsy显示文摘Rectal bleeding is frequently seen in patients undergoing transrectal ultrasound(TRUS)-guided multiple biopsy of the prostate,but is usually mild and stops spontaneously.We report what is believed to be the first case of life-threatening rectal bleeding following this procedure,which was successfully treated by endoscopic intervention through placement of three clips on the sites of bleeding.This case emphasizes endoscopic intervention associated with endoclipping as a safe and effective method to achieve hemostasis in massive rectal bleeding after prostate biopsy.Additionally,current data on the complications of the TRUS-guided multiple biopsy of the prostate and the options for treating fulminant rectal bleeding, a consequence of this procedure,are described. | Panagiotis Katsinelos Jannis Kountouras Georgios Dimitriadis Grigoris Chatzimavroudis Christos Zavos Ioannis Pilpilidis George Paroutoglou George Germanidis Kostas Mimidis | 2009 | World Journal of Gastroenterology2009，15，9： | 4 |
| 9 | An unusual case of prolonged post-endoscopic retrograde cholangiopancreatography jaundice显示文摘Despite the effectiveness of endoscopic retrograde cholangiopancreatography(ERCP) for the treatment of choledocholithiasis, various complications have been described. We herein report the first case of prolonged postERCP jaundice due to toxicity of the contrast agent Iobitridol(~174;XENETIX, Guerbet, Roissy Cd G Cedex, France) in a patient who underwent ERCP with sphincterectomy and common bile duct stone removal. While clinical improvement and normalization of aminotransferases and cholestatic enzymes after the procedure, an unexplained increase of direct bilirubin was noticed. A second ERCP was performed one week later, excluding possible remaining choledocholithiasis. Nevertheless, serum direct bilirubin increased further up to 15 mg/d L. Other potential causes of direct hyperbilirubinemia were ruled out and patient's liver biopsy was compatible with drug-induced liver toxicity. Additionally, the cause-result time connection between the use of Iobitridol and bilirubin increase indicated the possibility of a toxic effect related to the repeated use of the particular contrast agent. Iobitridol, a contrast agent, can induce prolonged direct hyperbilirubinemia. | Georgios Tziatzios Paraskevas Gkolfakis Ioannis S Papanikolaou George Dimitriadis Konstantinos Triantafyllou | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，2： | 4 |
| 10 | Improved bowel preparation increases polyp detection and unmasks significant polyp miss rate显示文摘AIM: To retrospectively compare previous-day vs splitdose preparation in terms of bowel cleanliness and polyp detection in patients referred for polypectomy. METHODS: Fifty patients underwent two colonoscopies: one diagnostic in a private clinic and a second for polypectomy in a University Hospital. The latter procedures were performed within 12 wk of the index ones. Examinations were accomplished by two experienced endoscopists, different in each facility. Twenty-seven patients underwent screening/surveillance colonoscopy, while the rest were symptomatic. Previous day bowel preparation was utilized initially and splitdose for polypectomy. Colon cleansing was evaluated using the Aronchick scale. We measured the number of detected polyps, and the polyp miss rates per-polyp.RESULTS: Excellent/good preparation was reported in 38 cases with previous-day preparation(76%) vs 46 with split-dose(92%), respectively(P = 0.03). One hundred and twenty-six polyps were detected initially and 169 subsequently(P < 0.0001); 88 vs 126 polyps were diminutive(P < 0.0001), 25 vs 29 small(P = 0.048) and 13 vs 14 equal or larger than 10 mm. The miss rates for total, diminutive, small and large polyps were 25.4%, 30.1%, 13.7% and 6.6%, respectively. Multivariate analysis revealed that split-dose preparation was significantly associated(OR, P) with increased number of polyps detected overall(0.869, P < 0.001), in the right(0.418, P = 0.008) and in the left colon(0.452, P = 0.02). CONCLUSION: Split-dose preparation improved colon cleansing, enhanced polyp detection and unmasked significant polyp miss rates. | Ioannis S Papanikolaou Athanasios D Sioulas Nektarios Magdalinos Iosif Beintaris Lazaros-Dimitrios Lazaridis Dimitrios Polymeros Chrysoula Malli George D Dimitriadis Konstantinos Triantafyllou | 2015 | World Journal of Clinical Cases2015，3，10： | 4 |
| 11 | Effects of glucocorticoid excess on the sensitivity of glucose trans- port and metabolism to insulin in rat skeletal muscle显示文摘 | Dimitriadis G Leighton B Parry-Billlngs M | 1997 | Biochem J1997，321，3： | 1 |
| 12 | Flutter prediction from flight flutter test data显示文摘 | Dimitriadis G Cooper J E | | 0，，02： | 1 |
| 13 | Effect of hyperthyr-oidism on clearance and secretion of glucagon in man显示文摘 | Dimitriadis G Hatziagelaki E Mitrou P | 2011 | Exp Clin Endocrinol Diabetes2011，119，4： | 1 |
| 14 | Maternal transfer of humoral specific and non-specific immune parameters to sea bream (Sparus aurata) larvae 显示文摘 | Hanif A Bakopoulos V Dimitriadis G J | 2004 | Fish Shellfish Immunology2004，17，41： | 1 |
| 15 | Managing the ne-w service development process:towards a systemic model显示文摘 | STEVENS E DIMITRIADIS S | 2005 | European Journal of Marketing2005，39，12： | 1 |
| 16 | Myocardial and aortic stiffening in the early course of primary aldosteronism 显示文摘 | Tsioufis C Tsiachris D Dimitriadis K | 2008 | Clin Cardiol2008，31，9： | 1 |
| 17 | Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle显示文摘 | Dimitriadis G Leighton B Parry-Billings M | 1997 | Biochem J1997，321，： | 1 |
| 18 | Satellite handover techniques for LEO networks显示文摘 | Papapetrou E Karapantazis S Dimitriadis G and Pavlidou F | 2004 | International Journal of Satellite Communications and Networking2004，22，2： | 1 |
| 19 | Management of bile duct injury during and after laparoscopic cholecystectomy显示文摘 | Tsalis KG Christoforidis EC Dimitriadis CA | 2003 | Surg Endosc2003，17，1： | 1 |
| 20 | Cytokines and ehemokines during human embryo implantation: Roles in implantation and early placentation显示文摘 | SALAMONSEN L A HANNAN N J DIMITRIADIS E | 2007 | Semin Reprod Med2007，25，6： | 1 |
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