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| 1 | Diagnostic accuracy of endoscopic ultrasound in pancreatic neuroendocrine tumors: A systematic review and meta analysis显示文摘AIM: To detect pancreatic neuroendocrine tumors (PNETs) has been varied. This study is undertaken to evaluate the accuracy of endoscopic ultrasound (EUS) in detecting PNETs.METHODS: Only EUS studies confirmed by surgery or appropriate follow-up were selected. Articles were searched in Medline, Ovid journals, Medline nonindexed citations, and Cochrane Central Register of Controlled Trials and Database of Systematic Reviews. Pooling was conducted by both fixed and random effects model). RESULTS: Initial search identified 2610 reference articles, of these 140 relevant articles were selected and reviewed. Data was extracted from 13 studies (n = 456) which met the inclusion criteria. Pooled sensitivity of EUS in detecting a PNETs was 87.2% (95%CI: 82.2-91.2). EUS had a pooled specificity of 98.0% (95%CI: 94.3-99.6). The positive likelihood ratio of EUS was 11.1 (95%CI: 5.34-22.8) and negative likelihood ratio was 0.17 (95%CI: 0.13-0.24). The diagnostic odds ratio, the odds of having anatomic PNETs in positive as compared to negative EUS studies was 94.7 (95%CI: 37.9-236.1). Begg-Mazumdar bias indicator for publication bias gave a Kendall's tau value of 0.31 (P = 0.16), indication no publication bias. The P for χ2 heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION: EUS has excellent sensitivity and specificity to detect PNETs. EUS should be strongly considered for evaluation of PNETs. | Srinivas R Puli Nikhil Kalva Matthew L Bechtold Smitha R Pamulaparthy Micheal D Cashman Norman C Estes Richard H Pearl Fritz-Henry Volmar Sonu Dillon Michael F Shekleton David Forcione | 2013 | World Journal of Gastroenterology2013，19，23： | 14 |
| 2 | Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury. | Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，1： | 12 |
| 3 | Storage of hydrogen in single-walled carbon nanotubes显示文摘 | Dillon A C Jones K M Bekkedahl T A | 1997 | Nature1997，386，6623： | 2 |
| 4 | Transcriptional complementarity in breast cancer:application to detection of circulating tumor cells显示文摘 | Houghton R L Dillon D C Molesh D A | 2001 | Mol Diagn2001，6，2： | 1 |
| 5 | The actin cytoskeleton: integrating form and function at the synapse 显示文摘 | DILLON C GODA Y | 2005 | Annual review of neuroscience2005，28，： | 1 |
| 6 | Hydrogen storage using carbon adsorbents: past, present and future显示文摘 | Dillon A C Heben M J | 2001 | Appl Phys A2001，72，2： | 1 |
| 7 | Storage of hydrogen in single-walled carbon nanotubes 显示文摘 | DILLON A C JONES K M BEKKEDAHL T A | 1997 | Nature1997，386，6623： | 1 |
| 8 | A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference显示文摘 | Rubinson D A Dillon C P Kwiatkowski A V | 2003 | Nat Genet2003，33，3： | 1 |
| 9 | Protein kinase A- dependent phosphorylation of Rapl regulates its membrane localization and cell migration显示文摘 | Takahashi M Dillon TJ Liu C | 2013 | J t3iol Chem2013，288，27： | 1 |
| 10 | Storage of hydrogen in single-walled carbon nanotubes显示文摘 | DILLON C JONES K M BEKKEDAHL T A | 1997 | Nature1997，386，： | 1 |
| 11 | Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo 显示文摘 | Mailleux AA Spencer - Dene B Dillon C | 2002 | Development2002，129，1： | 1 |
| 12 | Interleukin 31,a cytokine produced by actived T cell,induces dermatitis in mice显示文摘 | Dillon SR Sprecher C Hammond A | 2004 | Nat Immunol2004，5，7： | 1 |
| 13 | Alentivirus-based system to functionally silence genes in primarymammalian cells, stem cells and transgenic mice by RNAinterference 显示文摘 | Rubinson D A Dillon C P Kwiatkowski A J | 2003 | Nat Genet2003，33，3： | 1 |
| 14 | On-site, rapidHIV testing with same-day results and counseling 显示文摘 | Kassler WJ Dillon BA Haley C | 1997 | AIDS1997，11，8： | 1 |
| 15 | Separation and charac- terization of Nom by high - performance liquid chromatography and on - line three - dimensional excitation emission matrix fluo- rescence detection 显示文摘 | Wu F C Evans R D Dillon P J | 2003 | Environmental Science & Technology2003，37，16： | 1 |
| 16 | Storage ofhydrogen in single - walled carbon nanotubes显示文摘 | A C Dillon K M Jones T A Bekkedahl C H Kiang D S Bethune M J Heben | 1997 | Nature1997，386，： | 1 |
| 17 | Metal oxide nano-particles for improved electrochromic and lithium battery technologies显示文摘 | DILLON A C MAHAN A H DESHPANDE R PARILLA P A JONES K M LEE K H | 2008 | Thin Solid Films2008，516，： | 1 |
| 18 | Storage of hydrogen in single- walled carbon nanotubes 显示文摘 | Dillon A C Jones K M Bekkedahl T A | 1997 | Nature1997，386，6623： | 1 |
| 19 | Storage of hydrogen in single walled carbon nanotubes显示文摘 | Dillon A C Jones K M Bekkedahl T A | 1997 | Nature1997，386，： | 1 |
| 20 | Storage of hydrogen in single-walled carbon nanotubes 显示文摘 | Dillon A C Jones K M Bekkedahl T A B | 1997 | Nature1997，386，： | 1 |
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