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| 1 | Requirement for cyclin D3 in germinal center formation and function显示文摘第二等的淋巴的纸巾的幼芽的中心(GC ) 对装高亲密关系的体液的有免疫力的回答批评。当多样化他们的抗体基因时,在 GC 以内的 B 房间经历快速的同种细胞的扩大和选择。尽管 GC B 房间采用一个唯一的 proliferative 程序提供这些进程,这通常被相信,很少联系 GC 的房间周期怎么被安排被知道。D 类型 cyclins 组成使房间能对生理的变化作出回应的房间周期引擎的一个重要部件。房间类型 -- 并且 D 类型 cyclins 的发展阶段特定的角色被描述了,但是 cyclin D 要求没在 GC 反应期间被探讨。在这研究,我们报导 cyclin D3 为切换的增长和 Ig 班大部分是非必需的在 vitro 激活的 B 房间。相反,在 Ccnd3 的 GC 开发 ?/ ?老鼠显著地被损害,作为是 T 房间依赖者抗体反应。在 GC 以内,尽管切换, unswitched B 房间被 cyclin D3 inactivation 影响, IgM?水池更严重地被减少。有趣地尽管有 cyclin D2 表示的补偿增加, Ccnd3 的一个重要数字 ?/ ?GC B 房间处于静止 G0 状态积累。最后,尽管 cyclin D3 inactivation 没在 GC B 房间破坏 BCL6 表示,支持 BCL6 overexpression 的效果完全堵住了 GC,建议 cyclin D3 调整 GC 形成的 BCL6 下游地行动。这是 cyclin D3 玩的第一示范在 B 房间开发的 GC 阶段的一个重要、唯一的角色。 | Jonathan U Peled J Jessica Yu Jeganathan Venkatesh Enguang Bi B Belinda Ding Melissa Krupski-Downs Rita Shaknovich Piotr Sicinski Betty Diamond Matthew D Scharff B Hilda Ye | 2010 | Cell Research2010，20，6： | 3 |
| 2 | Financial intermediation and delegated monitoring 显示文摘 | DIAMOND D | 1984 | Review of Economic Studies 51:393 -4141984，，： | 1 |
| 3 | Competitive interactions between endogenous LTD and LTP in the hippoeampus underlie the storage of emo- tional memories and stress-induced amnesia 显示文摘 | Diamond D M Park C R Campbell A M Woodson J C | 2005 | Hip- pocampus2005，15，： | 1 |
| 4 | Disclosure,Liquidity and the Cost of Capital显示文摘 | Diamond D Verrecchia R E | | 0，，66： | 1 |
| 5 | Vascular injuries to the extremities in a suburban trauma center显示文摘 | Diamond S Gaspard D Katz S | 2003 | Am Surg2003，69，： | 1 |
| 6 | Embryos generated using testicular spermatozoa have higher develop- mental potential than those obtained using epididymal spermatozoa in men with obstructive azoospermia 显示文摘 | Dozortsev D Neme R Diamond MP | 2006 | Fertil Steril2006，86，3： | 1 |
| 7 | Dependence of intestinal amino acid up take on dietary protein or amino acid levels 显示文摘 | Karasov W H Solberg D H Diamond J M | 1987 | Am J Physiol1987，252，： | 1 |
| 8 | Efficiency with uncertain supply 显示文摘 | Diamond D | 1980 | Review of Economics Studies1980，，48： | 1 |
| 9 | Effects of methyltestosterone on insulin secretion and sensitivity in women显示文摘 | Diamond MP Grainger D Diamond MC | 1998 | J Clin Endocrinol Metab1998，83，12： | 1 |
| 10 | Optimal Release of Information by Firms显示文摘 | Diamond D | 1983 | Journal of Finance1983，，： | 1 |
| 11 | Financial Intermediation and Delegated Monitoring 显示文摘 | Diamond D | 1984 | Review of Economic Studies1984，51，3： | 1 |
| 12 | Monitoring and reputation: The choice between bank loans and directly placed debt显示文摘 | Diamond D W | 1991 | Journal of Political Economy1991，99，： | 1 |
| 13 | Phospholipase C gamma- 1 is required downstream of vascular endothelial growth factor during arterial development显示文摘 | LAWSON N D MUGFORD J W DIAMOND B A | 2003 | Genes Dev2003，17，： | 1 |
| 14 | Correlation of protein partitioning in aqueous polymer two-phase systems 显示文摘 | DIAMOND A D HSU J T | 1990 | J Chromatogr A1990，513，： | 1 |
| 15 | Printing chemical libraries on microarrays for fluid phase naliter reactions 显示文摘 | Gosalia D Diamond S | 2003 | Proc Natl Acad Sci USA2003，100，： | 1 |
| 16 | Block and tackle:CTLA4Ig takes on lupus显示文摘 | Davidson A Diamond B Wofsy D | 2005 | Lupus2005，14，3： | 1 |
| 17 | Early and persistent up-regulated expression of renal cortical osteopontin in experimental hydronephrosis显示文摘 | Diamond JR Kess Folts D Ricardo SD | 1995 | Am J Path1995，146，4： | 1 |
| 18 | Disclosure, Liquidity and the Cost of Capital显示文摘 | Diamond D C Verrecchia R E | 1991 | Journal of Finance1991，46，： | 1 |
| 19 | Debt maturity structure and liquidity risk 显示文摘 | Diamond D W | 1991 | Quarterly Journal of Economics1991，106，： | 1 |
| 20 | Acute mortality associated with in- juries to the pelvic ring:the role of early patient mobilization and external fixation 显示文摘 | Riemer B L Butterfield S L Diamond D L | 1993 | J Trauma1993，49，3： | 1 |
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