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| 1 | The safety and efficacy of modified minimally invasive trabeculectomy for the treatment of primary chronic angle-closure glaucoma显示文摘Background: Primary chronic angle-closure glaucoma(PCACG) is one of the main types of glaucoma in China. Trabeculectomy is the most commonly used glaucoma filtration surgery for glaucoma in the world. Conventional trabeculectomy is prone to anesthesia-related complications intraoperative and operationrelated complications postoperative in PCACG treatment. Modified minimally invasive trabeculectomy maybe can reduce the incidence of complications.Methods: We conducted a prospective case series study and performed modified fornix-based trabeculectomy in 27 patients(30 eyes) under topical anesthesia; we then observed intraoperative anesthesia and cooperation ef ect, intraoperative and postoperative complications, preoperative and postoperative visual acuity, intraocular pressure(IOP), visual field, and the use of ocular hypotensive drugs. The patients were followed up for at least 12 months.Results: All operations were completed successfully with no intraoperative complications. All 27 patients(30 eyes) were followed up for at least 12 months. No significant decrease in visual acuity was observed at days 1 or 7 and at months 1, 3, 6, and 12 after operation; however, a signii cant decrease in IOP was observed at days 1 and 7 and at months 1, 3, 6, and 12 after operation. Moreover, no significant progression in visual field mean defect was observed at month 12 after operation, and the number of ocular hypotensive drugs required was significantly reduced at months 6 and 12 after operation. By month 12 after operation, the overall success rate was 93.33%(28/30).Conclusions: Modii ed minimally invasive trabeculectomy is safe and ef ective for the treatment of PCACG. | Zhenggen Wu Chukai Huang Ce Zheng Yuqiang Huang Wanqi Zhang Di Ma | 2015 | Eye Science2015，30，4： | 3 |
| 2 | SRSF1 plays a critical role in invariant natural killer T cell development and function显示文摘Invariant natural killer T(iNKT)cells are highly conserved innate-like T lymphocytes that originate from CD4^(+)CD8^(+)double-positive(DP)thymocytes.Here,we report that serine/arginine splicing factor 1(SRSF1)intrinsically regulates iNKT cell development by directly targeting Myb and balancing the abundance of short and long isoforms.Conditional ablation of SRSF1 in DP cells led to a substantially diminished iNKT cell pool due to defects in proliferation,survival,and TCRαrearrangement.The transition from stage 0 to stage 1 of iNKT cells was substantially blocked,and the iNKT2 subset was notably diminished in SRSF1-deficient mice.SRSF1 deficiency resulted in aberrant expression of a series of regulators that are tightly correlated with iNKT cell development and iNKT2 differentiation,including Myb,PLZF,Gata3,ICOS,and CD5.In particular,we found that SRSF1 directly binds and regulates pre-mRNA alternative splicing of Myb and that the expression of the short isoform of Myb is substantially reduced in SRSF1-deficient DP and iNKT cells.Strikingly,ectopic expression of the Myb short isoform partially rectified the defects caused by ablation of SRSF1.Furthermore,we confirmed that the SRSF1-deficient mice exhibited resistance to acute liver injury uponα-GalCer and Con A induction.Our findings thus uncovered a previously unknown role of SRSF1 as an essential post-transcriptional regulator in iNKT cell development and functional differentiation,providing new clinical insights into iNKT-correlated disease. | Jingjing Liu Menghao You Yingpeng Yao Ce Ji Zhao Wang Fang Wang Di Wang Zhihong Qi Guotao Yu Zhen Sun Wenhui Guo Juanjuan Liu Shumin Li Yipeng Jin Tianyan Zhao Hai-Hui Xue Yuanchao Xue Shuyang Yu | 2021 | Cellular & Molecular Immunology2021，18，11： | 3 |
| 3 | Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-as-sociated lactonase and protects low density lipoprotein against oxidation显示文摘 | Stetson PL Watson CE | 2000 | J Biol Chem2000，275，33： | 1 |
| 4 | Arbovirus infections in Sarawak:the role of the domestic pig显示文摘 | Simpson DI Smith CE Marshall TF | 1976 | Trans R Soc Trop Med Hyg1976，70，1： | 1 |
| 5 | Mechanisms of apoptosis induced by purine nucleosides in astrocytes显示文摘 | Di Iorio P Kleywegt S Ciccarelli R Traversa U Andrew CM Crocker CE | 2002 | Glia2002，38，3： | 1 |
| 6 | Ondansetron is effective in decreasing postoperative nausea and vomiting显示文摘 | Dershwitz M Rosow CE Di Blase PM | 1992 | Clin Pharmacol Ther1992，52，1： | 1 |
| 7 | C-Peptide-based assessment of insulin secretion in the Zucker fatty rat:a modelistic study显示文摘 | Di Nardo F Cogo CE Faelli E | 2015 | PLo S One2015，10，01： | 1 |
| 8 | Detection of Helicobacter pylori associated with zooplankton 显示文摘 | Cellini L Di CE Grande R | 2005 | Aquatic Microbial Ecology2005，40，2： | 1 |
| 9 | In vitro activities of oral β-lactams at concentrations achieved in humans against penicillinsusceptible and-resistant pneumococci and potential to select resistance显示文摘 | Thorbum CE Knott SJ Edwards DI | 1998 | Antimicrob Agents Chemother1998，42，： | 1 |
| 10 | Cardiac expression of 52beta,an alternative transcript of the congenital heart block-associated 52-kd SS-A/Ro autoantigen,is maximal during fetal development显示文摘 | Buyon JP Tseng CE Di Donato F | 1997 | Arthritis Rheumatism1997，40，4： | 1 |
| 11 | Inverse associationbetween physical inactivity and mental health in men and wom-en显示文摘 | Galper DI Trivedi MH Barlow CE | 2006 | Med Sci Sports Exerc2006，38，1： | 1 |
| 12 | Cardiac expression of 52beta,an alternative transcript of the congenital heart block-associated 52-kd SS-A/Ro autoantigen, is maximal during fetal development 显示文摘 | Buyon JP Tseng CE Di Donato F | 1997 | Arthritis Rheum1997，40，： | 1 |
| 13 | Role of IL-21 in immune- regulation and tumor immunotherapy 显示文摘 | di CE de Totero D Piazza T | 2007 | Cancer Immunol Immunother2007，56，9： | 1 |
| 14 | Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-associ- ated lactonase and protects low density lipoprotein against oxidation显示文摘 | Draganov DI Stetson PL Watson CE | 2000 | J Biol Chem2000，275，33： | 1 |
| 15 | Inverse association between physical inactivity and mental health in men and women显示文摘 | Galper DI Trivedi MH Barlow CE | 2006 | Med Sci Sports Exerc2006，38，1： | 1 |
| 16 | Company wide quality control ( total quality) : methodological principles and intervention techniques for step-by- step improvement显示文摘 | Corbara F Di CE | 1996 | G Ital Cardiol1996，26，： | 1 |
| 17 | Monitoring cleavage of fusion proteins by matrix-assisted laser desorption ionization/mass spectrometry:recombinant HIV-1ⅢB p26显示文摘 | Parker CE Papac DI Tomer KB | 1996 | Anal Biochem1996，239，1： | 1 |
| 18 | Associative learning,acquired equivalence,and flexible generalization of knowledge in mild Alzheimer disease显示文摘 | Bódi N Csibri E Myers CE | 2009 | Cogn Behav Neurol2009，22，2： | 1 |
| 19 | Genetic and environmental influences on cross-gender behavior and relations to behavior problems: a study of Dutch twins at ages 7 and 10 years 显示文摘 | Von Beijsterveldt CE Hudziak JJ Boomsma DI | 2006 | Arch Sex Behav2006，35，： | 1 |
| 20 | Routine neonatal postextuba-tion chest physiotherapy:A randomized controlled trial 显示文摘 | Bagley CE Gray PH Tudehope DI | 2005 | J Paediatr Child Health2005，41，11： | 1 |
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