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| 1 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 2 | An X-band microwave life-detection system显示文摘 | Devendra M Wang H | 1986 | IEEE Trans BMS1986，33，7： | 1 |
| 3 | On the corrosion behavior of magnesium and its alloy using electro-chemical techniques显示文摘 | UDHAYAN R DEVENDRA P B | 1996 | Journal of Power Sources1996，63，： | 1 |
| 4 | Do UGT1A1 and HMOX1 gene promoter polymorphisms increase the risk of hyperhilirubinemia and gallstones in patients with he- reditary spherocytosis 显示文摘 | Warang P Devendra R D'silva S | 2015 | Ann Hematol2015，94，1： | 1 |
| 5 | On the corrosion behaviour of magnesium and its alloys using electrochemi- cal techniques 显示文摘 | UDHAYAN R DEVENDRA P B | 1996 | J Power Sources1996，63，： | 1 |
| 6 | Studies in 3,4 diaryl-1,2,5-oxadiazoles and their N oxides: Search for better COX-2 inhibitors显示文摘 | Mange R Y Shrikant T S Devendra S P | 2007 | Acta Pharm2007，57，： | 1 |
| 7 | An allele-specific PCR assay for the rapid and serotypespecific detection of Salmonella pullorum显示文摘 | DESAI A R DEVENDRA A CHAE J S | 2005 | Avian Diseases2005，49，4： | 1 |
| 8 | Centrifuge modeling of moisture migration in silty soils 显示文摘 | Asha Poulose Smitha R Nair Devendra N Singh | 2000 | Joiumal of Geotechnical and Geoenvironmental Engineering2000，，： | 1 |
| 9 | Treatment glycated haemoglobin and blood pressure-lowering effect of cinna- mon in multi-ethnic type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial 显示文摘 | Akilen R Tsiami A Devendra D | 2010 | Diabet Med2010，27，10： | 1 |
| 10 | Cinnamon in gly- caemic control: systematic review and meta analysis显示文摘 | Akilen R Tsiami A Devendra D | 2012 | Clin Nutr2012，31，5： | 1 |
| 11 | Enhanced resistance to coldwater disease following feeding of probiotic bacterial strains to rainbow trout(Oncorhynchus mykiss)显示文摘 | DAVID R B DEVENDRA H S | 2011 | Aquaculture2011，321，34： | 1 |
| 12 | ()n the corrosion behaviourof magnesium and its alloys using electrochemical lech- niques显示文摘 | Udhayan R Devendra P B | 1996 | Power Sources1996，63，： | 1 |
| 13 | Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo- controlled, double-blind clinical trial显示文摘 | Akilen R Tsiami A Devendra D | 2010 | Diabet Med2010，27，10： | 1 |
| 14 | Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic type 2 diabetic patients in the UK:a randomized,placebo-controlled,double-blind clinical trial显示文摘 | Akilen R Tsiami A Devendra D | 2010 | DiabetMed2010，27，10： | 1 |
| 15 | Nitrate availability under low irradiance and its effect on the nitrate reductase activity 显示文摘 | DEVENDRA R REDDY V S | 1981 | New Phytol1981，88，： | 1 |
| 16 | On the corrosion behavfour of magnesium and its alloys using electrochemical techniques显示文摘 | Udhayan R Devendra P B | 1996 | J Power Sources1996，63，： | 1 |
| 17 | On the corrosion behavior of magnesium and its alloy using electrochemical techniques显示文摘 | Udhayan R Devendra Prakash Bhatt | 1996 | Journal of Power Sources1996，63，： | 1 |
| 18 | Cinnamon in glycaemic control: Systematic显示文摘 | Akilen R Tsiami A Devendra D | 2012 | Clin Nutr2012，31，5： | 1 |
| 19 | Allele-specific PCR method based on rfbS sequence for distinguishing Salmonella gallinarum from Salmonella pullorum:serotype-specific rfbS sequence polymorphism显示文摘 | DEVENDRA H S PARK J H CHO M R | 2005 | J Microbiol Methods2005，60，： | 1 |
| 20 | An allele-specific PCR assay for the rapid and serotype-specific detection of Salmonella pullorum显示文摘 | ATUL R D DEVENDRA H S SMRITI S | 2005 | Avian Dis2005，49，4： | 1 |
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