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| 1 | A novel pentasaccharide from immunostimulant oligosacchasride fraction of buffalo milk 显示文摘 | Desh Deepak | 1999 | Biochem Biophys Acta1999，1428，23： | 1 |
| 2 | Emerging roles of microRNAs as diagnostics and potential therapeutic interest in type 2 diabetes mellitus显示文摘BACKGROUND Type 2 diabetes mellitus(T2DM)is a metabolic disease of impaired glucose utilization.Uncontrolled high sugar levels lead to advanced glycation end products(AGEs),which affects several metabolic pathways by its receptor of advanced glycation end products(RAGE)and causes diabetic complication.MiRNAs are small RNA molecules which regulate genes linked to diabetes and affect AGEs pathogenesis,and target tissues,influencing health and disease processes.AIM To explore miRNA roles in T2DM's metabolic pathways for potential therapeutic and diagnostic advancements in diabetes complications.METHODS We systematically searched the electronic database PubMed using keywords.We included free,full-length research articles that evaluate the role of miRNAs in T2DM and its complications,focusing on genetic and molecular disease mechanisms.After assessing the full-length papers of the shortlisted articles,we included 12 research articles.RESULTS Several types of miRNAs are linked in metabolic pathways which are affected by AGE/RAGE axis in T2DM and its complications.miR-96-5p,miR-7-5p,miR-132,has_circ_0071106,miR-143,miR-21,miR-145-5p,and more are associated with various aspects of T2DM,including disease risk,diagnostic markers,complications,and gene regulation.CONCLUSION Targeting the AGE/RAGE axis,with a focus on miRNA regulation,holds promise for managing T2DM and its complications.MiRNAs have therapeutic potential as they can influence the metabolic pathways affected by AGEs and RAGE,potentially reducing inflammation,oxidative stress,and vascular complications.Additionally,miRNAs may serve as early diagnostic biomarkers for T2DM.Further research in this area may lead to innovative therapeutic strategies for diabetes and its associated complications. | Dharmsheel Shrivastav Desh Deepak Singh | 2024 | World Journal of Clinical Cases2024，12，3： | 0 |
| 3 | Comparative study on various dielectric barriers and their effect on breakdown voltage显示文摘Non-pressurised air is extensively used as basic insulation medium in high-voltage equipment.Unfortunately,an inherent property of air-insulated design is that the system tends to become physically large.On the other hand,the application of dielectric barriers can increase the breakdown voltage and therefore decrease the size of the equipment.In this study,the impact of dielectric barriers on breakdown voltage enhancement is investigated under both direct current(dc)and alternating current(ac)applied voltages.For this purpose,three kinds of dielectric barriers in two different high-voltage electrode structures are investigated.In the first structure,several experiments are carried out with four different electrode arrangements,keeping the inter-electrode gap constant while varying the position of the dielectric barrier between the electrodes.In the second structure,the inter-electrode gap is varied while the high-voltage electrode is covered with dielectric materials.The influences of different parameters such as inter-electrode spacing,electric field non-uniformity factor,and dielectric materials on the breakdown voltage are investigated for applied 50 Hz ac and dc voltages.In addition,a simulation model to approximately calculate the breakdown voltage is proposed and validated with the experimental results. | Elham Foruzan Amir A.S.Akmal Kaveh Niayesh Jeremy Lin Desh Deepak Sharma | 2018 | High Voltage2018，3，1： | 0 |
| 4 | Unusual skeletal muscle metastasis from carcinoma cervix显示文摘Cervical cancer is the most common malignancy in Indian women.It usually spreads locally or via regional lymphatics to retroperitoneal lymph nodes and hematogenous spread is rare.The occurrence of skeletal muscle metastases is a very rare event and only a few cases have been reported in literature.The authors present an unusual case of cervical carcinoma in a patient that presented with skeletal muscle metastasis 1 year after the treatment. | Mehlam Kausar Desh Deepak Ladia Abhinav Mutneja Virendra Bhandari | 2016 | Journal of Cancer Metastasis and Treatment2016，2，1： | 0 |
| 5 | What,why and how to monitor blood glucose in critically ill patients显示文摘Critically ill patients are prone to high glycemic variations irrespective of their diabetes status.This mandates frequent blood glucose(BG)monitoring and regulation of insulin therapy.Even though the most commonly employed capillary BG monitoring is convenient and rapid,it is inaccurate and prone to high bias,overestimating BG levels in critically ill patients.The targets for BG levels have also varied in the past few years ranging from tight glucose control to a more liberal approach.Each of these has its own fallacies,while tight control increases risk of hypoglycemia,liberal BG targets make the patients prone to hyperglycemia.Moreover,the recent evidence suggests that BG indices,such as glycemic variability and time in target range,may also affect patient outcomes.In this review,we highlight the nuances associated with BG monitoring,including the various indices required to be monitored,BG targets and recent advances in BG monitoring in critically ill patients. | Deven Juneja Desh Deepak Prashant Nasa | 2023 | World Journal of Diabetes2023，14，5： | 0 |
| 6 | Co-positivity of anti-dengue virus and anti-Japanese encephalitis virus IgM in endemic area:co-infection or cross reactivity?显示文摘Objective:To report high co-positivity of anti-dengue virus(DV)and anti-Japanese encephalitis virus(JEV)IgM in an area endemic for both the viruses and to discuss the possibilities of coinfection.Methods:Serum samples from the patients who presented with fever,suspected central nervous system infection and thrombocytopenia,were tested for anti-DV IgM and antiJEV IgM antibodies.Conventional reverse transcriptase polymerase chain reaction was done for detection of DV RNA and JEV RNA.Results:Of 1 410 patient sera tested for anti-DV and antiJEV antibodies,129(9.14%)were co-positive for both.This co-positivity was observed only in those months when anli-JEV IgM positivily was high.Tilers of both anli-DV IgM and anti-JEV IgM were high in most of the co-positive eases.Among these 129 co-positive cases,76 were lesled by conventional reverse Iranscriplase polymerase chain reaction for both flaviviruses,of which eight cases were co-positive for DV and JEV.Conclusions:Co-infection with more than one fluvivirus species can occur in hyperendemic areas. | Kaleshwar Prasad Singh Gitika Mishra Parul Jain Nidhi Pandey Rachna Nagar Shikha Gupta Shantanu Prakash Om Prakash Danish Nasar Khan Sakshi Shrivastav Desh Deepak Singh Amita Jain | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，2： | 0 |
| 7 | Comparative analysis of Nε-carboxymethyl-lysine and inflammatory markers in diabetic and non-diabetic coronary artery disease patients显示文摘BACKGROUND Coronary artery disease(CAD)is a major cause of death worldwide,and India contributes to about one-fifth of total CAD deaths.The development of CAD has been linked to the accumulation of Nε-carboxymethyl-lysine(CML)in heart muscle,which correlates with fibrosis.AIM To assess the impact of CML and inflammatory markers on the biochemical and cardiovascular characteristics of CAD patients with and without diabetes.METHODS We enrolled 200 consecutive CAD patients who were undergoing coronary angiography and categorized them into two groups based on their serum glycosylated hemoglobin(HbA1c)levels(group I:HbA1c≥6.5;group II:HbA1c<6.5).We analyzed the levels of lipoproteins,plasma HbA1c levels,CML,interleukin-6(IL-6),tumor necrosis factor alpha(TNF-α),and nitric oxide.RESULTS Group I (81 males and 19 females) patients had a mean age of 54.2 ± 10.2 years, with a mean diabetes duration of4.9 ± 2.2 years. Group II (89 males and 11 females) patients had a mean age of 53.2 ± 10.3 years. Group I had moresevere CAD, with a higher percentage of patients with single vessel disease and greater stenosis severity in the leftanterior descending coronary artery compared to group II. Group I also exhibited a larger left atrium diameter.Group I patients exhibited significantly higher levels of CML, TNF-α, and IL-6 and lower levels of nitric oxide ascompared with group II patients. Additionally, CML showed a significant positive correlation with IL-6 (r = 0.596,P = 0.001) and TNF-α (r = 0.337, P = 0.001) and a negative correlation with nitric oxide (r=-4.16, P = 0.001). Oddsratio analysis revealed that patients with CML in the third quartile (264.43-364.31 ng/mL) were significantlyassociated with diabetic CAD at unadjusted and adjusted levels with covariates. | Dharmsheel Shrivastav Desh Deepak Singh Rashid Mir Pratishtha Mehra Vimal Mehta Pradeep Kumar Dabla | 2023 | World Journal of Diabetes2023，14，12： | 0 |
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